The purpose of this study is to explore the biological effects of ultrasound exposure on growth of Saccharomyces cerevisiae. The result shows the biological effects of ultrasound exposure. The resonance frequencies and a non-resonance frequency were used with different intensities to find the relations between ultrasonic and cell growth. The methods of this study adopted finite element method and Rayleigh-Plesset theory to calculate the resonance frequencies. And then, the study set a diffuse field to exposure the yeast cells. In the experiment, cell growths were analyzed by a 600 nm ultraviolet spectrophotometer measuring the cell mass concentration. The results show that the restrained time under high intensity ultrasonic exposure was longer than low intensity in 0.306 and 11.6625 MHz. However, the restrained effects were the same between high and low irradiation intensity in 2.4079 MHz. By 10 MHz low irradiation intensity, the restrained time was 0.5 hr after sonication. The restrain effects were not obvious under low and high irradiation intensity in 16.124 MHz.

The goal of this thesis is to develop a novel polishing tool system. This system can be attached to a CNC machine and execute a precision polishing job mainly for an axially symmetric free surface. The precision polishing job is to remove the error surface profile on the work to improve its form precision, which was left by the previous machining process. An inferential rule, which was based on a top-down planning strategy, was utilized to gradually decompose the design goals of the tool system to facilitate the process for generating all of the possible design proposals. The major design goal is to render all the rotational axes of the tool system to exactly intersect at the tool center. To analyze the effects of the structure and interface stiffness of tool system on the major goal, the finite element method was adopted. Further, the homogeneous transformation scheme is applied to establish the forward kinematic error of the designed system and to analyze the effect of different manufacturing and assembly errors on the major goal.Accordingly, two novel polishing tool systems were developed. The simulation study indicated that the total errors after assembly at the tool center and the two rotation axes were dominated by the stiffness at the interfaces of the tool system, in addition to the influence of structure stiffness. An assembly strategy was then proposed in the study to reduce the total error.

Ball bonding with gold wire has been the preferred choice to connect semiconductor chip and a lead frame. Recently, copper wires have been increasingly used to replace gold wires because of the rising price of gold. However, copper is harder than gold and has the tendency to induce the damage of bond pad or other underlying layers. Herein, Al pad material has to be changed from bulk to single crystal with (100) surface orientation in order to improve bonding reliability. Firstly, finite element method was adopted to simulate 3D wire bonding. Also, from the impact of gold wire bonding, the stress concentration was found on pad and underlying layers due to the higher elastic modulus of bulk Al. During copper ball impact, there is not only the serious stress concentration at pad, but also a pad splash due to the insufficient strength of bulk Al, even though bulk Al has a lower elastic modulus. Secondly, material properties of Al(100) were obtained by uniaxial tensile tests at constant speed. With molecular dynamics method, the incorporated result showed that Al(100) has the lower elastic modulus and higher yield strength than those of bulk material. Finally, single crystal Al(100) was used, instead of bulk material, to carry out copper ball impact process by using multi-scale simulation. Al(100) material is able to transform impact energy into the resilience of strain energy effectively owing to its high yield stress and low elastic modulus. Results show that the application of Al(100) material reduces the effects of stress concentration and pad ¡§splashing¡¨ successfully during copper ball impact process.

The mechanical and electrical properties of thin films have been become important and urgent in recent years, especially, the laminated structure made by films stacked over hundreds of layers. For example, the Multi-Layered Ceramic Capacitors (MLCCs) are such structures fabricated by one layer ceramic film interleaves with one layer electrode film repeatedly a hundred times. Thus, the advantages of MLCCs include small volume, mass product, and high capacity. That makes the MLCCs the necessary part of passive components. The Finite element method is adopted in the study. The model is built by the simulation program of ANSYS. After meshing and setting boundary conditions, the numerical process is performed. The numerical simulation was started first by applying a uniformly distributed pressure on the top of near hundred layers of MLCCs before sintering process with the bottom plate fixed. Then, the displacement and stress fields of MLCCs under five pressures were obtained and discussed. In order to visualize the results, the data of displacement and the stress fields were listed in Tables and plot in Figures. In addition to the MLCCs under vertically and uniformly distributed pressure, the slightly slant distributed pressure and gradient distributed pressure had been simulated. Next, the results of changing Young¡¦s modulus had also been received. It is found that the vertical distributed pressure and slant distributed pressure were not the main factor led to the side deformation. The lateral constraint of gradient distributed pressure would influence the deformation of the MLCCs significantly.

The purpose of the study is to better understand the factors that affect melt-wear in the armature-to-rail contact interface of an electromagnetic launcher (EML). In order to investigate the factors, the study uses finite element analysis (FEA) to vary parameters of a lab-scale EML at the Georgia Institute of Technology. FEA is used due to the complex nature of the system, which includes the geometry and various engineering aspects that the EML incorporates. The study focuses on an uncoupled analysis of the structural, electromagnetic (EMAG), thermal, and modal aspects. The reason for the uncoupled analysis was because the system was complex and there were computational limits. Also, by uncoupling the analysis fields, the way the parameters affected melt-wear could be viewed separately. The study varied the geometry of the armature, the stiffness of the rail system (compliance layer), and the material of the armature. The structural analysis was for the initial contact of the rail to the armature and found the von Mises stresses, contact area, and contact pressure. The EMAG analysis found the Lorentz forces in the system based on a current curve used in the lab-scale EML. The thermal analysis consisted of friction heating and Joule heating. The modal analysis was for the unstressed and pre-stressed armature. Based on the study conducted, it was found that aluminum would provide the best speeds due to its lighter mass, but lacked in the thermal resistance area. Tungsten provided the better thermal resistance, but lacked in the potential speed due to its heavier mass.

As silicon meets its performance limits, new materials and methods for advancing computing and electronics as a whole are being intensely researched, as described in Chapter 1. Memristors are a fusion of these two research areas, with new materials being pursued concurrently to development of novel architectures to take advantage of these new devices. A background of memristors and an overview of different memristive developments in the field are reviewed in Chapter 2. Chapter 3 delves into the physical mechanisms of analog memristors. To investigate and understand the operation of analog memristors, a finite element method model has been developed. More specifically, the devices simulated include a simple memristor simulation where the lithium ions (dopants) are confined to the device, but allowed to move in response to a voltage applied across the device. To model a more physical memristor, charge carrier mobility dependence on dopant levels was added to the device, resulting in a simulated device that operates similarly to the first simulation. Thereafter, the effect of varying geometries was modeled, and it was determined that both the speed and the resistance change of the device were improved by increasing the ratio of the top and bottom metal contact lengths in a restrictive flow geometry. Finally, the effect of dopant removal was investigated. It was determined that if the greatest change in resistance is required, then the removal of dopants is the optimal operating regime for an analog memristor. Through a greater understanding of analog memristors developed by the simulation described herein, researchers will be able to better harness their power and implement them in bio-inspired systems and architectures.

<p>Injuries to the neck, or cervical region, are very importantsince there is a potential risk of damage to the spinal cord.Any neck injury can have devastating if not life threateningconsequences. High-speed transportation as well as leisure-timeadventures have increased the number of serious neck injuriesand made us increasingly aware of its consequences.Surveillance systems and epidemiological studies are importantprerequisites in defining the scope of the problem. Thedevelopment of mechanical and clinical tools is important forprimary prevention of neck injuries.</p><p>Thus, the main objectives of the present doctoral thesisare:- To illustrate the dimension of cervical injuries inSweden,- To develop a Finite Element (FE) model of the uppercervical spine, and- To study spinal stability for cervical injuries.</p><p>The incidence studies were undertaken with data from theinjury surveillance program at the Swedish National Board ofHealth and Welfare. All in-patient data from Swedish hospitals,ranging over thirteen years from 1987 to 1999, were analyzed.During this period 14,310 nonfatal and 782 fatal cervicalinjuries occurred. The lower cervical spine is the mostfrequent location for spinal trauma, although, this changeswith age so that the upper cervical spine is the most frequentlocation for the population over 65 years of age. The incidencefor cervical fractures for the Swedish population decreased forall age groups, except for those older than 65 years of age.The male population, in all age groups, has a higher incidencefor neck fractures than females. Transportation relatedcervical fractures have dropped since 1991, leaving fallaccidents as the sole largest cause of cervical trauma.</p><p>An anatomically detailed FE model of the human uppercervical spine was developed. The model was validated to ensurerealistic motions of the joints, with significant correlationfor flexion, extension, lateral bending, axial rotation, andtension. It was shown that an FE-model could simulate thecomplex anatomy and mechanism of the upper cervical spine withgood correlation to experimental data. Three studies wereconducted with the FE model. Firstly, the model of the uppercervical spine was combined with an FE model of the lowercervical spine and a head model. The complete model was used toinvestigate a new car roof structure. Secondly, the FE modelwas used for a parameter study of the ligament materialcharacteristics. The kinematics of the upper cervical spine iscontrolled by the ligamentous structures. The ligaments have tomaintain spinal stability while enabling for large rotations ofthe joints. Thirdly, the FE-model was used to study spinalinjuries and their effect on cervical spinal stability inflexion, extension, and lateral bending. To do this, the intactupper cervical spine FE model was modified to implementruptures of the various spinal ligaments. Transection of theposterior atlantooccipital membrane, the ligametum flavum andthe capsular ligament had the most impact on flexion, while theanterior longitudinal ligament and the apical ligamentinfluenced extension.</p><p>It is concluded that neck injuries in Sweden is a problemthat needs to be address with new preventive strategies. It isespecially important that results from the research on fallaccidents among the elderly are implemented in preventiveprograms. Secondly, it is concluded that an FE model of thecervical region is a powerful tool for development andevaluation of preventive systems. Such models will be importantin defining preventive strategies for the future. Lastly, it isconcluded that the FE model of the cervical spine can increasethe biomechanical understanding of the spine and contribute inanalyses of spinal stability.</p>

<p>In the past two decades depth-sensing indentation has becomea widely used technique to measure the mechanical properties ofmaterials. This technique is particularly suitable for thecharacterisation of materials at sub-micro or nano scale thoughthere is a tendency to extend its application to the micro ormacro scale. The load-penetration depth curve of depth-sensingindentation is a characteristic of a material and can be usedfor analysing various mechanical properties in addition tohardness. This thesis deals with the mechanicalcharacterisation of bulk materials, thin films and coatings,gradient materials, and composites using depth-sensingindentation. Finite element method has been resorted to as atool to understand the indentation behaviour of materials.</p><p>The piling-up or sinking-in behaviour of materials plays animportant role in the accurate determination of materialsproperties using depth-sensing indentation. Finite elementsimulations show that the piling-up or sinking-in behaviour isdetermined by the material parameters, namely<i>E/σ</i><i>y</i>ratio and strain hardening exponent orexperimental parameter<i>h</i><i>e</i><i>/h</i><i>max</i>ratio, and the contact friction. Anempirical model has been proposed to relate the contact area ofindentation to the<i>E/σ</i><i>y</i>ratio and the<i>h</i><i>e</i><i>/h</i><i>max</i>ratio and used to predict thepiling-up orsinking-in of materials. The existence of friction is found toenhance the sinking-in tendency of materials. A generalrelationship between the hardness and the indentationrepresentative stress valid for both soft and hard materialshas been obtained. A possible method to estimate the plasticproperties of bulk materials has been suggested.</p><p>Measuring the coating-only properties requires theindentation to be done within a critical penetration depthbeyond which substrate effect comes in. The ratio of thecritical penetration depth to the coating thickness determinedby nanoindentation is independent of coating thickness andabout 0.2 for gold / nickel, 0.4 for aluminium / BK7 glass, and0.2 for diamond-like-carbon / M2 steel and alumina / nickel.Finite element simulations show that this ratio is dependent onthe combination of the coating and the substrate and moresensitive to differences in the elastic properties than in theplastic properties of the coating/substrate system. Thedeformation behaviour of coatings, such as, piling-up of thesoft coatings and cracking of the hard coatings, has also beeninvestigated using atomic force microscope.</p><p>The constraint factors, 2.24 for WC phase and 2.7 for WC-Cocemented carbides, are determined through nanoindentation andfinite element simulations. A modified hardness model of WC-Cocemented carbides has been proposed, which gives a betterestimation than the Lee and Gurland hardness model. Finiteelement method has also been used to investigate theindentation behaviour of WC-Co gradient coatings.</p><p><b>Keywords:</b>depth-sensing indentation, nanoindentation,finite element method, atomic force microscope, mechanicalproperties, hardness, deformation, dislocations, cracks,piling-up, sinking-in, indentation size effect, thin coatings,composite, gradient materials, WC-Co, diamond-like-carbon,alumina, gold, aluminium, nickel, BK7 glass, M2 steel.</p>

Thesis (M.S.)--West Virginia University, 2001. / Title from document title page. Document formatted into pages; contains x, 114 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 108-113).

Thesis (Ph.D.) -- University of Glasgow, 2008. / Ph.D. thesis submitted to the Department of Mechanical Engineering, Faculty of Engineering, University of Glasgow, 2008. Includes bibliographical references. Print version also available.