Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2016-06-10T00:23:43Z No. of bitstreams: 1 MariaDaConceicaoGuilhermeCoelho_TESE.pdf: 2617180 bytes, checksum: 61e2fd661b35f4b903e89e8658320d7f (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2016-06-13T19:22:30Z (GMT) No. of bitstreams: 1 MariaDaConceicaoGuilhermeCoelho_TESE.pdf: 2617180 bytes, checksum: 61e2fd661b35f4b903e89e8658320d7f (MD5) / Made available in DSpace on 2016-06-13T19:22:30Z (GMT). No. of bitstreams: 1 MariaDaConceicaoGuilhermeCoelho_TESE.pdf: 2617180 bytes, checksum: 61e2fd661b35f4b903e89e8658320d7f (MD5) Previous issue date: 2012-03-26 / O presente trabalho tem como escopo a an?lise da presen?a da justi?a, personificado nos ju?zes de ?rf?os, no incentivo, orienta??o e guarda dos menores herdeiros da Povoa??o de Currais Novos, do Serid? norte-riograndense, principalmente no que tange ? educa??o no s?culo XIX. Busca-se a abrang?ncia e significado da atua??o dos ju?zes na educa??o e de suas pr?ticas, considerando que tal figura tinha um poder que ia al?m de sua fun??o meramente, mas exercia um papel pol?tico, responsabilizando-se pela guarda e prote??o dos bens deixados pelas fam?lias do per?odo Imperial. O estudo debru?a-se sobre o conjunto de documentos cartoriais, invent?rios, partilhas, auto de contas e despachos, pertencente ao F?rum da Comarca de Currais Novos, no per?odo compreendido entre os anos de 1822 a 1829. Por fim, a conclus?o demonstra como os ju?zes controlavam a educa??o dos ?rf?os, atrav?s dos tutores, e utilizavam-se, para tal fim, dos autos de conta como um mecanismo processual e documental de sua atividade jurisdicional. / This work has the objective to analyze the presence of justice, embodied in the orphans of judges, the encouragement, guidance and custody of minor heirs of the Village of Currais Novos, the area called Serid? of Rio Grande do Norte, especially with regard to education in the century XIX. Aims the meaning of the performance of judges in education and their practices, whereas this figure had a power that went beyond its mere function, but played a political role, taking responsibility for guarding and protection of property left by families of the Imperial period. The study focuses on the set of notary offices documents, inventories, sharing, self accounts and orders, belonging to the District of Currais Novos Forum in the period between the years 1822 to 1829. Finally, the conclusion demonstrates how Judges controlled the education of orphans, through tutors, and it is used for this purpose, the account acts as a procedural mechanism and documentary of its judicial activity.

Made available in DSpace on 2014-12-17T15:32:24Z (GMT). No. of bitstreams: 1 ThamaraMMB_DISSERT.pdf: 1856423 bytes, checksum: d77238963a3bf6663f56d36a18db57b6 (MD5) Previous issue date: 2014-02-27 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior / Th17 cells have been strongly associated to the pathogenesis of inflammatory and autoimmune diseases, although their influence on the carcinogenesis is still little known, there are reports of anti-tumor and protumoral actions. The objective of this study is to research the presence of Th17 lineage in lip and tongue SCC, using the analysis of the immunoexpression of IL-17 and ROR?t, relating this immunoexpression with clinical and morphological findings in the attempt to better comprehend the role of these cells on the tumoral immunity of OSCCs. The results were submitted to non-parametric statistical tests with significance level of 5%. On the histomorphological analysis, it was observed the predominance of low level lesions on lip and high level lesions on tongue (p=0,024). It was not observed statistical significance between clinical stage and histological gradation of malignancy (p=0,644). For the immunohistochemical study, 5 random fields with greater immunoreactivity of the peritumoral inflammatory infiltrate were photomicrographed on the 400x magnification. It was done the count of lymphocytes which showed cytoplasmic and pericytoplasmic staining for the IL-17 cytokine as well as nuclear and cytoplasmic staining for ROR?t. It was observed statistical significance difference on the quantity of immunopositive lymphocytes to IL-17 between the groups of SCC of lip and tongue (p=0,028). For the ROR?t it was not observed statistical significance difference between the groups of SCC of lip and tongue (p=0,915). It was not observed statistical difference between the immunostaining of IL-17 and ROR?t with histological gradation of malignancy and clinical staging. The findings of this research suggest a possible anti-tumor role of IL-17 for cases of lip. The results of the analysis of the ROR?t are possibly due to the wide duality of the anti-tumor and protumoral role of the Th17 cells and their plasticity which, in the presence of different cytokines expressed on the tumor microenvironment, can alter its phenotype. / As c?lulas Th17 t?m sido fortemente associadas ? patogenia de doen?as autoimunes e inflamat?rias, por?m sua influ?ncia na carcinog?nese ainda ? pouco conhecida, havendo relatos de suas a??es tanto antitumorais quanto pr?-tumorais. O objetivo do presente trabalho foi pesquisar a presen?a da linhagem Th17 intratumoral em CCE de l?bio e l?ngua, atrav?s da an?lise da imunoexpress?o da IL-17 e do ROR?t, relacionando estes achados com dados cl?nicos e morfol?gicos na tentativa de melhor compreender o papel dessas c?lulas na imunidade tumoral dos CCEOs. Na an?lise histomorfol?gica, observou-se predom?nio de les?es de baixo grau em l?bio e de alto grau em l?ngua (p = 0,024). N?o foi observada signific?ncia estat?stica entre estadiamento cl?nico e grada??o histol?gica de malignidade (p = 0,644). Para o estudo imunoistoqu?mico, 5 campos aleat?rios com maior imunorreatividade do infiltrado inflamat?rio peritumoral foram fotomicrografados no aumento de 400x. Realizou-se a contagem de linf?citos que exibiram marca??o citoplasm?tica e pericitoplasm?tica para a citocina IL-17 bem como nuclear e citoplasm?tica para o ROR?t. Foi observada diferen?a estatisticamente significativa na quantidade de linf?citos imunopositivos para IL-17 entre os grupos de CCE de l?bio e l?ngua (p = 0,028). Para o ROR?t n?o foi observada diferen?a estatisticamente significativa entre os grupos de CCE de l?bio e l?ngua (p = 0,915). N?o foi observada diferen?a estat?stica entre a imunomarca??o da IL-17 e ROR?t com grada??o histol?gica de malignidade e com estadiamento cl?nico. Os achados dessa pesquisa sugerem um poss?vel papel antitumoral da IL-17 para os casos de l?bio. Os resultados da an?lise do ROR?t, possivelmente se devem ? ampla dualidade do papel pr?-tumoral e antitumoral das c?lulas Th17 e ? sua plasticidade que, na presen?a de diferentes citocinas expressas no microambiente tumoral, podem alterar seu fen?tipo