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Previous issue date: 2010-02-11 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior, CAPES / Interest in fungi and the mycotoxins is enormous, not only from the scientific point of view,
but also in the economic outlook. There are many problems arising from the farmer to the
consumer. Low yields, deteriorating levels in commercial husbandry of animals and disease in
them, changes in food, loss of sensory and nutritional characteristics, increased costs resulting
from the prevention and treatment of decontamination are among some of the disorders
generated by the presence of fungi and their matab?litos. Ochratoxin A occupies every day a
major role in the setting of Mycotoxicology due to its importance. Many efforts have been
undertaken to define the global situation of occurrence of this mycotoxin. This study focused
on a set in specific areas the occurrence of this mycotoxin, which not long ago was ignored in
the setting of contaminants in Brazil as well as putting into practice the methods of detection
of OTA in pig serum. We collected 400 samples of blood serum from pig slaughterhouses in
four different states. These samples were processed and subjected to techniques for
determining liquid chromatography with high efficiency to determine concentrations of the
toxin in the study. RESULTS: The mean concentration of ochratoxin A in pig blood serum
samples with levels above the limit of detection was 23.729 ?g/L. CONCLUSIONS:
Ochratoxin A is present in the pork produced in Brazil. All the samples surveyed were above
the limit of detection and quantification. The colder climate favors the development of
ochratoxin A, demonstrated the highest level of positive samples with limits above 5 ?g/L in
the State of Santa Catarina (52%). The state of Mato Grosso showed the highest number of
positive samples for ochratoxin A above the limit detectable by the technique used (69%).
The State of Bahia showed the greatest number of samples below the detectable limit (64%). / O interesse pelos fungos e pelas micotoxinas ? enorme, n?o s? do ponto de vista cient?fico,
como tamb?m sob a perspectiva econ?mica. S?o muitos os problemas gerados desde o
agricultor at? o consumidor final. Baixos rendimentos da colheita, deterioramento de n?veis
zoot?cnicos na produ??o comercial de animais e doen?a nos mesmos, altera??es nos
alimentos, perdas de caracter?sticas sensoriais e nutricionais, aumento dos custos derivados da
preven??o e do tratamento descontaminante est?o entre alguns dos transtornos gerados pela
presen?a dos fungos e seus matab?litos. A ocratoxina A ocupa a cada dia um papel de
destaque no cen?rio da micotoxicologia devido a sua import?ncia. Muitos esfor?os t?m sido
empreendidos para se definir a situa??o mundial da ocorr?ncia desta micotoxina. Este trabalho
teve como foco principal definir em algumas ?reas espec?ficas a ocorr?ncia desta micotoxina,
que h? pouco tempo atr?s era ignorada dentro do cen?rio dos contaminantes nos produtos
brasileiros, al?m de colocar em pr?tica a metodologia de detec??o de OTA em soro su?no.
Foram coletadas 400 amostras de soro sangu?neo su?no em diferentes matadouros de quatro
estados brasileiros. Estas amostras foram processadas e submetidas a t?cnicas de
determina??o por cromatografia l?quida de alta efici?ncia para se determinar suas
concentra??es da toxina em estudo. RESULTADOS: A concentra??o m?dia de ocratoxina A
no soro sangu?neo su?no das amostras com n?veis acima do limite de detec??o foi de 23,729
?g/L. CONCLUS?ES: A ocratoxina A est? presente no su?no produzido no Brasil. Todos os
Estados pesquisados apresentaram amostras acima do limite de detec??o e quantifica??o. O
clima mais frio favorece o aparecimento de ocratoxina A, demonstrado no maior n?vel de
amostras positivas com limites acima de 5 ?g/L no Estado de Santa Catarina (52%). O Estado
de Mato Grosso apresentou o maior n?mero de amostras positivas para ocratoxina A acima do
limite detect?vel pela t?cnica utilizada (69%). O Estado da Bahia foi o que apresentou maior
quantidade de amostras abaixo do limite detect?vel (64%).
Identifer | oai:union.ndltd.org:IBICT/oai:localhost:jspui/1153 |
Date | 11 February 2010 |
Creators | KRUGER, Cesar Daniel |
Contributors | Rosa, Carlos Alberto da Rocha, Direito, Gloria Maria, Cavaglieri, Lilia Renee |
Publisher | Universidade Federal Rural do Rio de Janeiro, Programa de P?s-Gradua??o em Ci?ncias Veterin?rias, UFRRJ, Brasil, Instituto de Veterin?ria |
Source Sets | IBICT Brazilian ETDs |
Language | Portuguese |
Detected Language | English |
Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
Format | application/pdf |
Source | reponame:Biblioteca Digital de Teses e Dissertações da UFRRJ, instname:Universidade Federal Rural do Rio de Janeiro, instacron:UFRRJ |
Rights | info:eu-repo/semantics/openAccess |
Relation | ABARCA M.L., ACCENSI F., BRAGULAT M.R., CABA?ES F.J. Current importance of ochratoxin A-producing Aspergillus spp. Journal of Food Proteccion, v. 64, p. 903-906, 2001. ABRAMSON, D. Toxicants of the Genus Penicillium. In: D'MELLO, J. P. F. (Org.). Handbook of Plant and Fungal Toxicants. New York: CRC Press, 1997. p. 303-317. ABRAMSON, D.; MILLS, J. T.; SINHA, R. N. Mycotoxin production in amber durum weath stored at 15 and 19% moisture content. Food Additives and Contaminants, v. 7, p. 617-627, 1990. ABRAMSON, D.; SINHA, R. N.; MILLS, J. T. Mycotoxin formation in HY-320 wheat during granary storage at 15 and 19% moisture content. Mycophatologia, v. 11, p. 181-189, 1990. ABRUNHOSA, L., PATERSON, R. R., KOZAKIEWICZ, Z., LIMA, N., VEN?NCIO, A. Mycotoxin production from fungi isolated from grapes. Letters in Applied Microbiology, v. 32, p. 240-242, 2001. ALEXOPOLUS, C. J.; MIMS, C. W.; BLACKWELL, M. Introductory mycology. 4. ed. New York: Jhon Wiley and Sons Inc., 1996. 254 p. ALLCROFT, R.; CARNAGHAN, R.B.A.; SARGEANT, K.; O?KELLEY, J. A toxic factor in Brazilian groundnut meal. Veterinary Record. v. 73, n. 17, p. 428-429, 1961. ALMEIDA, A.P.; ALABURDA, J.; RUVIERI, V.; SABINO, M. Ochratoxin A in raisins samples marketed in S?o Paulo, Brazil. Revista do Instituto Adolfo Lutz. v. 65, p. 171-175, 2006. ?LVAREZ, L; GIL, A.G.; EZPELETA, O.; GARCI?-JAL?N, J.A.; CERAIN, L.A. Immunotoxic effects of ochratoxin A in wistar rats after oral administration. Food and Chemical Toxicology, v.42, n.5, p.825?834, 2004. AOAC. Association of Official Analytical Chemists, Official Methods of Analysis..Sec. 972-26 - 976-22. Gaithersburg, MD, 1995. ASEVEDO, I.G.; GAMBALE, W.; CORREA, B.; PAULA, C.R.; ALMEIDA, R.M.A.; SOUZA, V.M. Mycoflora and aflatoxigenic species of Aspergillus spp isolated from stored maize. Revista de Microbiologia.v.25, n.1, p.46-50, 1994. ASSOCIA??O BRASILEIRA DA IND?STRIA PRODUTORA E EXPORTADORA DE CARNE SU?NA ? ABIPECS. Relat?rio Anual 2004. Dispon?vel em: <http://www.abipecs.org.br>. Acesso em: 01 fev. 2009. BARISIC, K.; PETRIK, J.; RUMORA, L.; CEPELAK, I.; GRUBISIC, T.Z.; Expression of Hsp70 in kidney cells exposed to ochratoxin A. Archives of toxicology. v.76, n.4, p.218-226, 2002. Bell?, N., Mar?n, S., Duaigues, A., Ramos, A. J., & Sanchis, V. (2004a). Ochratoxin A in wines, musts and grape juices from Spain. Journal of the Science of Food and Agriculture 84, 591-594. BELL?, N., MAR?N, S., SANCHIS, V., RAMOS, A. J. Review: Ochratoxin A (OTA) in Wines, Musts and Grape Juices: Occurrence, Regulations and Methods of Analysis. Food Science and Technology International. v. 8, p. 325-335, 2002. 60 BENNETT, J.W.; KLICH, M. Mycotoxins. Clinical Microbiology Reviews. v.16, n.3, p.497- 516, 2003. BERETTA, B., DE DOMENICO, R., GAIASCHI, A., BALLABIO, C., GALLI, C. L., GIGLIOTTI, C. Ochratoxin A in cereal-based baby foods: occurrence and safety evaluation. Food Additives and Contaminants. v. 19, p. 70-75, 2002. BERGER, V.; GABRIEL, A.F.; SERGENT, T.; TROUET, A.; LARONDELLE, Y.; SCHNEIDER, Y.J. Interaction of ochratoxin A with human intestinal Caco-2 cells: possible implication of a multidrug resistance-associated protein (MRP2). Proceedings of EUROTOX 2002, The XL congress of the European societies of Toxicology. Hungary. Toxicology Letters. v.140-141, p.465-476, 2003. BETINA, V. Mycotoxins as secondary metabolites. In: BETINA V. (Org.). Mycotoxins: chemical, biological and environmental aspects. New York: Elsevier, 1989. p. 25-47. BIGELIS, R. Fungal metabolites in food processing. In: BHATNAGAR, D.; LILLEHOJ, E.B.; ARORA, D.K. Handbook of Applied Mycology: Foods and feeds. New York: Mercel Dekker, INC., 1992. p.415-443. BILGRAMI, K. S., CHOUDHARY, A. K. Mycotoxins in preharvest contamination of agricultural crops. In: SINHA, K.K., BHATNAGAR, D. (Org.), Mycotoxins in agriculture and food safety, New York: Marcel Dekker, 1998. p. 1-43. BIRO, K.; BARNA-VETRO, H.; PEESI, T.; SZABO, E.; WINKLER, G.; FINKGREMMELS, J.; SOLTI, LASZLO. Evaluation of spermatological parametres in ochratoxin A ? challenge boars. Theriogenology. v.60, p.199-207, 2001. BLESA, J., SORIANO, J. M., MOLT?, J. C., MA?ES, J. Concentration of ochratoxin A in wines from supermarkets and stores of Valencian Community (Spain). Journal of Chromatography A 1054, 397-401, 2004. BLESA, J.; BERRADA, H.; SORIANO, J.M.; MOLT?, J.C.; MA?ES, J. Rapid determination of ochratoxin A in cereals and cereal products by liquid chromatography. Journal of Chromatography A. v.1046, n.1-2, p.127?131, 2004. BLOUNT, W. P. Turkey X disease, Journal British Turkey Feeding, v. 9, n. 2, p. 52-77, 1961. BOUTRIF, E.; CANET, C. Mycotoxin prevention and control. FAO programs. Revue M?dicine V?terinaire, v. 149, p. 681-694, 1998. BOZIC, Z., DUANCIC, V., BELICZA, M., KRAUS, O., & SKLJAROV, I.. Balkan endemic nephropathy: still a mysterious disease. European Journal of Epidemiology, v. 11, p. 235- 238, 1995. STUDER-ROHR, I; SCHLATTER, J.; DIETRICH, D.R. Kinetic parameters and intraindividual fluctuations of ochratoxin A plasma levels in humans. Archives of Toxicology. v. 74, p. 499-510, 2000. BRANCO, E.L.C. B?lc?s: Eterna instabilidade pol?tico-geogr?fico. Dispon?vel em: <http://www.eduquenet.net/balcas.htm>. Acesso em: 03 fev. 2006. BRASIL. Minist?rio da Agricultura, do Abastecimento e da Reforma Agr?ria. Portaria no 183, de 21 de mar?o de 1996. Adota o regulamento t?cnico MERCOSUL sobre seus limites. BRASIL. Minist?rio da Sa?de. RDC 274 da ANVISA, de 15 de outubro de 2002. Aprova o regulamento t?cnico sobre limites m?ximo de aflatoxina admiss?veis no leite, no 61 amendoim, no milho, constante do anexo desta resolu??o. Di?rio Oficial [da] Rep?blica Federativa do Brasil, Bras?lia, DF, 16 out. 2002. BRAUNBERG, R.C.; BARTON, C.; FRIEDMAN, L. In vitro effects of the nephrotoxins ochratoxin A and citrinin upon biochemical function of porcine kidney. Archives of Environmental Contamination and Toxicology. v.22, n. 4, p.464 - 470, 1992. BRAUNBERG, R.C.; BARTON, C.N.; GANTT, O.O.; FRIEDMAN, L. Interaction of citrinin and ochratoxin A. Natural Toxins. v.2, n.3, p.124-131, 1994. B?CHMANN, N.B.; HALD, B. Analysis, occurrence and control of ochratoxin A residues in Danish pig kidneys. Food additives and contaminants, v.2, n.3, p.193-199, 1985. BULLERMAN, L. B.; SCHROEDER, L. L.; PARK, K. Y. Formation and control of mycotoxins in food. Journal of Food Protection, v. 47, n. 8, p. 637-646, 1984. CALDAS, E.D.; SILVA, S.C.; OLIVEIRA, J.N. Aflatoxinas e ocratoxina A em alimentos e riscos para a sa?de humana. Revista de Sa?de P?blica. v.36, n.3, p.319-323, 2002. CAMPBELL, H., CHOO, T. M., VIGIER, B., & UNDERHILL, L. Mycotoxins in barley and oat samples from eastern Canada. Canadian Journal of Plant Science 80, 977-980, 2000. CAMPBELL, I. M. Secondary metabolism and microbial physiology. Advances in Microbiological Physology, v. 25, p. 198-201, 1984. CAMPOS, S.G. Micotoxicose. Revista do Conselho Federal de Medicina Veterin?ria. v.5, n.16, p.28-29, 1999. CAMPOS, S.G.; CAVAGLIERI, L. R, FERN?NDEZ JURI, M. G, DALCERO, A. M.,KR?GER, C.D., KELLER, L.A.M., MAGNOLI, C.E., ROSA, C.A. R. Mycobiota and aflatoxins in raw materials and pet food in Brazil. Journal of Animal Physiology and Animal Nutrition. v. 92, p.377?383, 2008. CANELA, R.; VILADRICH, R.; VELAZQUEZ, C.A.; SANCHIS, V. A survey of porcine kidneys and chicken liver for ochratoxin A in Spain. Mycopathologia. v.125, n.1, p.29-32, 1994. CARDOZO, S.V.; TEIXEIRA FILHO, W.L.; KRUGER, C.D.; ROSA, C.A.R.; FERREIRA, A.M.R.; MACEDO, H.W.; LOPES, C.W.G. Altera??es hep?ticas na aflatoxicose experimental em codornas japonesas (Coturnix japonica) em fase inicial de crescimento. Revista Brasileira de Medicina Veterin?ria. v.30, n. 4, p. 210-214, 2008. CAST. Mycotoxins: risks in plant, animal and human systems. In: Task Force Report 139. Ames: Council for Agricultural Science and Technology, 2003. CAST. Mycotoxins. Economic and healt risks. In: Task Force Report 116. Ames: Council for Agricultural Science and Technology, 1989. 199 p. CASTELLARI, M., FABBRI, S., FABIANI, A., AMATI, A., GALASSI, S. Comparison of different immunoaffinity clean-up procedures for high-performance liquid chromatographic analysis of ochratoxin A in wines. Journal of Chromatography A, v. 888, p. 129-136. 2000. CECCI, E.; BOZZO, G.; BONERBA, E.; DI PINTO, A.; TANTILLO, M.G. Ochratoxin A detection by HPLC in target tissues of swine and cytological and histological analysis. Food Chemistry. n.105, p.364-368, 2007. CERAIN, A.L.; JIM?NEZ, A.M.; EZPELETA, O.; BELLO, J. Efectos t?xicos de la ocratoxina A. Reviews in Toxicology. v.17, p.61-69, 2000. 62 CHIAVARO, E., LEPIANI, A., COLLA, F., BETTONI, P., PARI, E., SPOTTI, E. Ochratoxin A determination in ham by immunoaffinity clean-up and a quick fluorometric method. Food Additives and Contaminants 19, 575-581. 2002. CHU, F.S. Recent progress in analytical techniques for mycotoxins in feedstuffs. Journal of Animal Science. v.70, n.12, p.3950-3963, 1992. CLEAR, R. M., PATRICK, S. K., GABA, D. Prevalence of fungi and fusariotoxins on barley seed from western Canada, 1995 to 1997. Canadian Journal of Plant Pathology. v. 22, p. 44-50, 2000. COELHO, C.S.P.; FURLONG, E.B.; ALMEIDA, T.L. Migra??o de micotoxinas durante a parboiliza??o do arroz. Brazilian Journal of Food Technology. p. 39-44, v.2; n.1,2, 1999. COMISS?O ECON?MICA EUROP?IA (CEE). DIRETIVA 2002/26/CE de 13 de mar?o de 2002. Fixa os m?todos de colheita de amostras e de an?lise para o controlo oficial do teor de ocratoxina A nos g?neros aliment?cios. Jornal Oficial das Comunidades Europ?ias. L.75, p.38-43, 16 mar. 2002. Dispon?vel em: <http://europa.eu.int/eurlex/ pt/consleg/pdf/2002/pt_2002L0026_do_001.pdf >. Acesso em: 20 jan 2006. COOK, W.O.; OSWEILER, G.D.; ANDERSON, T.D.; RICHARD, J.L. Ochratoxicosis in Iowa swine. Journal the American Veterinary Medical Association. v.188, n.12, p.1399- 1402, 1986. COSTA, T.P.; GERMANO, P.M.L.; GERMANO, M.I.S. Seguran?a alimentar e a cerveja: o perigo das micotoxinas. Higiene Alimentar. v.19, n.137, p.39-46, 2006. CREPPY, E. E., BAUDRIMONT, I., ANNE, M. How aspartame prevents the toxicity of ochratoxin A. Journal of Toxicological Sciences, v. 23, supl. 2, p. 165-172, 1998. CREPPY, E.E. Update of survey, regulation and toxic effects of mycotoxins in Europe. Toxicology Letters. v.127, n.1-3, p.19-28, 2002. CRUZ, L. C. H.; ROSA, C. A. R. Aborto mic?tico em bovinos. Considera??es sobre o diagn?stico e revis?o de literatura relevante. Revista Brasileira de Medicina Veterin?ria, v.4, n. 1, p. 16-19, 1981. CRUZ, L.C.H.; ROSA, C.A.R.; CAMPOS, J.C.; TURATTI, J.A. Ocratoxicose em su?nos no Estado de Santa Catarina. Revista Brasileira de Medicina Veterin?ria. v.6, n.1, p.17, 1984. CURTUI, V.G.; GAREIS, M. A simple HPLC method for the determination of the mycotoxins ochratoxin A and B in blood serum of swine. Food Additives and Contaminants. v.18, n.7, p.635-643, 2001. CURTUI, V.G; GAREIS, M.; USLEBER, E.; M?RTLBAUER, E. Survey of Romanian slaughtered pigs for the occurrence of mycotoxins ochratoxins A and B, and zearalenona. Food Additives and Contaminats. v.18, n.8, p.730-738, 2001. CZERWIECKI, L.; CZAJKOWSKA, D.; WITKOWSKA-GWIAZDOWSKA, A. On ochratoxin A and fungal flora in Polish cereals from conventional and ecological farms. Part 2: Occurrence of ochratoxin A and fungi in cereals in 1998. Food additives and contaminants. v.19, n.11, p.1051-1057, 2002. DALCERO, A., MAGNOLI, C., CHIACCHIERA, S., PALACIOS G., REYNOSO, M. Mycoflora and incidence of aflatoxin B1, zearalenone and deoxinyvalenol in poultry feeds in Argentina. Mycopathologia, v. 137, p. 179-184, 1997. 63 DALCERO, A., MAGNOLI, C., LUNA, M., ANCASI, G., REYNOSO, M., CHIACCHIERA, S., MIAZZO, R., PALACIO, G. Mycoflora and naturally occurring mycotoxins in poultry feeds in Argentina.. Mycopathologia. v.141, p.37-43, 1998. DALCERO, A.; MAGNOLI, C.; HALLAK, C.; CHIACCHIERA, S.M.; PALACIO, G.; ROSA, C.A.R. Detection of ochratoxin A in animal feeds and capacity to produce this mycotoxin by Aspergillus section nigri in Argentina. Food additives and contaminants. v.19, n.11, p.1065-1072, 2002. DALL?ASTA, C., GALAVERNA, G., DOSSENA, A., MARCHELLI, R. Reverse-phase liquid chromatographic method for the determination of ochratoxin A in wine. Journal of Chromatography A 1024, 275-279, 2004. DESJARDINS, A. E., MANANDHAR, H. K., PLATTNER, R. D., MANANDHAR, G. G., POLING S. M., MARAGOS1C. M. Fusarium species from nepalese rice and production of mycotoxins and gibberellic acid by selected species. Applied and Environmental Microbiology, v.66, n.3, p.1020-1025, 2000. DI PAOLO, N. et al. Acute renal failure from inhalation of mycotoxins. Nephron. v.64, n.4, p.621-625, 1993. DILKIN, P. Micotoxicose su?na: aspectos preventivos, cl?nicos e patol?gicos. Biol?gico. v.64, n.2, p.187-191, 2002. DOMIJAN, A.M.; PERAICA, M.; MILETIC-MEDVED, M.; LUCIC, A.; FUCHS, R. Two different clean-up procedures for liquid chromatographic determination of ochratoxin A in urine. Journal of Chromatography B. v.798, n.2, p.317?321, 2003. DRAGACCI, S.; GROSSO, F.; BIRE, R.; FREMY, J.M.; COULON, S. A French monitoring programme for determining ochratoxin A occurrence in pig kidneys. Natural Toxins. v.7, n.4, p. 167?173, 1999. DUARTE, R.R.; CARVALHO, E.C.Q.; ROSA, C.A.R. Aflatoxina em f?gados de frangos de corte, com esteatose, abatidos industrialmente no Estado de Rio de Janeiro. Revista Brasileira de Ci?ncias Veterin?rias, v.4, p.117-120, 1997. DUNKEL, F. V. The stored grain ecosystem. Journal of Stored Products Research., v. 28, p. 73:87, 1992. DWIVEDI, P.; BURNS, R.B. Pathology of ochratoxicosis in young broiler chickens. Research in Veterinary Science. v.36, n.1, p.92-103, 1984. DWIVEDI, P.; BURNS, R.B.; MAXWELL, M.H. Ultrastructural study of the liver and kidney in ochratoxicosis A in young broiler chicks. Research in Veterinary Science. v.36, n.1, p.104-116, 1984. ELLING, F. Demonstration of ochratoxin A in kidneys of pigs and rats by immunofluorescence microscopy. Acta Pathologica et Microbiologica Scancinavica, Section A. v.85 A, n.2, p.151-156, 1977. ELLING, F.; HALD, B.; JACOBSEN, C.; KROGH, P. Spontaneous cases of toxic nephropathy in poultry associated with ochratoxin A. Acta Pathologica et Microbiologica Scancinavica, Section A. v.83, n.6, p.739-741, 1975. ELLING, F.; M?LLER, T. Mycotoxic nephropathy in pigs. Bulletin of the world health organization. v.49, n.4, p.411-418, 1973. 64 ELLING, F.; NIELSEN, J.P.; LILLEHOJ, E.B.; THOMASSEN, M.S.; STORMER, F.C. Ochratoxin a-induced porcine nephropathy: enzyme and ultrastructure changes after shortterm exposure. Toxicon. v.23, n.2, p.247-254, 1985. ENTWISLE, A.C.; JORGENSEN, K.; WILLIAMS, A.C.; BOENKE, A.; FARNELL, P.J. An intercomparison of methods for the determination of ochratoxin A in pig kidney. Food Additives and Contaminants. v.14, n.3, p.223-236, 1997. FAO. Manual on the Application of the HACCP System in Mycotoxin Prevention and Control. Food and Nutrition paper 73, 2001. Dispon?vel em: <http://www.fao.org> Acesso em 10 mar 2009. FAO. Worldwide regulations for mycotoxins in food and feed in 2003. Food and Nutrition paper 81, 2004. Dispon?vel em <ftp://ftp.fao.org> Acesso em 10 mai 2009. FAO,. Estrategia de la FAO relativa al enfoque de calidad e inocuidad de los alimentos basado en la cadena alimentaria: documento marco para la formulaci?n de la futura orientaci?n estrat?gica. COAG/2003/5, 2003. Dispon?vel em: <ftp://ftp.fao.org> Acesso em 10 jul 2008. FAZEKAS, B.; TAR, A. K.; ZOMBORSZKY-KOVACS, M. Ochratoxin A contamination of cereal grains and coffee in Hungary in the year 2001. Acta Veterinaria Hungarica. v. 50, p. 177-188, 2002. FILALI, A., OUAMMI, L., BETBEDER, A. M., BAUDRIMONT, I., SOULAYMANI, R., BENAYADA, A., CREPPY, E. E. Ochratoxin A in beverages from Morocco: a preliminary survey. Food Additives and Contaminants v.18, p. 565-568, 2001. FILALI, A.; BETBEDER, A.M.; BAUDRIMONT, I.; BENAYADA, A.; SOULAYMANI, R.; CREPPY, E.E. Ochratoxin A in human plasma in Marocco: preliminary survey. Human & Experimental Toxicology. v.21, n.5, p.241-245, 2002. FINK-GREMMELS, J. Mycotoxins: their implications in human and animal health. The Veterinary Quarterly. v.21, n.4, p.115-120, 1999. FLEURAT-LESSARD, F. Qualitative reasoning and integral mangment of the quality of stored grain: a promising new approach. Journal of Stored Products Research, v. 38, p. 191-218, 2002. FONSECA, H. Micotoxinas on line. Dispon?vel em <http://www.micotoxinas.com.br>. Acesso em: 29 jan 2009. FRAGA, M. E.; CURVELLO, F. A.; GATTI, M. J.; CAVAGLIERI, L. R.; DALCERO, A. M.; ROSA, C. A. R. Potential aflatoxin and ochratoxin A producing by Aspergillus species in poultry feed processing. Veterinary Research Communications, v. 31, n. 3, p. 343-353, 2007. FRIIS, C.; BRINN, R.; HALD, B. Uptake of ochratoxin A by slices of pig kidney cortex. Toxicology. v.14, n.52, p.209-217, 1988. FRISVAD, J.C; SAMSON, R.A. Filamentous fungi in food and feeds. In: BHATNAGAR, D.; LILLEHOJ, E.B.; ARORA, D.K. Handbook of Applied Mycology: Foods and feeds. New York: Mercel Dekker, INC., 1992. p.31-68. FROHLICH, A.A.; MARQUARDT, R.R.; OMINSKI, K.H. Ochratoxin A as a contaminant in the human food chain: A Canadian perspective. International agency for research on cancer. v.115, p.139-143, 1991. 65 FUKAL, L. A survey of cereals, cereal products, feedstuffs and porcine kidneys for ochratoxin A by radioimmunoassay. Food Additives and Contaminants. v.7, n.2, p.253-258, 1990. FURLONG, E.B.; SOARES, L.A.S.; VIEIRA, A.P.; DADALT, G. Aflatoxinas, ocratoxina A e zearalenona em alimentos da regi?o do Rio Grande do Sul. Revista Instituto Adolfo Lutz, v. 58, p. 105-111, 1999. GALTIER, P. Pharmacokinetics of ochratoxin A in animals. International agency for research on cancer. v.115, p.187-200, 1991. GATENBECK, S.; HULT, K.; RUTQVIST, L. A fluorospectrophotometric method for ochratoxin analysis and the spontaneous occurrence of ochratoxin A in pig kidneys in Sweden. Archives de L?Institut Pasteur de Tunis. v. 56, n.3-4, p.257-260, 1977. GATHUMBI, J. K.; USLEBER E., NGATIA, T.A., KANGETHE, E. K. M?RTLBAUER, E. Application of Immunoaffinity Chromatography and Enzyme Immunoassay in Rapid Detection of Aflatoxin B1 in Chicken Liver Tissues. Poultry Science. v. 82, p.585?590, 2003. GHALI, R.; HMAISSIA-KHLIFA, K.; GHORBEL, H.; MAAROUFI, K.; HEDILI, A. Incidence of aflatoxins, ochratoxin A and zearalenone in Tunisian foods. Food Control. v.19, p.921-924, 2008. GODIN, M.; FILLASTRE, J.-P.; SIMON, P.; FRANCOIS, A.; LE ROY, F.; MORIN, J.-P. Is ochratoxin A nephrotoxic in human beings? Advances in Nephrology. v.26, p.181-206, 1997. GOLINSKI, P.; HULT, K.; GRABARKIEWICZ-SZCZESNA, J.; CHELKOWSKI, J.; KNEBLEWSKI, P.; SZEBIOTKO, K. Mycotoxic porcine nephropathy and spontaneous occurrence of ochratoxin A residues in kidneys and blood of polish swine. Applied and Environmental Microbiology. v.47, n.6, p.1210-1212, 1984. GOLINSKI, P.; HULT, K.; GRABARKIEWICZ-SZCZESNA, J.; CHELKOWSKI, J.; SZEBIOTKO, K. Spontaneous occurence of ochratoxin A residues in porcine kidney and serum samples in Poland. Applied and Environmental Microbiology. v.49, n.4, p.1014- 1015, 1985. GROSSO, F.; SAID, S.; MABROUK, I.; FREMY, J.M.; CASTEGNARO, M.; JEMMALI, M.; DRAGACCI, S. New data on the occurence of ochratoxin A in human sera from patients affected or not by renal diseases in Tunisia. Food and Chemical Toxicology. v.41, n.8, p.1133-1140, 2003. HALD, B. Porcine nephropathy in Europe. International agency for research on cancer. v.115, p.49-56, 1991. HALSTENSEN, A.S.; NORDBY, K-C; ELEN, O.; EDUARD, W. Ochratoxin A in grain dust ? estimated exposure and relations to agricultural practices in grain production. Annals of Agriculture Environmental Medicine. v.11, p.245-254, 2004. HARVEY, R.B.; HUFF, W.E.; KUBENA, L.F.; PHILLIPS, T.D. Evaluation of diets contaminated with aflatoxin and ochratoxin fed to growing pigs. American Journal of Veterinary Research. v.50, n.8, p.1400-1405, 1989. HARVEY, R.B.; KUBENA, L.F.; ELISSALDE, M.H.; ROTTINGHAUS, G.E.; CORRIER, D.E. Administration of ochratoxin A and T-2 toxin to growing swine. American Journal of Veterinary Research. v.55, n.12, p.1757-1761, 1994. 66 HENDRY, K.M.; COLE, E.C. A review of mycotoxins in indoor air. Journal of toxicology and environmental health. v.38, n.2, p.183-198, 1993. HENKE, S. E.; BALLARDO, V. C.; MARTINEZ, B.; BALLEY, R. Survey of aflatoxin concentration in wild bird seed purchased in Texas. Journal of Wildlife Diseases, v. 37, p. 831-835, 2001. HERRMAN, J.L. Risk evaluation of ochratoxin A by the joint FAO/WHO expert committee on food additives. International agency for research on cancer. v.115, p.327-329, 1991. HULT, K.; H?KBY, E.; H?GGLUND, U.; GATENBECK, S.; RUTQVIST, L. Ochratoxin A in blood from slaughter pigs in Sweden: use in evaluation of toxin content of consumed feed. Applied and environmental microbiology. v.39, n.4, p.828-830, 1980. HULT, K.; H?KBY, E.; H?GGLUND, U.; GATENBECK, S.; RUTQVIST, L; SELLYEY, G. Ochratoxin A in pig blood: method of analysis and use as a tool for feed studies. Applied and environmental microbiology. v.38, n.5, p.772-776, 1979. HUNT, D.C.; PHILP, L.A.; CROSBY, N.T. Determination of ochratoxin A in pig's kidney using enzymic digestion, dialysis and high-performance liquid chromatography with postcolumn derivatisation. The Analyst. v. 104, n.1245, p. 1171-1175, 1979. HUSSEIN, S. H.; BRASSEL, J. M. Toxicity, metabolism and impact of mycotoxins on human and animals. Toxicology, v. 167, p. 101-134, 2001. JIMENEZ, A.M.; LOPEZ de CERAIN, A.; GONZALES-PE?AS, E.; BELLO, J. A high performance liquid-chromatographic method for the determination of ochratoxin A in human plasma. Chromatographia. v.50, n. 7/8, p.457-460, 1999. JIMENEZ, M.; SANCHIS, V.; SANTAMARINA, P.; HERN?NDEZ, E. Penicillium in preharvest corn from Valencia (Spain): Influence of different factors on the contamination. Mycopathologia, v. 92, p. 53-57, 1985. JORGENSEN, K., JACOBSEN, J. S. Occurrence of ochratoxin A in Danish wheat and rye, 1992-99. Food Additives and Contaminants 19, 1184-1189, 2002. JORGENSEN, K. Survey of pork, poultry, coffee, beer and pulses for ochratoxin A. Food Additives and Contaminants. v.15, n.5, p.550-554, 1998. JORGENSEN, K.; PETERSEN, A. Content of ochratoxin A in paired kidney and meat samples from healthy Danish slaughter pigs. Food Additives and Contaminants. v.19, n.6, p.562-567, 2002. JORGENSEN, K.; VAHL, M. Analysis of ochratoxin A in pig kidney and rye flour using liquid chromatography tandem mass spectrometry (LC/MS/MS). Food Additives and Contaminants. v.16, n.11, p.451-456, 1999. KALE, S.; BENNET, J. W. Strain instability in filamentous fungi. In: BHATNAGAR, D.; LILLEHOJ, E. B.; ARORA, D. K. (Org.). Handbook of applied mycology: Mycotoxins in ecological systems. 5. ed. New York: Marcell Dekker, Inc., 1992. p. 311-331. KELLER, K. M.; QUEIROZ, B. D.; KELLER, L. A. M.; RIBEIRO, J. M. M.; CAVAGLIERI, L. R.; PEREYRA, M. I. G.; DALCERO, A. M.; ROSA, C. A. R. The mycobiota and toxicity of equine feed. Veterinary Research Communications, v. 31, p. 621-630, 2007. KLICH, M. A., PITT, J. I. A laboratory guide to common Aspergillus species and their teleomorphs. North Ryde: Commonwealth Scientific and Industrial Research Or-ganization (CSIRO), Division of Food Processing. Austr?lia: Academic Press, 1988. 549 p. 67 KOE, W. J. Regulations of the European Union for mycotoxins in foods. Archives Higyene Rada Toksikol, v. 50, p. 37-46, 1999. K?LLER, G.; ROLLE-KAMPCZYK, U.; LEHMANN, I.; POPP, P.; HERBARTH, O. Determination of Ochratoxin A in small volumes of human blood serum. Journal of Chromatography B, v.804, n.2, p.313?317, 2004. KROGH, P. Epidemiology of mycotoxic porcine nephropathy. Nordisk Veterinaermedicin. v.28, n.9, p.452-458, 1976. KROGH, P. Ochratoxin A Residues in Tissues of Slaughter Pigs with Nephropathy. Nordisk Veterinaermedicin, v.29, n.9, p.402-405, 1977. KROGH, P. Ochratoxins in food. In: KROGH, P. (Org.). Mycotoxins in food. London: Academic Press, 1987. p. 97-121. KROGH, P., ELLING, F., HALD, B., JYLLING, B., PETERSEN, V. E. & SKADHAUGE, E. Experimental avian nephropathy. Changes of renal function and structure induced by ochratoxin A contaminated feed. Acta Pathologica et Microbiologica Scandinavica. Section A, Pathology, v. 84, p. 215-221, 1976. KROGH, P.; ELLING, F.; FRIIS, Chr.; HALD, B.; LARSEN, A.E.; LILLEHOJ, E.B.; MADSEN, A.; MORTENSEN, H.P.; RASMUSSEN, F.; RAVNSKOV, U. Porcine Nephropathy induced by long-term ingestion of ochratoxin A. Veterinary Pathology. v.16, n.4, p.466-475, 1979. KROGH, P.; ELLING, F.; HALD, B.; LARSEN, A.E.; LILLEHOJ, E.B.; MADSEN, A.; MORTENSEN, H.P. Time-dependent disappearance of ochratoxin A residues in tissues of bacon pigs. Toxicology. v.6, n.2, p.235-242, 1976. KROGH, P.; GYRD-HANSEN, N.; HALD, B.; LARSEN, S.; NIELSEN, J.P.; SMITH, M.; IVANOFF, C.; MEISNER, H. Renal enzyme activities in experimental ochratoxin A-induced porcine nephropathy: diagnostic potencial of phosphoenolpyruvate carboxykinase and gamma-glutamyl transpeptidase activity. Journal of toxicology and environmental health. v.23, n.1, p.1-14, 1988. KROGH, P.; HALD, B.; PEDERSEN, E.J. Occurence of ochratoxin A and citrinin in cereals associated with mycotoxic porcine nephropathy. Acta Pathologica et Microbiological Scandinavia. section B. v.81, p.689-695, 1973. KROGH, P.; HASSELAGER, E.; FRIIS, P. Studies on fungal nephrotoxitcity. II - Isolation of two nephrotoxic compounds from Penicilium viridicatum Westling: citrinin and oxalic acid. Acta Pathologica et Microbiological Scandinavia. section B. v.78, p. 401-413, 1970. KUIPER-GOODMAN, T. Risk assessment of ochratoxin A residues in food. International agency for research on cancer. v.115, p.307-320, 1991. KUIPER-GOODMAN, T., OMINSKI, K., MARQUARDT, R. R., MALCOLM, S., MCMULLEN, E., LOMBAERT, G. A., MORTON, T. Estimating human exposure to ochratoxin A. In: CREPPY, E. E., CASTEGNARO, M., DIRHEIMER, G. (Org.) Human Ochratoxicosis and its Pathologies. Paris: Editions INSERM, 1993. p. 167-174. LACEY, J. Prevention of mold growth and mycotoxin production through control of environmental factors. In: NATORI, S., KASHIMOTO, K.; UENO Y. (Org.). Mycotoxins and phycotoxins. Amsterdam: Elsevier, 1989. p. 161-168. 68 LACEY, J.; MAGAN, N. Fungi in cereal grains: their occurrence and water and temperature relationships. In: CHELKOWSKI, J. (Org.). Cereal grain, mycotoxins, fungi and quality in drying and storage. Amsterdam: Elsevier, 1991. p. 77-118. LACEY, J.; RAMAKRISHNA, N.; HAMER, N.; MAGAN, I.C. Grain Fungi. In: BHATNAGAR, D.; LILLEHOJ, E.B.; ARORA, D.K. Handbook of Applied Mycology: Foods and feeds. New York: Mercel Dekker, INC., 1992. p.121-177. LAWLOR, P.G.; LYNCH, P.B. Mycotoxins in pig feeds 2: clinical aspects. Irish Veterinary Journal. v.54, n.4, p.172-176, 2001. LEONI, L. A., SOARES, L. M., OLIVEIRA, P. L. Ochratoxin A in Brazilian roasted and instant coffees. Food Additives and Contaminants, v.17, p. 867-870, 2000. LINDBLAD, C.; BRUBEN, L. Small farm grain storage. 3. ed. Washington: VITA Publications, 1980. 250 p. LINDNER, E. 1990. Toxicolog?a de los Alimentos. 2a ed. Ed.Acribia, Zaragosa. LINSELL, C.A. The mycotoxins and the human health hazards. Pure and Apllied Chemistry. v. 49, p. 1765-1769, 1977. LOMBAERT, G., A., PELLAERS, P., CHETTIAR, M., LAVALEE, D., SCOTT, P. M., LAU, B. P. Survey of Canadian retail coffees for ochratoxin A. Food Additives and Contaminants, v. 19, p. 869-877. 2002. MACDONALD, S., ANDERSON, S., BRERETON, P., WOOD, R. Determination of ochratoxin A in currants, raisins, sultanas, mixed dried fruit, and dried figs by immunoaffinity column cleanup with liquid chromatography: interlaboratory study. Journal of AOAC International, v. 86, p. 1164-1171. 2003. MADSEN, A.; MORTENSEN, H.P.; HALD, B. Feeding experiments with ochratoxin A contaminated barley for bacon pigs I. Influence on pig performance and residues. Acta Agriculturae Scandinavica. v.32, n.2, p.225-239, 1982. MAGNOLI, C., HALLAK, C., ASTORECA, A., PONSONE, L., CHIACCHIERA, S.M., PALACIO, G., DALCERO. A. Surveillance of Toxigenic Fungi and Ochratoxin A in Feesdtuffs from C?rdoba Province, Argentina. Veterinary Res. Com., v. 29, p. 431-445, 2005. MAGNOLI, C., ASTORECA, A., PONSONE, L., COMBINA, M., PALACIO, G., ROSA, C.A., DALCERO, A. M. Survey of mycoflora and ochratoxin A in dried vine fruits from Argentina markets. Letters in Applied Microbiology, v. 39, p. 326-331, 2004. MAGNOLI, C., VIOLANTE, M., COMBINA, M., PALACIO, G., DALCERO, A. Mycoflora and ochratoxin-producing strains of Aspergillus section Nigri in wine grapes in Argentina. Letters in Applied Microbiology, v. 37, p. 179-184, 2003. MAGNOLI, C.; CHIACCHIERA, S. M.; MIAZZO, R.; PALACIO, G.; ANGELETTI, A.; HALLAK, C.; DALCERO, A. The mycoflora and toxicity of feedstuffs from a production plant in C?rdoba, Argentina. Mycotoxin Research, v. 18, p. 8-22, 2002. MAGNOLI, C.; DALCERO, A.; CHIACCHIERA, S.; MIAZZO, R.; SAENZ, M. Enumeration and identification of Aspergillus group and Penicillium species in poultry feeds from Argentina. Mycopathologia, v. 142, p. 27-32, 1998. MAJERUS, P., MAX, M., KLAFFKE, H., PALAVINSKAS, R. Ochratoxin A in liquorice root, sweet liquorice and their products. Deutsche Lebensmittel-Rundschau. v. 96, p. 451- 454, 2000. 69 MALAGUTTI, L.; ZANNOTTI, M.; SCAMPINI, A.; SCIARAFFIA, F. Effects of ochratoxin A on heavy pig production. Animal Research, v.54, p.179-184, 2005. MALLMANN, C.A.; SANTURIO, J.M.; BALDISSERA, M.A.; MICKWITZ, G. Determination of ochratoxin A in blood serum pigs by using thin layer chromatography. Revista de Microbiologia. v. 2, n. 25, p. 107-111, 1994. MANNING, R.O.; BROWN, T.P.; WYATT, R.D.; FLETCHER, O.J. The individual and combined effects of Citrinin and Ochratoxin A in broiler chicks. Avian Diseases. v.29, n.4, p.986-997, 1985. MARKAKI, P., DELPONT-BINET, C., GROSSO, F., DRAGACCI, S. Determination of Ochratoxin A in Red Wine and Vinegar by Immunoaffinity High-Pressure Liquid Chromatography. Journal of Food Protection, v. 64, p. 533-537, 2001. MARQUARDT, R.R.; FROHLICH, A.A. A review of recents advances in understanding ochratoxicosis. Journal of animal science. v.70, n.12, p.3968-3988, 1992. MARQUARDT, R.R.; FROHLICH, A.A.; SREEMANNARAYANA, O.; ABRAMSON, D.; BERNATSKY, A. Ochratoxin A in blood from slaughter pigs in western Canada. Canadian Journal of Veterinary Research. v.52, n.2, p.186-190, 1988. MATRELLA, R.; MONACI, L.; MILILO, M..A.; PALMISANO, F.; TANTILLO, M.G. Ochratoxin A determination in paired kidneys and muscle samples from swines slaughtered in southern Italy. Food Control. v.17, n.2, p.114-117, 2006. MIDIO, A.F.; MARTINS, D.I. Toxicologia de alimentos. S?o Paulo: Varela editora e livraria LTDA, 2000. 295p. MILANEZ, T.V.; SABINO, M., Ocratoxina A em feij?o comercializado no Estado de S?o Paulo e sua estabilidade no cozimento. Revista de Instituto Adolf Lutz. v. 49, n. 2, p. 131- 135, 1989. MILANEZ, T.V.; SCHOENLEIN-CRUSIUS, I.H.; OKINO, L.K. Evaluation of Brazilian terrestrial Aspergillus strains for mycotoxin production. Revista do Instituto Adolfo Lutz. v.61, n.1, p.7-11, 2002. MILICEVIC, D.; JURIC, V.; MANDIC, M.; DORDEVIC, M. The presence of ochratoxin A residue in blood plasma of slaughtered swine. Processing Natural Science. v.113, p.55-62, 2007. MILICEVIC, D.; JURIC, V.; STEFANOVIC, S.; JOVANOVIC, M.; JAKOVIC, S. Survey of slaughtered pigs for occurrence of ochratoxin A and porcine nephropathy in Serbia. |
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