Metabolic Environment and Cellular Signaling in Haematopoietic Stem Cells and Progenitor Cells

Description

This work demonstrates how the nutrient and physico-chemical environment can indeed affect the self-renewal versus differentiation of haematopoietic progenitor cells in vitro, consistent with the proposed existence of metabolic niches in vivo that contribute to the organization and control of haematopoiesis. The identification of Nme2 as a key link between metabolic and signaling activities should enable more detailed analysis of these relationships in the future.

Links & Downloads

1. urn:nbn:de:bsz:15-qucosa2-385784
2. https://ul.qucosa.de/id/qucosa%3A38578
3. https://ul.qucosa.de/api/qucosa%3A38578/attachment/ATT-0/

Tags

Stem cells, Self-renewal, STAT5, Nme2

info:eu-repo/classification/ddc/610

ddc:610

Additional Fields

Identifer	oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:38578
Date	28 February 2020
Creators	Mohammed Ali Nasr, Waseem
Contributors	Universität Leipzig
Source Sets	Hochschulschriftenserver (HSSS) der SLUB Dresden
Language	English
Detected Language	English
Type	info:eu-repo/semantics/acceptedVersion, doc-type:doctoralThesis, info:eu-repo/semantics/doctoralThesis, doc-type:Text
Rights	info:eu-repo/semantics/openAccess