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Chemosensitivity of prostatic tumour cell lines under conditions of G2 block abrogation

Thesis (MTech (Biomedical Technology))--Cape Technikon, 2011. / Cancer of the prostate gland is now recognised as one of the principal medical problems in males.
In the USA, cancer of the prostate is the second most commonly diagnosed cancer after skin cancer
and the second most common cause of death from cancer after lung cancer. In South Africa,
prostate cancer is the second most common cancer, with an estimated annual incidence of 19.1 per
LOO000 men (Sitas, 1994). However, this incidence is probably under-estimated, due to incomplete
records. Comparison of the incidence of prostate cancer in the different racial groups shows that it
is the second most common malignancy in the White, Black (African) and Mixed (Coloured) race
groups, and the fourth most common malignancy in Asian (Indian) men in South Africa.
Metastatic prostate cancer is refractory to hormone therapy and remains incurable. Hence, novel
therapeutic approaches are needed. These anticancer drugs can be tested in tumour cell lines, and
cell culture methods also permit testing of optimum conditions.

Identiferoai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:cput/oai:localhost:20.500.11838/2245
Date January 2000
CreatorsSerafin, Antonio Mendes
ContributorsTruter, E. J., Bohm, E. L. J. F.
PublisherCape Technikon
Source SetsSouth African National ETD Portal
LanguageEnglish
Detected LanguageEnglish
TypeThesis
Rightshttp://creativecommons.org/licenses/by-nc-sa/3.0/za/

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