Merkel cell polyomavirus (MCPyV) is an oncogenic virus exist in about 80% of Merkel Cell Carcinoma (MCC), an aggressive human skin cancer. Evidence of MCPyV existing in other kind of skin neoplasms such as cutaneous squamous cell carcinomas (SCCs) has been reported. Since the major type of cervical cancer is SCCs, MCPyV may be associated with cervical cancer tumorigenesis. A Japanese research group has documented the presence of MCPyV DNA in both cervical SCCs and cervical adenocarcinomas (ACs) from Japanese patients. Nevertheless, the association between MCPyV and cervical cancer remains inconclusive and the prevalence of MCPyV in cervical cancer may show demographic variation. This study is aimed to examine whether MCPyV is present in some of the most common gynaecological cancers, namely cervical cancer, ovarian cancer, endometrial cancer, and gestational choriocarcinoma, in Hong Kong patients. Genomic DNA was obtained from 50 cases of cervical cancer, 20 cases of ovarian cancer, and 35 common gynaecological cancers cell lines. Genomic DNA extracted from four MCC samples were used as positive controls. The integrity of the samples was first checked by β-globin PCR. Detection of MCPyV was then performed by MCPyV Large T antigen (LT-ag) PCR. Our PCR analysis showed that only 1 out of 50 (2%) of the cervical cancer samples was positive for MCPyV DNA. The PCR product was purified and cloned for sequencing analysis. Comparing the LT-ag sequence obtained from the only MCPyV positive cervical cancer with reference sequence and with the MCPyV sequence from one of the control cases revealed the presence of different MCPyV variants in Hong Kong patients. None of the ovarian cancer, endometrial cancer, or choriocarcinoma was positive for MCPyV. Our data did not support the notion that MCPyV is associated with gynaecological malignancies. MCPyV may hence be a fairly specific oncogenic agent for Merkel cell carcinoma. / published_or_final_version / Pathology / Master / Master of Medical Sciences

Mental health services for women in correctional settings have long been overlooked. The result is that while these women often need help, their unique needs are unmet. The purpose of this dissertation is to elucidate some of the specific characteristics of this population that is poorly understood. Due to the distinct relational needs of female offenders, it is proposed that an understanding of the attachment characteristics of this population is particularly valuable, and should perhaps be the basis for approaching treatment. Therefore, this study examined the relationship between personality characteristics, attachment organizations, and psychological distress in a sample of young female offenders who were incarcerated at Texas Youth Commission. Based on the research findings of Espelage et al. (2003) that describe personality characteristics in this population, and the attachment framework of Bartholomew and Horowitz (1991), it was expected that participants in this study would primarily be characterized by antisocial and borderline personality features (as measured by the MCMI-III; Millon, 1994). In addition, it was proposed that participants characterized by antisocial personality features would exhibit a dismissing style of adult attachment and a lack of psychological distress while participants with borderline personality features would exhibit a fearful style of adult attachment and an expression of psychological distress. Results provide support for the prominence of antisocial and borderline personality features in this sample of female offenders. However, there was no relationship between personality characteristics, attachment style and psychological distress. In order to further examine the nature of attachment in this sample, exploratory results investigated the relationship between attachment style and gang membership, and found that endorsement of gang membership was related to secure attachment, and to a lesser degree, preoccupied attachment. Implications of these findings were further discussed. Limitations and contributions of this study in addition to suggestions for future were also explored. In particular, it was suggested that future research examine these same characteristics of personality and attachment from a broader and more nuanced lens, which would reflect the complexities inherent in the population of female offenders. / text

No description available.

No description available.

This paper provides the theoretical component to a blog I wrote as part of an academic program in Cultural Studies for a period from March 2, 2011 until September 30, 2011. Called The Last Triangle: Sex, Money and the Politics (http://www.thelasttriangle.com), I set out to explore the increasing normalization of pubic hair removal among women in North America. The reasons for the upswing in the popularity of pubic hair removal are hard to pinpoint, but seem to be motivated by a number of forces. From the ready accessibility of pornography, where pubic hair is currently so rare it has spawned its own fetish, to the widespread attention Brazilian waxing has received in the media, pubic hair removal is merely one among a myriad of body grooming practices many women increasingly indicate they feel obliged follow. This paper will explore some of those ideas, taking a critical view of the practice in light of questions around performing femininity, how pubic hair removal pertains to body control, and how pubic hair removal is, for many, increasingly viewed as a practice closely connected with good hygiene. Because it is intimately tied to the purchase of dedicated products, pubic hair removal will also be considered in as much as it relates to capitalism. Because the blog was a fundamental component of my research experience, excerpts of both my own writing, as well as comments from readers, will be included in conversation here with the theoretical questions. / Thesis (Master, Cultural Studies) -- Queen's University, 2011-10-14 09:54:11.802

When the Y chromosome of a Mus musculus domesticus mouse is placed onto the C57BL/6J (B6) inbred genetic background, the XY (B6.Y TIR) progeny develop only ovaries or ovotestes during fetal life. At puberty, while some of the hermaphroditic males become fertile, none of the XY sex-reversed females produce litters. The objective of my study was to clarify the cause of infertility in B6.YTIR females. We have previously demonstrated that the eggs ovulated from B6.YTIR ovaries undergo fertilization efficiently, but cannot develop beyond the 2-cell stage. In the present study, we collected oocytes directly from XY ovaries, and examined their maturation, fertilization and embryonic development in vitro. The results show that the majority of fertilized eggs fail to reach the blastocyst stage. To determine whether developmental incompetence of XY oocytes can be attributed to defects in the oocytes themselves or the surrounding XY somatic cells, we constructed female mouse chimera composed of B6.YTIR and XX BALB/c cells. All chimeric females produced progeny exclusively derived from XX oocytes. For comparison, most of XX ↔ XX chimeric females produced progeny derived from oocytes of either strain. / The ability of XY oocytes to regulate granulosa cell differentiation and functions was assessed in oocyte-cumulus complexes (OCC) in vitro . Microsurgical removal of oocytes prevented cumulus cell expansion and suppressed estradiol production while it promoted progesterone production. Coculture of the oocytectomized OCC with denuded oocytes from either XX or XY ovaries resumed cumulus expansion and the normal endocrine profile. Morphometric analyses indicated that XY oocytes were significantly smaller and their zona pellucida layer thinner than XX oocytes as early as the preantral stage. Furthermore, XY oocytes were attached with fewer cumulus cells in antral follicles. To determine whether developmental incompetence of the zygotes from XY ovaries resides in the nuclear or cytoplasmic component, we exchanged the pronuclei between the zygotes derived from B6.YTIR oocytes and those from XX oocytes and examined their development in vitro. The results indicate that both compartments are defective in the B6.YTIR oocyte. / In conclusion, the XY oocyte becomes cell-autonomously defective in both nuclear and cytoplasmic components during early oogenesis.

A study to determine the prevalence of infertility in females in a patient population attending a general practice in Katlehong was done over seven weeks in 1985. In this study 40.6% out of a total of 143 patients interviewed were found to be infertile. Contributing factors to infertility included an advanced age of patients and use of intra-uterine contraceptive devices. Pelvic inflammatory diseases, fibroid uteri, fixed retroverted uteri and a poor socio-economic status of patients were also found to be associated with infertility. The above factors associated with infertility in females are discussed and recommendations directed to the reduction of infertility are submitted. / Thesis (M.Med.)-University of Natal, Durban, 1987.

Comparative political economy studies of welfare states have focused on either general processes of modernization or the evolution of different welfare state 'regimes' - such as the social democratic, liberal and conservative types identified by Esping-Andersen. Variations in women's role in the workforce tend to be seen as closely allied with 'welfare regime' types or associated with welfare state modernization. But there are relatively few empirical studies in the political economy field of how, within the overall policy configuration of the state, welfare policies influence women's labour force participation. First, using a quantitative analysis of country-level data for 17 OECD countries from 1960 to 1987, this study identifies clusters of countries consistent with the Esping-Andersen classification, which share distinct patterns of women's role in the workforce and have different paths of development over time. However, the analysis shows that important anomalies exist and key questions remain unresolved. Second, case studies are used to analyse policy configurations and developments in women's employment over time. 'Core' examples are drawn from each main welfare regime - the USA (liberal), Sweden (social democratic) and Germany (conservative). The Netherlands is examined as a key anomalous case. Third, the lessons from the empirical analyses are used to reconsider aspects of the 'social democratic' and 'modernization' models of welfare state development. Across the period as a whole female labour force participation has grown in most countries. The most rapid growth of women's involvement has taken place in core countries with either liberal or social democratic welfare configurations (the USA and Sweden). There has been less change in 'conservative' countries (such as Germany) and in the Netherlands despite its 'social democratic' classification. Yet apparent linkages between labour market trends and welfare policies do not necessarily stand up to close over-time or comparative analysis. In the USA there are only weak connections between welfare policies and women's changing role in the labour market, whereas the two factors are closely and directly linked in Sweden. Particular policies contributed to expanding women's employment in Germany, but the overall policy configuration has bolstered broader patterns of social stratification inimical to women playing a larger role. In the Netherlands, welfare policies have clearly restrictive effects on women's participation in job markets, although some growth has occurred since the 'welfare explosion' of the 1960s. These findings show that welfare states' impacts on women's employment do not fit neatly into the 'modernization' or 'social democratic' models. 'One path fits all' models perform particularly poorly, but even differentiated analyses of 'welfare state regimes' pay insufficient attention to the location of social welfare within the state's overall policy configuration. A clearer distinction between the 'welfare state' construed as form of state and as a particular sector of state activity can help comparative analysis eliminate the residual influence of 'one-path' models, and provide more compelling analyses of variations in women's employment trajectories.

No description available.

This thesis investigated and statistically analyzed the responses of delinquent and non-delinquent female adolescent subjects to J. B. Rotter's Internal-External Locus of Control Scale. Internal control refers to the perception of positive and/or negative events as being a consequence of one's own actions and under personal control. External control refers to the perception of positive and/or negative events as being unrelated to one's own behaviors and beyond personal control.Delinquent subjects were obtained through a juvenile court. Non-delinquent subjects were obtained from schools and social agencies. Variables of age, race, socio-economic level and number of parents in the home were controlled.Delinquent females were found to be significantly more external than the non-delinquent females. Race was not found to be significant for the total sample, but the black non-delinquent females scored significantly more external than did the white non-delinquent females.