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Previous issue date: 2017-02-21 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / Brazil is among the world?s largest fish producers, and the state of Rio de Janeiro is one of the main responsible for this production. In addition, there is a substantial increase in fish consumption which is associated to its functional and nutritional properties, such as its lipid profile. Today the hydrographic bays of Rio de Janeiro suffer the impacts of excessive use of toxic substances, such as Organoclorine Pesticides (OCPs), which has a characteristic lipophilicity and tend to accumulate in adipose tissue of organisms. As a consequence, this may pose risk to consumers of fish from polluted environments. The human exposure to these pollutants is highly related to health problems, such as cancer, immunity diseases and endocrine disruptions. Thus, the present study aims at investigating the occurence of OCPs in sardine (Sardinella brasiliensis), whitemouth croaker (Micropogonias furnieri) and mullet (Mugil liza) from Guanabara Bay, located in the state of Rio de Janeiro, and also to estimate the OCPs intake through fish consumption. The analyses were carried out at the Laboratory of de Radioisotopes Eduardo Penna Franca at UFRJ. The analitical steps included sohxlet extration, purification and subsequent injection in a Gas Chromatography system coupled to a Mass Spectrometer on Negative Chemical Ionization mode (GC/MS/ENCI) to determine the OCPs concentrations. The estimative of the toxic compound intake was performed based on the obtained data for OCP in fish samples, the fish intake of the brazilian population, andavailable data of Acceptable Daily Intake (ADI) for each investigated pesticide. All samples had at least one OCP. Metoxichlor had the highest concentration for the three studied species. There was significant difference between the species concerning the concentration of o,p?-DDD and o,p?-DDT. These DDT metabolites were found at higher concentration in sardine samples in comparison to croaker and mullet ones. However, there was no significant difference between the species in relation to ?OCP. It was evidenced the greater proportion of DDE among the DDT metabolites which suggests the past use of this pesticide. Results for ?-HCH isomer indicate the contamination by the use of Lindane instead of the technical HCH mixture. There was no significant difference among the contamination of the three studied species in regard to sample's acquisition locations, showing that the locality does not influence the content of OCPs in fish, probably due the species behavior which travel big distances along the brazilian coast throughout their life cycle. No sample exceeded the maximum residue limit stipulated for OCPs at both national or international level. Based on the estimated intake data no species exceeded the toxicological safety parameter. Thus, the three studied fish species can be considered safe for human consumptiom in regard to OCPs exposure / O Brasil est? entre os maiores produtores mundiais de pescado, sendo o estado do Rio de Janeiro um dos principais respons?veis por essa produ??o. Al?m disso, existe um aumento substancial do consumo de peixes, que est? associado ? suas propriedades nutricionais e funcionais, como o seu excelente perfil lip?dico. As bacias hidrogr?ficas do Rio de Janeiro sofrem hoje os impactos do uso excessivo de subst?ncias t?xicas, como os Pesticidas Organoclorados (OCPs), que devido ? caracter?stica lipof?lica, tendem a se acumular no tecido adiposo de organismos aqu?ticos, o que pode representar um risco a sa?de de quem consome pescado oriundos de ambientes contaminados. Por sua vez, a exposi??o humana a estes poluentes est? altamente relacionada a problemas de sa?de, tais como o surgimento de c?ncer, problemas de imunidade e interfer?ncias end?crinas. Desta forma, o presente estudo tem por objetivo investigar a ocorr?ncia de OCPs em amostras de sardinha-verdadeira (Sardinella brasiliensis), corvina (Micropogonias furnieri) e tainha (Mugil liza) capturados na Ba?a de Guanabara, localizada no estado do Rio de Janeiro, assim como estimar a ingest?o de OCPs por meio do consumo de pescado. As an?lises foram realizadas no Laborat?rio de Radiois?topos Eduardo Penna Franca da UFRJ, atrav?s de sua extra??o, purifica??o e posterior inje??o em um sistema de Cromatografia Gasosa acoplada a um Espectr?metro de Massa por ioniza??o qu?mica negativa (CG/EM/NCI) para determinar as concentra??es de OCPs. Para estimar a ingest?o desses compostos t?xicos foram utilizados os dados de contamina??o das amostras, consumo do pescado pela popula??o brasileira, assim como os dados de Ingest?o Di?ria Aceit?vel (IDA) para cada contaminante. Todas as amostras investigadas estavam contaminadas com pelo menos um OCP, o Metoxicloro foi o pesticida encontrado em maior concentra??o nas tr?s esp?cies estudadas e houve diferen?a significativa entre as esp?cies em rela??o a concentra??o de o,p?-DDD e o,p?-DDT, estes metab?litos do DDT foram encontrados em maior concentra??o nas amostras de sardinha-verdadeira em rela??o as amostras de corvina e tainha, entretanto n?o houve diferen?a significativa entre as esp?cies em rela??o ao ?OCP. Ficou evidenciada a maior propor??o do DDE entre os metab?litos de DDT, n?o sugerindo o uso recente deste pesticida, e do is?mero ?-HCH entre os demais is?meros de HCH, evidenciando a contamina??o pelo uso de Lindano em rela??o ao HCH t?cnico. N?o houve diferen?a significativa entre a contamina??o das tr?s esp?cies com base nos diferentes pontos de coleta, demonstrando que a localidade de aquisi??o do pescado n?o influenciou no teor dessas subst?ncias, uma vez que estas esp?cies ao longo de seu ciclo de vida percorrem grandes dist?ncias pela costa brasileira. Nenhuma amostra excedeu os limites m?ximos de res?duo estipulados para esses contaminantes tanto a n?vel de regulamenta??o nacional quanto internacional. Com base nos dados de estimativa de ingest?o nenhuma esp?cie excedeu o par?metro toxicol?gico de seguran?a, sendo assim, as tr?s esp?cies estudadas s?o consideradas seguras para o consumo humano em rela??o a exposi??o a OCPs
| Identifer | oai:union.ndltd.org:IBICT/oai:localhost:jspui/2041 |
| Date | 21 February 2017 |
| Creators | FERREIRA, Verona Borges |
| Contributors | Oliveira, Gesilene Mendon?a de, Finco, Fernanda Dias Bartolomeu Abadio, Gamalho, Ormindo Domingues, Torres, Jo?o Paulo Machado |
| Publisher | Universidade Federal Rural do Rio de Janeiro, Programa de P?s-Gradua??o em Ci?ncia, Tecnologia e Inova??o em Agropecu?ria, UFRRJ, Brasil, Instituto de Tecnologia |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da UFRRJ, instname:Universidade Federal Rural do Rio de Janeiro, instacron:UFRRJ |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | AGENCY FOR TOXIC SUBSTANCES AND DISEASE REGISTRY (ATSDR). Toxicological profile for endosulfan. U.S. Department of health and human services. Public Health Service. 2015. 376 p. Dispon?vel em: <http://www.atsdr.cdc.gov/toxprofiles/tp41.pdf>. Acesso em 07 out. 2015. AGENCY FOR TOXIC SUBSTANCES AND DISEASE REGISTRY (ATSDR). Toxicological profile for DDT, DDE, and DDD. Agency for Toxic Substances and Disease Registry. Department of Health and Human Services. p.403. 2002. Dispon?vel em: < http://www.atsdr.cdc.gov/toxprofiles/tp35.pdf> AGENCY FOR TOXIC SUBSTANCES AND DISEASE REGISTRY (ATSDR). Toxicological Profile for Alpha-, Beta-, Gamma-, and Delta-Hexachlorocyclohexane. Agency for Toxic Substances and Disease Registry. Department of Health and Human Services. 2005. Dispon?vel em: <http://www.atsdr.cdc.gov/toxprofiles/tp43.pdf> AGUILAR, A. Relationship of DDEIEDDT in Marine Mammals to the Chronology of DDT Input into the Ecosystem. Can. J. Fisheries and Aquatic Sciences, v. 41, n. 6, p. 840-844, 1984. Dispon?vel em: < http://www.nrcresearchpress.com/doi/abs/10.1139/f84-100?journalCode=cjfas#citart1 >. AKAN, J. C. et al. Organochlorine Pesticide Residues in Fish Samples from Alau Dam, Borno State, North Eastern Nigeria. Environmental & Analytical Toxicology, v. 3, n. 3, p. 171, 2013. Dispon?vel em: < http://www.omicsonline.org/organochlorine-pesticide-residues-in-fish-samples-from-alau-dam-borno-state-north-eastern-nigeria-2161-0525.1000171.pdf >. ALMEIDA, F. V. et al. Subst?ncias t?xicas persistentes (STP) no Brasil. Qu?mica Nova, v. 30, p. 1976-1985, 2007. Dispon?vel em: < http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422007000800033&nrm=iso >. AMATO, C. D.; TORRES, J. P. M.; MALM, O. DDT (Dicloro Difenil Tricoloroetano): Toxicidade e Contamina??o Ambiental-Uma Revis?o. Qu?mica Nova, v. 25, n. 6, p. 995-1002, 2002. Dispon?vel em: < http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422002000600017 >. 46 ANDROUTSOPOULOS, V. P. et al. A mechanistic overview of health associated effects of low levels of organochlorine and organophosphorous pesticides. Toxicology, v. 307, p. 89-94, 2013. Dispon?vel em: < http://www.sciencedirect.com/science/article/pii/S0300483X12003502 >. ANTONIJEVIC, B. et al. Risk characterization for mercury, dichlorodiphenyltrichloroethane and polychlorinated biphenyls associated with fish consumption in Serbia. Food and Chemical Toxicology, v. 49, n. 10, p. 2586-2593, 2011. Dispon?vel em: < http://www.sciencedirect.com/science/article/pii/S0278691511003231 >. ASSOCIA??O BRASILEIRA DE SA?DE COLETIVA (ABRASCO). Dossi? ABRASCO: um alerta sobre os impactos dos agrot?xicos na sa?de. Rio de Janeiro: EPSJV; S?o Paulo: Express?o Popular, 2015. Dispon?vel em: <http://abrasco.org.br/dossieagrotoxicos/>. Acesso em: 21 set. 2015. AYLWARD, L. L. et al. Biomonitoring equivalents for hexachlorobenzene. Regulatory Toxicology and Pharmacology, v. 58, n. 1, p. 25-32, 2010. Dispon?vel em: < http://www.sciencedirect.com/science/article/pii/S0273230010000954 >. BAIRD, C.; CANN, M. Qu?mica Ambiental. Porto Alegre: Bookman, 2011. 844p. BARROSO, R. M.; WIEFELS, A. C. O mercado de pescado na regi?o metropolitana do Rio de Janeiro. S?rie: O mercado do pescado nas grandes cidades latino-americanas. Infopesca. 2010. Dispon?vel em: <http://www.infopesca.org/sites/default/files/complemento/publilibreacceso/287/mercado-rio-de-janeiro-final.pdf>. Acesso em: 12 out. 2015. BINELLI, A.; PROVINI, A. DDT is still a problem in developed countries: the heavy pollution of Lake Maggiore. Chemosphere, v. 52, n. 4, p. 717-723, 2003. Dispon?vel em: < http://www.sciencedirect.com/science/article/pii/S0045653503001887 >. BOOTH, S. et al. Global deposition of airborne dioxin. Marine Pollution Bulletin, v. 75, n. 1?2, p. 182-186, 2013. Dispon?vel em: < http://www.sciencedirect.com/science/article/pii/S0025326X13004281 >. BOTARO, D. et al. Organochlorine pesticides residues in feed and muscle of farmed Nile tilapia from Brazilian fish farms. Food and Chemical Toxicology, v. 49, n. 9, p. 2125-2130, 47 2011. Dispon?vel em: < http://www.sciencedirect.com/science/article/pii/S0278691511002390 >. BRASIL. AG?NCIA NACIONAL DE VIGIL?NCIA SANIT?RIA (ANVISA). Nota T?cnica sobre a reavalia??o toxicol?gica do ingrediente ativo lindano. Ger?ncia Geral de Toxicologia, 2006. Dispon?vel em: <http://portal.anvisa.gov.br/wps/wcm/connect/c99bf100474595769d6bdd3fbc4c6735/lindano.pdf?MOD=AJPERES>. Acesso em: 30 set. 2015 BRASIL. AG?NCIA NACIONAL DE VIGIL?NCIA SANIT?RIA (ANVISA). Programa de An?lise de Res?duos de Agrot?xicos em Alimentos-PARA. Ger?ncia Geral de Toxicologia. Bras?lia, out. 2010. Dispon?vel em: < http://portal.anvisa.gov.br/wps/wcm/connect/d67107004634368583a5bfec1b28f937/Relat%C3%B3rio+PARA+2012+2%C2%AA+Etapa+-+17_10_14-Final.pdf?MOD=AJPERES>. Acesso em: 28 out. 2015 BRASIL. ANVISA - Ag?ncia Nacional de Vigil?ncia Sanit?ria. Nota t?cnica sobre a reavalia??o toxicol?gica do ingrediente ativo Lindano. Gerencia Geral de Toxicologia. 7p. 2006. Dispon?vel em: < http://portal.anvisa.gov.br/documents/111215/117797/lindano.pdf/39f519f7-ee51-4fd8-9528-23c1826ce2be?version=1.0> BRASIL. Economia e Emprego. ?Agrot?xico endosulfan ser? totalmente banido do Brasil at? 2013?. Maio 2011. Dispon?vel em: <http://www.brasil.gov.br/economia-e-emprego/2011/05/agrotoxico-endosulfan-sera-totalmente-banido-do-brasil-ate-2013>. Acesso em: 20 ago. 2015. BRASIL. FUNDA??O INSTITUTO DE PESCA DO ESTADO DO RIO DE JANEIRO (FIPERJ). Governo do Estado do Rio de Janeiro. Relat?rio Final, 2014. Dispon?vel em: < http://www.fiperj.rj.gov.br/fiperj_imagens/arquivos/revistarelatorios2014.pdf>. Acesso em: 15 set. 2015. BRASIL. INSTITUTO BRASILEIRO DE GEOGRAFIA E ESTAT?STICA (IBGE). Pesquisa Nacional de Sa?de 2013. Percep??o do estado de sa?de, estilos de vida e doen?as cr?nicas. Diretoria de pesquisas. Minist?rio da sa?de. Fiocruz. Rio de Janeiro, 2014. 181p. 48 Dispon?vel em: < http://www.ibge.gov.br/home/estatistica/populacao/pns/2013/default.shtm>. Acesso em: 28 out. 2015. BRASIL. INSTITUTO BRASILEIRO DE GEOGRAFIA E ESTAT?STICA (IBGE). Pesquisa de or?amentos familiares 2008-2009: Antropometria e Estado Nutricional de Crian?as, Adolescentes e Adultos no Brasil. Coordena??o de Trabalho e Rendimento, Rio de Janeiro, 2010. 130 p. Dispon?vel em: <http://www.ibge.gov.br/home/estatistica/populacao/condicaodevida/pof/2008_2009_encaa/pof_20082009_encaa.pdf>. Acesso em: 12 out. 2015. BRASIL. INSTITUTO BRASILEIRO DO MEIO AMBIENTE E DOS RECURSOS NATURAIS RENOV?VEIS (IBAMA). Plano de Gest?o para o uso sustent?vel de Sardinha-verdadeira (Sardinella brasiliensis) no Brasil. S?rie Plano de Gest?o dos Recursos Pesqueiros, 5. Bras?lia, 2011. Dispon?vel em: <http://www.ibama.gov.br/phocadownload/plano_gestao_sardinha_verdadeira_2011.pdf>. Acesso em: 24 set. 2015. BRASIL. Minist?rio da Agricultura, Pecu?ria e Abastecimento (MAPA). Resultado Geral do Monitoramento PNCRC ano de 2014. Portaria DAS n?22, de 07 de abril de 2015. Dispon?vel em: < http://www.agricultura.gov.br/arq_editor/file/CRC/Publicacao%20resultados%20PNCRC%202014f.pdf>. Acesso em: 28 out. 2015. BRASIL. MINIST?RIO DA AGRICULTURA, PECU?RIA E ABASTECIMENTO (MAPA). Programa de Controle de Res?duos em Pescado ? PCRP. 2000. Dispon?vel em: < http://extranet.agricultura.gov.br/sislegis-consulta/servlet/VisualizarAnexo?id=11054> BRASIL. MINIST?RIO DA AGRICULTURA, PECU?RIA E ABASTECIMENTO (MAPA). Programa Setorial de Controle de Res?duos e Contaminantes em Carnes ? PNCRC. 2011. Dispon?vel em: < http://www.agricultura.gov.br/arq_editor/file/CRC/IN%2024%20-%20PNCRB%202011%20-%20VERSAO%20-%204-8-2011%20enviado%20para%20publica%C3%A7%C3%A3o.pdf> BRASIL. Minist?rio da Agricultura. Portaria n. 329 de 02 de setembro de 1985. Pro?be em todo o territ?rio nacional a comercializa??o, o uso e a distribui??o de produtos agrot?xicos organoclorados destinados ? agropecu?ria. Di?rio Oficial da Rep?blica Federativa do Brasil, 49 Bras?lia. 1985. Dispon?vel em: < http://www.vieiracastro.com.br/legislacao/Portaria%20MA%20n%C2%BA%20329-85.pdf>. Acesso em: 28 out. 2015. BRASIL. Minist?rio da Pesca e Aquicultura (MAPA). Boletim Estat?stico da Pesca e Aquicultura. Bras?lia: Minist?rio da Pesca e Aquicultura, 2013. Dispon?vel em: <http://www.mpa.gov.br/files/docs/Boletim_MPA_2011_pub.pdf>. Acesso em: 15 set. 2015 BRASIL. Minist?rio da Pesca e Aquicultura (MAPA). Boletim Estat?stico da Pesca e Aquicultura. Bras?lia: Minist?rio da Pesca e Aquicultura, 2012. Dispon?vel em: <http://www.mpa.gov.br/files/docs/Informacoes_e_Estatisticas/Boletim%20Estat%C3%ADstico%20MPA%202010.pdf>. Acesso em: 15 set. 2015. BRASIL. Minist?rio da Pesca e Aquicultura (MAPA): 1? Anu?rio Brasileiro da Pesca e Aquicultura, 2014. Dispon?vel em: < http://formsus.datasus.gov.br/novoimgarq/16061/2489520_218117.pdf>. Acesso em: 12 de nov. 2016. BRASIL. MINIST?RIO DA PESCA E AQUICULTURA (MPA). Plano de Gest?o para o uso sustent?vel da Tainha, Mugil liza Valenciennes, 1836, no Sudeste e Sul do Brasil. Minist?rio do Meio Ambiente. 2011. Dispon?vel em: < http://www.icmbio.gov.br/cepsul/images/stories/biblioteca/download/relatorio_de_ordenamento/tainha/rel_2015_plano_gestao_tainha_mpa_mma_revisado.pdf> CARVALHO, C. V. A. Exig?ncia prot?ica de juvenis de tainha Mugil platanus. 2008. 42 f. Disserta??o (Mestrado em Aquicultura) - Programa de P?s Gradua??o em Aquicultura, Universidade Federal do Rio Grande, Rio Grande, 2008. Dispon?vel em: <http://repositorio.furg.br/handle/1/2679>. Acesso em: 24 set. 2015. CASTELLO, J. P. S?ntese sobre distribui??o, abund?ncia, potencial pesqueiro e biologia da sardinha verdadeira (Sardinella brasiliensis). Avalia??o do Potencial Sustent?vel de Recursos Vivos na Zona Econ?mica Exclusiva MMA-REVIZEE. An?lise/Refinamento de Dados sobre Prospec??o Pesqueira. Departamento de Oceanografia. Funda??o Universidade do Rio Grande, 2006, 15 p. Dispon?vel em: <http://www.mma.gov.br/estruturas/revizee/_arquivos/sinsard.pdf>. Acesso em: 12 out. 2015. 50 CHAIJAN, M. et al. Chemical compositions and characteristics of farm raised giant catfish (Pangasianodon gigas) muscle. LWT - Food Science and Technology, v. 43, n. 3, p. 452-457, 2010. Dispon?vel em: < http://www.sciencedirect.com/science/article/pii/S0023643809002710 >. CHRISTOFORIDIS, A. et al. Organochlorine and mercury contamination in fish tissues from the River Nestos, Greece. Chemosphere, v. 70, n. 4, p. 694-702, 2008. Dispon?vel em: < http://www.sciencedirect.com/science/article/pii/S0045653507008399 >. COMPANHIA DE TECNOLOGIA DE SANEAMENTO AMBIENTAL (CETESB). Ficha de Informa??o Toxicol?gica ? FIT. Clordano. Jan. 2012. Dispon?vel em: <http://laboratorios.cetesb.sp.gov.br/wpcontent/uploads/sites/47/2013/11/Clordano.pdf>. Acesso em: 07 out. 2015. COMPANHIA DE TECNOLOGIA DE SANEAMENTO AMBIENTAL (CETESB). Valores de refer?ncia de toxicidade para a sa?de humana, Aldrin, dieldrin e endrin. Governo do Estado de S?o Paulo, Secretaria do Meio Ambiente, 2008. Dispon?vel em: <http://www.cve.saude.sp.gov.br/htm/doma/pdf/2008CETESB%20Aldrin%20D.pdf>. Acesso em 7 out. 2015. CONNELL, D. W. et al. Persistent Lipophilic Contaminants and Other Chemical Residues in the Southern Hemisphere. Critical Reviews in Environmental Science and Technology, v. 29, n. 1, 1999. Dispon?vel em: < http://dx.doi.org/10.1080/10643389991259173 >. DA SILVA, A. M. F. et al. Organochlorines and polychlorinated biphenyl environmental pollution in south coast of Rio De Janeiro state. Marine Pollution Bulletin, v. 108, n. 1?2, p. 325-331, 2016. Dispon?vel em: < http://www.sciencedirect.com/science/article/pii/S0025326X16301953 >. DA SILVA, A. M. F. et al. Polychlorinated Biphenyls and Organochlorine Pesticides in Edible Fish Species and Dolphins from Guanabara Bay, Rio de Janeiro, Brazil. Bulletin of Environmental Contamination and Toxicology, v. 70, n. 6, p. 1151-1157, 2003. Dispon?vel em: < http://dx.doi.org/10.1007/s00128-003-0102-5 >. DALLAIRE, R. et al. Exposure to organochlorines and mercury through fish and marine mammal consumption: Associations with growth and duration of gestation among Inuit 51 newborns. Environment International, v. 54, p. 85-91, 2013. Dispon?vel em: < http://www.sciencedirect.com/science/article/pii/S0160412013000330 >. DU, Z.-Y. et al. Risk?benefit evaluation of fish from Chinese markets: Nutrients and contaminants in 24 fish species from five big cities and related assessment for human health. Science of The Total Environment, v. 416, p. 187-199, 2012. Dispon?vel em: < http://www.sciencedirect.com/science/article/pii/S0048969711014288 >. EC - European Commission, 2000. Directorate General Health and Consumer Protection. Quality control procedures for pesticide residue analysis. North Yorkshire, 30 p. (Documento SANCO /3103/00, second edition). ENDO, J.; ARITA, M. Cardioprotective mechanism of omega-3 polyunsaturated fatty acids. Journal of Cardiology, v. 67, n. 1, p. 22-27, 2016. Dispon?vel em: < http://www.sciencedirect.com/science/article/pii/S0914508715002300 >. EUROPEAN FOOD SAFETY AUTORITHY (EFSA). Panel on Contaminants in the Food Chain (CONTAM); Scientific Opinion on Emerging and Novel Brominated Flame Retardants (BFRs) in Food. EFSA Journal, v. 10, n. 10, 133 p. 2013. Dispon?vel em: < http://www.efsa.europa.eu/sites/default/files/scientific_output/files/main_documents/2908.pdf>. Acesso em: 12 out. 2015. FERREIRA, C.; DE-OLIVEIRA, A. C. A. X.; PAUMGARTTEN, F. J. R. Serum concentrations of DDT and DDE among malaria control workers in the Amazon region. Journal of Occupational Health v. 53, n. 2, p. 115 - 122, 2011. Dispon?vel em: < https://www.ncbi.nlm.nih.gov/pubmed/21233591 > FIGUEIREDO, V. O. et al. Organophosphorus Pesticides Residues in Cooked Capsicum annuum. Chemical Engineering Transactions, v. 44, p. 241-246, 2015. Dispon?vel em: < http://www.aidic.it/cet/15/44/041.pdf >. FONSECA, E. M. et al. Stormwater impact in Guanabara Bay (Rio de Janeiro): Evidences of seasonal variability in the dynamic of the sediment heavy metals. Estuarine, Coastal and Shelf Science, v. 130, p. 161-168, 20137714. Dispon?vel em: < http://www.sciencedirect.com/science/article/pii/S0272771413002163 >. 52 FOOD AND AGRICULTURAL ORGANIZATION OF THE UNITED NATIONS (FAO).Submission and evaluation of pesticide residues data for the estimation of maximum residue levels in food and feed. FAO Plant, production and protection paper n? 197, 2nd ed. Rome, 2009. Dispon?vel em: <http://www.fao.org/fileadmin/templates/agphome/documents/Pests_Pesticides/JMPR/FAO_manual2nded_Oct07.pdf>. Acesso em: 12 out. 2015. FOOD AND AGRICULTURE ORGANIZATION OF THE UNITED NATIONS (FAO). Fisheries and Aquaculture Department: National Aquaculture Sector Overview Brazil, 2010. Dispon?vel em: <http://www.fao.org/fishery/countrysector/naso_brazil/en>. Acesso em: 16 set. 2015. FOOD AND AGRICULTURE ORGANIZATION OF THE UNITED NATIONS (FAO). Fisheries and Aquaculture Departament. Search Aquatic Species Fact Sheets. Dispon?vel em: < http://www.fao.org/fishery/species>. Acesso em: 13 jan. 2017. FOOD AND DRUG ADMINISTRATION (FDA). Fish and Fishery Products Hazards and Controls Guidance. U. S. Department of Health and Human Services Public Health Service. P.468. 2011. Dispon?vel em: < http://www.fda.gov/downloads/Food/GuidanceRegulation/UCM251970.pdf> FORNS, J. et al. Novel application of statistical methods for analysis of multiple toxicants identifies DDT as a risk factor for early child behavioral problems. Environmental Research, v. 151, p. 91-100, 2016. Dispon?vel em: < http://www.sciencedirect.com/science/article/pii/S0013935116302973 >. GALVAO, P. et al. Distinct bioaccumulation profile of pesticides and dioxin-like compounds by mollusk bivalves reared in polluted and unpolluted tropical bays: Consumption risk and seasonal effect. Food Chemistry, v. 134, n. 4, p. 2040-2048, 2012. Dispon?vel em: < http://www.sciencedirect.com/science/article/pii/S0308814612006437 >. GALVAO, P. et al. Partition of organochlorine concentrations among suspended solids, sediments and brown mussel Perna perna, in tropical bays. Chemosphere, v. 114, p. 9-15, 2014. Dispon?vel em: < http://www.sciencedirect.com/science/article/pii/S004565351400441X >. 53 HE, K. Fish, Long-Chain Omega-3 Polyunsaturated Fatty Acids and Prevention of Cardiovascular Disease?Eat Fish or Take Fish Oil Supplement? Progress in Cardiovascular Diseases, v. 52, n. 2, p. 95-114, 2009. Dispon?vel em: < http://www.sciencedirect.com/science/article/pii/S0033062009000401 >. Acesso em: 2009/10//. IBASE. Pesca na Ba?a de Guanabara cai 62%. Canal Ibase, abr. 2014. Dispon?vel em: <http://www.canalibase.org.br/pesca-na-baia-cai-62-em-dez-anos/>. Acesso em: 12 out. 2015. INTERNATIONAL AGENCY FOR RESEARCH ON CANCER (IARC). Agents Classified by the IARC Monographs, Volumes 1?113, 2015. Dispon?vel em: <http://monographs.iarc.fr/ENG/Classification/>. Acesso em: 03 out. 2015. JARMAN, W. M.; BALLSCHMITER, K. From coal to DDT: the history of the development of the pesticide DDT from synthetic dyes till Silent Spring. Endeavour, v. 36, n. 4, p. 131-142, 2012. Dispon?vel em: < http://www.sciencedirect.com/science/article/pii/S0160932712000634 >. KRIS-ETHERTON, P. M.; HARRIS, W. S.; APPEL, L. J. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. . Circulation, v. 106, n. 21, p. 2747-2757, 2002. Dispon?vel em: < http://www.ncbi.nlm.nih.gov/pubmed/12438303 >. LANGER, P. The impacts of organochlorines and other persistent pollutants on thyroid and metabolic health. Frontiers in Neuroendocrinology, v. 31, n. 4, p. 497-518, 2010. Dispon?vel em: < http://www.sciencedirect.com/science/article/pii/S0091302210000567 >. LEE, I. et al. Developmental neurotoxic effects of two pesticides: Behavior and neuroprotein studies on endosulfan and cypermethrin. Toxicology, v. 335, p. 1-10, 2015. Dispon?vel em: < http://www.sciencedirect.com/science/article/pii/S0300483X15300056 >. LIU, W. et al. Transport of Semivolatile Organic Compounds to the Tibetan Plateau: Spatial and Temporal Variation in Air Concentrations in Mountainous Western Sichuan, China. Environmental Science & Technology, v. 44, n. 5, 2010. Dispon?vel em: < http://pubs.acs.org/doi/abs/10.1021/es902764z >. 54 LOOMIS, D. et al. Carcinogenicity of lindane, DDT, and 2,4-dichlorophenoxyacetic acid. The Lancet Oncology, v. 16, n. 8, p. 891-892, 2015. Dispon?vel em: < http://www.sciencedirect.com/science/article/pii/S1470204515000819 >. MAHMOUD, A. F. A. et al. Distribution and health risk assessment of organochlorine pesticides (OCPs) residue in edible cattle tissues from northeastern part of Egypt: High accumulation level of OCPs in tongue. Chemosphere, v. 144, p. 1365-1371, 2016. Dispon?vel em: < http://www.sciencedirect.com/science/article/pii/S0045653515302149 >. MAZZEO, M. et al. Fish authentication by MALDI-TOF mass spectrometry. J Agric Food Chem., v. 56, n. 23, p. 11701-11706, 2008. Dispon?vel em: < http://www.ncbi.nlm.nih.gov/pubmed/19007297 >. MENDOZA-CARRANZA, M.; VIEIRA, J. Whitemouth croaker Micropogonias furnieri (Desmarest, 1823) feeding strategies across four southern Brazilian estuaries. Aquatic Ecology, v. 42, n. 1, p. 83, 2007. Dispon?vel em: < http://dx.doi.org/10.1007/s10452-007-9084-4 >. MIRANDA, A. L. et al. Bioaccumulation of chlorinated pesticides and PCBs in the tropical freshwater fish Hoplias malabaricus: Histopathological, physiological, and immunological findings. Environment International, v. 34, n. 7, p. 939-949, 2008. Dispon?vel em: < http://www.sciencedirect.com/science/article/pii/S0160412008000251 >. MREMA, E. J. et al. Persistent organochlorinated pesticides and mechanisms of their toxicity. Toxicology, v. 307, p. 74-88, 2013. Dispon?vel em: < http://www.sciencedirect.com/science/article/pii/S0300483X1200412X >. MULATO, I. P.; CORR?A, B.; VIANNA, M. DISTRIBUI??O ESPA?O-TEMPORAL DE Micropogonias furnieri (PERCIFORMES, SCIAENIDAE) EM UM ESTU?RIO TROPICAL NO SUDESTE DO BRASIL. Boletim do Instituto de Pesca, v. 41, n. 1, 2014. Dispon?vel em: < ftp://ftp.sp.gov.br/ftppesca/41_1_1-18.pdf >. MUMTAZ, M. et al. Human health risk assessment, congener specific analysis and spatial distribution pattern of organochlorine pesticides (OCPs) through rice crop from selected districts of Punjab Province, Pakistan. Science of The Total Environment, v. 511, p. 354-361, 2015. Dispon?vel em: < http://www.sciencedirect.com/science/article/pii/S004896971401732X >. 55 PADULA, D. et al. Australian seafood compositional profiles: A pilot study. Vitamin D and mercury content. Food Chemistry, v. 193, p. 106-111, 2016. Dispon?vel em: < http://www.sciencedirect.com/science/article/pii/S0308814614017865 >. POSE-JUAN, E.; FERN?NDEZ-CRUZ, T.; SIMAL-G?NDARA, J. State of the Art on Public Risk Assessment of Combined Human Exposure to Multiple Chemical Contaminants. Trends in Food Science & Technology, p. 68, 2016. PUERTAS, R. et al. Prenatal exposure to mirex impairs neurodevelopment at age of 4 years. NeuroToxicology, v. 31, n. 1, p. 154-160, 2010. Dispon?vel em: < http://www.sciencedirect.com/science/article/pii/S0161813X0900223X >. ROSENFELDER, N. et al. Thorough analysis of polyhalogenated compounds in ray liver samples off the coast of Rio de Janeiro, Brazil. Environmental Science and Pollution Research, v. 19, n. 2, p. 379-389, 2012. Dispon?vel em: < http://dx.doi.org/10.1007/s11356-011-0569-2 >. SILVA, G. R. N?veis de Agrot?xicos Organoclorados e Perfil Alimentar na Cidade dos Meninos Duque de Caxias, RJ, Brasil, entre 2003 e 2004. 2009. 82 f. Disserta??o (Mestrado em Ci?ncias na ?rea de Sa?de P?blica e Meio Ambiente) - Escola Nacional de Sa?de P?blica Sergio Arouca, Rio de Janeiro, 2009. Dispon?vel em: <http://arca.icict.fiocruz.br/handle/icict/2399>. Acesso em: 03 out. 2015. SOUZA, A. S. D. et al. Organochlorine pesticides (OCs) and polychlorinated biphenyls (PCBs) in sediments and crabs (Chasmagnathus granulata, Dana, 1851) from mangroves of Guanabara Bay, Rio de Janeiro State, Brazil. Chemosphere, v. 73, n. 1, p. S186-S192, 2008. Dispon?vel em: < http://www.sciencedirect.com/science/article/pii/S0045653508003068 >. STRANDBERG, B. et al. Concentrations, biomagnification and spatial variation of organochlorine compounds in a pelagic food web in the northern part of the Baltic Sea. Science of The Total Environment, v. 217, n. 1?2, p. 143-154, 1998. Dispon?vel em: < http://www.sciencedirect.com/science/article/pii/S0048969798001739 >. SUDARYANTO, A. et al. Levels and distribution of organochlorines in fish from Indonesia. Environment International, v. 33, n. 6, p. 750-758, 2007. Dispon?vel em: < http://www.sciencedirect.com/science/article/pii/S0160412007000268 >. 56 TORRES, J. P. M. et al. Persistent toxic substances in the Brazilian Amazon: contamination of man and the environment. Journal of the Brazilian Chemical Society, v. 20 n. 6, p. 1175-1179, 2009. ISSN 1678-4790. Dispon?vel em: < http://dx.doi.org/10.1590/S0103-50532009000600024 >. TSUKINO, H. et al. Fish intake and serum levels of organochlorines among Japanese women. Science of The Total Environment, v. 359, n. 1?3, p. 90-100, 2006. Dispon?vel em: < http://www.sciencedirect.com/science/article/pii/S0048969705003219 >. UNITED NATIONS ENVIRONMENT PROGRAMME (UNEP). Stockholm Convention on persistent organic pollutants (POPs); The 9 new POPs: An introduction to the nine chemicals added to the Stockholm Convention by the Conference of the Parties at its fourth meeting, 2010. Dispon?vel em: <http://chm.pops.int/Implementation/NewPOPs/Publications/tabid/695/Default.aspx>. Acesso em: 29 jul. 2015. VETTER, W. et al. Formation of polybrominated dibenzofurans (PBDFs) after heating of a salmon sample spiked with decabromodiphenyl ether (BDE-209). Environmental Science and Pollution Research, v. 22, n. 19, p. 14530-14536, 2015. ISSN 1614-7499. Dispon?vel em: < http://dx.doi.org/10.1007/s11356-014-3267-z >. VIEIRA, M. F. P. Determina??o de Ba, Cd, Cr, Cu, Ni, Pb, Sn e Zn em Tainha (Mugil brasiliensis) nos estu?rios potiguares. 2007. 184 f. Tese (Doutorado em Qu?mica) ? Programa de P?s Gradua??o em Qu?mica, Universidade Federal do Rio Grande do Norte, Natal-RN, 2007. Dispon?vel em: <http://repositorio.ufrn.br:8080/jspui/handle/123456789/17686>. Acesso em: 25 set. 2015. VISENTAINER, J. V. et al. Lipid Content and Fatty Acid Composition of 15 Marine Fish Species from the Southeast Coast of Brazil. Journal of the American Oil Chemists' Society, v. 84, p. 543-547, 2007. Dispon?vel em: < http://link.springer.com/article/10.1007/s11746-007-1070-4 >. WORLD HEALTH ORGANIZATION (WHO) Inventory of IPCS and other WHO pesticide evaluations and summary of toxicological evaluations performed by the Joint 57 Meeting on Pesticide Residues (JMPR) through 2009, 2011. Dispon?vel em: < http://www.who.int/ipcs/publications/jmpr/pesticide_inventory_edition10.pdf> WORLD HEALTH ORGANIZATION (WHO). Global Environment Monitoring System/Codex Alimentarius Commission. Guidelines for predicting dietary intake of pesticides residues, Geneva, 1997. Dispon?vel em: <http://www.bvl.bund.de/SharedDocs/Downloads/04_Pflanzenschutzmittel/rueckst_who_diet_intake_en_pdf.pdf?__blob=publicationFile&v=3>. Acesso em: 12 out. 2015. |
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