Structured Product Labels (SPLs), the package inserts that accompany drugs governed by the Food and Drugs Administration (FDA), hold information about Adverse Drug Reactions (ADRs) that exists associated with drugs post-market. This information is valuable for actors working in the field of pharmacovigilance aiming to improve the safety of drugs. One such actor is Uppsala Monitoring Centre (UMC), a non-profit conducting pharmacovigilance research. In order to access the valuable information of the package inserts, UMC have constructed an SPL mining pipeline in order to mine SPLs for ADRs. This project aims to investigate new approaches to the solution to the Scan problem, the part of the pipeline responsible for extracting mentions of ADRs. The Scan problem is solved by approaching the problem as a Named Entity Recognition task, a subtask of Natural Language Processing. By using the transformer-based deep learning model BERT, with domain-specific pre-training, an F1-score of 0.8220 was achieved. Furthermore, the chosen model was used in an iteration of Active Learning in order to efficiently extend the available data pool with the most informative examples. Active Learning improved the F1-score to 0.8337. However, the Active Learning was benchmarked against a data set extended with random examples, showing similar improved scores, therefore this application of Active Learning could not be determined to be effective in this project.
| Identifer | oai:union.ndltd.org:UPSALLA1/oai:DiVA.org:uu-513442 |
| Date | January 2023 |
| Creators | Norén, Erik |
| Publisher | Uppsala universitet, Avdelningen för beräkningsvetenskap |
| Source Sets | DiVA Archive at Upsalla University |
| Language | English |
| Detected Language | English |
| Type | Student thesis, info:eu-repo/semantics/bachelorThesis, text |
| Format | application/pdf |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | UPTEC IT, 1401-5749 ; 23034 |
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