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Previous issue date: 2016-09-19 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / The Myrtaceae family comprises more than 3,500 species, which are widely distributed on all continents (except Antarctica). The chemical diversity and the biological potential of essential oils extracted from fresh leaves of Myrtaceae species cultivated in the Botanical Garden of UFRRJ were described. Six different species were studied: Eugenia uniflora L. (?pitanga?), Eugenia brasiliensis L. (?grumixama?), Psidium cattleianum Sabine (?ara???), Psidium guajava L. (?goiaba?), Syzygium cumini (?jamel?o?) and Syzygium malaccense (L.) (?jambo?). Chemical, statistical and biological methods were used, with the aid of chromatographic analysis (GC-FID and GC-MS), chemometrics (PCA and HCA statistical analysis) and biological activities (larvicide, trypanocidal, fungicidal and antioxidant) to determine these essencial oils. The essential oil of species E. uniflora L, E. brasiliensis, P.cattleianum and P. guajava showed mainly sesquiterpenes in its compositions, while the oil from S. cumini was rich in monoterpenes and S. malaccense presented, mostly, chemical constituents not derived isoprene metabolites.. The chemometric analysis of GC-MS data of the oils extracted from leaves of six species, discriminated three groups of essential oils, according to the similarity of the composition of volatile components for each species. Specifically, for the P.cattleianum and P. guajava data, the ?-caryophyllene and ?-humuleno constituents could be considered markers of Psidium genus. The biological results suggested that the essential oils of the species studied were effective as they showed larvicide and fungicidal activity . The essential oil of E. uniflora and its isolated furanodiene showed antioxidant activity, with the TBARS method, and also showed potential anti-Trypanosoma cruzi activity, which suggests that both are an interesting alternative to combat infectious diseases such as Chagas disease / A fam?lia Myrtaceae compreende mais de 3.500 esp?cies, que est?o amplamente distribu?das por todos os continentes (exceto Ant?rtida). Este trabalho descreve a diversidade qu?mica e o potencial biol?gico dos ?leos essenciais extra?dos de folhas frescas de esp?cies de Myrtaceae cultivadas no Jardim Bot?nico da UFRRJ. Seis esp?cies diferentes foram estudadas: Eugenia uniflora L.(pitangueira), Eugenia brasiliensis Lam (grumixameira), Psidium cattleianum Sabine (ara?azeiro), Psidium guajava L. (goiabeira), Syzygium cumini (jameleiro) e Syzygium malaccense (L.) Merr. & L. M. Perry (jambeiro vermelho). Os seus ?leos essenciais foram extra?dos por hidrodestila??o e avaliados com o aux?lio de an?lises cromatogr?ficas (CG-DIC e CG-EM), quimiometria (utilizando An?lise de Componentes Principais - ACP e An?lise de Agrupamentos Hier?rquicos ? AAH) e atrav?s de atividades biol?gicas (larvicida, tripanocida, fungicida e antioxidante). O ?leo essencial das esp?cies E. uniflora L, E. brasiliensis P.cattleianum e P. guajava apresentou, principalmente, sesquiterpenos em sua composi??o, enquanto o ?leo de S. cumini foi rico em monoterpenos e o de S. malaccense apresentou constituintes qu?micos n?o oriundos de metab?litos do isopreno. Os resultados obtidos atrav?s da quantifica??o e identifica??o qu?mica dos ?leos essenciais por Cromatografia em Fase Gasosa acoplada a Espectrometria de Massas (CG-EM) aplicadas ?s an?lises quimiom?tricas permitiu discriminar tr?s agrupamentos de ?leos essenciais, de acordo com a similaridade na composi??o de constituintes vol?teis para cada esp?cie. Especificamente para P. cattleianum e P. guajava os constituintes ?-cariofileno e ?-humuleno foram considerados os marcadores do g?nero Psidium. Para os ensaios biol?gicos realizados, os resultados obtidos com os ?leos essenciais das esp?cies estudadas mostraram-se eficazes quanto ? atividade larvicida e fungicida. O ?leo essencial de E. uniflora e o furanodieno isolado apresentaram atividade antioxidante pelo m?todo TBARS, e tamb?m apresentaram potencial atividade tripanocida, sugerindo que ambos sejam uma alternativa interessante para combater doen?as parasit?rias como a doen?a de Chagas
| Identifer | oai:union.ndltd.org:IBICT/oai:localhost:jspui/1971 |
| Date | 19 September 2016 |
| Creators | Santos, Frances Regiane dos |
| Contributors | Castro, Rosane Nora, Braz Filho, Raimundo, Martins, Roberto Carlos Campos, Silva, Fernando Catinguiba da, Fernandes, Maria do Carmo de Ara?jo, Souza, Marco Andr? Alves de |
| Publisher | Universidade Federal Rural do Rio de Janeiro, Programa de P?s-Gradua??o em Qu?mica, UFRRJ, Brasil, Instituto de Ci?ncias Exatas |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da UFRRJ, instname:Universidade Federal Rural do Rio de Janeiro, instacron:UFRRJ |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | ADAMIS, P. D.; GOMES, D. S.; PINTO, M. L.; PANEK, A. D.; ELEUTHERIO, E. C. The role of glutathione transferases in cadmium stress. Toxicol.Lett., 54, 81-88, 2004. ADAMS, R. P.; Identification of Essential Oil Components by Gas Chromatography/Mass Spectrometry, 4th ed., All.Pub.Corp. Illinois, 2007. ADIO, A. M. Germacrenes A?E and related compounds: thermal, photochemical and acid induced transannular cyclizations. Tetrahedron, 65, 1533-1552, 2009. ALMEIDA. D. J. A.; FARIA, M. V.; SILVA, P. R. Biologia experimental em Pitangueira: uma revis?o de cinco d?cadas de publica??es cient?ficas. Ambi?ncia, 8, 177-193, 2012. ALVARENGA, F. Q.; MOTA, B. C. F.; LEITE, M.; FONSECA, J. M. S. OLIVEIRA, D. A.; ROYO, V. A.; SILVA, M. L.A.; C.; ESPERANDIM, V. BORGES, A.; LAURENTIZ, R. S. In vivo analgesic activity, toxicity and phytochemical screening of the Hydroalcoholic extract from the leaves of Psidium cattleianum Sabine. J.Ethnopharmacol., 150, 280?284, 2013. ALVES, C.Q.; DAVID, J.M.; DAVID, J.P.; BAHIA, M.V.; AGUIAR, R.M. M?todos para determina??o de atividade antioxidante in vitro em substratos org?nicos. Quim.Nova, 10, 2202-2210, 2010. AMORIM, A. C. L.; LIMA, C. K. F.; HOVELL, A. M. C.; MIRANDA, A. L.; REZENDE, C. M. Antinociceptive and hypothermic evaluation of the leaf essential oil and isolated terpenoids from Eugenia uniflora L. (Brazilian Pitanga). Phytomedicine, 16, 923-928, 2009. APEL, M.A.; LIMA, M.E.L.; SOUZA, A.; CORDEIRO, I.;. YOUNG, M.C.M.; SOBRAL, M.E.G.; SUFFREDINI, I.B.; MORENO, P.R.H. Screening of the biological activity from essential oil of native species from the Atlantic Rain Forest (S?o Paulo, Brazil). Pharmacologyonline 3: 376-383, 2006. ASCENS?O, L. Estruturas secretoras em plantas. Uma abordagem morfo-anat?mica. In: Figueiredo et al (Eds). Potencialidade e aplica??es das plantas arom?ticas e medicinais. Lisboa, Portugal, pp 19-28, 2007. AZEREDO, C.M.O.; SANTOS, T.G.; MAIA, B.H.L.N.S.; Soares, M.J. In vitro biological evaluation of eight diferente essential oils against Trypanosoma cruzi, with emphasis on Cinnamomum verum essential oil. BMC Complement.Altern.Med., 14:309, 2014 (doi:10.1186/1472-6882-14-309). BADAWY, E.I.; ABDELGALEIL, S.A.M. Composition and antimicrobial activity of essential oils isolated from Egyptian plants against plant pathogenic bacteria and fungi. Ind.Crop.Prod., 52, 776? 782, 2014. BAKKALI F, AVERBECK S, AVERBECK D, IDAOMAR M. Biological effects of essential oils ? A review. Food Chem. Toxicol., 46, 446?47, 2008. 102 BALDOVANI, N.; TOMI, F.; CASANOVA, J. Identification and Quantitative Determination of Furanodiene, a Heat-sensitive Compound, in Essential Oil by 13C-NMR. Phytochem.Anal. 12, 58-63, 2001. BARBOSA, K.B.F.; COSTA, N.M.B; ALFENAS, R.C.G; DE PAULA, S.O.; MINIM, V.P.R.; BRESSAN, J. Estresse Oxidativo: conceito, implica??es e fatores modulat?rios. Rev. Nutr. Campinas, 23, 629 643, 2010 BARREIROS, A.L.B.S.; DAVID, J.M.; DAVID, J.D. Estresse Oxidativo: Rela??o entre Gera??o de Esp?cies Reativas. Quim. Nova, 29, 113-123, 2006. BARTRAM, S.; JUX, A.; GLEIXNER, G.; BOLAND, W. Dynamic pathway allocation in early terpenoid biosynthesis of stress-induced lima bean leaves. Phytochem., 67, 1661?1672, 2006. BICAS, J. L.; MOLINA, G.; DION?SIO, A. P.; BARROS, F. F. C.; WAGNER, R.; MAR?STICA JR., M. R.; PASTORE, G. M. Volatile constituents of exotic fruits from Brazil. Food Res.Int. 44, 1843-1855, 2011. BOFFO, E. F. Tese Doutorado. Utiliza??o de RMN aliada a M?todos Quimiom?tricos na an?lise de mel e aguardentes.. S?o Carlos ?UFSCar, 2009. BORGES, L.L.; LUCIO, T.C.; GIL, E.S.; BARBOSA, E.F. Uma abordagem sobre m?todos anal?ticos para determina??o da atividade antioxidante em produtos naturais. Enciclop?dia Biosfera, Centro Cientifico Conhecer - Goi?nia, 7, 1-20, 2011. BRAIBANTE, M.E.F.; ZAPPE, J.A. A qu?mica dos agrot?xicos. QNEsq, 34, 10-15, 2012. BRUN, G.R.; MOSSI, A.J. Caracteriza??o qu?mica e atividade antimicrobiana do ?leo vol?til de pitanga (Eugenia uniflora L.). Perspectiva, 34, 135-142, 2010. CALIXTO, J.B. Efficacy, safety, quality control, marketing and regulatory guidelines for herbal medicines (phytotherapeutic agents). Braz.J.Med.Biol.Res., 33, 179-189, 2000. CAREY, F.A.; GIULIANO, R.M. Organic Chemistry. 9th Ed., New York, MacGraw Hill. 2014, p. 1005-1013. CARNEIRO, F.M.; SILVA, M.J.P.; BORGES, L.L.; ALBERNAZ, L.C; COSTA, J.D.P.Tend?ncias dos estudos com plantas medicinais no Brasil. Rev.Sapi?ncia, 3, 44-75, 2014. CAROVIC-STANKO, K.; ORLIC, S.; POLITEOM, O.; STRIKIC, F.; KOLAK, I.; MILOS, M.; SATOVIC, Z. Composition and antibacterial activities of essential oils of seven Ocimum taxa. Food Chem., 119, 196?201, 2010. CASTRO, M.R.; VICTORIA, F.V.; OLIVEIRA, D.H..; JACOB, R.G.; SAVEGNAGO, L.; ALVES, D. Essential oil of Psidium cattleianum leaves: antioxidant and antifungal activity.. Pharm.Biol., 53, 242?250, 2015. 103 CERQUEIRA, M. D.; MARQUES, E. J.; MARTINS, D.; CRUZ, N. F. R. F. G. VARIA??O SAZONAL DA COMPOSI??O DO ?LEO ESSENCIAL DE Myrcia salzmannii Berg. (Myrtaceae). Qu?m.Nova, 32, 1544-1548, 2009. CHANG, R.; MORAIS, A. L.; NAPOLITANO, D. R.; DUARTE, K.C.; GUSMAN, V. B.; NASCIMENTO, E. A. A new approach for quantifying furanodieno and curzerene. A case study on the essential oils of Eugenia uniflora (pitangueira) leaves. Braz.J.Pharmacogn., 21, 392-396, 2011. CHEN, H.C.; SHEU, M.J.; LIN, L.Y.; WU,C.M. Chemical Composition of the Leaf Essential Oil of Psidium guajava L. from Taiwan. J.Essent.Oil Res. 19, 345-347, 2007. CONSOLINI, A. E.; BALDINI, A. N.; AMAT, A. G. Pharmacological basis for the empirical use of Eugenia uniflora L. (Myrtaceae) as antihypertensive. J.Ethnopharmacol., 66, 33-39, 1999. COSTA, D. P.; SANTOS, S. C.; SERAPHIN, J. C.; FERRI, P. H. Seasonal Variability of Essential Oils of Eugenia uniflora Leaves. J. Braz. Chem. Soc., 20, 1287-1293, 2009. COSTA, D. P.; ALVES FILHO, E. G.; SILVA, L. M. A.; SANTOS, S. C.; PASSOS, X. S.; SILVA, M. R. R.; SERAPHIN, J.C.; FERRI, P. H. J. Influence of Fruit Biotypes on the Chemical Composition and Antifungal Activity of the Essential Oils of Eugenia uniflora Leaves. J.Braz.Chem.Soc., 21, 851-858, 2010. COSTA, V.; MORADAS-FERREIRA, P. Oxidative stress and signal transduction in Saccharomyces cerevisiae: insights into ageing, apoptosis and diseases. Mol.Aspects Med., 22, 217-246, 2001. COTINGUIBA, G.G.; SILVA, J.R.N.; AZEVEDO, R.R.S.; ROCHA, T.J.M.; SANTOS, A.F.N. M?todo de Avalia??o da Defesa Antioxidante: Uma Revis?o de Literatura. UNOPAR, Cient. Ci?nc. Biol. Sa?de, 15, 231-237, 2013. CRIVELENTI, L. Z., GUILHERME, L. C.; MORELLI, S.; BORIN, S. Toxicidade do Inseticida Organofosforado Abate? em Alevinos de Poecilia reticulata., J.Braz.Soc. Ecotoxicol., 6, 65-68, 2011. CROTEAU, R.; KUTCHAN, T.M.; LEWIS, N.G. Natural Products (Secondary Metabolites). In: BUCHANAN, B.B.; GRUISSEM, W.; JONES, R.L. (Eds) Biochemistry & Molecular Biology of Plants, New Jersey, John Wiley & Sons, Ltd. 2000, cap.24, p.1250-1318. CRUZ, A.V.M.; KAPLAN, M.A.C. Uso medicinal de esp?cies das fam?lias Myrtaceae e Melastomataceae no Brasil. Floresta e Ambiente, 11, 47-52, 2004. CYSNEIROS, V. C., PEREIRA-MOURA, M. V. L., PAULA, E. P. E BRAZ, D. M.: Arboreal Eudicotyledons, Universidade Federal Rural do Rio de Janeiro Botanical Garden, state of Rio de Janeiro, Brazil. Check List, 7(1), 1-6, 2011. 104 DA SILVA ,J.D.; LUZ A.I.R.; DA SILVA, M.H.L.; ANDRADE, E.H.A.; ZOGHBI M.D.G.B.; MAIA, J.G.S. Essential oils of the leaves and stems of four Psidium spp. Flav.Fragr., 18, 240-243, 2003. DEBEKO, A.; DAGNE, E.; STERNER, O. Furanosesquiterpenes from Commiphora sphaerocarpa and related adulterants of true myrrh. Fitoterapia, 73, 48-55, 2002. DE OLIVEIRA, A.C.; VALENTIM, I.B.; GOULART, M.F.; SILVA, C.A.; BECHARA, E.J.H.; TREVISAN, M.T.S. Fontes vegetais naturais de antioxidantes. Quim.Nova, 32, 689-702, 2009. DEWICK, P.M. Medicinal Natural Products. A Biosynthetic Approach. 2th Ed., England, John Wiley & Sons, Ltd. 2002. p.167-202. DIAS, C.N.; MORAES, D.F.C. Essential oils and their compounds as Aedes aegypti L. (Diptera: Culicidae) larvicides: review. Parasitol.Res. 113, 565?592, 2014. DIAS, C.N.; RODRIGUES, K.A.F.; CARVALHO, F.A.A.; CARNEIRO, S.M.P.; MAIAC, J.G.S.; ANDRADE, E.H.A.; MORAES, D.F.C. Molluscicidal and Leishmanicidal Activity of the Leaf Essential Oil of Syzygium cumini (L.) Skeels from Brazil. Chem.Biodivers.10, 1133-1141, 2013. DIAS, L.C.; DESSOY, M.A.; SILVA, J.J.N.; THIEMANN, O.H.; OLIVA, G.; ANDRICOPULO, A.D. Quimioterapia da doen?a de chagas: estado da arte e perspectivas no desenvolvimento de novos f?rmacos. Quim Nova, 32, 2444-57, 2009. DJILANI, A.; DICKO, A. The therapeutic benefits of essential oils. In: Bouayed, J., Bohn, T. (Eds.), Nutrition, Well-being and Health. In Tech, Croatia, pp. 155?178, 2012. DOLARA, P.; LUCERI, C.; GHELARDINI, C.; MONSERRAT, C.; AIOLLI, S. LUCERI, F.; LODOVICI, M.; MENICHETTI, S.; ROMANELLI, M.N. Analgesic effects of myrrh. Nature, 379, 29, 1996. DONATO, A.M.; MORRETES, B.L.. Anatomia foliar de Eugenia brasiliensis Lam. (Myrtaceae) proveniente de ?reas de restinga e de floresta. Rev.Bras.Farmacog. 17, 426-443, 2007. ELANSARY, H.O.; SALEM, M.Z.M.; ASHMAWY, N.A.; YACOUT, M.M. Chemical Composition, Antibacterial and Antioxidant Activities of Leaves Essential Oils from Syzygium cumini L., Cupressus sempervirens L. and Lantana camara L. from Egypt. J.Agric.Sci.; 4, 144-152, 2012. FETTER, M.R.; VIZZOTTO, M.; CORBELINI, D.D.; GONZALEZ, T.N. . Propriedades funcionais de ara??-amarelo, ara??-vermelho (Psidium cattleianum Sabine) e ara??-pera (P. acutangulum D.C.) cultivados em Pelotas/RS. Braz.J.Food Technol., III, 92-95, 2010. FIGUEIREDO, A.C.; BARROSO, J.G.; PEDRO, L.G.; SCHEFFER, J.J.C. Factors affecting secondary metabolite production in plants: volatile components and essential oils. Flavour Fragr. J., 23, 213?226, 2008. Factors affecting volatile and essential oil production in plants 105 FIGUEIREDO, F.G.; TINTINO, S.R; BRITO, D.I.V.; BRAGA, M.F.B.M.; LEITE, N.F; LUCENA; B.F.F.; SOBRAL-SOUZA; C.E.; GOMEZ; M.C.V.; COUTINHO, H.D.M. Avalia??o das potenciais atividades tripanocida e antileishmania do extrato de folhas de Piper arboreum (Piperaceae) e de suas fra??es. Rev.Ci?nc.Farm.B?sica Apl., 35, 149-154, 2014. FISCHER, D. C.; LIMBERG, R.P.; HENRIQUES, A. T.; MORENO, P. R.H. Essential oil from leaves of two Eugenia brasiliensis specimens from southeastern Brazil. J.Essent.Oil Res., 17, 499-500, 2005. FRANZ, C.M. Essential oil research: past, present and future. Flavour.Frag.J., 25, 112-13, 2010. FUNDA??O BIODIVERSITAS: Lista da flora brasileira amea?ada de extin??o segundo avalia??o no workshop da Funda??o Biodiversitas em 2005. Dispon?vel em: http://www.biodiversitas.org.br/florabr/lista_florabr.pdf. Acesso em 15/03/2016). GOBBO-NETO, L. E.; LOPES, N. P. Plantas medicinais: fatores de influ?ncia no conte?do de metab?litos secund?rios. Quim. Nova, 30, 374-381, 2007. GON?ALVES, F.A.; ANDRADE NETO, M.; BEZERRA, J.N.S.; MACRAE, A.; SOUSA, O.V.; FONTELES-FILHO, A.A.; VIEIRA, R.H.S.F. - Antibacterial activity of guava, Psidium guajava Linnaeus, leaf extracts on diarrhea-causing enteric bacteria isolated from Seabob shrimp. Xiphopenaeus kroyeri (Heller). Rev.Inst.Med.trop.S. Paulo, 50, 11-15, 2008. GRESSLER, E.; PIZO, M.A.; MORELLATO, L.P.C. Poliniza??o e dispers?o de sementes em Myrtaceae do Brasil. Rev.Brasil.Bot., 29, 509-530, 2006. GROVER, J. K; VATS, V; RATHI, S. S. Anti-hyperglycemic effect of Eugenia jambolana and Tinospora cordifolia in experimental diabetes and their effects on key metabolic enzymes involved in carbohydrate metabolism. J.Ethnopharmacol., 73, 461-470, 2000. GUTTERIDGE, J.M.C.; HALLIWELL, B. Antioxidants: Molecules, medicines, and myths. Biochem.Biophys.Res.Commun., 393 561?564, 2010. HENRIQUES, A.T.; SOBRAL, M.E.; CAUDURRO, A.D.; SCHAPOVAL, E.E.S, BASSANI, V.L.; LAMATY, G.; MENUT, G.; BESSI?RRE, J.M. Aromatic plants from Brazil. II. The chemical composition of some Eugenia essential oils. J Essent Oil Res. 5: 501-505, 1993. HERRERO, M.; MENDIOLA, J. A. CIFUENTES, A.; IB??EZ, E.. Review: Supercritical fluid extraction: recent advances and applications. J.Chromatogr.A, 1217, 2495?2511, 2010. ISMAIL, I.S.; ISMAIL, N.; LAJIS, N. Ichthyotoxic properties and essential oils of Syzygium malaccense (Myrtaceae). Pertanika J.Sci.Technol. 18, 1-6, 2010. ISMAN, M.B., GRIENEISEN, M.L. Botanical insecticide research: many publications, limited useful data. Trends Plant.Sci., 19, 140?145, 2014. 106 JOSEPH, B.; PRIYA, R.M. In vitro antimicrobial activity of Psidium guajava L. leaf essential oil and extracts using agar well diffusion method. Int.J.Curr.Pharmaceutical Res., 2, 28-32, 2010. JOSEPH, B.; PRIYA, R.M.; HELEN, P.A.M.; SUJATHA, S. Bio-active compounds in essential oil and its effects of antimicrobial cytotoxic activity from the Psidium guajava (L) leaf. J.Adv.Biotechnol., 9, 10-14, 2010. JUNG, P.H.; SILVEIRA, A. C.; NIERI, E. M.; POTRICH, M.; LOZANO, E. R.; REFATTI, M. Atividade Inseticida de Eugenia uniflora L. e Melia azedarach L. sobre Atta laevigata Smith. Floresta e Ambiente, 20, 191-196, 2013. KALEMBA, D.; KUNICKA, A. Antibacterial and Antifungal Properties of Essential Oils. Curr.Med.Chem., , 10, 813-829, 2003. KARIOTI, A.; SKALTSA, H.; GBOLADE, A. A. Analysis of the leaf Oil of Syzygium malaccense Merr. Et Perry from Nigeria. J. Essent.Oil Res., 19, 313-315, 2007. KNAAK, N.; FIUZA, L.M. Potencial dos ?leos essenciais de plantas no controle de insetos e microrganismos. Neotrop.Biol.Conserv., 5, 120-132, 2010. KOMALAMISRA, N.; TRONGTOKIT, Y.; RONGSRIYAM, Y.; APIWATHNASORN, C. Screening for larvicidal activity in some Thai plants against four mosquito vector species. Southeast Asian J.Trop.Med.Public Health, 36, 1412-1422, 2005. KUBECZKA, K. H. History and sources os essential oil reseach. In: BASER, K.H.C.; BUCHABAUER, G. (eds). Handbook of Essential Oils: Science, Technology, and Applications. CRC Press, Florida,USA. 2010, cap. 2, p.3-38. KUTCHAN, T.M.; GERSHENZON, J.; M?LLER, B.L.; GANG, D.R. Natural Products. In: BUCHANAN, B.B.; GRUISSEM, W.; JONES, R.L. (Eds) Biochemistry & Molecular Biology of Plants, 2th Ed., New Jersey, John Wiley & Sons, Ltd. 2015, cap.24, p.1132-1206. LAGO, J. H. G.; SOUZA, E. D.; MARIANE, B.; PASCON, R.; VALLIM. M. A.; MARTINS, R.C.; BAROLI, A. A.; CARVALHO, B. A.; SOARES, M. G., SANTOS, R. T.; SARTORELLI, P.: Chemical and Biological Evaluation of Essential Oils from Two Species of Myrtaceae ? Eugenia uniflora L. And Plinia trunciflora (O. Berg) Kausel. Molecules, 16, 9827-9837, 2011. LAGUERRE, M.; LECOMTE, J.; VILLENEUVE, P. Evaluation of the ability of antioxidants to counteract lipid oxidation: Existing methods, new trends and challenges. Prog.Lipid Res., 46, 244?282, 2007. LANDRUM, L.R.; KAWASAKI, M.L. The genera of Myrtaceae in Brazil. An illustrate synoptic treatment and identification keys. Brittonia, New York, 49, 508-536, 1997. LAWAL, O.A.; OGUNWANDE, I.A.; BULLEM, C.A.; TAIWO, O.T.; OPOKU, A.R. Essential oil compositions and in vitro biological activities of three Syzygium species from Nigeria. In: New developments in terpenes research. Hu, J. ed.; Nova Science Publ., Inc, Nova York, 2014, cap. 5, p.93-112. 107 LEE, W.C.; MAHMUD, R.; PILLAI, S.P.; PERUMAL,S.; ISMAIL, S. Antioxidant Activities of Essential Oil of Psidium guajava L. leaves. APCBEE Procedia 2, 86 ? 91, 2012. LEE, W.C.; MAHMUD, R.; NOORDIN, R.; PILLAI,S.P.; PERUMAL,S.; ISMAIL, S. Free Radicals Scavenging Activity, Cytotoxicity and Anti-parasitic Activity of Essential Oil of Psidium guajava L. Leaves against Toxoplasma gondii. J.Res.Oil Bear.Pl., 16, 32 ? 38, 2013. LEITE, A.M.; LIMA, E.O.; SOUZA, E.L.; DINIZ, M.F.F.M.; LEITE, S.P.; XAVIER, A.L.; MEDEIROS, I.A. Preliminary study of the molluscicidal and larvicidal properties of some essential oils and phytochemicals from medicinal plants. Rev.Bras.Farmacog. Braz.J.Pharmacog., 19, 842-846, 2009. LIMA, M.A.A.; OLIVEIRA, F.F.M.; GOMES, G.A.; LAVOR, P.L.; SANTIAGO, G.M.P.; NAGAO-DIAS, A.T.; ARRIAGA, A.M.C.; LEMOS, T.L.G.; CARVALHO, M.G. Evaluation of larvicidal activity of the essential oils of plants species from Brazil against Aedes aegypti (Diptera: Culicidae). Afr.J.Biotechn., 10, 11716-11720, 2011. LIMA, N. P.; CERQUEIRA, S. H. F.; F?VERO, O. A.; ROMOFF, P.; LAGO, J. H.G. Composition and chemical variation of the essential oil from leaves of Eugenia brasiliensis Lam. And Eugenia sp. (Myrtaceae). J. Essent. Oil Res., 20, 223-225, 2008. LIRA J?NIOR, J.S.; BEZERRA, J. E. F.; LEDERMAN, I. E.; SILVA JUNIOR, J. F.. Pitangueira. Empresa Pernambucana de Pesquisa Agropecu?ria-IPA, Recife, 2007. 87p. LIU, Y.; NAIR, M.G. Curcuma longa and Curcuma mangga leaves exhibit functional food property. Food Chem., 135, 634?640, 2012. LOMONACO, D.; SANTIAGO, G.M.P.; FERREIRA, Y.S.; ARRIAGA, A.M.C.; MAZZETTO, S.E.; MELEC, G.; VASAPOLLO, G. 2009. Study of technical CNSL and its main components as new green larvicides. Green Chem., 2009, 11, 31?33, 2009. LOPES, M. M. Composi??o qu?mica, atividade antibacteriana e alelop?tica dos ?leos essenciais de Eugenia uniflora L. e Myrciaria glazioviana (Kiaersk) G. M. Barroso e Sobral (myrtaceae). 2008. 48p. Disserta??o (Mestrado em Agroqu?mica) - Setor de Agroqu?mica, Universidade Federal de Vi?osa Minas Gerais, Vi?osa, MG. LORENZI, H. ?rvores Brasileiras: Manual de Identifica??o e Cultivo de Plantas Arb?reas Nativas do Brasil. Nova Odessa: Instituto Plantarum, 1992. 368 p. LORENZI, H.; MATOS, F.J.A. Plantas medicinais no Brasil: nativas e ex?ticas. Instituto Plantarum, p.350-351, 2002. LUCIA, A.; AUDINO, P.G.; SECCACINI, E.; LICASTRO, S.; ZERBA, E.; MASUH, H. Larvicidal effect of Eucalyptus grandis essential oil and turpentine and their major components on Aedes aegypti larvae. J.Am.Mosq.Control.Assoc., 23, 299?303, 2007. LUCINI, E.I.; ZUNINO, M.P.; LOPEZ, M.L.; ZYGADLO, J.A. Effect of monoterpenes on lipid composition and sclerotial development of Sclerotium cepivorum Berk. J.Phytopathol., 154, 441?446, 2006. 108 MACHADO, B. F. M. T.; FERNANDES JUNIOR, A. ?leos essenciais: aspectos gerais e usos em terapias naturais. Cad. acad., Tubarao, 3, 105-127, 2011. MACHADO R.R.P.; JARDIM, D.F.; SOUZA, A.R.; SCIO E.; FABRI, R.L.; CARPANEZ, ARTHUR G.; GRAZUL, R.M.; MENDON?A, J.P.R.F.; LESCHE, B.; AARESTRUP, F.M. The effect of essential oil of Syzygium cumini on the development of granulomatous inflammation in mice. Braz.J. Pharmacog., 23, 488-496, 2013 MAGINA, M. D. A.; DALMARCO, E. M.; WISNIEWSKI Jr., A.; SIMIONATTO, E. L.; DALMARCO, J. B.; PISSOLATI, M. G.; BRIGHENTE, I. M. C. Chemical composition and antibacterial activity of essential oil of Eugenia species. J.Nat.Med., 63, 345-350, 2009. MAIA, T.F.; DE DONATO, A.; FRAGA, M.E. Review: Atividade antif?ngica de ?leos essenciais de plantas. Rev.Brasil.Prod.Agroind., 17, 105-116, 2015. MAKABE, H.; MARU, N.; KUWABARA, A.; KAMO, T.; HIROTA, M. Anti-inflammatory sesquiterpenes from Curcuma zedoaria. Nat.Prod.Res. 20,680?685, 2006. MARANGONI, C.; MOURA,N.F.; GARCIA, F.R.M. Utiliza??o de ?leos essenciais e extratos de plantas no controle de insetos. Rev.Ci?n.Amb., Canoas, 6. 95-112, 2012. MARQUES, F. A.; WENDLER, E. P.; MAIA, B. H. L. N. S. Volatile Oil of Psidium cattleianum Sabine from the Brazilian Atlantic Forest. J.Essent. Oil Res., 20, 519-520, 2008. MASSART, D. L.; VANDEGINSTE, B. G. M. ; BUYDENS, L. M. C.; DE JONG, S.; LEWI, P. J. ; SMEYERS-VERBEKE, J. Handbook of Chemometrics and Qualimetrics, Part A, Elsevier, Amsterdam, vol. 20, 1998. MATSUDA, H.; NINOMIYA, K.; MORIKAWA, T.; YOSHIKAWA, M. Inhibitory effect and action mechanism of sesquiterpenes from Zedoariae rhizoma on galactosamine/lipopolysaccharide-induced liver injury. Bioorg.Med.Chem.Lett. 8, 339?344, 1998. MAZARO, S. M.; CITADIN, I.; DE GOUV?A, A.; LUCKMANN, D.; GUIMAR?ES, S. S. Indu??o de fitoalexinas em cotil?dones de soja em resposta a derivados de folhas de pitangueira. Cienc. Rural, 38, 1824-1829, 2008. MAY, A.; MORAES, A.R.A.; PINHEIRO, M. Q. Teor de ?leo essencial de pitanga em fun??o de tratamentos p?s-colheita. Rev. Caatinga (Mossor?, Brasil), .20, 186-190, 2007. MELO, R. M.; CORR?A, V. F. S.; AMORIM, A. C. L.; MIRANDA, A. L.; REZENDE, C. M. Identification of Impact Aroma Compounds in Eugenia uniflora L. (Brazilian Pitanga) Leaf Essential Oil. J.Braz.Chem.Soc., 18, 179-183, 2007. MELO, R.R.; ARA?JO; E.R.S.A.; SILVA, A.A.L.; RANDAU, K.P.; XIMENES, E.C.P.A. Caracter?sticas farmacobot?nicas, qu?micas e biol?gicas de Syzygium malaccense (l.) Merr. & l. M. Perry. Rev.Bras.Farm., 90, 298-302, 2009. 109 MELO-SANTOS, M.A.V.; VARJAL-MELO, J.J.M.; ARA?JO, A.P.; GOMES, T.C.S.; PAIVA, M.H.S.; REGIS, L.N.; FURTADO, A.F.; MAGALH?ES, T.; MACORIS, M.L.G.; ANDRIGHETTI, M.T.M.; AYRES, C.F.J. Resistance to the organophosphate temephos: Mechanisms, evolution and reversion in an Aedes aegypti laboratory strain from Brazil. Acta Trop., 113: 180-189, 2010. MENDON?A, P.S.; CARIOCA, A.A.F.; MAIA, F.M.M. Intera??es entre Estresse Oxidativo, Terapia Utilizada e Estadiamento em Pacientes com C?ncer Colorretal. Rev.Bras.Cancer., 60, 129-134, 2014. MIGUEL, M.G. Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review. Molecules, 15, 9252-9287, 2010. MOHAMED, A.A.; ALI, S.I.; EL-BAZ, F.K. Antioxidant and Antibacterial Activities of Crude Extracts and Essential Oils of Syzygium cumini Leaves. PLOS ONE, 8, 1-7,2013. MOITA, J.M.N.; MOITA, G.C. Uma introdu??o ? an?lise explorat?ria de dados multivariados. Quim.Nova, 21, 467-469, 1998. MORAIS, L.A.S.. Influ?ncia dos fatores abi?ticos na composi??o qu?mica dos ?leos essenciais. Hortic.Bras. 27: S4050-S4063, 2009. MORAIS, L.M.F.; CONCEI??O, G.M.; NASCIMENTO, J.M. Fam?lia Myrtaceae: an?lise morfol?gica e distribui??o geogr?fica de uma cole??o bot?nica. Agrarian Academy, Centro Cient?fico Conhecer - Goi?nia, 1, 317-346, 2014. MORAIS, S. M.; CRAVEIRO, A. A.; MACHADO, M. I. L.; ALENCAR, J. W.; MATOS, J. A. Volatiles constituents of Eugenia uniflora leaf oil from northeastern Brazil. J.Essent.Oil Res., 8, 449- 451, 1996. NIKI, E. Assessment of antioxidant capacity in vitro and in vivo. Free Radic.Biol.Med., 49, 503?515, 2010. NISHA, K.; DARSHANA, M.; MADHU, G.; BHUPENDRA, M.K. GC-MS analysis and antimicrobial activity of Psidium guajava (leaves) grown in Malva region of India. Int.J.Drug Dev.Res. 3, 237-245, 2011. NISHANDHINI, S.; SUDHA, V.; MALLAVARAPU, G.R.; MURUGAN, R. Chemical compositions, ?-amylase inhibitory and antioxidant activities of the essential oils from unripe fruit pulp and leaves of Syzygium cumini. Int.J.Pharm.Pharm.Sci., 7, 511-514, 2015. OATANI, M.A.; AGUIAR, R.W.; RAMOS, A.C.C.; BRITO, D.R.; SILVA, J.B.; CAJAZEIRA, J.P. Utiliza??o de ?leos essenciais na agricultura. J.Biotec.Biodivers. 4, 162-175, 2013. OGUNWANDE, I. A., OLAWORE, N. O., ADELEKE, K. A., EKUNDAYO, O., KOENIG, W. A. JoChemical composition of the leaf volatile oil of Psidium guajava L. growing in Nigeria. Flav.Fragr.J., 18: 136?138, 2003. 110 OGUNWANDE, I. A.; OLAWORE, N. O.; EKUNDAYO, O.; WALKER, T. M.; SCHMIDT, J. M.; SETZER, W. N. Studies on the essential oils composition, antibacterial and cytotoxicity of Eugenia uniflora L. Int. J. Aromather., 15, 147-152, 2005. OLIVEIRA, C. B.; SOARES, D. G. S.; PAULO, M. Q.; PADILHA, W. W. N. Atividade Antimicrobiana in vitro da Eugenia uniflora L. (Pitanga) sobre Bact?rias Cariog?nicas. Rev.Bras. Ci?nc. Sa?de, 12, 239-250, 2008. OKOH, O. O.; SADIMENKO, A. P.; AFOLAYAN, A.J. Comparative evaluation of the antibacterial activities of the essential oils of Rosmarinus officinalis L. obtained by hydrodistillation and solvent free microwave extraction methods. Food Chem. 120, 308?312, 2010. OOTANI, M.A.; AGUIAR, R.W.; RAMOS, A.C.C.; BRITO, D.R.; SILVA, J.B.; CAJAZEIRA, J.P. Utiliza??o de ?leos essenciais na agricultura. J.Biotec.Biodivers. 4, 162-175, 2013. OYINLADE, O.C. Phytochemical and Physicochemical Analysis of Three Different Types of Apples. Inter.J.Scient.Res.Rev., 3, 67-78, 2014. PAROUL, N.; MOSSI, A.; CANSIAN, R. L.; EMMERICH, D.; FAGGION, A.; SCOLOSKI, E.; LIOTTO, F. R.; ROVANI, A. S.; FILLA, J.; MUNIK, R. Caracteriza??o qu?mica e atividade antimicrobiana do ?leo essencial de Psidium cattleianum (ara??-do-campo). 25? Reuni?o Anual da SBQ, Po?os de Calda (MG), 2002. PAVARINI, D. P.; SILVA, D. B.; LOPES, J. L. C.; LOPES, N. P. Subst?ncias vol?teis: t?cnicas de extra??es das cl?ssicas ?s avan?adas. In: Souza, B.H.B. et al. (org.): Revis?es em processos e t?cnicas avan?adas de isolamento e determina??o estrutural de ativos de plantas medicinais. Ed. UFOP, Ouro Preto, 2012, p. 19-54. PAVELA, R. Essential oils for the development of eco-friendly mosquito larvicides: A review. Ind.Crops Prod., 76, 174?187, 2015. PAVELA, R.; VRCHOTOV?, N.; T??SKA, J. Mosquitocidal activities of thyme oils (Thymus vulgaris L.) against Culex quinquefasciatus (Diptera: Culicidae). Parasitol.Res., 105, 1365?1370, 2009. PEIXOTO, C.A., OLIVEIRA, A.L., CABRAL, F.A. Composition of supercritical carbon dioxide extracts of pitangueira (Eugenia uniflora L.) leaves. J Food Process Eng 33: 848-860, 2010. PERUMALSAMY, H.; KIM, N.J.; AHN, A.J. Larvicidal activity of compounds isolated from Asarum heterotropoides against Culex pipiens pallens, Aedes aegypti, and Ochlerotatus togoi (Diptera: Culicidae). J.Med.Entomol. 46, 1420?1423, 2009. PIETROVSKI, E.F.; MAGINA, M.D.A.; GOMIG, F.; PIETROVSKI, C.F.; MICKE, G.A.; BARCELLOS, M.; PIZZOLATTI, M.G.; CABRINI, D.A.; BRIGHENTE, I.M.C.; OTUKI, M.F. Topical anti-inflammatory activity of Eugenia brasiliensis Lam. (Myrtaceae) leaves. J.Pharm.Pharmacol. 60, 479-487, 2008. 111 PINHO, A.I.; WALLAU, G.L.; NUNES, M.E.M.; LEITE, N F.; TINTINO, S.R.; CRUZ, L. C.; CUNHA, F.A.B.; COSTA, J G.M.; COUTINHO, H.D.M.; POSSER, T.; FRANCO, J.L. Fumigant activity of the Psidium guajava Var. Pomifera (Myrtaceae) essential oil in Drosophila melanogaster by means of oxidative stress. Oxid.Med.Cell Longev.2014, 1-8, 2014. PINO, J. A.; AG?ERO, J.; MARBOT, R.; FUENTES, V. Leaf Oil of Psidium guajava L. from Cuba. J.Essent.Oil Res., 13, 61-62, 2001. PINO, J. A.; BELLO, A.; URQUIOLA, A.; MARBOT, R.; MARTI, M.P. Leaf Oil of Psidlum parvifolium Griseb and Psidium cattleianum Sabine from Cuba. J.Essent.Oil Res., 16, 370-371, 2004. RAMALHO, V.C.; JORGE, N. Antioxidantes utilizados em ?leos, gorduras e alimentos gordurosos. Quim.Nova, 29, 755-760, 2006. RANGEL, C.F.; ROSA, A.C.S.; SARCINELLI, P.N. Uso de agrot?xicos e suas implica??es na exposi??o ocupacional e contamina??o ambiental. Cad. Sa?de Colet., Rio de Janeiro, 19, 435-442, 2011. RATTAN, R.S. Mechanism of action of insecticidal secondary metabolites of plant origin. Crop Prot., 29, 913?920, 2010. RAUT, J.S.; KARUPPAYIL, S.M. A status review on the medicinal properties of essential oils. Industrial Crops and Products, 62, 250?264, 2014. REDDY, L.J.; JOSE, B. Evaluation of antibacterial and DPPH radical scavenging activities of the leaf extracts and leaf essential oil of Syzygium cumini Linn. from South India Int.J.Pharm.Pharm.Sci., 5, 358-361, 2013. REZENDE, W.P.; BORGES, L.L.; ALVES, N.M.; FERRI, P.H.; PAULA, J.R. Chemical variability in the essential oils from leaves of Syzygium jambos. Rev.Bras. Farmacogn. 23, 433-440, 2013. RODRIGUES, K.A.F.; AMORIM, L.V.; OLIVEIRA, J.M.G.; DIAS, C.N.; MORAES, D.F.C.; ANDRADE, E.H.A.; MAIA, J.G.S.; CARNEIRO, S.M.P.; CARVALHO, F.A.A. Eugenia uniflora L. essential oil as a potential anti-Leishmania agent: Effects on Leishmania amazonenses and possible mechanisms of action. 2013 (http://dx.doi.org/10.1155/2013/279726). RODRIGUES, K.A.F.; AMORIM, L.V.; DIAS, C.N.; MORAES, D.F.C.; CARNEIRO, S.M.P.; CARVALHO, F.A.A. Syzygium cumini (L.) Skeels essential oil and its major constituent ?-pinene exhibit anti-Leishmania activity through immunomodulation in vitro. J.Ethnopharmacol., 160, 32?40, 2015. SACCHETTI, G.; MAIETTI, S.; MUZZOLI, M.; SCAGLIANTI, M.; MANFREDINI, S.; RADICE, M.; BRUNI, R. Comparative evaluation of 11 essential oils of different origin as functional antioxidants, antiradicals and antimicrobials in foods. Food Chem. 91, 621?632, 2005. 112 SAGRERO-NIEVES, L.; BARTLEY, J.P; PROVIS-SCHWEDE, A. Supercritical fluid extraction of the volatile components from the leaves of Psidium guajava L. (guava). Flav. Fragr. J., 9, 135-137, 1994. SALGUEIRO, L.; MARTINS, A.P.; CORREIRA, H. Raw materials: the importance of quality and safety. A review. Flav.Fragr.J., 25, 253?271, 2010. SANTOS, F.R.; BRAZ-FILHO, R.; CASTRO, R.N. Influ?ncia da idade das folhas de Eugenia uniflora L. na composi??o qu?mica do ?leo essencial. Quim. Nova, 38, 762-768, 2015. SANTOS, K.K.; MATIAS E.F.F.; TINTINO, S.R.; SOUZA, C.E.; BRAGA, M.F.B.M.; GUEDES, G.M.M.; ROL?N, M.; VEJA, C.; ARIAS, A.R.; COSTA, J.G.M.; MENEZES, I.R.A.; COUTINHO, H.D.M. Anti-Trypanosoma cruzi and cytotoxic activities of Eugenia uniflora L. Exp.Parasitol. 131, 130?132, 2012a. SANTOS, K.K.; MATIAS E.F.F.; TINTINO, S.R.; SOUZA, C.E.; BRAGA, M.F.B.M.; GUEDES, G.M.M.; ROL?N, M.; VEJA, C.; ARIAS, A.R.; COSTA, J.G.M.; MENEZES, I.R.A.; COUTINHO, H.D.M. Anti-Trypanosoma cruzi and cytotoxic activities of Eugenia jambolana L. J.Med.Food, 15, 66?70, 2012b. SANTOS, S.R.L.; SILVA, V.B.; MELO, M.A.; BARBOSA, J.D.F.; SANTOS, R.L.C.; DE SOUSA, D.P.; CAVALCANTI, S.C.H. Toxic effects on and structure-toxicity relationships of phenylpropanoids, terpenes, and related compounds in Aedes aegypti Larvae. Vector-Borne Zoonotic.dis., 10, 1049-1054, 2010. SANTOS, S.R.L.; SILVA, V.B.; MELO, M.A.; CARDOSO, A.V.; SANTOS, R.L.C.; DE SOUSA, D.P.; CAVALCANTI, S.C.H Structure?activity relationships of larvicidal monoterpenes and derivatives against Aedes aegypti Linn. Chemosphere 84, 150?153, 2011. SATYAL, P.; PAUDEL, P.; LAMICHHANE, B.; SETZER, W.N.. Leaf essential oil composition and bioactivity of Psidium guajava from Kathmandu, Nepal. Am.J.Essent.Oils Nat.Prod., 3, 11-14, 2015. SCHAPOVAL, E. E. S.; SILVEIRA, S. M.; MIRANDA, M. L.; ALICE, C. B.; HENRIQUES, A. T. J. Evaluation of some pharmacological activities of Eugenia unijlora L. Ethnopharmacol., 44, 137-142, 1994. SCOTTI, L.; SCOTTI, M.T.; SILVA, V.B.; SANTOS, S.R.L.; CAVALCANTI, S.C.H.; MENDON?A JUNIOR? F.J.B. Chemometric studies on potential larvicidal compounds against Aedes aegypti. Med.Chem. 9, 1?10, 2013. SCUR, M.C.; PINTO, F.G.S.; PANDINI, J.A.; COSTA, W.F.; LEITE, C.W.;. TEMPONI. L.G. Antimicrobial and antioxidant activity of essential oil and different plant extracts of Psidium cattleianum Sabine. Braz.J.Biol., 76, 101-108, 2016. SELL,C. Chemistry of Essential oils. In: BASER, K.H.C.; BUCHABAUER, G. (eds). Handbook of Essential Oils: Science, Technology, and Applications. CRC Press, Florida,USA. 2010, cap. 5, p.121-150. 113 SHAFI, P.M.; ROSAMMA, M.K.; JAMIL, K.; REDDY, P.S. Antibacterial activity of Syzygium cumini and Syzygium travancoricum leaf essential oils. Fitoterapia, 73, 414-416, 2002. SHARMA, B. S.; NASIR, A.; PRABHU, K.M.; MURTHY, P.S.. Antihyperglycemic effect of the fruit-pulp of Eugenia jambolana in experimental diabetes mellitus. J.Ethnopharmacol., 104, 367-373, 2006. SHEN SC, CHEN FC, WU NJ. Effect of guava (Psidium guajava Linn.) leaf soluble solids on glucose methabolism in type 2 diabetic rats. Phytother.Res. 22: 1458-1464, 2008. SIANI, A.C.; SAMPAIO, A.L.F.: SOUSA, M.C.; HENRIQUES, M.G.M.O.; RAMOS, M.F.S. ?leos essenciais ? potencial anti-inflamat?rio. Biotecnol.Ci?nc.Desenvol. 16, 38-43, 2000. SIANI, A.C.; SOUZA, M.C.; HENRIQUES, M.G.M.O.; RAMOS, M.F.S Anti-inflammatory activity of essential oils from Syzygium cumini and Psidium guajava. Pharm. Biol. Early Online: 1?7, 2013. SIDDIQUE, S.; PERVEEN, Z.; NAWAZ, S.; SHAHZAD, K.; ALI, Z.. Chemical Composition and Antimicrobial Activities of Essential Oils of Six Species from Family Myrtaceae. J.Essent.Oil Bear.Pl., 18, 950-956, 2015. SIEBERT, D.A.; TENFEN, A.; YAMANAKA, C.N.; DE CORDOVA, C.M.M.; SCHARF, D.R.; SIMIONATTO, E.L.; ALBERTON, M.D. Evaluation of seasonal chemical composition, antibacterial, antioxidant and anticholinesterase activity of essential oil from Eugenia brasiliensis Lam. 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