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Previous issue date: 2009-03-06 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / Several studies are carried out with aim to establish parameters to determine biologic behavior of oral squamous cell carcinoma, in order this neoplasm presents high rates of morbidity and mortality. The purpose of present research was to performe a clinic, morphologic and immunohistochemical analysis by the expression of galectins 1, 3, 4 and 7 in 65 cases of tongue squamous cell carcinoma, correlating this expression with clinics (outcome of the disease, metastasis and clinical staging) and morphologic parameters (malignancy histologic gradation system). The clinical and morphologic parameters analysed and
expression of galectins 1, 3, 4 and 7 were submitted to statistical analysis (Qui2 test), observing that can be utilized as indicators of the biological behavior of the tongue squamous cell carcinoma. The galectin 1 was expressed in 87,7% of cases studied and it exhibit
statistically significant correlation with metastasis (p=0,033) and clinical staging (p=0,016), it is located mostly in the citoplasm of the stomal cells. The immunoexpression of galectin 3 in 87,7% of cases was correlated with the presence of metastasis (p=0,033) and malignancy histological gradation system (p=0,031), observed, mostly of cases, in tongue squamous cell
carcinoma of malignancy high grading. The galectin 4 showed no statistical significance to any of the parameters evaluated. The expression of galectin 7 in 73,8% of cases showed statistically significant correlation with the malignancy histologic grading (p=0,005), which is marking exclusively found in neoplastic epithelial cells, in the mostly of cases, it is found in cytoplasm and membrane (50%). The expressive immunopositivy of the galectins 1, 3 and 7, observed in this research, leads us to suggest a broad participation of these proteins in oral carcinogenesis, and its possible use as markers of biological behavior and tumor progression in cases of squamous cell carcinoma of the tongue / Diversos estudos s?o desenvolvidos com o intuito de se estabelecer par?metros para determinar o comportamento biol?gico do carcinoma epiderm?ide oral, tendo em vista que esta neoplasia apresenta altas taxas de morbidade e mortalidade. O objetivo do presente trabalho foi realizar uma an?lise cl?nica, morfol?gica e imuno-histoqu?mica atrav?s da
express?o das galectinas 1, 3, 4 e 7 em 65 casos de carcinoma epiderm?ide de l?ngua, correlacionando essa express?o ? par?metros cl?nicos (desfecho da doen?a, met?stase, estadiamento cl?nico) e morfol?gicos (sistema de grada??o histol?gica de malignidade). Os par?metros cl?nicos e morfol?gicos analisados e a express?o das galectinas 1, 3, 4 e 7 foram
submetidos a an?lise estat?stica (teste do Qui
2), observando-se que os mesmos podem ser
utilizados como indicadores do comportamento biol?gico do carcinoma epiderm?ide de l?ngua. A galectina 1 foi expressa em 87,7% dos casos, apresentando correla??o estatisticamente significativa com a met?stase (p=0,033) e o estadiamento cl?nico (p=0,016), localizando-se principalmente no citoplasma das c?lulas estromais. A imunomarca??o da galectina 3, em 87,7% dos casos, correlacionou-se com a presen?a de met?stases (p=0,033) e a grada??o histol?gica de malignidade (p=0,031), sendo encontrada, na maioria dos casos, em carcinoma epiderm?ide de l?ngua de alto grau de malignidade. A galectina 4 n?o exibiu
signific?ncia estat?stica com nenhum dos par?metros avaliados. A marca??o da galectina 7, em 73,8% dos casos, exibiu correla??o estatisticamente significativa com a grada??o histol?gica de malignidade (p=0,005), sendo esta marca??o exclusivamente encontrada nas
c?lulas neopl?sicas, e na maioria dos casos, encontrada no citoplasma e membrana (50%). A expressiva imunomarca??o das galectinas 1, 3 e 7, verificada em nossa pesquisa, nos leva a sugerir uma ampla participa??o dessas prote?nas na carcinog?nese oral, bem como a sua poss?vel utiliza??o como marcadores do comportamento biol?gico e da progress?o tumoral
em carcinoma epiderm?ide de l?ngua
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/17143 |
| Date | 06 March 2009 |
| Creators | Alves, Pollianna Muniz |
| Contributors | CPF:59539224420, http://lattes.cnpq.br/3265824235655776, Godoy, Gustavo Pina, CPF:85762997472, http://lattes.cnpq.br/5655149996985928, Figueiredo, Cl?udia Roberta Leite Vieira de, CPF:50417703449, http://lattes.cnpq.br/9812014935249748, Souza, L?lia Batista de, http://lattes.cnpq.br/6671914892609743, Medeiros, Ana Miryam Costa de, CPF:14068850453, http://lattes.cnpq.br/8375651517819318, Queiroz, L?lia Maria Guedes |
| Publisher | Universidade Federal do Rio Grande do Norte, Programa de P?s-Gradua??o em Patologia Oral, UFRN, BR, Odontologia |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Format | application/pdf |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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