Dialyzable leucocytic extracts (Transfer Factor) were prepared from guinea pigs, rabbits, dogs and cattle sensitized to tuberculin, from cattle and dogs reactive to coccidioidin and from cattle sensitized to 2,4 dinitrochlorobenzene and Pasteurella multocida. These Transfer Factor (TF) preparations were used in intra- and interspecies transfers of delayed hypersensitivity (DH) and cellular immunity (CMI) in guinea pigs, rabbits, dogs, cattle and humans. Various doses and routes of administration were employed. Success of transfer was based upon dermal skin reactivity and/or clinical improvement. Our results suggest the following: (a) interspecies transfer of DH is effective with a variety of species, (b) oral administration of TF is effective and (c) cattle are effective donors of TF for use in humans and other animals because of potential quantity and strong potency of transfer material.
| Identifer | oai:union.ndltd.org:arizona.edu/oai:arizona.openrepository.com:10150/282271 |
| Date | January 1980 |
| Creators | Soli, Teri Cullen |
| Contributors | Jeter, Wayburn S. |
| Publisher | The University of Arizona. |
| Source Sets | University of Arizona |
| Language | en_US |
| Detected Language | English |
| Type | text, Dissertation-Reproduction (electronic) |
| Rights | Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author. |
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