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Investiga??o de aspectos neuropsicol?gicos e acad?micos em crian?as e adolescentes sobreviventes de leucemia linfoide aguda - LLAGomes, Ediana Rosselly de Oliveira 29 September 2017 (has links)
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Previous issue date: 2017-09-29 / A leucemia linfoide aguda (LLA) ? o tipo de c?ncer mais comum entre crian?as e
adolescentes. A sofistica??o dos processos diagn?sticos e terap?uticos promoveu a
eleva??o da sobrevida e a redu??o das reca?das da doen?a. A inclus?o do tratamento
profil?tico direcionado ao SNC, realizado atrav?s de quimioterapia e/ou radioterapia, tem
sido apontada como essencial para o sucesso terap?utico, todavia parece relacionar-se ?
emerg?ncia de efeitos neuropsicol?gicos tardios em cerca de 30% dos sobreviventes.
Estudos sugerem que altera??es sobre dom?nios cognitivos espec?ficos contribuem para
o decl?nio do funcionamento intelectual e dificuldades acad?micas. O objetivo geral da
presente pesquisa foi investigar aspectos neuropsicol?gicos e acad?micos de crian?as e
adolescentes sobreviventes de LLA. A pesquisa foi dividida em quatro estudos: 1)
Funcionamento intelectual de crian?as e adolescentes diagnosticados com LLA; 2)
Aten??o e fun??es executivas em pacientes pedi?tricos sobreviventes de LLA; 3)
Tradu??o e adapta??o do Question?rio Comportamental Deasy-Spinetta (DSBQ); 4)
Investiga??o de aspectos acad?micos em crian?as e adolescentes diagnosticados com
LLA. Participaram desse estudo 26 crian?as e adolescentes sobreviventes de LLA
submetidas exclusivamente ? quimioterapia (grupo cl?nico) e 26 crian?as e adolescentes
saud?veis (grupo controle), al?m de 26 pais e 46 professores. O protocolo de avalia??o
neuropsicol?gica contemplou os seguintes dom?nios: funcionamento intelectual, aten??o,
mem?ria, fun??es executivas, habilidades acad?micas e aspectos comportamentais. Os
resultados foram analisados por ferramentas estat?sticas descritivas e inferenciais. No
estudo 1 o grupo cl?nico apresentou desempenho significativamente inferior ao grupo
controle. A baixa escolaridade materna foi associada a menor desempenho nos dom?nios
verbal, n?o-verbal e funcionamento intelectual global. A menor idade ao diagn?stico foi
correlacionada com baixos desempenhos no dom?nio verbal, capacidade intelectual global e mem?ria operacional, estando esta ?ltima tamb?m associada ao maior tempo de
conclus?o do tratamento. O estudo 2 evidenciou desempenho significativamente inferior
do grupo cl?nico em aten??o e fun??es executivas, especialmente no subgrupo de crian?as
diagnosticadas antes dos cinco anos de idade. Os resultados do estudo 3 sugeriram que o
DSBQ apresenta validade aparente ou de face, sendo um instrumento de f?cil utiliza??o.
No estudo 4 o grupo cl?nico apresentou resultados inferiores em aritm?tica, compreens?o
de textos e nos processos de armazenamento, evolu??o da aprendizagem e recupera??o
de informa??es. Dificuldades espec?ficas do funcionamento escolar associaram-se
predominantemente com a menor idade da crian?a ao diagn?stico. Espera-se que o
conhecimento produzido por esse estudo possa contribuir com o desenvolvimento de
programas voltados para a reinser??o escolar e a elabora??o de pol?ticas p?blicas para
essa popula??o cl?nica, bem como a realiza??o de estudos futuros em neuropsicologia do
desenvolvimento e da aprendizagem. / Acute lymphoblastic leukemia (ALL) is the most common type of cancer among children
and adolescents. The sophistication of the diagnostic and therapeutic processes has
promoted an increase in survival and reduction of relapse of the disease. The inclusion of
prophylactic CNS therapy, performed through chemotherapy and/or radiotherapy, has
been identified as essential for therapeutic success, but it seems to be related to the
emergence of late neuropsychological effects in about 30% of survivors. Studies suggest
that changes in specific cognitive domains contribute to the decline of intellectual
functioning and academic difficulties presented by this clinical population. The main
objective of the present study was to investigate the neuropsychological and academic
aspects of children and adolescents who survived ALL. The research was divided into
four studies: 1) The intellectual functioning of children and adolescents diagnosed with
ALL; 2) Attention and executive functions in pediatric survivors of ALL; 3) Translation
and adaptation of the Deasy-Spinetta Behavioral Questionnaire (DSBQ); 4) Investigation
of academic aspects in children and adolescents diagnosed with ALL. 26 children and
adolescents surviving ALL who underwent chemotherapy (clinical group), 26 healthy
children and adolescents (control group), 26 parents and 46 teachers took part in this
study. The neuropsychological evaluation protocol included the following domains:
intellectual functioning, attention, memory, executive functions, academic abilities and
behavioral aspects. The results were analyzed by descriptive and inferential statistical
tools. In study 1, the clinical group performed significantly lower than the control group.
Maternal low schooling was associated with lower performance in verbal, nonverbal and
global intellectual functioning. The younger age at diagnosis was correlated with low
verbal domain, global intellectual capacity and working memory, and the latter was also
associated with longer treatment completion time. Study 2 evidenced significantly lower performance of the clinical group in attention and executive functions, especially in the
subgroup of children diagnosed before the age of five. The results of study 3 suggested
that the DSBQ has an apparent or face validity, being a readily usable instrument. In study
4 the clinical group presented lower results in arithmetic, text comprehension and storage
processes, learning evolution and information retrieval. Specific difficulties of school
functioning were associated predominantly with the child's lower age at diagnosis. It is
hoped that the knowledge produced by this study may contribute to the development of
programs aimed at the reinsertion of the school and the elaboration of public policies for
this clinical population, as well as the accomplishment of future studies in
neuropsychology of development and learning.
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Avalia??o das habilidades neurocognitivas em crian?as e adolescentes sobreviventes da Leucemia Linfoide Aguda - LLASilva, D?bora Sunaly Leite da 11 July 2014 (has links)
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Previous issue date: 2014-07-11 / Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico / The present study investigated the impact of the treatment modalities of Acute Lymphoblastic
Leukemia on neurocognitive abilities of children and adolescents survivors, aged between 6
and 16 years of age, accompanied in pediatric oncology sectors of public health services in the
cities of Campina Grande-PB and Natal-RN. The study included 52 children, 13 of these being
children and adolescents diagnosed with leukemia and 39 healthy children matched in relation
to the study group considering gender, age, school type and level of maternal education. Later
the group of children with leukemia was subdivided into two subgroups depending on
treatment modality which were submitted: Group 1A (only chemotherapy) and 1B
(chemotherapy and radiotherapy). All participants were subjected to a battery of
neuropsychological tests that investigated the following neurocognitive abilities: intellectual
ability, memory system, attention, visuospatiality and visuoconstruction, processing speed and
executive functions. Data were analyzed using descriptive and inferential measurements with
the aid of the U test of Mann-Whitney and T test, considering the influence of the variables:
sex, age at diagnosis, time since completion of treatment and level of schooling mothers, on
the performance of children. Overall, it is concluded that the illness and the treatment of acute
lymphoblastic leukemia significantly favors the emergence of cognitive deficits, particularly in
terms of visuospatial skills, and executive skills visoconstrutivas. In turn, the treatment
modality of radiotherapy is associated with the presence of more severe deficits, highlighting
the significant impact on the speed of information processing. It is hoped that the results
presented here will contribute to a better understanding of the nature and extent of
neurocognitive effects arising ALL treatment / O presente estudo investigou o impacto das modalidades de tratamento da Leucemia
Linf?ide Aguda sobre as habilidades neurocognitivas de crian?as e adolescentes
sobreviventes, com faixa et?ria entre 6 e 16 anos de idade, acompanhados nos setores de
oncologia pedi?trica de servi?os p?blicos de sa?de das cidades de Campina Grande- PB
e Natal-RN. Participaram deste estudo 52 crian?as, sendo destas 13 crian?as e
adolescentes diagnosticados com leucemia e 39 crian?as saud?veis pareadas em rela??o
ao grupo de estudo considerando-se o sexo, idade, tipo de escola e n?vel de escolaridade
materna. Posteriormente o grupo de crian?as com leucemia foi subdividido em dois
subgrupos em fun??o da modalidade de tratamento as quais foram submetidos: Grupo
1A (exclusivamente tratamento quimioter?pico) e 1B (tratamento quimioter?pico e
radioter?pico). Todos os participantes foram submetidos ? bateria de testes
neuropsicol?gicos que investigou as seguintes habilidades neurocognitivas: capacidade
intelectiva, sistema mnem?nico, aten??o, visoespacialidade e visoconstru??o,
velocidade de processamento e fun??es executivas. Os dados foram analisados atrav?s
de medidas descritivas e inferenciais com o aux?lio do Teste U de Mann-Whitney e do
Teste t, considerando-se a influ?ncia das vari?veis: sexo, idade ao diagn?stico, tempo
decorrido desde o t?rmino do tratamento e n?vel de escolariza??o das m?es, sobre o
desempenho das crian?as. De forma geral, conclui-se que o adoecimento e o tratamento
da leucemia linfoide aguda favorece significativamente o surgimento de d?ficits
cognitivos, em especial em termos de habilidades visoespaciais, visoconstrutivas e
habilidades executivas. Por sua vez, a modalidade de tratamento da radioterapia est?
associada ? presen?a de d?ficits mais severos, com destaque para o impacto
significativo sobre a velocidade no processamento da informa??o. Espera-se que os
resultados ora apresentados venham a contribuir para uma melhor compreens?o acerca
da natureza e da extens?o dos efeitos neurocognitivos advindos do tratamento da LLA
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Caracteriza??o do perfil neuropsicol?gico, acad?mico e comportamental de crian?as e adolescentes sobreviventes de tumores de fossa posteriorCampelo, Danielle Ferreira Garcia Mafra 01 December 2016 (has links)
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Previous issue date: 2016-12-01 / O c?ncer ? a primeira causa de morte de crian?as no Brasil, com 12.600 casos estimados para
2017. Tumores de sistema nervoso central (SNC) s?o os mais comuns na inf?ncia e 60%
atingem cerebelo e adjac?ncias na fossa posterior. A les?o e o tratamento impactam o SNC e
altera??es em fun??es complexas v?m sendo associadas ? interrup??o de conex?es entre o
cerebelo e ?reas corticais. A radioterapia, respons?vel pelo aumento da sobrevida em casos de
tumores malignos, possui a??o neurot?xica sobre o SNC em desenvolvimento. O objetivo do
presente estudo ? investigar o funcionamento neuropsicol?gico e acad?mico de crian?as e
adolescentes sobreviventes de tumores de fossa posterior. A pesquisa foi subdividida em tr?s
estudos: 1) Caracteriza??o da capacidade intelectual de pacientes pedi?tricos diagnosticados
com tumores de fossa posterior; 2) Investiga??o das fun??es executivas em pacientes
pedi?tricos sobreviventes de tumores de fossa posterior e; 3) Proposi??o de modelo conceitual
para explicar o perfil neuropsicol?gico de crian?as e adolescentes submetidas ? radia??o
craniana. 37 sujeitos com idades entre seis e 16 anos compuseram o grupo cl?nico e 24
sujeitos saud?veis compuseram grupo controle, pareados 1:1 segundo sexo, idade, tipo de
escola e n?vel socioecon?mico dos participantes dos estudos 2 e 3. Os participantes passaram
por avalia??o neuropsicol?gica, com resultados analisados por ferramentas estat?sticas
descritivas e inferenciais e an?lise cl?nico-qualitativa. No estudo 1, crian?as submetidas ?
radioterapia apresentaram desempenho significativamente inferior ao de crian?as submetidas
apenas ? neurocirurgia em todos os dom?nios intelectuais, notadamente os n?o-verbais e
velocidade de processamento. O dom?nio n?o verbal revelou diferen?as significativas em
fun??o do tipo de tratamento, enquanto o dom?nio verbal acarretou diferen?as significativas
em fun??o da escolaridade materna, revelando dissocia??o quanto aos dom?nios cognitivos
mais afetados pelo tumor e pelo tratamento, e aqueles mais impactados por fatores socioculturais. Crian?as diagnosticadas tardiamente apresentaram pior desempenho,
contradizendo estudos anteriores. O estudo 2 revelou altera??es executivas nos dom?nios da
mem?ria de trabalho, inibi??o, flexibilidade e planejamento em ambos os grupos cl?nicos.
Crian?as submetidas ? radioterapia apresentaram mais dom?nios afetados e preju?zos mais
severos. Crian?as tratadas apenas com neurocirurgia apresentaram dificuldades restritas a
tarefas com demandas executivas mais sofisticadas, enquanto crian?as submetidas ?
radioterapia apresentaram dificuldades nestes e em tarefas mais simples. O estudo 3
apresentou importantes resultados em dire??o ? compreens?o do perfil neuropsicol?gico de
crian?as submetidas ? radioterapia. Os dados sugerem que a desmieliniza??o provocada pela
radioterapia acarreta altera??es t?picas de les?es do hemisf?rio direito, em padr?o semelhante
ao perfil do Transtorno N?o-Verbal de Aprendizagem (TNVA). As reflex?es te?ricas
resultantes da interpreta??o dos dados levaram ? proposi??o de modelo conceitual,
compreensivo e sist?mico como hip?tese explicativa para a emerg?ncia do perfil
neuropsicol?gico apresentado por sobreviventes de meduloblastoma. Espera-se que o estudo
estimule o interesse pelo aprofundamento da compreens?o acerca das dificuldades e desafios
enfrentados por essa popula??o, visando contribuir para a proposi??o de pol?ticas p?blicas que
promovam a reinser??o social e acad?mica das crian?as ap?s o tratamento, bem como para a
cria??o de programas de interven??o que garantam a melhoria da qualidade de vida dos
sobreviventes. / Cancer is the leading cause of death among Brazilian children, and 12.600 cases are estimated
for 2017. Central nervous system (CNS) tumors are the most common on childhood, from
which 60% arise in cerebellum or adjacent structures of posterior fossa. The lesion and
treatment affect CNS functioning, and alterations in higher order functions have been related
to the interruption of important connections between the cerebellum and cortical areas.
Radiotherapy is responsible for increasing survivorship in malignant tumor cases, but it also
promotes neurotoxic effects to the developing CNS. This study aimed to investigate
neuropsychological and academic functioning in survivors of posterior fossa tumors. The
research was subdivided into three studies: 1) Description of intellectual performance of
pediatric patients diagnosed with posterior fossa tumors; 2) Investigation of executive
functions in pediatric survivors of posterior fossa tumors and; 3) Proposal of a conceptual
model to explain the neuropsychological profile of children and adolescents submitted to
cranial radiation. 37 subjects aged 6-16 integrated clinical group, and 24 subjects formed a
healthy control group matched 1:1 with the participants of studies 2 and 3 according to sex,
age, type of school and socioeconomic level. Participants were submitted to
neuropsychological evaluation and results were analyzed through descriptive and inferential
statistical tools and clinic-qualitative analysis. In the first study, children who underwent
radiotherapy had significantly lower performances on intellectual domains compared to
children only surgically treated, mainly in nonverbal and processing speed domains.
Nonverbal domain revealed significant differences according to treatment modality, while
verbal domain led to significant differences according to mother educational level, which
reveals a dissociation regarding to the domains more strongly affected by the tumor and the
treatment, and the domains more affected by sociocultural factors. Children diagnosed later showed lower performances, which disagree with previous studies. The second study revealed
executive impairments on both clinical groups in terms of working memory, inhibition,
flexibility and planning. Children submitted to radiotherapy showed a broader range of
affected domains and the most serious impairments compared to children who did not
undergo radiotherapy. These children showed difficulties only in measures with more
sophisticated executive demands, while children submitted to radiotherapy also presented
impairments in more simple executive tasks. The third study presented important results
towards the comprehension of the neuropsychological profile of children submitted to cranial
radiation therapy. Data suggest that demyelination caused by radiotherapy leads to right
hemisphere typical impairments, in a pattern which is similar to the Nonverbal Learning
Disability (NLD) profile. Theoretical reflections resulting from data interpretation led to the
proposition of a conceptual, comprehensive and systemic model as an explanation hypothesis
to the emergency of childhood medulloblastoma neuropsychological profile. It is expected
that this study encourage research interest towards the understanding of difficulties and
challenges faced by this population, in order to contribute to the creation of public policies
which enable children?s social and academic reinsertion after treatment, as well as to the
creation of intervention programs which ensure the improvement of survivors? quality of life.
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Investiga??o da capacidade intelectiva de pacientes pedi?tricos diagnosticados com tumores de fossa posteriorGarcia, Danielle Ferreira 01 April 2011 (has links)
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Previous issue date: 2011-04-01 / Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico / Central Nervous System are the most common pediatric solid tumors. 60% of these
tumors arise in posterior fossa, mainly in cerebellum. The first therapeutic approach is
surgical resection. Malignant tumors require additional strategies - chemotherapy and
radiotherapy. The increasing survival evidences that childhood brain tumors result in
academic and social difficulties that compromise the quality of life of the patients. This
study investigated the intellectual functioning of children between 7 to 15 years
diagnosed with posterior fossa tumors and treated at CEHOPE - Recife / PE. 21 children
were eligible - including 13 children with pilocytic astrocytoma (G1) who underwent
only surgery resection, and eight children with medulloblastoma (G2) - submitted to
surgical resection, chemotherapy and craniospinal radiotherapy. Participants were
evaluated by the Wechsler Intelligence Scale for Children - WISC-III. Children of G1
scored better than children of G2. Inferential tools (Mann-Whitney ? Test) identified
significant diferences (p ≤ 0.05) between the Performance IQ (PIQ) and Processing
Speed Index (PSI) as a function of treatment modality; Full Scale IQ (FSIQ), PIQ and
PSI as a function of parental educational level; PIQ, FSIQ, IVP and Freedom from
Distractibility (FDI) as a function of time between diagnosis and evaluation. These
results showed the late and progressive impact of radiotherapy on white matter and
information processing speed. Furthermore, children whose parents have higher
educational level showed better intellectual performance, indicating the influence of
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socio-cultural variables on cognitive development. The impact of cancer and its
treatment on cognitive development and learning should not be underestimated. These
results support the need to increase the understanding of such effects in order to propose
therapeutic strategies which ensure that, in addition to the cure, the full development of
children with this pathology / Os tumores de Sistema Nervoso Central s?o as neoplasias s?lidas mais frequentes na
inf?ncia. 60% desses tumores ocorrem na fossa posterior, cujo principal componente ? o
cerebelo. A primeira interven??o ? a ressec??o cir?rgica; tumores malignos requerem
estrat?gias terap?uticas complementares quimioterapia e radioterapia. O aumento da
sobrevida evidenciou que crian?as com tumores cerebrais apresentam dificuldades
acad?mico-sociais que comprometem sua qualidade de vida. O objetivo deste estudo foi
investigar a capacidade intelectiva de crian?as de 6 a 16 anos com tumores de fossa
posterior. Participaram 21 crian?as atendidas pelo CEHOPE Recife/PE sendo 13
crian?as com astrocitoma piloc?tico (G1) - submetidas ? cirurgia de ressec??o e; oito
crian?as com meduloblastoma (G2) submetidas a cirurgia de ressec??o, quimioterapia
e radioterapia de cr?nio e neuro-eixo. Os participantes foram avaliados pelas Escalas
Wechsler de Intelig?ncia para Crian?as WISC-III. Crian?as de G1 obtiveram
desempenho superior ao de crian?as de G2. An?lises estat?sticas inferenciais (Teste ?
de Mann-Whitney) identificaram contrastes estatisticamente significativos (p≤0,05),
entre o QI de Execu??o (QIE) e ?ndice Fatorial Velocidade de Processamento (IVP) em
fun??o da modalidade de tratamento; QI Total, QIE e IVP em fun??o do n?vel de
escolaridade dos pais; QIE, QIT, IVP e ?ndice Fatorial Resist?ncia ? Distra??o (IRD)
em fun??o do tempo entre o diagn?stico e a avalia??o. Sugere-se o impacto tardio e
progressivo da radioterapia sobre a subst?ncia branca e sobre a velocidade de
processamento; crian?as cujos pais possuem maior n?vel de instru??o formal apresentam
melhor capacidade intelectiva, sugerindo a influ?ncia de vari?veis s?cio-culturais sobre
o desenvolvimento cognitivo. O impacto do c?ncer e seu tratamento sobre o
desenvolvimento e a aprendizagem n?o deve ser subestimado. Tais resultados refor?am
a necessidade de aprofundar a compreens?o sobre tais efeitos, visando propor
estrat?gias terap?uticas que garantam, al?m da reabilita??o cl?nica, o pleno
desenvolvimento das crian?as com esta patologia.
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Investiga??o do funcionamento cognitivo de pacientes pedi?tricos diagnosticados com leucemia linf?ide aguda - LLAGomes, Ediana Rosselly de Oliveira 01 April 2011 (has links)
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Previous issue date: 2011-04-01 / The present work investigated the cognitive operation of children diagnosed with acute
lymphoblastic leukaemia (ALL), accompanied at pediatric oncologic institutions at the
city of Natal/RN. Had participated in this study twenty children, of both sexes, between
six and twelve years old, with the ALL diagnostic, who were in treatment (n=10) and
out of treatment for at least one year (n=10) and were submitted exclusively to
chemotherapy as CNS prophylaxis. The utilized protocol of neuropsychological
evaluation covered the following cognitive abilities: intellective capability, attentional
and memory systems, and executive functions. Data was analyzed through descriptive
and inferential measures, with the support of the Mann-Whitney U Test and T-test,
considering the influence of the variables sex, age at diagnostic and the past time since
the beginning of the treatment over children s performance. The intellective capability
evaluation showed low score to the out-of-treatment groups, female and children under
five years old to the diagnostic. In concern of attentional systems, groups showed the
expected performance. In a relevant way, in the evaluation of executive functions, were
found reduced scores within all groups, especially inside the in-treatment group.
Memory evaluation pointed to reduced performance in items concerning to learning
evolution and spontaneous evocation after interference to the several groups. It can be
concluded, reffer to the occurrence of transitory and permanent impact associated to the
intrusion of chemotherapic components during the maturational course of the CNS. It s
expected that the present investigation and the development of similar studies enable
major comprehension about the mode, extension and repercussion of these damages
subsidizing the development of strategies which may minimize them and provide better
xxiii
life quality to this clinical subgroup / O presente trabalho investigou o funcionamento cognitivo de crian?as diagnosticadas
com Leucemia Linf?ide Aguda (LLA) acompanhadas por institui??es oncol?gicas
pedi?tricas no munic?pio de Natal/RN. Participaram deste estudo 20 crian?as
diagnosticadas com LLA, de ambos os sexos, com idades entre seis e doze anos, que
estavam em tratamento (n=10) e fora de tratamento h? pelo menos 1 ano (n=10),
submetidas exclusivamente ? quimioterapia como profilaxia do SNC. O protocolo de
avalia??o neuropsicol?gica utilizado contemplou as seguintes habilidades cognitivas:
capacidade intelectiva, sistemas atencionais e de mem?ria e fun??es executivas. Os
dados foram analisados atrav?s de medidas descritivas e inferenciais com o aux?lio do
Teste U de Mann-Whitney e do Teste t, considerando-se a influ?ncia das vari?veis sexo,
idade ao diagn?stico e tempo decorrido desde o in?cio do tratamento sobre o
desempenho das crian?as. A avalia??o da capacidade intelectiva revelou baixas
pontua??es para os grupos fora de tratamento, sexo feminino e crian?as menores de
cinco anos ao diagn?stico. Quanto aos sistemas atencionais os grupos apresentaram
desempenho dentro do esperado. De forma relevante, na avalia??o das fun??es
executivas foram encontradas pontua??es reduzidas em todos os grupos, com destaque
para o grupo em tratamento. A avalia??o da mem?ria indicou desempenho rebaixado em
itens concernentes ? evolu??o da aprendizagem e evoca??o espont?nea ap?s
interfer?ncia para os diversos grupos. Conclui-se que estas informa??es aludem ?
ocorr?ncia de impactos transit?rios e permanentes associados ? intrus?o de componentes
quimioter?picos no curso maturacional do SNC. Espera-se que a presente investiga??o e
o desenvolvimento de estudos semelhantes possibilitem maior compreens?o acerca da
modalidade, extens?o e repercuss?o de tais preju?zos, subsidiando o desenvolvimento de
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estrat?gias que possam minimiz?-los e proporcionar maior qualidade de vida para este
subgrupo cl?nico
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