Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.

OBJETIVO: Determinar los predictores no invasivos de la severidad de la fibrosis hepática en pacientes con infección crónica por hepatitis C del Servicio de Gastroenterología del Hospital IV Alberto Sabogal (EsSALUD), durante el período diciembre 2000 – diciembre 2002. MATERIAL Y MÉTODOS: Se incluyeron a 30 pacientes con serología positiva para HCV que fueron sometidos a Laparoscopia más biopsia hepática. Estudio observacional, descriptivo, retrospectivo y de corte transversal. Se usó la base de datos del programa SPSS versión 10.0, y se evaluó la asociación mediante el test de Chi cuadrado (_i2), con una significancia estadística del 5%. RESULTADOS: La edad promedio fue de 56.27 ± 12.55 años, Se demostró asociación entre fibrosis severa y radio TGO/TGP mayor de 1 y esplenomegalia(p=0.018 y 0.001, respectivamente) en forma estadísticamente significativa,mientras que la plaquetopenia menor de 150,000 no mostró asociación con fibrosis hepática severa en el grupo de pacientes estudiados (p=0.136). CONCLUSIONES: El radio TGO/TGP mayor de 1 y la esplenomegalia pueden ser considerados como predictores de fibrosis avanzada en pacientes con infección crónica por hepatitis c. En estos pacientes quizás no sea necesaria una biopsia hepática. / --- OBJETIVE: To Determine the non-invasive predictors from Hepatic Fibrosis severity in patients with Hepatitis C chronic infection at Gastroenterology Service from Alberto Sabogal Hospital (EsSALUD), since december 2000 – december 2002. MATERIAL AND METHODS: 30 patients were included with positive HCV serology who had Laparoscopy and hepatic biopsy. This is an observational, descriptive, retrospective and transversal study. It was used SPSS 10.0 database program, and was evaluated its association with chi-square test (_i2), with 5% statistical significance. RESULTS: The age average was 56.27 ± 12.55 years old. A TGO/TGP ratio of major of 1 and splenomegaly correlated significantly with advance stage of fibrosis (p=0.018 and 0.001 respectively) but there wasn’t correlation between platelet count major of 150,000 and severe fibrosis (p=0.136). CONCLUSIONS: A TGO/TGP ratio of major of 1 and splenomegalia can predict advance stage of fibrosis in patients with chronic hepatitis C infection .In these patients, a liver biopsy may not be necessary. Key words: Hepatitis C chronic infection, Hepatic Fibrosis.

Title: GIMPLE Model Checker Author: Ondrej Krč-Jediný Department: Department of Distributed and Dependable Systems Supervisor: RNDr. Ondřej Šerý Ph.D. Supervisor's e-mail address: Ondrej.Sery@mff.cuni.cz The goal of the thesis is a prototype implementation of explicit-state model checker of C - an advanced tool for finding errors in programs. This tool ex- plores all possible paths of program execution as well as all thread interleavings. It is based on GIMPLE - output of front-end of GCC compiler, which is the input language for GMC. The thesis is based on the previous work 'Memory represen- tation for GIMPLE Model Checker', that implements work with memory for this tool. Since it is based on GIMPLE, it makes it possible to verify systems directly in C. In addition, it is easily extensible to other languages supported by GCC. Keywords: model checking, GIMPLE, GCC, C 1

In Chapter 0, we give a brief discussion of positive linear functionals on C^*-algebras. We discuss the relation between states and representations of C^*-algebras in section 0.1. Some properties of factorial states and primal ideals of C^*-algebras are considered in section 0.2. In Chapter 1, we determine the primal ideals in certain C^*-algebras. We study an antiliminal C^*-algebra considered by Vesterstro m [38] in section 1.1. A variant of a nonliminal postliminal C^*-algebra constructed by Kadison, Lance and Ringrose ([18] and [3]) is considered in section 1.2. Also, we study in section 1.3 a liminal C^*-algebra constructed by J. Dixmier [10]. Chapter 2 is concerned with tensor products and primal ideals of C^*-algebras. In Chapter 3, we try to answer the following question 'when can the pure state space overlineP(A) be written as a union of weak^*-closed simplicial faces of the quasi state space Q(A)?' In section 3.1, we define a condition which we call (*), in terms of equivalent pure states, and we prove that it is equivalent to the pure state space overlineP(A) being a union of weak^*-closed simplicial faces of the state space S(A), where A is a unital C^*-algebra. We prove that the latter condition is equivalent to the pure state space overlineP(A) being a union of weak^*-closed simplicial faces of the quasi state space Q(A). In section 3.2, we consider questions of stability for the condition (*). Some C^*-algebras whose irreducible representations are of finite dimension are studied in section 3.3. Their pure state spaces are determined, thus giving examples and counter examples in connection with condition (*). Finally, in section 3.4, we prove that the factorial state space overlineF(A) is a union of weak^*-closed simplicial faces of Q(A) if, and only if, A is abelian.

Los antioxidantes son esencialmente importantes para el organismo por la capacidad que tienen de proteger a las macromoléculas biológicas contra el daño oxidativo. Objetivos: determinar la capacidad antioxidante de la raíz y hojas frescas de yacon“Smallanthus sonchifolia”, variedades blanca y morada, en sus variedades blanco y morado. Diseño de investigación: Analítico, experimental, prospectivo y de corte longitudinal. Metodología: Se procedió a realizar un extracto acuoso al 25% con las raíces y hojas frescas del Yacón y al sobrenadante se le determinó la capacidad antioxidante mediante los métodos de DPPH+, ABTS+, FRAP y frente al Sistema Ascorbato/Cu-II; además, se determinó la concentración de Polifenoles, Vitamina C, Flavonoides, y Antocianinas. Resultados: En relación con el comportamiento del yacón frente al radical ABTS+ pudo apreciarse que los menores valores CI50 correspondieron a la hoja morada y a la raíz morada, muestras que tuvieron valores de 4.75mg/mL y 5.38 mg/mL respectivamente, así mismo, la hoja blanca y la raíz blanca mostraron valores CI50 de 7.0 mg/mL y 10.0 mg/mL respectivamente, correspondiendo de esta manera la mayor eficacia antioxidante a la hoja morada. Las mayores concentraciones de Polifenoles, Vitamina C, Flavonoides, y Antocianinas se encontraron en: Polifenoles, Hoja Blanca 88.98 mg equivalentes de ácido gálico/100 g de muestra; Flavonoides, Hoja Blanca 48.23 mg equivalentes de catequina/100 g de muestra; Vitamina C, Hoja Blanca 26.54 mg/100 g de muestra; Antocianinas, Raíz Morada µmoles/100 g muestra. Conclusiones:. Las hojas de yacón blanco muestran los mayores contenidos de polifenoles, flavonoides y vitamina C. Las hojas y la raíz de yacón morado presentaron el más elevado contenido de antocianinas. La mayor capacidad antioxidante evaluada con la técnica FRAP correspondió a la hoja de yacón blanco. Las hojas de yacón morado ejercieron la mayor capacidad para captar el radical ABTS+. No se observó diferencia alguna con respecto a la captación del radical DPPH+ por las hojas y raíces de los dos tipos de yacón: blanco y morado. Palabras Clave: Antioxidante, Radicales Libres, Yacón, Polifenoles, Flavonoides, Antocianinas, Vitamina C. / --- Antioxidants are essentially important to the Agency by the capacity to protect against oxidative damage to biological macromolecules. Objectives: determine the antioxidant of the root and fresh yacon leaves "S " mallanthus " ramburei" purple and white varieties, in its white and purple varieties. Design research: Analytical experimental, prospective and longitudinal cut. Methodology: He proceeded to perform a water extract 25% fresh Yacon leaves and roots and to the supernatant found the antioxidant capacity using ABTS+, +DPPH, FRAP and front of the ascorbate/Cu-II system methods; In addition, found the concentration of polyphenols, vitamin C, flavonoids and anthocyanins. Results:In relation to the behavior of the yacon against the radical ABTS+ could see that minors values CI50 corresponded to the purple leaf and the purple root samples that had values of 4. 75 mg/mL and 5.38 mg/mL respectively, likewise, the white sheet and the white root showed values CI 7.050 mg/mL and 10.0 mg/mL respectivelycorresponding antioxidant efficiency in this way to the purple leaf; The highest concentrations of polyphenols, vitamin C, flavonoids and anthocyanins found in: polyphenols, blade white 88.98 mg equivalent of acid Gallic/100 g of sample; Flavonoids, blade white 48.23 equivalent mg of catechin/100 g of sample; Vitamin C, blade white 26.54 mg / 100 g sample. Anthocyanins, purple root µg moles/100 shows. Conclusions:. The white yacon leaves show higher levels of polyphenols, flavonoids and vitamin C. The leaves and the root of yacon purple presented the highest anthocyanin content. The highest antioxidant capacity evaluated with the FRAP technique corresponded to the white yacon leaf. Purple yacon leaves exerted the greatest capacity to capture the radical ABTS+. There was no difference with regard to the recruitment of the radical DPPH+ by the leaves and roots of the two types of yacon: white and purple. Keywords: Antioxidant, free radical, Yacon, polyphenols, flavonoids, anthocyanins, vitamin C.

Call number: LD2668 .T4 1951 W58 / Master of Science

The explosive growth in technology has led to a new league of a crime involving identity theft, stealing trade secrets, malicious virus attacks, hacking of DVD players, etc. The law enforcement community which has been trained to deal with traditional form of crime, is now being trained in a new realm of Digital Forensics. Forensics investigators have realized that often the most valuable resource available to them is experience and knowledge of fellow investigators. But there is seldom an explicit mechanism for disseminating this knowledge. Hence the same problems and mistakes continue to resurface and the same solutions are re-invented. In this Thesis we design and create a knowledge base, a Digital Forensics Repository, to support the sharing of experiences about the Forensics Investigation Process. It offers capabilities such as submission of lessons, online search and retrieval which will provide a means of querying into an ever increasing knowledge base.

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This dissertation involves inorganic/organometallic catalysis models, in particular the functionalization of carbon-hydrogen and carbon-carbon bonds. Computational methods have been utilized to better understand the factors affecting the kinetics and thermodynamics of C−H and C−C bond activation/functionalization in this dissertation. Chapter 2 investigates methane C−H activation with a diiminopyridine nitride/nitridyl complex of 3d transition metals and main group elements via three competing pathways: 1,2-addition/[2 + 2] addition, insertion and H-atom abstraction/proton coupled electron transfer. Chapter 3 investigates a transition metal catalyzed C=C bond functionalization involving C−N bond formations to synthesize aziridines from aromatic and aliphatic alkenes. The study focuses on anionic 3d transition metal (M = Mn, Fe, Co and Ni) triphenylamide-amine complexes with nitrene active intermediates for the aziridination reactions. Chapter 4 investigates a disphenoidal Ni(II) azido complex participating in intramolecular C−H functionalization and amination via a putative Ni nitridyl intermediate and a 1,2-addition/[2 + 2] addition pathway. In Chapter 5, methane oxidative addition to the Cp*ML (Cp* = η5-C5Me5; M = Co, Rh, Ir , L = CO, PMe3) motif is compared and contrasted when the classic CO and PMe3 ligands are replaced with the cyclic alkyl(amino) carbene (CAAC) as ancillary ligands.

The data of this thesis show an unexpected role of XIAP and c-IAPs in the turnover of C-RAF protein, thereby modulating the MAPK signaling pathway and cell migration / Die Daten dieser Doktorarbeit zeigen nun eine unerwartete Rolle für XIAP und c-IAPs. Durch ihren Einfluß auf den Proteinumsatz von C-RAF modulieren sie die MAPK-Kaskade und somit die Wanderung von Zellen.