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Previous issue date: 2015-05-08 / Estudos com tra?ador neuronal em rato tem demonstrado que os n?cleos anterior do
hipot?lamo, divis?o dorsomedial do n?cleo ventromedial do hipot?lamo e pr?-mamilar dorsal
s?o altamente conectados. Quando o rato ? exposto ao predador ou seu odor estes n?cleos
apresentam alta express?o de Fos e a les?o deles reduz o comportamento defensivo contra
predador. A este conjunto de n?cleos foi dado o nome de Sistema Hipotal?mico de Defesa.
No entanto, pouco se sabe sobre a resposta deste sistema ao odor de diferentes predadores ou
seu papel em camundongos. Neste trabalho, expusemos camundongos Swiss aos odores de
dois predadores (gato e cobra) para verificar a express?o de Fos no Sistema Hipotal?mico de
Defesa, assim como os comportamentos defensivos exibidos. A an?lise mostrou que a
exposi??o do camundongo ao odor de gato provocou um aumento na express?o da prote?na
Fos comparado ao controle, enquanto que o odor de cobra n?o teve o mesmo efeito, o que foi
corroborado pelos dados comportamentais. Nossos resultados indicam que esse distinto
circuito em camundongo parece agir diferencialmente aos est?mulos odor?feros de diferentes
predadores, provocando rea??es comportamentais distintas, sendo que o odor de cobra parece
n?o ser percebido como um est?mulo amea?ador pelos camundongos Swiss. / Studies using neuronal tract-tracer in rat have shown that the anterior hypothalamic nucleus,
dorsomedial division of the ventromedial nucleus of the hypothalamus and dorsal premammillary
nucleus are highly connected. When the rat is exposed to predator or its odor
these nuclei have shown a expression of Fos and their lesion reduces defensive behavior
against predator. This set of nuclei was named the Hypothalamic Defense System. However,
little is known about the response of this system to the odor of different predators or its role in
mice. In this work, we exposed Swiss mice to two different predators odor (cat and snake) to
verify the Fos expression in the Hypothalamic Defense System, as well as the defensive
behaviors displayed. The analysis showed that the mice exposure to cat odor had an increased
expression of Fos protein compared to control, while those exposed to snake odor showed no
rise in Fos expression, which was corroborated by the behavioral data. Our results indicate
that this distinct circuit in mice seems to act differentially to odorous stimuli of different
predators, causing distinct behavioral responses of mice and that the odor of snake seems not
to be perceived by Swiss mice as a threatening stimulus.
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/20308 |
| Date | 08 May 2015 |
| Creators | Oliveira, Karen Crisanto de |
| Contributors | 02588073425, http://lattes.cnpq.br/5233940343676740, Oliveira, Francisco Gilberto, 05671426391, http://lattes.cnpq.br/8555492166338935, Cavalcante, Judney Cley, 00932163432, http://lattes.cnpq.br/7975576082142180, Nascimento J?nior, Expedito Silva do |
| Publisher | Universidade Federal do Rio Grande do Norte, PROGRAMA DE P?S-GRADUA??O EM PSICOBIOLOGIA, UFRN, Brasil |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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