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Previous issue date: 2011-04-01 / The present work investigated the cognitive operation of children diagnosed with acute
lymphoblastic leukaemia (ALL), accompanied at pediatric oncologic institutions at the
city of Natal/RN. Had participated in this study twenty children, of both sexes, between
six and twelve years old, with the ALL diagnostic, who were in treatment (n=10) and
out of treatment for at least one year (n=10) and were submitted exclusively to
chemotherapy as CNS prophylaxis. The utilized protocol of neuropsychological
evaluation covered the following cognitive abilities: intellective capability, attentional
and memory systems, and executive functions. Data was analyzed through descriptive
and inferential measures, with the support of the Mann-Whitney U Test and T-test,
considering the influence of the variables sex, age at diagnostic and the past time since
the beginning of the treatment over children s performance. The intellective capability
evaluation showed low score to the out-of-treatment groups, female and children under
five years old to the diagnostic. In concern of attentional systems, groups showed the
expected performance. In a relevant way, in the evaluation of executive functions, were
found reduced scores within all groups, especially inside the in-treatment group.
Memory evaluation pointed to reduced performance in items concerning to learning
evolution and spontaneous evocation after interference to the several groups. It can be
concluded, reffer to the occurrence of transitory and permanent impact associated to the
intrusion of chemotherapic components during the maturational course of the CNS. It s
expected that the present investigation and the development of similar studies enable
major comprehension about the mode, extension and repercussion of these damages
subsidizing the development of strategies which may minimize them and provide better
xxiii
life quality to this clinical subgroup / O presente trabalho investigou o funcionamento cognitivo de crian?as diagnosticadas
com Leucemia Linf?ide Aguda (LLA) acompanhadas por institui??es oncol?gicas
pedi?tricas no munic?pio de Natal/RN. Participaram deste estudo 20 crian?as
diagnosticadas com LLA, de ambos os sexos, com idades entre seis e doze anos, que
estavam em tratamento (n=10) e fora de tratamento h? pelo menos 1 ano (n=10),
submetidas exclusivamente ? quimioterapia como profilaxia do SNC. O protocolo de
avalia??o neuropsicol?gica utilizado contemplou as seguintes habilidades cognitivas:
capacidade intelectiva, sistemas atencionais e de mem?ria e fun??es executivas. Os
dados foram analisados atrav?s de medidas descritivas e inferenciais com o aux?lio do
Teste U de Mann-Whitney e do Teste t, considerando-se a influ?ncia das vari?veis sexo,
idade ao diagn?stico e tempo decorrido desde o in?cio do tratamento sobre o
desempenho das crian?as. A avalia??o da capacidade intelectiva revelou baixas
pontua??es para os grupos fora de tratamento, sexo feminino e crian?as menores de
cinco anos ao diagn?stico. Quanto aos sistemas atencionais os grupos apresentaram
desempenho dentro do esperado. De forma relevante, na avalia??o das fun??es
executivas foram encontradas pontua??es reduzidas em todos os grupos, com destaque
para o grupo em tratamento. A avalia??o da mem?ria indicou desempenho rebaixado em
itens concernentes ? evolu??o da aprendizagem e evoca??o espont?nea ap?s
interfer?ncia para os diversos grupos. Conclui-se que estas informa??es aludem ?
ocorr?ncia de impactos transit?rios e permanentes associados ? intrus?o de componentes
quimioter?picos no curso maturacional do SNC. Espera-se que a presente investiga??o e
o desenvolvimento de estudos semelhantes possibilitem maior compreens?o acerca da
modalidade, extens?o e repercuss?o de tais preju?zos, subsidiando o desenvolvimento de
xxi
estrat?gias que possam minimiz?-los e proporcionar maior qualidade de vida para este
subgrupo cl?nico
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/17478 |
| Date | 01 April 2011 |
| Creators | Gomes, Ediana Rosselly de Oliveira |
| Contributors | CPF:71223010449, http://lattes.cnpq.br/5496201609189471, Fonseca, Rochele Paz, CPF:95609199034, http://lattes.cnpq.br/5918287268298812, Melo, Symone Fernandes de, CPF:73765562491, http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4775191U0, Pires, Izabel Augusta Hazin |
| Publisher | Universidade Federal do Rio Grande do Norte, Programa de P?s-Gradua??o em Psicologia, UFRN, BR, Psicologia, Sociedade e Qualidade de Vida |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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