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Previous issue date: 2014-02-28 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico - CNPq / As neoplasias de gl?ndulas salivares exibem uma grande diversidade morfol?gica e
comportamentos biol?gicos variados o que suscita o interesse na pesquisa destas les?es. A
dissemina??o das c?lulas tumorais ? um passo inicial para a progress?o de neoplasias malignas
e, dentro deste contexto, os vasos linf?ticos neoformados s?o considerados essenciais para que
ocorra essa dissemina??o. O papel do VEGF (fator de crescimento endotelial vascular) na
forma??o dos vasos ? fato conhecido mas, pouco se sabe a respeito de sua participa??o em
tumores de gl?ndula salivar. Desta forma, o objetivo deste estudo foi avaliar a express?o do
VEGF-C e VEGF-D, a densidade linf?tica tumoral (D2-40) e a prolifera??o endotelial linf?tica
(dupla marca??o D2-40/Ki-67) em uma s?rie de neoplasias de gl?ndulas salivares. A amostra
foi composta por 20 adenomas pleom?rficos, 20 carcinomas aden?ides c?sticos, 20 carcinomas
mucoepiderm?ides e 10 casos de tecido glandular salivar com caracter?sticas de normalidade
para efeito comparativo. Todos os casos estudados exibiram express?o positiva para VEGF-C
em regi?o peritumoral e intratumoral, n?o sendo encontrada diferen?as de imunoexpress?o
entre os grupos. No entanto, o grupo dos carcinomas aden?ides c?sticos demonstrou diferen?a
significativa da imunoexpress?o do VEGF-C segundo o padr?o cribriforme e s?lido (p = 0,004).
A maioria dos casos constantes do presente estudo, apresentou fraca marca??o para VEGF-D
em regi?o peritumoral e intratumoral. Na avalia??o da densidade endotelial linf?tica
peritumoral, intratumoral e total, os grupos estudados revelaram um gradiente crescente, com
valores menores para o grupo dos adenomas pleom?rficos, seguido dos carcinomas
mucoepiderm?ides e carcinomas aden?ides c?sticos. A densidade endotelial linf?tica foi maior
entre os tumores malignos do que nos tumores benignos. N?o foi observada correla??o entre a
imunoexpress?o de VEGF-C e VEGF-D em rela??o a densidade linf?tica tumoral e a
prolifera??o endotelial linf?tica / Salivary gland neoplasms exhibit a great morphological diversity and varied biological
behavior which raises the interest in the study of these lesions. The spread of tumor cells is an
early step in the progression of malignancies and the neoformed lymphatic vessels are
considered essential in tumor dissemination. Vascular endotelial growth fator (VEGF) is a
family of proteins involved in angiogenesis e lymphangiogenesis. However, in salivar tumors
we have limited information on the expression. The aim of this study was to assess the
expression of VEGF-C and VEGF-D, lymphatic vessel density (single-staining D2-40) and
lymphatic endothelial proliferation (double labeling D2-40/Ki-67) in a series of salivary glands
neoplasms. We selected 20 cases of pleomorphic adenoma, 20 of mucoepidermoide carcinoma,
20 of adenoid cystic carcinoma and 10 tissue sample of normal salivary gland. All cases studied
showed positive expression of VEGF-C in intratumoral and peritumoral region, no differences
in immunoreactivity was found between the groups. However, the group of adenoid cystic
carcinoma showed a significant difference in immunoreactivity of VEGF-C by the cribriform
and solid pattern (p = 0.004). Most of the cases included in this study showed weak
immunoreactivity for VEGF-D in intratumoral and peritumoral region. In the assessment of
lymphatic endotelial density peritumoral, intratumoral and total, the groups showed an
increasing gradient, with lower values for the group of pleomorphic adenomas followed by
mucoepidermoid carcinoma and adenoid cystic carcinoma. Lymphatic endothelial cell density
was higher in malignant than benign tumors. No correlation was observed between the
immunoreactivity of VEGF-C and VEGF-D in relation to tumor lymphatic density and
lymphatic endothelial proliferation
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/19651 |
| Date | 28 February 2014 |
| Creators | Barroso, Keila Martha Amorim |
| Contributors | 08588724472, http://lattes.cnpq.br/6671914892609743, Pinto, Le?o Pereira, 01608789420, http://lattes.cnpq.br/7040457616034306, Freitas, Roseana de Almeida, 28444361453, http://lattes.cnpq.br/9512014003639405, Godoy, Gustavo Pina, 85762997472, http://lattes.cnpq.br/5655149996985928, Cavalcante, Roberta Barroso, 44581050359, http://lattes.cnpq.br/6510605059677599, Souza, L?lia Batista de |
| Publisher | Universidade Federal do Rio Grande do Norte, PROGRAMA DE P?S-GRADUA??O EM PATOLOGIA ORAL, UFRN, Brasil |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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