A previous study in chickens revealed that myosin light chain kinase (MLCK), f actin, and myosin are found on the crystalline lens. Their polygonal arrangement at the posterior surface resembles a muscle tissue, which suggests that these proteins may have a contractile role in accommodation. The ciliary muscle in chickens is skeletal in nature and, therefore, chickens were used to test the hypothesis that contractile microfilaments play a role in accommodation. Ciliary nerve-induced accommodation was measured in the presence of an MLCK inhibitor 1-(5-Iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride (ML-7). Eyes of 6-day old white Leghorn chickens (gallus gallus domesticus) were enucleated in Tyrode’s saline solution while keeping the ciliary nerve intact. One eye was treated with ML-7 and the other eye was treated with vehicle only. Three concentrations of ML-7 were used: 1 µM, 10 µM, and 100 µM. Two experiments were carried out, one including a (3×10 min) wash and one without. Focal lengths of the vehicle- and ML-7-treated eyes were measured before, during and after accommodation. Immunoblots were used to detect the amount of phosphorylated myosin with and without the inhibitor. Focal lengths for accommodation were shorter than those at rest (p<0.001). In the wash experiment, vehicle-treated eyes had higher accommodative amplitudes compared to ML-7-treated eyes for all three dosage groups. In the no-wash experiment, only the 1 µM group demonstrated the same trend as the wash experiment. For the 10 µM and 100 µM groups, ML-7-treated eyes had higher accommodative amplitudes compared to vehicle-treated eyes. Immunoblots revealed varying amounts of inhibition within pairs of eyes as well as between birds for both experiments. Results from this experiment indicate that ML-7 was not effective at determining whether contractile microfilaments found on the lens contribute to accommodation.

We present a new sub-optimal near-maximum-likelihood (ML) detection method for the family of variable-rate space-time block codes (VRSTBC). The proposed detection method is based on the concept of symbol reliability and provides a wide range of performance-complexity trade-offs. The reliability measures are defined with the help of a recent generic ML metric expression. The error performance and complexity analysis of the method via simulations show an achievable near-ML error performance with significant reduction in complexity. The performance of the proposed method is also compared with the group interference cancellation (GIC) method which was the detection method originally applied to VRSTBCs and the results show a significant improvement. The new method offers various levels of error protection via a simple parameter and hence can provide the users of a wireless network with different performance levels according to their cost allowance. Unequal error protection by VRSTBCs under the new detection method was explored. Several applications integrating data with different levels of sensitivity to error can benefit from the wide range of possibilities that the combination of the proposed detection method and VRSTBCs provides. To further explore these flexibilities, four practically interesting power allocation schemes were applied to the transmission and the behaviors were observed through case studies. / Thesis (Master, Electrical & Computer Engineering) -- Queen's University, 2008-09-26 23:45:07.81

Many people listen to, or at least hear, some form of music almost every day of their lives. However, only some of the processes involved in creating the sensations and emotions evoked by the music are understood in any detail. The problem of unravelling these processes has been much less thoroughly investigated than the comparable topics of speech and image recognition; this has almost certainly been caused by the existence of a greater number of applications awaiting this knowledge. Nevertheless, the area of music perception has attracted some attention over the last few decades and there is an increasing interest in the subject largely arising from the availability of suitably powerful technology. It is becoming feasible to use such technology to construct artificial hearing devices which attempt to reproduce the functionality of the human auditory system. The construction of such devices is both a powerful method of verifying operational theories of the human auditory system and may ultimately provide a means of analysing music in more detail than man. In addition to the analytical benefits, techniques developed in this manner are readily applicable to the creative aspects of music, such as the composition of new music and musical sounds.

Zugl.: Rostock, Univ., Diss., 2006

Thesis (Ph. D.)--University of Oregon, 2004. / Typescript. Includes vita and abstract. Includes bibliographical references (leaves 152-155). Also available for download via the World Wide Web; free to University of Oregon users.

University, Diss., 2002--Freiburg (Breisgau).

This thesis consists of three studies that cover topics in inflation and output growth, and their uncertainties in G7 and developing countries. We utilise the Consumer Price Index (CPI) and Industrial Price Index (IPI) as proxies for the inflation rate (price level) and the growth rate (output), respectively. Chapter 2 considers the case of three developing countries Turkey, Egypt and Syria. We analyse the inflation and growth using asymmetric PGARCH model. In accordance with this, we estimate all the models using two alternative distributions the normal and Student’s t. Moreover, dummy variables are chosen in the inflation data according to some economic events in Turkey, Egypt and Syria. Even more, the mean equation is adjusted to include these dummy variables on the intercept. To summarize, the results show an evidence of the Cukierman–Meltzer (1986) hypothesis, which is labelled as the ‘opportunistic Fed’ by Grier and Perry (1998), in Egypt and Syria. On the other hand, an evidence of the Holland (1995) hypothesis is obtained in Turkey, this result suggests that the ‘stabilizing Fed’ notion is plausible. Moreover, an evidence for the first leg of Friedman (1977) hypothesis is obtained in Egypt and Turkey. Chapter 3 examines the causal relationship between inflation and output growth, and their variabilities for G7 countries by applying the bivariate constant conditional correlation CCC – GARCH (1,1)-ML models. Moreover, we employ the models including dummy variables in the mean equations to investigate the impact of economic events on inflation and output. Briefly, there are evidences of the second leg of Friedman (1977) hypothesis in the US, UK, Germany, Italy, France and Canada while there is an evidence of Dotsey and Sarte (2000) in Japan. In addition, there are evidences for positive effect of inflation uncertainty on inflation in the US, Germany, Japan and France in line of Cukierman and Meltzer (1986) hypothesis. Moreover, the results of estimation CCC-GARCH (1,1) in mean models including dummy variables highlight a strong support for the two legs of Friedman (1977) hypothesis and Cukierman and Meltzer (1986). Lastly, Chapter 4 is based on examining the inflation rates for three developing countries Turkey, Syria and Egypt by applying the Bai and Perron (2003) breakpoint specification technique in the monthly inflation data of our sample. As a result, three possible break points for each of the inflation rates in the conditional variance have been determined. In addition, we employ GARCH model to control the breaks in the conditional mean and variance equations. To conclude, the autoregressive coefficients seem to cause a statistically significant impact on the breaks only in the case of Turkey, also, the parameters of the mean equation show time varying characteristics across three breaks. As far as the conditional variance is concerned the ARCH parameter (?) shows no time varying behaviour while for the GARCH parameter only one significant break seems to impact the inflation rate in Syria.

Due to the inadequate schooling system and the underpreparedness of learners in South African High Schools, Higher Education Institutions are faced with learners who do not meet the minimum criteria for acceptance into mainstream science programmes. In an attempt to increase access into the institution and meet the demands of more science and technology graduates, the Department of Chemistry at the historically disadvantaged ML Sultan Technikon introduced the Augmented programme for the National Diploma: Analytical Chemistry in 1994. This study provides a report on the profile of the students registered from 1994 to 1996, their graduation rate and a correlation of their points calculated for matric symbols with their graduation rate as well as their performance in Analytical Chemistry, the major subject of their diploma. Interviews are used to determine the perceptions of the lecturers regarding the structure of and teaching in the Augmented programme. / Chemistry / M.Sc. (Chemical Education)

This thesis investigates how recommendation systems has been used and can be used with the help of different machine learning algorithms. Algorithms used and presented are decision tree, random forest and singular-value decomposition(SVD). Together with Tingstad, we have tried to implement the SVD function on their recommendation engine in order to enhance the recommendation given. A trivial presentation on how the algorithms work. General information about machine learning and how we tried to implement it with Tingstad’s data. Implementations with Netflix’s and Movielens open-source dataset was done, estimated with RMSE and MAE.

The introduction of learning technologies into education is making the design of courses and instructional materials an increasingly complex task. Instructional design languages are identified as conceptual tools for achieving more standardized and, at the same time, more creative design solutions, as well as enhancing communication and transparency in the design process. In this article we discuss differences in cognitive aspects of three visual instructional design languages (E²ML, PoEML, coUML), based on user evaluation. Cognitive aspects are of relevance for learning a design language, creating models with it, and understanding models created using it. The findings should enable language constructors to improve the usability of visual instructional design languages in the future. The paper concludes with directions with regard to how future research on visual instructional design languages could strengthen their value and enhance their actual use by educators and designers by synthesizing existing efforts into a unified modeling approach for VIDLs.