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Previous issue date: 2017-12-12 / O v?rus da Chikungunya (CHIK) ? uma epidemia no Brasil com 170.000 casos no primeiro semestre de 2016. Mais de 60% dos pacientes apresentam rea??o e remiss?o de artralgia cr?nica com dor debilitante que dura anos. N?o existem agentes terap?uticos espec?ficos para tratar e reabilitar pessoas infectadas com CHIK. Dor persistente pode levar ? incapacita??o exigindo tratamento farmacol?gico de longo prazo. Os avan?os nos tratamentos n?o farmacol?gicos s?o necess?rios para promover o al?vio da dor sem efeitos colaterais e restaurar a funcionalidade. Aqui, n?s demonstramos que a Estimula??o Transcraniana com Corrente Cont?nua (ETCC) sobre o c?rtex motor prim?rio reduz significativamente a dor na fase cr?nica da CHIK. Nossos achados sugerem que a ETCC pode ser uma terapia eficaz, barata e implant?vel em ?reas que n?o possuem recursos e que apresentam um grande n?mero de pacientes com dor cr?nica persistente gerada pela CHIK. / The Chikungunya (CHIK) virus is epidemic in Brazil, with 170,000 cases in the first half of 2016. More than 60% of patients present relapsing and remitting chronic arthralgia with debilitating pain lasting years. There are no specific therapeutic agents to treat and rehabilitee infected persons with CHIK. Persistent pain can lead to incapacitation, requiring long-term pharmacological treatment. Advances in non-pharmacological treatments are necessary to promote pain relief without side effects and to restore functionality. Here, we demonstrate that the transcranial direct current stimulation (tDCS) across the primary motor cortex significantly reduces pain in the chronic phase of CHIK. Our findings suggest tDCS could be an effective, inexpensive and deployable therapy to areas lacking resources with a great number of patients with chronic CHIK persistent pain.
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/24763 |
| Date | 12 December 2017 |
| Creators | Silva Filho, Edson Meneses da |
| Contributors | 02797506413, Morya, Edgard, 13691469817, Belchior, Hindiael Aeraf, 01465918604, Freitas, Rodrigo Pegado de Abreu, Cacho, Enio Walker Azevedo |
| Publisher | PROGRAMA DE P?S-GRADUA??O EM CI?NCIAS DA REABILITA??O, UFRN, Brasil |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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