Effects of drugs are in clinical trials often measured on categorical scales. These measurements are increasingly being analyzed using mixed-effects logistic regression. However, the experience with such analyzes is limited and only a few models are used. The aim of this thesis was to investigate the performance and improve the use of models and methods for mixed-effects categorical data analysis. The Laplacian method was shown to produce biased parameter estimates if (i) the data variability is large or (ii) the distribution of the responses is skewed. Two solutions are suggested; the Gaussian quadrature method and the back-step method. Two assumptions made with the proportional odds model have also been investigated. The assumption with proportional odds for all categories was shown to be unsuitable for analysis of data arising from a ranking scale of effects with several underlying causes. An alternative model, the differential odds model, was developed and shown to be an improvement, in regard to statistical significance as well as predictive performance, over the proportional odds model for such data. The appropriateness of the likelihood ratio test was investigated for an analysis where dependence between observations is ignored, i.e. performing the analysis using the proportional odds model. The type I error was found to be affected; thus assessing the actual critical value is prudent in order to verify the statistical significance level. An alternative approach is to use a Markov model, in which dependence between observations is incorporated. In the case of polychotomous data such model may involve considerable complexity and thus, a strategy for the reduction of the time-consuming model building with the Markov model and sleep data is presented. This thesis will hopefully contribute to a more confident use of models for categorical data analysis within the area of pharmacokinetic and pharmacodynamic modelling in the future.
| Identifer | oai:union.ndltd.org:UPSALLA1/oai:DiVA.org:uu-9333 |
| Date | January 2008 |
| Creators | Kjellsson, Maria C. |
| Publisher | Uppsala universitet, Avdelningen för farmakokinetik och läkemedelsterapi, Uppsala |
| Source Sets | DiVA Archive at Upsalla University |
| Language | English |
| Detected Language | English |
| Type | Doctoral thesis, comprehensive summary, info:eu-repo/semantics/doctoralThesis, text |
| Format | application/pdf |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy, 1651-6192 ; 83 |
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