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Previous issue date: 2016-10-31 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES) / O Toxoplasma gondii ? o principal agente etiol?gico respons?vel pelo acometimento do SNC em pacientes HIV/Aids. A triagem de pacientes portadores de HIV/Aids em rela??o ? positividade para T. gondii, associada ? determina??o do n?mero de linf?citos TCD4, pode auxiliar na redu??o da morbi-mortalidade relacionada a esta co-infec??o. O presente estudo teve como objetivo geral avaliar a frequ?ncia da infec??o pelo T. gondii em pacientes HIV positivos e correlacionar aos aspectos cl?nicos, sorol?gicos e epidemiol?gicos. Para isto, foram avaliados 179 pacientes HIV positivos acompanhados no Hospital Giselda Trigueiro. As an?lises sorol?gicas foram realizadas atrav?s da t?cnica de ELISA, enquanto que as an?lises cl?nicas e epidemiol?gicas ocorreram por meio da pesquisa em prontu?rios e aplica??o de question?rio, respectivamente. Al?m disso, foi realizada an?lise molecular a partir de PCR em amostras de sangue perif?rico de 11 pacientes HIV internados com neurotoxoplasmose (suspeita ou confirma??o). Nossos resultados indicam alta taxa de infec??o por T. gondii entre pacientes portadores de HIV/Aids (83,8%), sendo detectadas a neurotoxoplasmose (11,7%) e a toxoplasmose ocular (3,35%). A presen?a de gatos e a ingest?o de salada crua foram fatores de risco identificados, aumentando a chance de adquirir a infec??o em 2,6 e 3,4 vezes, respectivamente. As manifesta??es cl?nicas mais frequentes entre todos os pacientes acometidos pela toxoplasmose cerebral consistiram em: paresia/hemiparesia (65,62%), cefaleia (37,50%) e altera??es da consci?ncia (28,12%). Al?m disso, entre os pacientes HIV/Aids internados, a neurotoxoplasmose foi decorrente de reativa??o da infec??o latente. A avalia??o molecular apresentou limita??es quanto ao diagn?stico da neurotoxoplasmose. Conclui-se que a realiza??o deste trabalho permitiu uma caracteriza??o epidemiol?gica e cl?nica da toxoplasmose em pacientes HIV/Aids do Rio Grande do Norte, sendo um estudo pioneiro na regi?o. / Toxoplasma gondii is the main etiological agent responsible for central nervous system involvement in HIV / AIDS patients. The screening of patients with HIV / AIDS related to the positivity for T. gondii, associated to the determination of the number of CD4+ T lymphocytes, may help to reduce the morbidity and mortality related to this co-infection. The present study had as general objective to evaluate the frequency of T. gondii infection in HIV positive patients and to correlate clinical, serological and epidemiological aspects. For this, 179 HIV positive patients were evaluated at the Hospital Giselda Trigueiro. Serological tests were performed using the ELISA technique, while the clinical and epidemiological analyzes occured through research in medical records and questionnaire application, respectively. In addition, molecular analysis was performed by PCR in peripheral blood samples from 11 HIV patients hospitalized with neurotoxoplasmosis (suspected or confirmed). Our results indicate a high rate of T. gondii infection among patients with HIV / AIDS (83.8%), being detected neurotoxoplasmosis (11.7%) and ocular toxoplasmosis (3.35%). The presence of cats and raw salad ingestion were identified as risk factors, increasing the chance of acquiring the infection in 2.6 and 3.4 times, respectively. The most frequent clinical manifestations among all patients affected by cerebral toxoplasmosis consisted of: paresis / hemiparesis (65.62%), headache (37.50%) and changes in consciousness (28.12%). Besides that, among hospitalized HIV / AIDS patients, neurotoxoplasmosis was due to latent infection reactivation. The molecular evaluation presented limitations on the diagnosis of neurotoxoplasmosis. It is concluded that the accomplishment of this work allowed an epidemiological and clinical characterization of the toxoplasmosis in HIV / AIDS patients of Rio Grande do Norte, being a pioneer study in the region.
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/22615 |
| Date | 31 October 2016 |
| Creators | Oliveira, Marianne Garcia de |
| Contributors | 59626305487, http://lattes.cnpq.br/4863082845974813, Feitosa, Ana Paula Sampaio, 01262261481, http://lattes.cnpq.br/7741235050382403, Guedes, Paulo Marcos da Matta, 02351506731, http://lattes.cnpq.br/5445410844075357, Bay, M?nica Baumgardt, Andrade Neto, Valter Ferreira de |
| Publisher | PROGRAMA DE P?S-GRADUA??O EM CI?NCIAS BIOL?GICAS, UFRN, Brasil |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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