Yes / Curiouser and curiouser! A biarylpyrimidine ligand (see picture: N blue, H cyan, S yellow) shows a marked structure and sequence selectivity for the poly(dA)⋅poly(rU) hybrid duplex. An intercalative binding site was discovered where the ligand occupies a surprising ten base pairs. A strong correlation between hybrid duplex and DNA triplex binding indicates new directions for ligand design.
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/6233 |
| Date | 2010 March 1929 |
| Creators | Wheelhouse, Richard T., Garbett, N.C., Buurma, N.J., Chaires, J.B. |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Article, Accepted manuscript |
| Rights | © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Full-text reproduced in accordance with the publisher's self-archiving policy. This is the peer-reviewed version of the following article: Wheelhouse RT, Garbett NC, Buurma NJ and Chaires JB (2010) Probing the Molecular Recognition of a DNA·RNA Hybrid Duplex. Angewandte Chemie. 49(18): 3207-3210, which has been published in final form at http://dx.doi.org/10.1002/anie.200907235. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving, Unspecified |
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