Since the reform in the 1980s, the Chinese electric power industry has experienced rapid expansion in both capacity and outputs, which is surprising since the industry is still under a plan control. The shortage of supply is a common problem in a plan economy according to the conventional wisdom. But China provides very different experience that challenges the wisdom. Why? This thesis attempts to understand why the plan-controlled industry can achieve such rapid growth over a short period of time. The study pursues its investigation through exploring three issues: the price and cost structures, the pricing setting and the capacity expansion with reference to OECD experience. By comparing power prices of China with the West, we find that China has successfully kept its household prices as lower as its industrial prices, while the OECD economies are reverse, a lower power price for the industry but higher for the household users. The finding shows that the plan increases consumers‟ welfare more than the market does. With further investigation to the cost structure of Chinese power plants with reference to the UK experience, we find that the Chinese power producers have lower variable costs than the Western plants, but similar overheads costs. To further explain such finding, we studied a sample of 100 coal-fired power plants from 2003 to 2005 for their pricing behaviour. We find that the firms adopt a high cost strategy to bargain with the state for higher plan prices, because of the one-firm-with-one-plan-price policy. This causes a soft price constraint on costs, which inevitably protects high cost firms, driving up the total costs of the firm, and providing a lower incentive to the firm to improve their cost efficiency. The firms are planned by the state for their outputs. Will the state plan affect the capacity of power supply in favour? The study argues yes, because (1) entry is free and capacity investment is under firm‟s autonomy, (2) the firms are very responsive to capacity utilization and demand in choosing their capacity investment, and (3) the firms seek more profits through seeking more plan outputs that are linked with capacity. Therefore, the firms do not compete in prices but the capacity of power generation. These explain why the reformed plan system works in stimulating capacity growth.

Informed consent for pharmacogenomic testing in people with a learning disability Background Advances in genomic healthcare will enable medication to be tailored to each individual’s needs, based on subtle genetic variations. This will result in individuals being asked to consent to genetic testing for this purpose. The recent political agenda for social change has emphasised the right of people with learning disabilities to have more autonomy and make their own decisions. There have also been significant changes in the way healthcare practitioners relate to their patients, with a shift away from paternalism towards shared decision-making. Research Aim The aims of the study were (1) to explore the information needs of people with mild to moderate learning disabilities with respect to pharmacogenomic tests and (2) to identify ways of facilitating informed consent. Methods An integrative literature review was conducted to identify research on informed consent to healthcare interventions in people with learning disabilities (Phase 1). Subsequent phases (Phases 2-4) of the study were conducted using an ethnographic approach. Phase 2 involved observation of six participants with learning disabilities undergoing a routine blood test consultation in general practice. This was followed by Phase 3, in which semi-structured interviews with 14 participants with learning disabilities were conducted. In Phase 4, three different methods were used: focus groups with carers (four paid carers, five family carers), an on-line bulletin board for healthcare professionals (five participants) and interviews with six key informants from the field of learning disability. Findings The data showed consent procedures were often inadequate and there was inconsistent knowledge of mental capacity law amongst health professionals. Provision of information to patients prior to a blood test was variable, but interviews with people with learning disabilities revealed the fact that this information may not be wanted by them. People with learning disabilities viewed pharmacogenomic tests as similar to other blood tests and would want access to them. The attitudes of paid carers and family carers differed in terms of decision-making opportunities for people with learning disabilities. Conclusions Healthcare practitioners, carers and people with learning disability need to be familiar with the principles of the Mental Capacity Act to facilitate valid consent in the healthcare context. Healthcare practitioners also need to be made aware of developments in pharmacogenomics if it is to become part of routine health care. Finally, this study demonstrated the value of qualitative research in exploring the knowledge and attitudes of people with learning disability.

This study examined: 1) if estimated performance times (ETcom) at four different distances can be used to accurately define the parameters of the critical velocity (CV) test [CV and anaerobic running capacity (ARC)]; and 2) if those parameters can be used to predict time to completion (PTcom) of distances performed at velocities greater than CV. Twelve subjects provided an ETcom for maximal-effort runs at 400m, 800m, 1600m, and 3200m. The CV and ARC were derived from the total distance (TD) versus ETcom relationship. The equation: PTcom = ARC / (velocity-CV) was used to determine the PTcom for runs at 200m, 600m, and 1000m. The PTcom was validated against the actual time to complete (ATcom) runs at the same three distances. The TD versus ETcom relationship was highly linear and indicated a close relationship between running distance and time. The PTcom overestimated the ATcom at 200m, but was not different from ATcom at 600m and 1000m. The PTcom and ATcom were not related at any of the three distances. The CV model could be applied to estimated performance times to derive the CV and ARC parameters, but the parameters of the test did not accurately estimate performance times above CV.

The purpose of the study was to examine the relationship between treadmill time, maximal oxygen consumption and pace characteristics of the 1.5 and 3 mile runs and to compare the distances and pace characteristics as predictors of aerobic capacity. Subjects were 70 college aged males, ages 18 to 25, enrolled in jogging and conditioning classes at North Texas State University. Three tests were administered: the 1.5 mile run, the 3 mile run and the Bruce treadmill test. The data were analyzed using correlations and factor analysis. Conclusions of the investigation were (1) the 1.5 and 3 mile runs are valid measures of aerobic capacity, (2) the 3 mile run does not significantly increase the correlation between VO2max and endurance runs and (3) pacing characteristics are evident in the 1.5 and 3 mile runs.

This thesis focuses on legal capacity of minors. Maturity of a person depends on his or her age and the development of a personality is consecutive, therefore each legal system must deal with a question how to incorporate a capacity of minors (going through this development) to cause legal effects with own acts. These persons need a higher degree of protection and a different intensity of control or surveillance. Based on general description of several theoretical approaches to the issue the solution chosen in the Czech Republic and in Germany is being closely analyzed. The text of this thesis is divided into five chapters. Firstly, the Czech legislation concerning the issue is being explained. In the first chapter all the basic terms are defined and also the system of legislation regarding legal capacity is shortly outlined. The second chapter includes detailed analysis of legislation concerning legal capacity of minors. The basic criterion for assessment of capacity to cause legal effects with own acts is intellectual and volitional maturity. This criterion is complemented with special cases of a minor acting with consent of his legal representative, operation of business and performance of dependent work. The thesis also mentions acquisition of full legal capacity before reaching the age of majority...

Master of Science / Department of Kinesiology / Steven W. Copp / Cancer patients have a reduced exercise capacity compared to age-matched healthy counterparts which contributes to premature fatigue. The reductions in exercise capacity are multifactorial and vary depending on the type of treatments and the specific cancer. Given that cancer treatments have been shown to impair cardiovascular and/or skeletal muscle function, it is difficult to determine if cancer itself reduces exercise capacity. We used a rat prostate tumor model to test the hypothesis that cancer independently reduces endurance exercise capacity. Methods: In male Copenhagen rats (COP/CrCrl), an initial treadmill test to exhaustion was used to determine endurance exercise capacity. Subsequently, the prostates of the rats were injected with either prostate carcinoma cells (R-3327 AT-1) in Matrigel (cancer: n = 9) or Matrigel only (sham: n = 7). Treadmill tests to exhaustion were repeated four and eight weeks post-surgery. Results: Time to exhaustion decreased over the course of the experimental protocol in both the sham and cancer groups. However, the overall reduction in time to exhaustion in the cancer group (-16.7 ± 1.9 min) was significantly greater (p = 0.038) than the sham group (-10.1 ± 2.2 min). Despite no differences in total body mass at the end of the experimental protocol, heart, left ventricle, and gastrocnemius muscle mass were significantly lower in the cancer group compared to the sham group (p < 0.05 for all). Moreover, within the cancer group heart and left ventricle mass, but not gastrocnemius mass, were significantly inversely correlated with prostate tumor mass. Conclusion: Endurance exercise capacity was reduced in rats with untreated prostate cancer to a greater extent than it was reduced in sham operated rats. Although multiple mechanisms likely contributed to the reduced exercise capacity, reductions in heart and gastrocnemius muscle mass likely played an important role.

D.Phil.

The international community proclaims victory when a conflict-ridden state is able to get rid of the main cause of the conflict. However, all the problems of the state do not end with that victory. It rather triggers a whole new set of problems, which combined with the aftermath of the conflict, leads the country to a larger crisis. Afghanistan, after the fall of Taliban regime in 2001, faced various social, political and economic challenges that marked the beginning of a transition period that was much more challenging than the previous period. In this paper, I discuss the major problems of transition-period Afghanistan and how the handling of these problems has shaped the image of the government inside the country and outside. I look into various variables that have played leading roles in Afghanistan in the past ten years (legitimacy, corruption, and state capacity), analyze their interconnectedness, and examine the state‘s vulnerability, leading to a discussion of whether there is an immediate need for a changed approach by national leadership. I demonstrate the complex interaction of the variables in connection with their impact on economic development. Towards the end, I suggest the need for a balanced approach, including but not limited to the increase in sub- national capacity, which will involve strong leadership from the government to define and divide the functions of various actors involved in the stabilization of the country. We will see that Afghanistan‘s geographical location, its natural capacity and the international support it has been receiving provide it with immense prospect for stabilization and even development, providing that the variables analyzed in the paper are addressed.

Thesis advisor: Michael Graf / Bismuth is an interesting element to study because the low effective mass of its charge carriers makes the material sensitive to quantum confinement effects. When bismuth is reduced to the nanoscale two interesting phenomena may occur: it may transition from a semimetal to a semiconductor, or charge carriers in special surface states may begin to dominate the behavior of the material. Arrays of bismuth nanowires of various diameters were studied to investigate these possibilities. The magnetoresistance of the arrays was measured and the period of Shubnikov-de Haas oscillations suggested an increase in the effective mass and density of the material’s charge carriers for small nanowire diameters. These increases suggested that electrons were present in surface states and strongly influenced the material’s behavior when its dimensions were sufficiently reduced. The magnetization of the nanowire arrays was also measured and the lack of de Haas-van Alphen oscillations for certain diameter nanowires suggested that electrons were not present in surface states and that instead the material was transitioning from a semimetal to a semiconductor. Heat capacity measurements were planned to reconcile the two experiments. My detailed calculations demonstrated that heat capacity measurements were feasible to determine the presence, or absence, of surface charge carriers. Because the electronic contribution to the material’s heat capacity is small a calorimeter platform was constructed with ultra-low heat capacity components. / Thesis (BS) — Boston College, 2009. / Submitted to: Boston College. College of Arts and Sciences. / Discipline: College Honors Program. / Discipline: Physics.

Purpose: A systematic review and meta-analysis was conducted to identify what factors have been investigated as correlates of the 4 key domains of treatment decision making capacity (TDMC) in people who have experienced psychosis (understanding, reasoning, appreciation, communication) and to provide estimates of the magnitude of these correlations, taking into account study quality. A novel empirical study was conducted to test the hypothesis that variance in psychosis-specific cognitive biases (including the well-established ‘jumping to conclusions’ bias) would account for unique variance in TDMC domains in those with psychosis, after taking into account the known contribution of symptoms and insight. A secondary aim of the empirical study was to examine for the first time the relationship between TDMC and personal recovery in this group, and post hoc analyses of the relationship between cognitive biases, emotional distress and TDMC were also conducted. Methods: Electronic databases were systematically searched for literature on the schizophrenia and psychosis and treatment decision making capacity. Pooled estimates of correlation were estimated for factors with data from three or more studies, and both study and outcome quality were systematically assessed. A cross-sectional observational study was conducted, and individuals with psychosis completed measures of TDMC, cognitive biases, psychotic symptoms and recovery. Multiple regression was used to examine the primary and secondary hypotheses, and mediation analyses were used to conduct the post hoc analyses. Additional data from a parallel study was incorporated to increase power. Results: Twenty-four studies met inclusion criteria for the systematic review and meta-analysis. Low to moderate quality evidence suggested that the ability of people with psychosis to understand treatment-relevant information was strongly associated with overall psychotic symptom severity, verbal cognitive functioning and years of education, but not depression (moderate quality evidence). Low quality evidence suggested reasoning was strongly associated with verbal cognitive functioning and moderately associated with symptoms. Appreciation was associated with symptoms, but it and communication were generally poorly studied. Findings from the empirical study suggest that cognitive biases, and the Jumping to Conclusions bias in particular, predicts a moderate amount of the variance in the understanding and reasoning TDMC domains, but did not add predictive power to a model containing symptoms, insight, and cognition. The appreciation domain was strongly predicted by cognitive biases, insight, and cognition. TDMC was not found to be correlated with personal recovery and post hoc analyses did not find that emotional distress mediated any relationship between cognitive biases and TDMC. Conclusions: The meta-analysis confirms there is a robust association between symptoms and TDMC in psychosis, as currently conceived. The empirical study suggests cognitive biases may be related to TDMC, even after taking into account the contribution of symptoms. Larger studies, perhaps employing experimental procedures, are required to clarify the exact nature of this relationship. The lack of any relationship between TDMC and service-user defined recovery from psychosis is notable, and lends support to those calling for a conceptualisation of TDMC that takes greater account of this concept.