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Previous issue date: 2015-03-12 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico - CNPq / As nanoemuls?es s?o sistemas emulsionados, caracterizados pelo tamanho de
got?cula reduzido (50-500nm), que tem como principais caracter?sticas a estabilidade cin?tica
e a instabilidade termodin?mica. S?o sistemas promissores na ?rea cosm?tica devido ao seu
tamanho de got?cula que lhes atribui diferentes vantagens quando comparados aos sistemas
convencionais, dentre outras, maior ?rea de superf?cie e melhor permeabilidade. A Opuntia
ficus-indica ? uma planta cultivada no bioma brasileiro da Caatinga de grande import?ncia
socioecon?mica para a regi?o. Apresenta em sua composi??o qu?mica carboidratos utilizados
pela ind?stria cosm?tica como ativos hidratantes. Assim este estudo teve como objetivo
desenvolver, caracterizar, avaliar estabilidade e efic?cia hidratante de nanoemuls?es
cosm?ticas aditivadas com extrato vegetal de Opuntia ficus-indica (L.) Mill. A obten??o das
nanoemuls?es, foi realizada com metodologia de baixa energia. Foram formuladas diferentes
nanoemuls?es variando as propor??es das fases oleosa e aquosa e tensoativos al?m da adi??o
de goma xantana (0,5% e 1%) e a incorpora??o do extrato hidroglic?lico de Opuntia ficusindica
(L.) Mill nas concentra??es de 1 e 3%. As nanoemuls?es obtidas foram submetidas aos
testes de estabilidade preliminar e acelerada. Os par?metros avaliativos da estabilidade
acelerada monitorados foram: o aspecto macrosc?pico, determina??o do valor do pH, do
tamanho de got?cula, do potencial zeta e o do ?ndice de polidispers?o, durante 60 dias em
diferentes temperaturas. As formula??es est?veis foram submetidas ? avalia??o da efic?cia
hidratante por meio das metodologias de capacit?ncia e perda de ?gua transepidermal
durante 5 horas. As amostras est?veis apresentaram aspecto homog?neo, fluido e colora??o
branca, valores de pH dentro da faixa ideal (4,5-6,0) para aplica??o t?pica e tamanho de
got?culas abaixo de 200nm caracterizando o sistema como nanoemuls?o. As nanoemuls?es
desenvolvidas n?o reduziram a perda de ?gua transepidermal, no entanto aumentaram o
conte?do h?drico do estrato c?rneo, destacando-se a nanoemuls?o contendo 0,5% de goma
xantana e 1% de extrato hidroglic?lico. Esse trabalho apresenta nanoemuls?es cosm?ticas
hidratantes compostas com mat?ria-prima vegetal da Caatinga brasileira com potencial para
aplica??o na ?rea cosm?tica. / Nanoemulsions are emulsified systems, characterized for reduced droplet size (50-
500nm), which the main characteristic are kinect stability and thermodynamic instability.
These are promising systems on cosmetic area due to their droplet size that provide different
advantages when compared to conventional systems, among others, larger surface area and
better permeability. The Opuntia ficus-indica (L.) Mill is a plant cultivated on Caatinga Brazilian
biome, which has great socioeconomic importance to region. This plant shows carbohydrates
utilized for cosmetic industry as moisturizing active in their chemical composition. The aim of
study was to develop, characterize, evaluate stability and moisturizing efficacy of cosmetic
nanoemulsions added to Opuntia ficus-indica (L.) Mill extract. Nanoemulsions preparation was
made using a low energy method. Different nanoemulsions were formulated varying the ratio
of oil, water and surfactant phases beyond xanthan gum (0.5% e 1%) and Opuntia ficus-indica
(L.) Mill hydroglycolic extract addition on 1% and 3%. Obtained nanoemulsions were
submitted to preliminary and accelerated stability tests. The evaluated parameters monitored
were: macroscopic aspect, pH value, droplet size, zeta potential and polydispersion index,
during 60 days on different temperatures. Stable formulations were submitted to moisturizing
efficacy assessment by capacitance and transepidermal water loss methodologies during 5
hours. Stable samples were white and showed homogeneous and fluid aspect, pH value was
inside ideal range (4,5-6,0) to topical application and droplet size under 200nm characterizing
these system as nanoemulsions. Developed nanoemulsions did not decrease transepidermal
water loss, however increased the water content on stratum corneum, highlighting the
nanoemulsions containing 0.5% of xanthan gum and 1% of hydroglycolic extract. This work
presents cosmetic moisturizing nanoemulsions composed to vegetal raw material from
Brazilian Caatinga with potential to be used on cosmetic area.
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/20044 |
| Date | 12 March 2015 |
| Creators | Ribeiro, Renato C?sar de Azevedo |
| Contributors | 12835182870, http://lattes.cnpq.br/5782539548696465, Egito, Eryvaldo S?crates Tabosa do, 38878240400, http://lattes.cnpq.br/6907806915889763, Campos, Patr?cia Maria Berardo Gon?alves Maia, 06256891864, http://lattes.cnpq.br/1103573381816124, Ver?ssimo, Lourena Mafra, Ferrari, M?rcio |
| Publisher | Universidade Federal do Rio Grande do Norte, PROGRAMA DE P?S-GRADUA??O EM CI?NCIAS FARMACEUTICAS, UFRN, Brasil |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | Portuguese |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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