Diabetes mellitus is a systemic condition that remains undiagnosed in a large portion of the population, which presents potential challenges for implant-based rehabilitation. Currently, the effects of diabetes on bone healing are not fully understood. Thus prior to employing a model of diabetes in studies of peri-implant healing, it was important to investigate the temporal effects of hyperglycemia on bone healing. Bone healing of femoral drill-defects was compared between streptozotocin-induced hyperglycemic (DB) and normoglycemic (NDC) rats at 5, 10, 15, and 30 days P.O. Quantitative assessment of bone samples using μCT demonstrated a delay in bone formation occurring up to 10 days in DB animals. Histological assessment confirmed these quantitative findings. Additionally, fluorescently stained bone samples indicated possible defects in mineralization of bone in DB group. In summary hyperglycemia affects bone healing at the early stages of bone formation, concurrent with the osteoconduction phase of bone healing.
| Identifer | oai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/25839 |
| Date | 12 January 2011 |
| Creators | Mahno, Elena |
| Contributors | Davies, John Edward |
| Source Sets | University of Toronto |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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