In Corpus Based Knowledge Representation [CBKR], limited association capability, that is, no criteria in place to extract substantial associations in the corpus, and lack of support for hypothesis testing and prediction in context, restricted the application of the methodology by information specialists and data analysts. In this thesis, the researcher proposed a framework called CBKR+ to increase the expressiveness of CBKR by identifying and incorporating association criteria to allow the support of new forms of analyses related to hypothesis testing and prediction in context. <br /><br /> As contributions of the CBKR+ framework, the researcher (1) defined a new domain categorization model called Basis for Categorization model, (2) incorporated the Basis for Categorization model to (a) facilitate a first level categorization of the schema components in the corpus, and (b) define the Set of Criteria for Association to cover all types of associations and association agents, (3) defined analysis mechanisms to identify and extract further associations in the corpus in the form of the Set of Criteria for Association, and (4) improved the expressiveness of the representation, and made it suitable for hypothesis testing and prediction in context using the above. <br /><br /> The application of the framework was demonstrated, first, by using it on examples from the CBKR methodology, and second, by applying it on 12 domain representations acquired from multiple sources from the physical-world domain of Criminology. The researcher arrived at the conclusion that the proposed CBKR+ framework provided an organized approach that was more expressive, and supported deeper analyses through more diagnostic and probability-based forms of queries.

In Corpus Based Knowledge Representation [CBKR], limited association capability, that is, no criteria in place to extract substantial associations in the corpus, and lack of support for hypothesis testing and prediction in context, restricted the application of the methodology by information specialists and data analysts. In this thesis, the researcher proposed a framework called CBKR+ to increase the expressiveness of CBKR by identifying and incorporating association criteria to allow the support of new forms of analyses related to hypothesis testing and prediction in context. <br /><br /> As contributions of the CBKR+ framework, the researcher (1) defined a new domain categorization model called Basis for Categorization model, (2) incorporated the Basis for Categorization model to (a) facilitate a first level categorization of the schema components in the corpus, and (b) define the Set of Criteria for Association to cover all types of associations and association agents, (3) defined analysis mechanisms to identify and extract further associations in the corpus in the form of the Set of Criteria for Association, and (4) improved the expressiveness of the representation, and made it suitable for hypothesis testing and prediction in context using the above. <br /><br /> The application of the framework was demonstrated, first, by using it on examples from the CBKR methodology, and second, by applying it on 12 domain representations acquired from multiple sources from the physical-world domain of Criminology. The researcher arrived at the conclusion that the proposed CBKR+ framework provided an organized approach that was more expressive, and supported deeper analyses through more diagnostic and probability-based forms of queries.

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Thesis (M.S.)--West Virginia University, 2001. / Title from document title page. Document formatted into pages; contains vii, 60 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 57-60).

Thesis (M.S.)--West Virginia University, 2002. / Title from document title page. Document formatted into pages; contains vii, 64 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 48-63).

Thesis (Ph.D)--University of Chicago, 1902. / Double pagination. Appendices: I. Habeas corpus bills passed by either House, 1861-1862 (p. 268-277); II. The habeas corpus act of March 3, 1863 (p. 278-283) "Reprinted from the Bulletin of the University of Wisconsin, History series, vol. 1, no. 3." Reproduction of the original from the Library of Congress. Reproduced courtesy of World Microfilms Publications. Bibliography: p. 284-285.

Thesis (M.S.) in Human Development--University of Maine, 2002. / Includes vita. Includes bibliographical references (leaves 71-77).

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These studies were undertaken to characterize the adenylate cyclase system of the primate (rhesus monkey) corpus luteum, and to correlate gonadotropin-sensitive adenylate cyclase activity with the functional activity of the corpus luteum at specific stages of the luteal phase of the menstrual cycle, particularly near the time of luteolysis. The conversion of [α-³²P] ATP to [³²P] cAMP was assayed in preparations of luteal tissue obtained from rhesus monkeys at midluteal phase of the menstrual cycle. Cyclic AMP production was influenced by the pH, osmolality, and ionic strength of the assay buffer, and was acutely sensitive to Mg⁺². Michaelis-Menten kinetics were seen when the ATP:Mg ratio was constant. The gonadotropins, hLH and hCG but not hFSH, stimulated cAMP production in a similar dose-dependent manner. Deglycosylated hCG blocked the stimulation of adenylate cyclase by hLH and hCG. The addition of GTP increased maximal activation of adenylate cyclase by hLH or hCG but did not alter sensitivity to the hormones. The adenylate cyclase of macaque luteal tissue did not respond to the addition of isoproterenol or epinephrine; furthermore, these catecholamines did not affect hCG-stimulation of adenylate cyclase. Forskolin and fluoride stimulated cAMP production in a dose-dependent manner. The activity of adenylate cyclase was examined in corpora lutea obtained from rhesus monkeys at specific stages in the luteal phase of the menstrual cycle (days 3-5, 6-8, 9-12, 13-15, 16-menses after the midcycle LH surge). Basal adenylate cyclase activity, activity stimulated by GMP-P(NH)P, GTP, GTP + hLH, and GTP + hCG, sensitivity of the enzyme to hLH (measured by K(act)), and peripheral progesterone levels were low in the early luteal phase (days 3-5), increased by midluteal phase (days 6-8 and 9-12), and then decreased by the late luteal phase days 13-15 and 16-menses). In contrast, there were no significant differences among the age groups tested for forskolin-stimulated activity. Thus the adenylate cyclase system of the rhesus monkey undergoes significant changes during the luteal phase which are associated with the development and regression of the corpus luteum of the menstrual cycle. Mechanisms which modulate gonadotropin and nucleotide activation of adenylate cyclase without interfering directly with the catalytic unit are implicated in the changes which accompany luteolysis.

published_or_final_version / Physiology / Master / Master of Philosophy