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Previous issue date: 2015 / A doen?a renal cr?nica consiste em les?o renal com perda progressiva e
irrevers?vel da fun??o dos rins. Nesta fase, os pacientes recebem indica??o de terapia renal
substitutiva sendo a Hemodi?lise o recurso mais utilizado. Evid?ncias indicam que a pr?tica de
exerc?cio f?sico intradial?tico ? ben?fica. Entretanto, os benef?cios desta modalidade de
exerc?cio sobre par?metros end?crino-metab?licos e de estresse oxidativo ainda s?o poucos
conhecidos. Objetivo: Avaliar o efeito de uma sess?o de exerc?cio f?sico de intensidade leve a
moderada, sobre par?metros end?crino-metab?licos e de estresse oxidativo de pacientes com
doen?a renal cr?nica submetidos ? hemodi?lise. M?todos: Doze volunt?rios, alocados de forma
randomizada, do Servi?o de Hemodi?lise da Santa Casa de Caridade de Diamantina/MG
participaram do estudo. Todos foram cross-over durante o experimento, a fim de comparar os
resultados entre os dias de hemodi?lise sem exerc?cio (HD s/ exc) e hemodi?lise com exerc?cio
(HD c/exc), e os dias posterior ? sess?o de hemodi?lise sem exerc?cio (P-HD s/ exc) e posterior
? sess?o de hemodi?lise com exerc?cio (P-HD c/exc), para cada volunt?rio. O exerc?cio f?sico
intradial?tico ocorreu de maneira supervisionada, e por meio de um cicloerg?metro port?til. A
coleta de saliva para avalia??o dos par?metros end?crino-meteb?licos cortisol e testosterona
ocorreu durante todos os dias do protocolo experimental, em seis momentos ao longo do dia, a
saber: ao acordar (T1) e trinta minutos ap?s (T2), 12:00h (T3), 14:00h (T4), 16:00h (T5) e ?s
19h (T6). As amostras de sangue para avalia??o dos par?metros de estresse oxidativo foram
coletadas apenas em dias de hemodi?lise, em dois momentos: antes (T3) e ap?s (T4) a sess?o
de hemodi?lise. Resultados: As concentra??es de cortisol e testosterona para os dias de
hemodi?lise com exerc?cio f?sico (HD c/exc) n?o se elevaram significativamente em rela??o ?s
concentra??es apresentadas no dia de hemodi?lise sem exerc?cio f?sico (HD s/exc), o que
tamb?m ocorreu para os dias posteriores ? aplica??o do protocolo de exerc?cio intradial?tico (PHD
c/ exc e P-HD s/ exc). Entretanto, a raz?o testosterona/cortisol aumentou significativamente
no dia posterior ? sess?o de hemodi?lise com exerc?cio (P-HD c/ exc) quando comparada ao dia
posterior ? sess?o de hemodi?lise sem exerc?cio (P-HD s/ exc). Os par?metros de estresse
oxidativo n?o apresentaram altera??es induzidas pelo protocolo de exerc?cio f?sico. Conclus?o:
O exerc?cio f?sico intradial?tico alterou o status anab?lico 24 horas ap?s ? sua realiza??o e n?o
induziu altera??es significativas nos par?metros de estresse oxidativo.sumo / Programa Multic?ntrico de P?s-gradua??o em Ci?ncias Fisiol?gicas, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 2015. / Chronic kidney disease is a kidney injury with progressive and irreversible loss
of kidney function. At the severe stage, patients undergo renal replacement therapy and the
hemodialysis being the most used medical resource. Evidence indicates that the practical of
physical exercise during the hemodialysis sessions is beneficial. However, the benefits of this
exercise modality on endocrine-metabolic parameters and on oxidative stress remains
unknown. Objective: To evaluate the effect of an exercise session mild to moderate intensity,
on endocrine-metabolic parameters and oxidative stress in patients with chronic renal failure
undergoing hemodialysis. Methods: Twelve users of the Hemodialysis Service of Santa Casa
de Diamantina Charity / MG participated, were assigned randomly as volunteers in the study
and were cross-over during all the experiment in order to compare the results between the days
of hemodialysis session without exercise (HD s/ exc) and hemodialysis session with exercise
(HD c/ exc), and the subsequent days of hemodialysis session without exercise (P-HD s/ exc)
and after the hemodialysis session with exercise (P-HD w / exc) for each volunteer. The exercise
protocol was performed in a portable bicycle ergometer and its intensity was previously
determined for each volunteer as mild to moderate. Saliva samples were collected during all
days of the experimental protocol, six times throughout the day, namely on waking (T1) and
thirty minutes after (T2), 12: 00 (T3), 14 : 00 (T4), 16: 00h (T5) and 19h (T6) to determine the
salivary cortisol concentrations and salivary testosterone concentrations. Blood samples were
collected in days of hemodialysis sessions, in two times: pre (T3) and after (T4) hemodialysis
session to determine the REDOX status parameters. Results: The concentrations of cortisol and
testosterone on the days of hemodialysis with exercise (HD c / exc ) did not increase
significantly in relation to the concentrations shown on hemodialysis day without exercise (HD
s / exc ), which also happened after the exercise protocol application days (P-HD c/ exc and PHD
s/exc). However, the reason testosterone/cortisol increased significantly on the day after
the hemodialysis session with exercise (P-HD w / exc) when compared to the day after the
hemodialysis session without exercise (P-HD s / exc). The oxidative stress parameters did not
show induced changes by the physical exercise protocol. Conclusion: It was shown that the
exercise protocol induced changes in the anabolic status 24 hours after its realization and did
not induce changes in oxidative stress parameters.
| Identifer | oai:union.ndltd.org:IBICT/oai:acervo.ufvjm.edu.br/jspui:1/1035 |
| Date | 06 November 2015 |
| Creators | Domingues, Talita Emanuela |
| Contributors | Leite, Laura Hora Rios, Lacerda, Ana Cristina Rodrigues Lacerda, Balthazar, Cl?udio Heitor, Coimbra, C?ndido Celso, Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Balthazar, Cl?udio Heitor |
| Publisher | UFVJM |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Source | reponame:Repositório Institucional da UFVJM, instname:Universidade Federal dos Vales do Jequitinhonha e Mucuri, instacron:UFVJM |
| Rights | A concess?o da licen?a deste item refere-se ao ? termo de autoriza??o impresso assinado pelo autor, assim como na licen?a Creative Commons, com as seguintes condi??es: Na qualidade de titular dos direitos de autor da publica??o, autorizo a Universidade Federal dos Vales do Jequitinhonha e Mucuri e o IBICT a disponibilizar por meio de seus reposit?rios, sem ressarcimento dos direitos autorais, de acordo com a Lei n? 9610/98, o texto integral da obra disponibilizada, conforme permiss?es assinaladas, para fins de leitura, impress?o e/ou download, a t?tulo de divulga??o da produ??o cient?fica brasileira, e preserva??o, a partir desta data., info:eu-repo/semantics/openAccess |
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