Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2017-05-05T23:30:28Z No. of bitstreams: 1 SalomaoIsraelMonteiroLourencoQueiroz_DISSERT.pdf: 1011037 bytes, checksum: bc4665913958058e84b6df12f551ab60 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2017-05-05T23:44:21Z (GMT) No. of bitstreams: 1 SalomaoIsraelMonteiroLourencoQueiroz_DISSERT.pdf: 1011037 bytes, checksum: bc4665913958058e84b6df12f551ab60 (MD5) / Made available in DSpace on 2017-05-05T23:44:21Z (GMT). No. of bitstreams: 1 SalomaoIsraelMonteiroLourencoQueiroz_DISSERT.pdf: 1011037 bytes, checksum: bc4665913958058e84b6df12f551ab60 (MD5) Previous issue date: 2015-01-20 / O presente trabalho trata-se de um ensaio cl?nico, controlado, cego e randomizado com pacientes em terapia anticoagulante com varfarina comparando medidas de hemost?ticos locais para o controle do sangramento p?s-exodontias. Para isso foram empregados dois m?todos de hemostasia local, sendo o grupo I (controle) utilizando somente irriga??o, compress?o com gaze com soro fisiol?gico e sutura e o grupo II (estudo) utilizando irriga??o, compressa com gaze embebida com ?cido tranex?mico e sutura. A amostra foi composta de 37 pacientes com media de idade de 45,5 anos, sendo 62,2% do sexo feminino. Ap?s randomiza??o 20 foram alocados para o grupo controle e 17 para o grupo estudo, sendo realizado um procedimento cir?rgico por paciente. O tempo de realiza??o do procedimento cir?rgico durou em m?dia 30,9 (?7,5) minutos. Todas vari?veis que poderiam interferir no desfecho foram semelhantes entre os grupos, n?o sendo verificadas diferen?as significativas (p>0,05). Na avalia??o da hemostasia imediata a m?dia para conseguir o estancamento do sangramento foi de 9,1 (?3,6) minutos. No grupo estudo o tempo para conseguir essa hemostasia foi bem menor se comparado com o controle, sendo essa diferen?a (6,018 / IC 95%: 4,677-7,359) estatisticamente significante (p<0,001). Avaliando o controle do sangramento de forma mediata o uso do ?cido tranex?mico se mostrou mais associado significativamente com a n?o ocorr?ncia de sangramento, principalmente nas primeiras 24h. Assim sendo essa medida de hemostasia local de forma t?pica como compressa com gazes e irriga??o local foi eficaz como um protocolo de hemostasia local na redu??o do tempo de hemostasia imediata e preven??o do sangramento mediato. / The present work is a clinical trial, controlled, blinded and randomized with patients on anticoagulation therapy with warfarin comparing local hemostatic measures for the control of post-tooth extraction bleeding. For that were employed two local hemostasis methods, with group I (control) using only irrigation, compression with gauze with saline and suture and group II (study) using irrigation, compress with gauze soaked with tranexamic acid and suture. The sample consisted of 37 patients with mean age of 45,5 years and 62,2% were female. After randomization 20 were allocated to the control group and 17 in the study group, and performed a surgical procedure per patient. The surgical procedure time lasted an average of 30,9 (? 7,5) minutes. All variables that could influence the outcome were similar between the groups, no significant difference was seen (p> 0,05). In assessing the immediate hemostasis to get the stagnation of bleeding was 9,1 (? 3.6) minutes. In the study group the time to get that hemostasis was much lower compared with the control, and this difference (6,018 / IC 95%: 4,677-7,359) was statistically significant (p <0,001). Evaluating the control of bleeding mediately the use of tranexamic acid was more significantly associated with the non-occurrence of bleeding, especially in the first 24 hours. Therefore this measure of local hemostasis topic form with dressing with gauze and local irrigation was effective as a local hemostasis protocol in reducing the time of immediate hemostasis and preventing mediate bleeding.