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Previous issue date: 2017-06-26 / Ap?s vinte e seis anos de implanta??o da poliquimioterapia para o tratamento da hansen?ase no Brasil, ainda ? encontrado um n?mero significativo de casos nos servi?os de sa?de, condi??o que levou as autoridades sanit?rias a assumi-la como uma doen?a negligenciada. As consequ?ncias dessa neglig?ncia s?o graves para as pessoas acometidas, uma vez que a demora na chegada aos servi?os, frequentemente, ocasiona comprometimento de nervos, inclusive com incapacidades e deformidades desenvolvidas. Este estudo objetiva avaliar se os n?veis de anticorpos anti-Mycobacterium leprae est?o associados ao desenvolvimento de incapacidades em pacientes com hansen?ase. Trata-se de um estudo de abordagem quantitativa, com delineamento seccional, descritivo e anal?tico, com verifica??o da exist?ncia de associa??o entre a quantidade dos anticorpos espec?ficos da doen?a e a presen?a de incapacidades. Os sujeitos foram arrolados no per?odo de janeiro de 2014 a dezembro de 2015. O protocolo desta pesquisa foi submetido ? aprecia??o pelo Comit? de ?tica em Pesquisa da Universidade Federal do Rio Grande do Norte e aprovado de acordo com registro do CAAE no. 0042.0.051.051-09 e Parecer 280/2012. A coleta foi realizada com os pacientes registrados pelo Programa de Controle da Hansen?ase, dos setores de dermatologia do Hospital Universit?rio Onofre Lopes e do Hospital Estadual Giselda Trigueiro, ambos considerados refer?ncia para o tratamento da doen?a no Estado do Rio Grande do Norte. Os resultados evidenciam que o n?mero de casos novos ? crescente. Da amostra estudada 56% eram do sexo masculino e 44%, feminino; destes, 65,7%, Multibacilares e 34,3%, Paucibacilares. A faixa de idade mais atingida foi de 51 a 70 anos (41%). Dos pacientes que apresentaram Grau 2 de incapacidade, 92,3% eram do sexo masculino e, destes, 58,3% tinham mais de 60 anos. Verificou-se que a quantidade de anticorpos espec?ficos para a doen?a est? fortemente associada ao desenvolvimento de incapacidades, principalmente em pacientes do sexo masculino e em idade mais avan?ada. / After twenty-six years of implantation of polychemotherapy for the treatment of leprosy in Brazil, a significant number of cases are still found in health services, a condition that led the health authorities to assume it as a neglected disease. The consequences of this neglect are serious for people affected, since delayed arrival in services often leads to nerve involvement, including disability and deformities. This study aims to assess whether anti-Mycobacterium leprae antibody levels are associated with the development of disabilities in leprosy patients. This is a quantitative, cross-sectional, descriptive and analytical approach, with an association between the amount of disease-specific antibodies and the presence of disabilities. The subjects were enrolled from January 2014 to December 2015. The protocol of this research was submitted to the Ethics Research Committee of the Federal University of Rio Grande do Norte and approved according to the CAAE registration no. 0042.0.051.051-09 and Opinion 280/2012. The patients were enrolled in the Leprosy Control Program, from the dermatology departments of the Onofre Lopes University Hospital and the Giselda Trigueiro State Hospital, both of which were considered a reference for the treatment of the disease in the State of Rio Grande do Norte. The results show that the number of new cases is increasing. Of the sample studied, 56% were male and 44% female; Of these, 65.7%, Multibacillary and 34.3%, Paucibacillary. The most affected age range was 51 to 70 years (41%). Of the patients who presented Grade 2 disability, 92.3% were males and, of these, 58.3% were over 60 years old. It has been found that the amount of antibodies specific for the disease is strongly associated with the development of disabilities, especially in males and older patients.
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/24147 |
| Date | 26 June 2017 |
| Creators | Moreno, Cl?a Maria da Costa |
| Contributors | 81717881149, Barichello, Elizabeth, 63559935172, Silva, Fernando de Souza, 91745500472, Jer?nimo, Selma Maria Bezerra, 15603016434, Santos, Viviane Euz?bia Pereira, 72339039053, Ferreira J?nior, Marcos Antonio |
| Publisher | PROGRAMA DE P?S-GRADUA??O EM ENFERMAGEM, UFRN, Brasil |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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