Nicotinamide delivered in drinking water at about 2 g/kg/day significantly prolonged survival and showed a suggestive improvement on memory in the Npc1 (nih) / Npc1 (nih) mouse model of infantile NPC1 disease. It is likely that this role is due to its function as a histone deacetylase (HDAC) inhibitor although another HDAC inhibitor, valproic acid, was without effect. Nicotinamide could also work by preventing/reversing oxidative stress.
| Identifer | oai:union.ndltd.org:arizona.edu/oai:arizona.openrepository.com:10150/622828 |
| Date | 25 October 2016 |
| Creators | Marshall, Craig A., Borbon, Ivan A., Erickson, Robert P. |
| Contributors | Department of Pediatrics, University of Arizona |
| Publisher | SPRINGER HEIDELBERG |
| Source Sets | University of Arizona |
| Language | English |
| Detected Language | English |
| Type | Article |
| Rights | © Institute of Plant Genetics, Polish Academy of Sciences, Poznan 2016 |
| Relation | http://link.springer.com/10.1007/s13353-016-0367-0 |
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