Background: Cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH) has been
extensively investigated, but the impact of collateralization remains unclear. We investigated the
predictive value of collateral activation for delayed cerebral ischemia (DCI)-related infarctions and
functional outcome. Methods: Data from 43 patients with CVS (January 2014 to August 2021) were
evaluated for the angiographic presence of leptomeningeal and ophthalmic collaterals (anterior
falcine artery (AFA), supratrochlear artery (STA), dorsal nasal artery (DNA)) on internal carotid
artery angiograms. Vasospasm-related infarction and the modified Rankin Scale (mRS) score after
six months were chosen as the endpoints. Results: 77% of the patients suffered from DCI-related
infarctions. In 233 angiograms (at hospitalization, before spasmolysis, after six months), positive
vessel signs were observed in 31 patients for STA, 35 for DNA, and 31 for AFA. The STA sign
had the highest positive (84.6%) and negative (85.7%) predictive value for unfavorable outcome
(mRS 4–6) in patients aged 50 years. DNA and AFA signs were not meaningful predictors for either
endpoint. Leptomeningeal collaterals showed a positive Pearson’s correlation with the STA sign in
87.5% (p = 0.038) without providing any prediction for either endpoint. Conclusions: The STA sign is
associated with clinical outcome in patients with CVS after SAH aged 50 years, and was correlated
with the occurrence of leptomeningeal collaterals.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:90268 |
| Date | 29 February 2024 |
| Creators | Richter, Cindy, Werdehausen, Robert, Jentzsch, Jennifer, Lindner, Dirk, Gerhards, Thilo, Hantel, Torsten, Gaber, Khaled, Schob, Stefan, Saur, Dorothee, Quäschling, Ulf, Hoffmann, Karl-Titus, Ziganshyna, Svitlana, Halama, Dirk |
| Publisher | MDPI |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 2185 |
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