This work was supported by Cienciativa of CONCYTEC Peru, under contract number 164-2016-FONDECYT, and the Programa
Nacional de Innovación para la Competitividad y Productividad (Innóvate Perú), under contract number 116-PNICP-PIAP-2015. / Background: Huánuco is a central eastern region of Peru whose geography includes high forest and low jungle, as well as a mountain range that constitutes the inter-Andean valleys. It is considered a region endemic for dengue due to the many favorable conditions that facilitate transmission of the virus. Methods: A total of 268 serum samples from patients in Huánuco, Peru with an acute febrile illness were assessed for the presence of dengue virus (DENV) via RT-PCR and NS1, IgM, and IgG ELISA during December 2015 and March 2016. Results: DENV was detected in 25% of samples via RT-PCR, 19% of samples by NS1 antigen ELISA, and 10.5% of samples by IgM ELISA. DENV IgG was detected in 15.7% of samples by ELISA. The most frequent symptoms associated with fever across all groups were headache, myalgia, and arthralgia, with no significant difference between the four test methods Conclusions: In this study, DENV was identified in up to 25% of the samples using the standard laboratory method. In addition, a correlation was established between the frequency of positive results and the serological tests that determine NS1, IgM, and IgG. There is an increasing need for point-of-care tests to strengthen epidemiological surveillance in Peru. / Revisión por pares / Revisión por pares
| Identifer | oai:union.ndltd.org:PERUUPC/oai:repositorioacademico.upc.edu.pe:10757/625181 |
| Date | 04 1900 |
| Creators | Palomares-Reyes, Carlos, Silva-Caso, Wilmer, del Valle, Luis J., Aguilar-Luis, Miguel Angel, Weilg, Claudia, Martins-Luna, Johanna, Viñas-Ospino, Adriana, Stimmler, Luciana, Mallqui Espinoza, Naysha, Aquino Ortega, Ronald, Espinoza Espíritu, Walter, Misaico, Erika, del Valle-Mendoza, Juana |
| Contributors | juana.delvalle@upc.pe |
| Publisher | Elsevier B.V. |
| Source Sets | Universidad Peruana de Ciencias Aplicadas (UPC) |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/article |
| Format | application/pdf |
| Source | Universidad Peruana de Ciencias Aplicadas (UPC), Repositorio Academico - UPC, International Journal of Infectious Diseases, 81, 31, 37 |
| Rights | info:eu-repo/semantics/openAccess, Attribution-NonCommercial-ShareAlike 3.0 United States, http://creativecommons.org/licenses/by-nc-sa/3.0/us/ |
| Relation | https://linkinghub.elsevier.com/retrieve/pii/S1201971219300335 |
Page generated in 0.0018 seconds