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Previous issue date: 2011-07-18 / CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / A presente dissertação, intitulada Síntese de novos derivados de 1-(7-cloro-4-quinolinil) tiossemicarbazidas e semicarbazidas como potencias agentes antibacterianos e antiparasitários descreve a síntese de novos derivados de 1-(7-cloro-4-quinolinil) tiossemicarbazidas e semicarbazidas N-1-substituídas além dos respectivos derivados piridínicos como potenciais agentes antibacterianos e antiparasitários.
A síntese destes derivados procedeu-se via substituição nucleofílica aromática (SNAr) entre a 4,7-dicloroquinolina ou o cloridrato de 4-cloropiridina com as tiossemicarbazidas e semicarbazidas N-substituídas. As tiossemicarbazidas e semicarbazidas foram preparadas a partir da redução das respectivas tiossemicarbazonas e semicarbazonas com amalgama de sódio.
Os resultados da avaliação biológica dos derivados 1-(7-cloro-4quinolinil)tiossemicarbazidas, semicarbazidas e 1-(4-piridinil)tiossemicarbazidas contra a bactéria Mycobacterium tuberculosis também são discutidos. / This work, entitled “Synthesis of novel derivatives of 1-(7-chloro-4-quinolinyl) thiosemicarbazides and semicarbazides as potencial antibacterial and antiparasitic agents” describes the synthesis of new derivatives of 1-(7-chloro-4-quinolinyl) thiosemicarbazides and semicarbazides, N-1-substituted pyridine derivatives were also prepared and their evaluation as potential antibacterial and antiparasitic agents was investigated.
The synthesis of these compounds proceeded via nucleophilic aromatic substitution (SNAr) 4,7-dichloroquinoline or 4-chloropyridine hydrochloride by Nsubstituted thiosemicarbazides and semicarbazides. The thiosemicarbazides and semicarbazides were prepared by reduction of the respective thiosemicarbazones and semicarbazones with sodium amalgam.
The results of biological evaluation of these 1-(7-chloro-4- quinolinyl)thiosemicarbazides, semicarbazides and 1-(4-pyridinyl)thiosemicarbazides against the bacterium Mycobacterium tuberculosis are also discussed.
| Identifer | oai:union.ndltd.org:IBICT/oai:hermes.cpd.ufjf.br:ufjf/4293 |
| Date | 18 July 2011 |
| Creators | Machado, Rafael Carvalhaes |
| Contributors | Grazul, Richard Michael, Alves, Ricardo José, Almeida, Mauro Vieira de |
| Publisher | Universidade Federal de Juiz de Fora (UFJF), Programa de Pós-graduação em Química, UFJF, Brasil, ICE – Instituto de Ciências Exatas |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | Portuguese |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Source | reponame:Repositório Institucional da UFJF, instname:Universidade Federal de Juiz de Fora, instacron:UFJF |
| Rights | info:eu-repo/semantics/openAccess |
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