Introdução: Polineuropatia periférica (PNP) é descrita em diabéticos, porém estudos têm mostrado alterações neuropáticas em pacientes com pré-diabetes (Pre-DM), Síndrome Metabólica (SM), obesos e submetidos à cirurgia bariátrica (post-BS). Objetivo: Avaliar a prevalência de PNP entre pacientes com Diabetes Mellitus (DM), obesos graus II e III e pré-diabetes (OB-PRE-DM), obesidade graus II e III e síndrome metabólica (OB-SM), obesidade sem PREDM e SM (Ob No MS) e pacientes Post-BS e avaliar a sensibilidade e a especificidade da escala Neuropathy Disability Score (NDS) em comparação com Michigan Neuropathy Screening Instrument (MNSI). Método: Foi realizado um estudo transversal onde as prevalências de PNP foram avaliadas através do MNSI e do NDS. O desempenho do NDS foi comparado ao MNSI através de curvas Receiving Operating Characteristics Curves (ROC). Resultados: Considerando os escores MNSI ≥ 2,5 e ≥ 4 sintomas, MNSI ≥ 2,5 e ≥ 7 sintomas e NDS ≥ 3 em combinação com Neuropathy Symptom Score (NSS) score ≥ 3, houve a prevalência maior de PNP em DM e Pre-DM vs Ob-SM e Ob No MS e em todos vs Post-BS quando os grupos foram comparados entre si. As curvas ROC mostraram que o melhor desempenho do NDS foi ≥ 0,5. Conclusão: A prevalência de PNP descrita com o MNSI é maior em relação a com NDS. O baixo valor obtido para o melhor desempenho do NDS sugere que exploremos escores <3 para avaliar alterações neuropáticas com este escore. / Introduction: Peripheral polineuropathy (PNP) is seen in diabetics, however, studies have shown neuropathic alterations in patients with pre-diabetes (Pre-DM), Metabolic Syndrome (MS), obese and submitted to bariatric surgery (post-BS). Objective: To evaluate the prevalence of PNP among patients with Diabetes Mellitus (DM), obese grades II and III and pre-diabetes (OB-PRE-DM), obesity grades II and III and metabolic syndrome (OB-SM), obesity without PREDM and Ob No MS and Post-BS patients and to assess the sensitivity and specificity of Neuropathy Disability Score (NDS) compared to the Michigan Neuropathy Screening Instrument (MNSI). Method: A cross-sectional study was carried out in which PNP prevalence were evaluated through the MNSI and the Neuropathy NDS. The performance of the NDS was compared to the MNSI through Receiving Operating Characteristics Curves (ROC curves). Results: Considering MNSI scores ≥ 2.5 and ≥ 4 symptoms, MNSI ≥ 2.5 and ≥ 7 symptoms and NDS ≥ 3 in combination with NSS score ≥ 3, there was a higher prevalence of PNP in DM and Pre-DM vs Ob-SM and Ob No MS and in all vs. Post-BS when groups were compared to each other. The curves ROC showed that the best performance of NDS was ≥ 0.5. Conclusion: The prevalence of PNP described with MNSI is higher in relation to described with NDS. The low value obtained for the best performance of NDS suggest that we explore <3 scores to evaluate neuropathic alterations with this score.
| Identifer | oai:union.ndltd.org:IBICT/oai:lume56.ufrgs.br:10183/179831 |
| Date | January 2017 |
| Creators | Rodrigues, Daiane |
| Contributors | Schmid, Helena |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, instname:Universidade Federal do Rio Grande do Sul, instacron:UFRGS |
| Rights | info:eu-repo/semantics/openAccess |
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