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Previous issue date: 2017-12-19 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES) / A Cloro-alum?nio ftalocianina (AlClFc), como droga fotossensibilizadora, tem demonstrado resultados favor?veis em estudos cl?nicos e laboratoriais, no entanto ainda n?o h? ensaios cl?nicos que avaliem sua aplica??o na terapia fotodin?mica antimicrobiana (TFDA) em periodontite cr?nica (PC). Assim, o objetivo deste estudo foi avaliar o efeito da TFDA com AlClFc adjuvante ? raspagem e alisamento corono-radicular (RACR) nos par?metros cl?nicos periodontais de pacientes com PC. O estudo caracterizou-se por um ensaio cl?nico boca dividida, randomizado, duplo cego, longitudinal e prospectivo. Cinquenta e quatro s?tios periodontais foram randomicamente distribu?dos em dois grupos: 27 no grupo teste (RACR + TFDA) e 27 no controle (RACR). A RACR foi realizada em sess?o ?nica e os par?metros cl?nicos periodontais de ?ndice de placa vis?vel (IPV), ?ndice de sangramento ? sondagem (ISS), profundidade de sondagem (PS) e n?vel de inser??o cl?nica (NIC) foram avaliados na linha base (T0) e ap?s 3 meses (T3) da TFDA. Os dados foram submetidos ? an?lise estat?stica pelos testes n?o-param?tricos de Wilcoxon e Mann-Whitney, ao n?vel de signific?ncia de 5%. Observou-se redu??o do ISS em ambos os grupos de tratamento, com TFDA adjuvante (p = 0,003) e somente RACR (p = 0,001), entre T0 e T3. Na compara??o intergrupos n?o houve diferen?a estatisticamente significativa. Verificou-se redu??o da PS e ganho de inser??o cl?nica para ambos os grupos de tratamento (p<0,05) ap?s 3 meses da terapia. Na compara??o intergrupos n?o houve diferen?a estatisticamente significativa (p>0,05) em nenhum dos tempos analisados. A TFDA com AlClFc, adjuvante ? RACR, n?o proporcionou benef?cios adicionais na redu??o da profundidade de sondagem e ganho de inser??o cl?nica. / Chloro-aluminum phthalocyanine (AlClPc), as a photosensitizing drug, has shown favorable results in clinical and laboratory studies; however, there are no clinical trials evaluating its application in antimicrobial photodynamic therapy (PDTa) in chronic periodontitis (CP). Thus, the objective of this study was to evaluate the effect of adjuvant PDTa with AlClPc on scaling and root planing (SRP) in periodontal clinical parameters of patients with CP. The study was characterized as split-mouth randomized clinical trial, double-blind, longitudinal and prospective. Fifty-four periodontal sites were randomly distributed into two groups: 27 in the test group (SRP + PDTa) and 27 in the control group (SRP). The SRP was performed in a single session and clinical periodontal parameters of plaque index (PI), bleeding on probing (BOP), probing depth (PD) and clinical attachment level (CAL) were assessed at the baseline ( T0) and after 3 months (T3) of the PDTa. Data were submitted to statistical analysis by the non-parametric Wilcoxon and Mann-Whitney tests, at a significance level of 5%. There was a reduction in the BOP in both treatment groups, with adjuvant PDTa (p = 0.003) and only SRP (p = 0.001), between T0 and T3. In the inter-group comparison there was no statistically significant difference. PD reduction and clinical insertion gain were observed for both treatment groups (p <0.05) after 3 months of therapy. In the inter-group comparison there was no statistically significant difference (p> 0.05) in any of the times analyzed. PDTa with AlClPc, adjuvant to RACR, did not provide additional benefits in reducing depth of probing and gain of clinical insertion.
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/25008 |
| Date | 19 December 2017 |
| Creators | Sena, Israel Alexandre de Ara?jo |
| Contributors | 05143199417, Gurgel, Bruno C?sar de Vasconcelos, 02569549410, Moraes, Maiara de, 89092074187, Martins, Ana Rafaela Luz de Aquino |
| Publisher | PROGRAMA DE P?S-GRADUA??O EM SA?DE COLETIVA, UFRN, Brasil |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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