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Photodynamic therapy (PDT) in malignant glioma: is intra-tumoural injection of the photosensitizer by stereotactic technique superior to conventional intravenous administration?.

Chan Yung. / Publication date from spine. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1995. / Includes bibliographical references (leaves 80-95). / Acknowledgement --- p.3 / Abstract --- p.4 / Chapter Chapter 1 --- Introduction --- p.7 / Chapter "1,1" --- Current status in treatment of gliomas --- p.7 / Chapter 1.1.1 --- Surgery of gliomas --- p.7 / Chapter 1.1.2 --- Radiation therapy of gliomas --- p.9 / Chapter 1.1.3 --- Chemotherapy for gliomas --- p.10 / Chapter 1.1.4 --- New modalities --- p.11 / Chapter 1.2 --- Basic principle of photodynamic therapy --- p.13 / Chapter 1.2.1 --- Photosensitizer --- p.13 / Chapter 1.2.2 --- Photosensitising effect of HpD --- p.13 / Chapter 1.2.3 --- Mechanism of selectivity in PDT --- p.15 / Chapter 1.2.4 --- Selective localization and the blood brain barrier --- p.16 / Chapter 1.2.5 --- Cytotoxic effect of PDT --- p.18 / Chapter 1.2.6 --- PDT on normal brain --- p.19 / Chapter 1.3 --- Photodynamic therapy in clinical neurosurgery --- p.21 / Chapter 1.4 --- The aims of the study --- p.26 / Chapter Chapter 2 --- Materials and methods --- p.28 / Chapter 2.1 --- Patient population --- p.28 / Chapter 2.2 --- Photosensitizer --- p.28 / Chapter 2.3 --- Administration of HpD --- p.29 / Chapter 2.4 --- Measurement of HpD --- p.30 / Chapter 2.5 --- Fluorescence microscopic examination --- p.32 / Chapter 2.6 --- Confocal laser scanning microscopic examination --- p.33 / Chapter Chapter 3 --- Results --- p.38 / Chapter 3.1 --- HpD measurement --- p.38 / Chapter 3.2 --- Fluorescence microscope examination --- p.40 / Chapter 3.3 --- Confocal laser scanning microscope (CLSM) examination --- p.41 / Chapter Chapter 4 --- Discussion --- p.56 / Chapter 4.1 --- Quantifying HpD level --- p.58 / Chapter 4.2 --- Quantifying HpD in the intravenous administration group --- p.59 / Chapter 4.3 --- Quantifying HpD in the intratumoural injection group --- p.63 / Chapter 4.4 --- Flourescence microscopic study of HpD distribution of malignant gliomas --- p.67 / Chapter 4.5 --- Confocal laser scanning microscopy (CLSM) study of HpD localization of malignant gliomas --- p.72 / Chapter 4.6 --- Conclusion --- p.74 / Chapter Chapter 5 --- Summary --- p.76 / Chapter Chapter 6 --- References --- p.80

Identiferoai:union.ndltd.org:cuhk.edu.hk/oai:cuhk-dr:cuhk_321680
Date January 1996
ContributorsChan, Yung., Chinese University of Hong Kong Graduate School. Division of Surgical Sciences.
PublisherChinese University of Hong Kong
Source SetsThe Chinese University of Hong Kong
LanguageEnglish
Detected LanguageEnglish
TypeText, bibliography
Formatprint, 95 leaves : ill. (some col., some mounted) ; 30 cm.
RightsUse of this resource is governed by the terms and conditions of the Creative Commons “Attribution-NonCommercial-NoDerivatives 4.0 International” License (http://creativecommons.org/licenses/by-nc-nd/4.0/)

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