Yes / The imidazotetrazine ring is an acid-stable precursor and prodrug of highly reactive alkyl diazonium ions. We have shown that this reactivity can be managed productively in an aqueous system for the generation of aziridinium ions with 96% efficiency. The new compounds are potent DNA alkylators and have antitumor activity independent of the O6-methylguanine-DNA methyltransferase and DNA mismatch repair constraints that limit the use of Temozolomide.
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/7241 |
| Date | 2012 September 1918 |
| Creators | Garelnabi, Elrashied A.E., Pletsas, Dimitrios, Li, Li, Kiakos, K., Karodia, Nazira, Hartley, J.A., Phillips, Roger M., Wheelhouse, Richard T. |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Article, Accepted manuscript |
| Rights | (c) 2012 American Chemical Society. Full-text reproduced in accordance with the publisher's self-archiving policy., Unspecified |
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