This thesis explores the ways in which memories of the communist era in Romania are transmitted to young people with no first-hand experience of those times. It looks at how youth actively contribute to the process of mnemonic socialization, where they are exposed to technologies of memory conveying both nostalgic and anticommunist, state-sponsored, discourses. It argues that in this context young people create their own emotionally imbued versions of the past, ‘second-hand memories’ (Keightley and Pickering, 2012) that result after lengthy and intricate processes of distillation. Another main argument of the thesis is that the past influences the present. Hence, young people live in societies where the effects of the communist era are still identifiable. Such traces can be found in the built environment, in the material culture, in the behaviour and practices of people or in the state of postsocialist Romanian society. Youth make use of second-hand memories in order to understand past, present and future. The fact that they inhabit milieux de mémoire (Nora, 1989) could be a reason for their interest in the communist era. By engaging with the recent past, young people also endeavour to explore their own identities, which have, in turn, been influenced by the times that preceded their birth. Literature on processes and politics of memory transmission and production focuses primarily on media of memory per se and on first-hand accounts of ‘eyewitnesses’. This thesis, whose findings are based on the thematic analysis of 59 in-depth interviews with Romanian young people born between 1986 and 1996, takes individuals as active producers of memories and unravels the ways in which social actors interact with vehicles of memory transmission and with discourses on the past. It thus represents an empirical exploration of how second-hand memories are created in a postsocialist context. By doing this, it contributes to the development of memory studies by extending the theoretical concepts of ‘second-hand memories’ and ‘mnemonic imagination’ (Keightley and Pickering, 2012), and by demonstrating the wider applicability of notions such as Pierre Nora’s (1989) ‘milieux de mémoire’, with its ensuing implications, or that of ‘embodied memory’.

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This thesis is about the situation in the DR Congo from the time of the Belgian colony till the present. It discusses the historical development of the country, bloody conflicts in the end of the 20th century and the OSN mission MONUC which operates in the country. All of this is influenced by the potential of natural resources that can raise the country from the developing countries group, but it can cause also a deeper slump.

In einer Vielzahl von Arbeiten konnten anti-inflammatorische Eigenschaften von Ethylpyruvat (EP) aufgezeigt werden. An verschiedenen Modellen der Sepsis, des hämorrhagischen Schocks, von Verbrennungsschäden, des Apoplex oder der Ischämie und Reperfusion wurde bei der Behandlung mit EP ein protektiver Effekt sowie eine verminderte Produktion von pro-inflammatorischen Zytokinen nachgewiesen. Als biochemische Grundlage wurde die Interaktion von EP mit dem Transkriptionsfaktor NF-κB identifiziert, die spezifischen Regulationsmechanismen konnten bisher allerdings nicht zufriedenstellend aufgeklärt werden. In dieser Arbeit wurde als eine neue mögliche Erklärung für die anti-inflammatorischen Eigenschaften des EP und weiterer α-oxo-Karbonsäureester die Inhibierung der Glyoxalase I (Glo-I) aufgezeigt. In vitro-Experimente zur Enzymaktivität belegten die Hemmung der Glo-I durch EP, während α-Hydroxy-Karbonsäureester wie L-Ethyllaktat (EL) keine inhibierenden Eigenschaften aufwiesen. Dennoch waren sowohl EP als auch EL und weitere Laktatester in der Lage, die LPS-induzierte Produktion von pro-inflammatorischen Zytokinen wie IL-1β, IL-6, IL-8 und TNF-α von humanen immunkompetenten Zellen zu supprimieren und die Expression von Immunrezeptoren wie HLA-DR, CD14 und CD91 zu modulieren. Somit konnten erstmals anti-inflammatorische Eigenschaften von Laktatestern nachgewiesen sowie eine Verbindung zwischen den Glyoxalase-Enzymen und dem Immunsystem etabliert werden. Diese und weitere Ergebnisse zur Einflussnahme der Karbonsäureester auf die Zellvitalität präsentieren das Glyoxalasesystem als mögliches Ziel neuer Therapiekonzepte für die Immunsuppression und bestätigen dessen Bedeutung für die Entwicklung von Anti-Tumor-Agenzien.

Orientador: Manoel Barros Bertolo / Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas / Made available in DSpace on 2018-08-26T03:37:39Z (GMT). No. of bitstreams: 1 Pires_CatarinaFernandes_D.pdf: 2601322 bytes, checksum: 1acb7f604b763cb1fd45c71455e387bf (MD5) Previous issue date: 2014 / Resumo: O presente estudo de caso-controle avaliou 74 crianças piauienses com Artrite Idiopática Juvenil (AIJ) em suas diversas formas: Oligoarticular, Sistêmica, Poliarticular Fator Reumatoide Positivo (FR+), Poliarticular Fator Reumatoide Negativo (FR-), Artrite relacionada a Entesite (ERA), Artrite Psoriásica e Artrite indeterminada, classificadas de acordo com os Critérios da Liga Internacional de Associações de Reumatologia (ILAR) e cento e um controles saudáveis pareados de acordo com idade, sexo, procedência e etnia. Os objetivos foram identificar e determinar os alelos HLA-DR e HLA-DQ em uma amostra da população infanto-juvenil piauiense com AIJ nas formas oligoarticular, sistêmica, poliarticular FR+, poliarticular FR-, artrite psoriásica, artrite relacionada a entesite e artrite indeterminada e compará-las com as frequências observadas no grupo de controle saudáveis; conhecer os alelos HLA-DR e HLA-DQ que estão associados a maior susceptibilidade e os que conferem maior proteção na população de crianças com AIJ em suas diversas formas. As tipagens dos alelos HLA-DR e HLA-DQ foram realizadas por meio da técnica de amplificação pela Reação de Cadeia da Polimerase (PCR), utilizando cadeias específicas de primers DR e DQ. O resultado da análise demostrou que, entre todas as formas de apresentação da AIJ, houve associação estatística significativa para a susceptibilidade da doença com o HLA-DRB1*10 OR 8,8 (IC 1,1 a 74,9) e HLA-DRB1*16 OR 2,8 (IC 1,1 a 7.5). Na forma oligoarticular a associação estatística significativa para a susceptibilidade ocorreu com o alelo HLA-DRB1*08 OR 4,6 (IC 1,4 a 14,6). Na forma sistêmica, essa associação aconteceu com o alelo HLA-DRB1*10 OR 22,2 (IC 1,8 a 269,5).Na forma Poliarticular FR+ a associação estatística significativa para a susceptibilidade ocorreu com os alelos DRB1*09 OR 12,1 (IC 2,2 a 66,9) e DRB1*10 OR 28,5 (IC 2,3 a 355,0). Na forma Poliarticular FR-, a associação estatística significativa para a susceptibilidade foi com o alelo DRB1*16 OR 13,4 (IC 1,6 a 111,2). A Artrite Psoriásica não apresentou nenhuma associação estatística significativa com os HLA pesquisados. O resultado da análise demostrou que, entre todas as formas de apresentação da AIJ, houve associação estatística significativa para a proteção da doença com o HLA-DRB1*03 OR 0,7 (IC 0,5 a 0,9) e, na forma sistêmica, essa associação aconteceu igualmente com DRB1*03 OR 0,7 (IC 0,6 a 0,8). As outras formas de apresentação da doença não demonstraram associação estatística significativa para a proteção com nenhum tipo da HLA pesquisado. A população estudada não apresentou nenhum caso de ERA e de Artrite indeterminada. O estudo encontrou ainda, associação para o risco entre o HLA-DQB1*03 OR = 6,06 (IC 1,3 a 27,2) e uveíte em pacientes com a forma oligoarticular da AIJ. Desta forma, concluímos que os nossos resultados apresentam tanto semelhanças em relação a susceptibilidade, quanto diferenças, principalmente quanto a proteção, nas associações tipicamente encontradas na literatura / Abstract: This case-controle valuated 74 children from Piauí with Juvenile Idiopathic Arthritis (AIJ) in its various forms: Oligoarticular, Systemic, Polyarticular Rheumatoid Factor Positive (FR +), Polyarticular Rheumatoid Factor Negative (FR-), Enthesitis-related Arthritis (ERA), Arthritis Psoriatic and Arthritis indeterminate, classified according to the Criteria of the International League of Associations for Rheumatology(ILAR), and one hundred and one healthy control smatched according to age ,sex, origin and ethnicity. The objectives were to identify and determine the HLA-DR and HLA-DQ in a sample of Piauí juvenile population subtypes JIA in oligoarticular, systemic, polyarticular RF + polyarticular RF -, psoriatic arthritis, enthesitis-related arthritis and arthritis indeterminate and compares them with the observed frequencies in the group of healthy control; know the HLA-DR and HLA-DQ alleles are associated with increased susceptibility and conferring greater protection in the population with JIA in its various forms and identify a possible relationship between the alleles HLA-DR and HLA-DQ and the most frequent and most aggressive form of the disease in the population studied. Polymerase Chain Reaction (PCR) using primers specific chains of DR and DQ performed the typing of HLA-DR and HLA-DQ using the technique of amplification. The result of the analysis demonstrate damong all cases of JIA was statistically significant association for disease susceptibility with HLA-DRB1*10 OR 8.8 (CI 1.1 to 74.9) and HLA-DRB1*16 OR 2.8 (CI 1.1 to 7.5). In oligoarticular JIA significant statistical association to susceptibility occurred with HLA-DRB1*08 allele OR 4.6 (CI 1.4 to 14.6), association systemic form happened to HLA-DRB1*10 OR 22.2 (CI 1.8 to 269.5) allele in polyarticular RF + the statistically significant association to susceptibility occurred with the DRB1*09 alleles OR 12.1(CI 2.2 to 66.9) and DRB1*10 OR 28.5(CI 2.3 to 355.0) in polyarticular RF- significant statistical association to susceptibility was with DRB1*16 allele OR 13.4 (CI 1.6 to 111.2). The Psoriatic Arthritis showed no statistically significant association with HLA surveyed. The result of the analysis demonstrate damong all cases of JIA was statistically significant association for disease protection with HLA-DRB1*03 OR 0.7(CI 0.5 to 0.9) and the systemic form this association also happened DRB1*03 OR with 0.7 (CI 0.6 to 0.8). The other forms of the disease showed no statistically significant association for protection on any type of HLA searched. The study population did not show any cases of ERA and indeterminate Arthritis. The study also found, statistically significant difference between the HLA-DQB1*03 OR 6.0 (CI 1.3 to 27.2), and uveitis in patients with oligoarticular form of JIA. Thus, we conclude that our results show both similarities in terms of susceptibility, and differences, especially regarding the protection, associations typically found in the literature / Doutorado / Medicina Interna / Doutora em Ciências Médicas

The Sneetches is a theater piece for children based on the Dr. Suess story The Sneetches (Random House, New York, 1961). It is scored for narrator, flute, B6 clarinet, bassoon, violins I & II, viola, and cello with optional staging. The staged version of The Sneetches requires two to six actors/dancers, appropriate scenery and props, and the active participation of children from the audience, preferably ages eight or under. The Sneetches is essentially through-composed. The overall form of the music is shaped primarily by the events portrayed in the narrative. Although individual subsections may have traditional forms, they should not be viewed as independent movements of a larger work, but rather as fragments of a whole.

The problem of this study was to examine the community, stockholder, and consumer public relations of the Dr Pepper Company. The data were collected by an examination of the major areas in Dr Pepper's public relations department. Detailed questionnaires were used in interviewing the department's head, Harry Ellis, and his assistant, Jim Ball. Follow-up interviews clarified Ball's and Ellis's responses to the questionnaires. Chapter I introduces the thesis. Chapter II presents information about Dr Pepper's consumer relations, Chapter III presents data about stockholder relations, and Chapter IV presents information about community relations. Chapter V summarizes the study and makes conclusions and recommendations. Dr Pepper's overriding weakness was the lack of pre- or post-testing of its public relations efforts; and its strengths are that it has never been accused of doing misleading advertising and it labels its products so that the consumer knows its content. The recommendation was made to expand and departmentalize the public relations operation.

This thesis is concerned with main cultural discourses of the second phase of Communism in Romania (1964-1989), period largely identical with that of Ceauşescu’s rule. A secondary aim of the thesis is to look at the post-1989 continuations of these publicly influential discourses with the aim of understanding how the educational system (HE, in particular) is positioned in relation to the cultural domain. With regard to the Communist period, the main assertion of the thesis is that analysis of these discourses reveals an underlying cultural mechanism equivalent with a central mode of governance employed by the Communist party. According to this assertion, the mission of this cultural mechanism, with origins in Lenin’s drastic distinction between the party and the proletariat and in the idea that the party must bestow consciousness on the proletariat, is to create and regulate positive avatars (heroes imbued with the best of humanity) for each social category so as to fulfill and safeguard the aims of the Party. For this reason, this device has been entitled the hero-mirror mechanism. The device has also been linked with religion and theology. This perspective has found that the mirror-mechanism corresponds to the notion of “imago Dei,” and its axes to the notions of “kenosis” and “imitatio Dei.” The assessment of these cultural discourses via the mirror-mechanism results in three dimensions of research, each with its own universes of investigation, and each with its own findings. In the first dimension, the mirror-mechanism deals with discourses as identity, and thus with the deconstruction of Romanian identity. If, as observed, the mirror-mechanism receives its first major blow in the 1980s and begins to crumble after 1989, what has replaced it since and with what implications for Romanian identity? The second dimension views the same discourses as mainly intellectual. Here, the notion of ‘inner utopia’ is highlighted as a dominant and recurring theme, and, therefore, as possibly the dominant feature of the Romanian cultural/political scene during and after Communism. If, because of the notion of ‘inner utopia,’ ‘true education’ is viewed as lying outside the provinces of formal institutions, what then is the educational role ascribed to the public space in relation to the HE system? Finally, the third dimension assesses these discourses in terms of their claims for anti-Communist resistance while providing a typology for elucidating such claims.

From a broader perspective this cross-disciplinary and cross cultural thesis examines the relationships between identity, ideology and propaganda and their influence over the production of private and public memories. This examination is carried out through a case study investigating various representations of the Czech RAF airmen from selected British and Czech WW2 newspapers approached as an archive of memory, and from individual recollections of the Czech veterans – the living archive of memory. These representations in the context of this research become interacting versions of public and private memory which in a unique way and yet equally contribute towards the historical construction of the Second World War. This thesis proposes that the various versions of memory, in Rothberg’s (2009) words ‘multidirectional memory’, are a consequence of versioning, a constant creation and re-creation of different versions of memory due to numerous influences on the producers of such memory. However, this research also considers a presence of Second World War discourse, which underpinned public and private memory and transcended collective memories of the Britishness and Czechness forming a transnational or cross cultural (Radstone, 2010) WW2 memory. In other words, this project draws upon current theories about non competitive multiple, transnational and mediated memory (Dijck, 2007) and extends upon these by considering their existence within a potentially unifying WW2 discourse within which they connect and disconnect. By doing so, this thesis challenges master narratives of history. These memories are also seen as a base for multi-layered identity of the ones who remembered and had the right to remember. Furthermore this study explores the potential reasons behind the creation of the discovered qualitative treasure of this project The Czechoslovak, a small community newspaper produced by the Czech minority living in Britain during the WW2. The theoretical underpinning as well as the methodology of the project attempt to interrogate media studies, oral history and memory studies in order to create a most pertinent space in which the written and oral memory is explored effectively. This merger of theories and methodologies allowed me to investigate the various memories within the context of the WW2 and thus construct them from the past perspective when they were being created. A discourse analysis of selected British and Czech WW2 newspapers (The Times, Daily Mirror, News of the World and The Czechoslovak) has been employed distinguishing between traditional and tabloidised newspaper representations and investigating to what extend the Czechs were portrayed as the ‘other’ or the heroes in the British society. The outcome of this analysis was a discovery that the Czech RAF airmen had not been given much prominence in the British newspapers and that their representations varied according to the different type of newspaper and the different period of the war in which they were produced. Moreover, ideology, propaganda and the notion of Czech and British identity present in the newspapers played an important role in the creation of public memory versions of the Czech RAF airmen’s images. Besides newspapers, this study took the opportunity to reveal very fragile and valuable private recollections of the Czech WW2 RAF veterans (six former members of the Czech RAF settled in Britain after the WW2 and 1 widow were interviewed in the summer 2008); the men who played an important role in the success of the Allies in WW2. By doing this, the former Czech airmen were given a voice and the chance to contribute towards existing knowledge about the Czechs in the RAF and the Second World War. The various versions of the past produced by their private memory have been investigated in the view of various factors influencing these versions: notably their identity, war ideology, propaganda, and forgetting and in relation to WW2 media. Considering the occurrence of versioning, when critically reflecting upon all different memories, I position myself as a researcher into the shoes of yet another producer of another version of the past. Thus, this study creates a space where various, sometimes contrasting memories do not fight for recognition, but where official collective memory and individual memory influence each other and also enrich each other whilst they co-construct a historical representation of the past.

Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.