Submitted by Setor de Tratamento da Informa??o - BC/PUCRS (tede2@pucrs.br) on 2016-07-12T18:58:42Z
No. of bitstreams: 1
DIS_MORGANA_THAIS_CAROLLO_FERNANDES_PARCIAL.pdf: 412256 bytes, checksum: ed9b15670049bf6fd6c6f737d72389a7 (MD5) / Made available in DSpace on 2016-07-12T18:58:42Z (GMT). No. of bitstreams: 1
DIS_MORGANA_THAIS_CAROLLO_FERNANDES_PARCIAL.pdf: 412256 bytes, checksum: ed9b15670049bf6fd6c6f737d72389a7 (MD5)
Previous issue date: 2016-03-31 / Conselho Nacional de Pesquisa e Desenvolvimento Cient?fico e Tecnol?gico - CNPq / Objectives: The objective of this study is to analyze the effects of asthma and body mass on lung function in children. Methodology: Asthmatic children and healthy controls were recruited in public and private schools in Porto Alegre, Brazil. Spirometry, before and after bronchodilator was obtained in the Lung Function Laboratory (PUCRS) at the same time weight and height were measured. Lung function and body mass index were transformed to z-scoresfor all analysis using international equations. Results: 188 children (97 girls, 52%) were enrolled, 114(60%) with asthma and 85(45%) overweight. The mean and standard deviation of age, height and weight were 11.1+1.1, 146.7+8.4 and 44.2+12.3 respectively. There was a positive correlation between BMI and FVC and FEV1 and a negative correlation with FEV1/FVC. Children with asthmahad lower FEV1/FVC and FEF25-75 and higher FVC (p<0.05 for all). Overweight children had higher FVC and FEV1 and lower FEV1/FVC (p<0.05 for all). Stratifying the analysis by asthma (yes/no) and BMI (normal weight/overweight) we found significant differences between overweight asthmatic children and overweight/non-overweight controls for FEV1/FVC and FEF25-75 (ANOVA, p<0.01 for all comparisons). Overweight asthmatic children also had lower FEV1/FVC when compared to non-overweight asthmatic children (p<0.01 for all). There was a significant trend for higher FVC and lower FEV1/FVC and FEF25-75 in overweight children with asthma. (Jonckheere-Terpstra, p<0.01 for all analysis). Conclusion: It is noticed significant effect independent of asthma and overweight in lung function in schoolchildren. Both asthma and overweight reduce the FEV1 / FVC ratio / Objetivo: analisar o efeito de sobrepeso e da asma na fun??o pulmonar, avaliada por espirometria, em crian?as. M?todos: Crian?as asm?ticas e controles saud?veis foram recrutados em escolas p?blicas de Porto Alegre, Brasil. A espirometria foi obtida da fun??o pulmonar no Laborat?rio da PUCRS concomitante com a mensura??o do peso e altura. O ?ndice da fun??o pulmonar e a massa corporal foram transformados em z ? scores para todas as an?lises usando equa??es internacionais. Resultados: 188 crian?as (97 meninas, 52%) estavam matriculadas sendo 114 (60%) com asma e 85 (45%) com sobrepeso. A m?dia e o desvio padr?o da idade, altura e peso foram de 11,1 +/- 1,1; 146,7 +/- 8,4 e 44,2 +/- 12,3, respectivamente. Houve uma correla??o positiva entre IMC e CVF e FEV1 e uma correla??o negativa com FEV1/CVF. Crian?as com asma apresentaram menor FEV1/CVF e FEF25-75 e maior CVF (p<0,05). Crian?as com sobrepeso apresentaram maior CVF e FEV1 e menor FEV1/CVF (p < 0,05). Ao estratificar a an?lise por asma (sim/n?o) e IMC (peso normal/sobrepeso) encontramos diferen?as significativas entre as crian?as asm?ticas com sobrepeso e controles com sobrepeso para FEV1 /FVC e FEF25-75 (ANOVA, p <0,01 para todas as compara??es). Crian?as asm?ticas com sobrepeso tamb?m tiveram menor FEV1/CVF quando comparadas com crian?as asm?ticas eutr?ficas (p < 0,01). Houve uma tend?ncia significativa para uma maior CVF e inferior FEV1/ CVF e FEF25-75 em crian?as com sobrepeso asm?ticas (Jonckheere - Terpstra, P < 0,01 para todas as an?lises). Conclus?es: Percebe-se efeito significativo e independente de asma e sobrepeso na fun??o pulmonar de escolares. Tanto asma como sobrepeso reduzem a ?rela??o VEF1/CVF?.
| Identifer | oai:union.ndltd.org:IBICT/oai:tede2.pucrs.br:tede/6826 |
| Date | 31 March 2016 |
| Creators | Fernandes, Morgana Tha?s Carollo |
| Contributors | Jones, Marcus Herbert, Roncada, Cristian |
| Publisher | Pontif?cia Universidade Cat?lica do Rio Grande do Sul, Programa de P?s-Gradua??o em Medicina/Pediatria e Sa?de da Crian?a, PUCRS, Brasil, Faculdade de Medicina |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da PUC_RS, instname:Pontifícia Universidade Católica do Rio Grande do Sul, instacron:PUC_RS |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 3098206005268432148, 600, 600, 600, 600, -8624664729441623247, -969369452308786627, -2555911436985713659 |
Page generated in 0.003 seconds