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MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin

Yes / Phenylacetyl-peptide amphiphiles were designed, which upon cleavage by a disease-associated enzyme reconfigure from micellar aggregates to fibres. Upon this morphological change, a doxorubicin payload could be retained in the fibres formed, which makes them valuable carriers for localised formation of nanofibre depots for slow release of hydrophobic anticancer drugs.

Identiferoai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/11430
Date28 October 2014
CreatorsKalafatovic, D., Nobis, M., Javid, Nadeem, Frederix, P.W.J.M., Anderson, K.I., Saunders, B.R., Ulijn, R.V.
Source SetsBradford Scholars
LanguageEnglish
Detected LanguageEnglish
TypeArticle, Published version
Rights(c) 2015 The Authors. This is an Open Access article distributed under the Creative Commons CC-BY license (http://creativecommons.org/licenses/by/3.0/), CC-BY

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