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Spatiotemporal calcium-dynamics in presynaptic terminals

This thesis deals with a newly-developed model for the spatiotemporal calcium dynamics within presynaptic terminals. The model is based on single-protein kinetics and has been used to successfully describe different neuron types such as pyramidal neurons in the rat neocortex and the Calyx of Held of neurons from the rat brainstem. A limited number of parameters had to be adjusted to fluorescence measurements of the calcium concentration. These values can be interpreted as a prediction of the model, and in particular the protein densities can be compared to independent experiments. The contribution of single proteins to the total calcium dynamics has been analysed in detail for voltage-dependent calcium channel, plasma-membrane calcium ATPase, sodium-calcium exchanger, and endogenous as well as exogenous buffer proteins. The model can be used to reconstruct the unperturbed calcium dynamics from measurements using fluorescence indicators. The calcium response to different stimuli has been investigated in view of its relevance for synaptic plasticity. This work provides a first step towards a description of the complete synaptic transmission using single-protein data.

Identiferoai:union.ndltd.org:DRESDEN/oai:qucosa.de:swb:14-1120822103925-08165
Date14 June 2005
CreatorsErler, Frido
ContributorsTechnische Universität Dresden, Mathematik und Naturwissenschaften, Physik, Institut für theoretische Physik, Prof. Dr. Gerhard Soff, Prof. Dr. Santiago Schnell, Prof. Dr. Gehard Soff, Prof. Dr. Jonathan Howard
PublisherSaechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden
Source SetsHochschulschriftenserver (HSSS) der SLUB Dresden
LanguageEnglish
Detected LanguageEnglish
Typedoc-type:doctoralThesis
Formatapplication/pdf

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