For two decades, researchers and clinicians have been using the diagnostic criteria for FTD to generally diagnose a patient as suffering from PPA and the criteria of Neary et al. (1998) to further specify the diagnosis as progressive nonfluent aphasia or semantic dementia. However, there were a number of PPA cases that could not be classified according to the criteria of Neary and colleagues, which led to a revision of the diagnostic clinical and research criteria for PPA by Gorno-Tempini et al. (2011). The revised criteria encompass three PPA variants (svPPA, nfvPPA, and lvPPA) with three stages characterized by increasing evidence: clinical diagnosis, imaging-supported diagnosis, and diagnosis with definite pathology. As compared to the previous diagnostic criteria, more emphasis is placed on imaging markers as supportive features. These imaging criteria were however proposed based on a purely qualitative evaluation of the literature and have not been validated so far. The aim of this thesis was to quantitatively evaluate the validity of the new diagnostic imaging criteria for PPA variants using anatomical likelihood meta-analyses (study 1) and to investigate the usefulness of these imaging criteria for the individual diagnosis of PPA patients in clinical routine using support vector machine classification (study 2).
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:16850 |
| Date | 28 November 2017 |
| Creators | Bisenius, Sandrine |
| Contributors | Universität Leipzig |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | doc-type:doctoralThesis, info:eu-repo/semantics/doctoralThesis, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
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