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Previous issue date: 2015-07-31 / Introduction: recent evidence has linked vitamin D to benefits in lung health. Little is known, however, about the impact of vitamin D on clinical outcomes in children with cystic fibrosis (CF). In this study, we evaluated the association between vitamin D levels and nutritional status, pulmonary function (PF) and pulmonary exacerbations in children and adolescents with CF.
Methods: 25-hydroxyvitamin D (25[OH]D) levels of 37 children and adolescents were evaluated retrospectively. Pulmonary function data, albumin, body mass index (BMI), height for age (H/A) and pulmonary exacerbations episodes were associated with vitamin D levels divided into two groups: normal (?30ng/ml) and insufficient (<30ng/ml).
Results: hypovitaminosis D (25[OH]D <30ng/ml) was observed in 54% of patients. The mean of 25(OH)D was 30,53?12,14ng/ml. Pulmonary function and nutritional status were not associated with vitamin D levels. The number of pulmonary exacerbations over a period of two years (p=0,007) and post-dosing period of 25(OH)D (p=0,002) was significantly higher in patients with hypovitaminosis D. There was a trend of lower 25(OH)D levels during autumn and winter (p=0,067).
Conclusion: vitamin D deficiency was associated with higher rates of pulmonary exacerbation in children and adolescents with CF. Vitamin D can be a marker of disease severity or be a significant causal factor for a higher number of pulmonary exacerbations. Prospective studies can help to clarify the causality of this association. / Introdu??o: recentes evid?ncias t?m associado a vitamina D a benef?cios na sa?de pulmonar. Pouco se sabe, entretanto, sobre o impacto da vitamina D em desfechos cl?nicos na popula??o pedi?trica com fibrose c?stica (FC). Neste estudo, avaliamos as associa??es entre os n?veis de vitamina D e o estado nutricional, a fun??o pulmonar (FP) e as exacerba??es pulmonares (EP) em crian?as e adolescentes com FC.
M?todos: n?veis de 25-hidroxivitamina D (25[OH]D) de 37 crian?as e adolescentes foram avaliados retrospectivamente. Dados de fun??o pulmonar, albumina, ?ndice de massa corporal (IMC), estatura para idade (E/I) e epis?dios de exacerba??o pulmonar foram associados com n?veis de vitamina D divididos em dois grupos: normal (?30ng/ml) e insuficiente (<30ng/ml).
Resultados: a hipovitaminose D (25[OH]D <30ng/ml) foi observada em 54% dos pacientes. A m?dia de 25(OH) D foi 30,53?12,14ng/ml. Fun??o pulmonar e estado nutricional n?o se associaram com os n?veis de vitamina D. O n?mero de exacerba??es pulmonares em um per?odo de dois anos (p=0,007) e no per?odo p?s-dosagem da 25(OH)D (p=0,002) foi significativamente maior em pacientes com hipovitaminose D. Houve uma tend?ncia de menores n?veis de 25(OH)D nos per?odos de outono e inverno (p=0,067).
Conclus?o: a hipovitaminose D se associou com maiores taxas de exacerba??o pulmonar em crian?as e adolescentes com FC. A vitamina D pode ser um marcador de gravidade da doen?a ou ainda ser um fator causal relevante para um n?mero mais elevado de exacerba??es pulmonares. Estudos prospectivos podem contribuir para esclarecer a causalidade desta associa??o.
| Identifer | oai:union.ndltd.org:IBICT/oai:tede2.pucrs.br:tede/6350 |
| Date | 31 July 2015 |
| Creators | Ongaratto, Renata |
| Contributors | Pinto, Leonardo Ara?jo |
| Publisher | Pontif?cia Universidade Cat?lica do Rio Grande do Sul, Programa de P?s-Gradua??o em Medicina/Pediatria e Sa?de da Crian?a, PUCRS, Brasil, Faculdade de Medicina |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da PUC_RS, instname:Pontifícia Universidade Católica do Rio Grande do Sul, instacron:PUC_RS |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 3098206005268432148, 600, 600, 600, -8624664729441623247, -969369452308786627 |
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