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Previous issue date: 2016-12-01 / A s?ndrome metab?lica (SM) ? uma doen?a multifatorial, cujas altera??es fisiopatol?gicas podem comprometer o status de zinco. O objetivo deste estudo foi avaliar os biomarcadores do status de zinco e as associa??es com fatores de risco cardiometab?licos em indiv?duos com SM. Trata-se de um estudo tipo caso-controle, desenvolvido com 88 adultos e idosos com SM, caracterizados segundo os crit?rios do National Cholesterol Education Program - Adult Treatment Panel III (NCEP/ATP-III), e 37 indiv?duos sem SM ou outra condi??o cl?nica com influ?ncia nos par?metros de zinco. Foram realizadas avalia??es cl?nicas, antropom?tricas, perfil lip?dico, glic?mico e inflamat?rio. Verificou-se a ingest?o de zinco, concentra??es de zinco no plasma e eritr?cito, bem como a excre??o de zinco na urina, pelo m?todo de espectrofotometria de absor??o at?mica. Diferen?as entre os grupos foram avaliadas por modelos de regress?o. Correla??es foram identificadas pelo coeficiente de Pearson (r). A idade m?dia dos participantes foi de 50 (11) anos e 44 (11) anos para o grupo de pacientes com SM e controles, respectivamente. A m?dia da ingest?o cal?rica di?ria foi significativamente maior para os pacientes com SM (p = 0,003), e a ingest?o diet?tica de ambos os grupos caracterizou-se como hiperproteica, normoglic?dica e normolip?dica. O consumo m?dio de zinco foi significantemente menor no grupo SM comparado com o controle (6,57(1,64) mg/dia vs 9,37(2,41) mg/dia; p<0,001). N?o foram observadas diferen?as significativas nas concentra??es de zinco no plasma (88,81(18,28) ?g/dL vs 87,82(17,44) ?g/dL; p>0,05). Identificou-se concentra??es significantemente maiores de zinco no eritr?cito no grupo SM (47,47(8,29) ?g/gHb vs 41,43(7,37) ?g/gHb; p<0,001), independente dos ajustes por covari?veis. A excre??o de zinco na urina foi significantemente maior no grupo SM (554,80(291,00-787,60) ?g/24h vs 375,40(197,60-597,50) ?g/24h; p=0,008), e os ajustes por idade e sexo explicaram 21% das diferen?as (R2=0,21; p<0,001). No grupo SM foram constatadas associa??es significativas entre zinc?ria e a glicemia de jejum (r=0,479), circunfer?ncia da cintura (r=0,253), triglicer?deos (r=0,360), hemoglobina glicada (HbA1c) (r=0,250), Homeostasis model assessment ? insulin resistance (HOMA-IR) (r=0,223) e prote?na C reativa ultra-sens?vel (PCR-us) (r=0,427) (todos p<0,05). Na SM observamos inadequa??es na ingest?o de zinco e confirmamos comprometimento no status de zinco, caracterizadas por aumento do zinco no eritr?cito e maior zinc?ria, embora as concentra??es de zinco no plasma estejam dentro dos valores de refer?ncia. Altera??es dos fatores de risco cardiometab?licos influenciam na zinc?ria de pacientes com SM. / Metabolic syndrome (MS) is a multifactorial disease whose pathophysiological alterations might compromise zinc status. The aim of this study was to evaluate zinc status biomarkers and their associations with cardiometabolic risk factors in individuals with MS. This is a study case-control, developed with 88 adults and elderly with SM, according to the National Cholesterol Education Program - Adult Treatment Panel III (NCEP / ATP-III), and 37 individuals without MS or other clinical condition with influence on zinc status. Clinical and anthropometric assessments were performed and lipid, glycemic, and inflammatory profiles were also obtained. It was evaluated zinc intake, plasma zinc, erythrocyte zinc, and urinary zinc excretion levels, by atomic absorption spectrophotometry. Differences between groups were evaluated by regression models. Correlations were identified by Pearson coefficient (r). The average age of participants was 50 (11) years and 44 (11) years for the group of patients with MS and controls, respectively. The average energy intake was significantly higher in patients with MS (p = 0.003) and dietary intake in both groups was characterized as high percentage of protein intake, and a proper percentage of carbohydrate and fat intake. Zinc intake average was significantly lower in MS group compared with control group (6.57 (1.64) mg/day vs 9.37 (2.41) mg/day; p < 0,001). No significant differences were observed in plasma zinc levels (88.81(18.28) ?g/dL vs 87.82(17.44) ?g/dL; p > 0.05). It was found significantly higher erythrocyte zinc levels in the MS group (47.47(8.29) ?g/gHb vs 41.43(7.37) ?g/gHb;p < 0.001) independent from co-variable adjustments. Urinary zinc excretion level was significantly higher in the MS group (554.80(291.00-787.60) ?g/24h vs 375.40(197.60-597.50) ?g/24h; p = 0.008), and adjustments for age and sex explained 21% of the difference, (R2 = 0.21, p < 0.001). SM group were found significant associations between zincuria and fasting blood glucose level (r = 0.479), waist circumference (r = 0.253), triglyceride levels (r = 0.360), glycated hemoglobin (HbA1c) levels (r = 0.250), homeostatic model assessment - insulin resistance (HOMA-IR) (r = 0.223) and high-sensitivity C-reactive protein levels (hs-PCR) (r =0.427) (all p <0.05). In SM we confirmed inadequacies in zinc intake and confirmed impairments in zinc status, characterized by increasing the erythrocytes zinc and higher zincuria, although plasma zinc levels were within the reference values. plasm zinc levels into references values. Alterations in cardiometabolic risk factors influence zincuria in patients with MS.
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/22307 |
| Date | 01 December 2016 |
| Creators | Oliveira, Erika Paula Silva Freitas de |
| Contributors | 98142151472, http://lattes.cnpq.br/2628723272728505, Sousa, Andre Gustavo Pires de, 03442894433, http://lattes.cnpq.br/7508340761996478, Marreiro, Dilina do Nascimento, 47369060306, http://lattes.cnpq.br/1954506202364661, Evangelista, Karine Cavalcanti Mauricio de Sena |
| Publisher | SEM PROGRAMA, UFRN, Brasil |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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