In this thesis I explore functions of the neuromodulator dopamine in the context of autonomous learning and behaviour. I first investigate dopaminergic influence within a simulated agent-based model, demonstrating how modulation of synaptic plasticity can enable reward-mediated learning that is both adaptive and self-limiting. I describe how this mechanism is driven by the dynamics of agentenvironment interaction and consequently suggest roles for both complex spontaneous neuronal activity and specific neuroanatomy in the expression of early, exploratory behaviour. I then show how the observed response of dopamine neurons in the mammalian basal ganglia may also be modelled by similar processes involving dopaminergic neuromodulation and cortical spike-pattern representation within an architecture of counteracting excitatory and inhibitory neural pathways, reflecting gross mammalian neuroanatomy. Significantly, I demonstrate how combined modulation of synaptic plasticity and neuronal excitability enables specific (timely) spike-patterns to be recognised and selectively responded to by efferent neural populations, therefore providing a novel spike-timing based implementation of the hypothetical ‘serial-compound' representation suggested by temporal difference learning. I subsequently discuss more recent work, focused upon modelling those complex spike-patterns observed in cortex. Here, I describe neural features likely to contribute to the expression of such activity and subsequently present novel simulation software allowing for interactive exploration of these factors, in a more comprehensive neural model that implements both dynamical synapses and dopaminergic neuromodulation. I conclude by describing how the work presented ultimately suggests an integrated theory of autonomous learning, in which direct coupling of agent and environment supports a predictive coding mechanism, bootstrapped in early development by a more fundamental process of trial-and-error learning.

One of the central tenets of the embodied theory of language comprehension is that the process of understanding prompts the same perceptuo-motor activity involved in actual perception and action. This activity is a component of comprehension that is not memory–dependent and is hypothesized to be intact in Alzheimer's Disease (AD). Each article in this thesis is aimed at answering the question whether individuals with probable AD, healthy older adults and younger adults show differences in their performance on tests where perceptual and motoric priming take place during language comprehension. The second question each article asks is whether language comprehension in AD can be facilitated by the specific use of this perceptual and motoric priming. Article I examines whether the way individuals with pAD represent verbs spatially matches the way healthy older and younger adults do, and how stable these representations are. It also explores in what way spatial representations may relate to verb comprehension, more specifically, whether representations matching the norms translate into a better quality of verb comprehension. Article II tests the interaction between the verbs' spatial representations taking place during comprehension and perceptual cues - compatible and incompatible to the representations - in order to investigate whether individuals with pAD show differences in susceptibility to perceptual cues, compared to healthy older and younger participants. The second aim of this article is to explore in what way performance on a word-picture verification task can be affected, with reference to the fact that in previous studies on young participants, both priming and interference have resulted from the interaction of linguistic and perceptual processing. Article III explores the Action Compatibility Effect (ACE) (Glenberg & Kaschak, 2002) with the aim of finding out whether the ACE exists for volunteers with pAD and whether it can facilitate language comprehension. The order of presentation of language and movement is manipulated to establish whether there is a reciprocal relationship between them. This information could be crucial in view of possible applications to individuals with pAD. These articles test, for the first time, the effects of the manipulation of the perceptuo-motor component during language comprehension in individuals with pAD; they are intended as a methodological exploration contributing to a better understanding of the potential of embodiment principles to support language comprehension changes associated with pAD. Embodiment effects need to be studied further with a view to putting them to use in either clinical or real-life applications.

It is often reported that after amputation people experience "a constant or inconstant ... sensory ghost ... faintly felt at time, but ready to be called up to [their] perception" (Mitchell, 1866). Perceptual abnormalities have been highlighted in amputees, such as sensations in the phantom when being stroked elsewhere (Ramachandran et al., 1992) or when observing someone in pain (Giummarra and Bradshaw, 2008). This thesis explored the perceptual changes that occur following amputation whist focusing on pain, vision and touch. A sample of over 100 amputees were recruited through the National Health Service. Despite finding no difference in phantom pain based on physical amputation details or nonpainful perceptual phenomena, results from Paper 1 indicated that phantom pain may be more intense, with sensations occurring more frequently, in amputees whose pain was triggerinduced. The survey in Paper 2 identified a group of amputees who in losing a limb acquired mirror-touch synaesthesia. Higher levels of empathy found in mirror-touch amputees might mean that some people are predisposed to develop synaesthesia, but that it takes sensory loss to bring dormant cross-sensory interactions into consciousness. Although the mirror-system may reach supra-threshold levels in some amputees, the experiments in Paper 3 suggested a relatively intact mirror-system in amputees overall. Specifically, in a task of apparent biological motion, amputees showed a similar, although weaker, pattern of results to normalbodied participants. The results of Paper 4 showed that tactile spatial acuity on the face was also largely not affected by amputation, as no difference was found between the sides ipsilateral and contralateral to the stump. In Paper 5 cross-modal cuing was used to investigate whether referred tactile sensations could prime a visually presented target in space occupied by the phantom limb. We conclude that perception is only moderately affected in most amputees, but that in some the sensory loss causes normally sub-threshold processing to enhance into conscious awareness.

Face adaptation techniques have been used extensively to investigate how faces are processed. It has even been suggested that face adaptation is functional in calibrating the visual system to the diet of faces to which an observer is exposed. Yet most adaptation studies to date have used unfamiliar faces: few have used faces with real world familiarity. Familiar faces have more abstractive representations than unfamiliar faces. The experiments in this thesis therefore examined face adaptation for familiar faces. Chapters 2 and 3 explored the role of explicit recognition of familiar faces in producing face identity after-effects (FIAEs). Chapter 2 used composite faces (the top half of a celebrity's face paired with the bottom half of an unfamiliar face) as adaptors and showed that only recognised composites produced significant adaptation. In Chapter 3 the adaptors were cryptic faces (unfamiliar faces subtly transformed towards a celebrity's face) and faces of celebrity's siblings. Unrecognised cryptic and sibling faces produced FIAEs for their related celebrity, but only when adapting and testing on the same viewpoint. Adaptation only transferred across viewpoint when a face was explicitly recognised. Chapter 4 demonstrated that face adaptation could occur for ecologically valid, personally familiar stimuli, a necessary pre-requisite if adaptation is functional in calibrating face processing mechanisms. A video of a lecturer's face produced FIAEs equivalent to that produced by static images. Chapters 5 and 6 used a different type of after-effect, the face distortion after-effect (FDAE), to explore the stability of our representations for personally familiar faces, and showed that even representations of highly familiar faces can be affected by exposure to distorted faces. The work presented here shows that it is important to take facial familiarity into account when investigating face adaptation effects, as well as increasing our understanding of how familiarity affects the representations of faces.

In human fear conditioning 'resistance to extinction' occurs when the removal of the aversive outcome fails to produce a reduction in conditioned responding. This phenomenon is important to understanding the persistence of anxiety disorders such as phobias. The research presented in this thesis examines factors that promote the acquisition and maintenance of learned fear response and attempts to differentiate between different explanations of the resistance to extinction phenomenon. To investigate the impact of different conditioning procedures (evaluative or classical conditioning) on the durability of the conditioned response (CR), event-related potential (ERP) methodology was employed. In addition, the role of the fear-relevance of the conditioned stimulus (CS), in supporting the acquisition and resistance to extinction of the CR, was explored. Evidence suggested that extinction effects are likely to reflect procedural differences in conditioning rather than different underlying learning processes. Extinction effects were dissociable across procedures, supporting the role of the type of unconditioned stimulus (US) in explaining past demonstrations of extinction when responses were indexed by physiological measures. Verbally transmitted, threat information heightened aversive US-expectancies and fear beliefs without the need for conditioning. Additionally, fear-beliefs were reduced without the need for extinction training when positive information was provided. Contrary to Davey's (1997) expectancy bias model, the results do not support the hypothesis that verbal information interacts with direct contingency experience to create fear responses; instead, information appears to be a direct pathway to fear. ERP measures for fear responses did not echo the effects of verbal information and contingency on fear-beliefs. However, the comparability of our ERP data, to other research using physiological measures of response, is discussed regarding the number of trials required to calculate the average ERP response. Due to averaging over a large number of trials the ERP measure may not be sensitive to fluctuations in response that may be dependent on information or contingency manipulations. In conclusion our data suggests the importance of verbal information as a pathway to fear and the role of cognitive factors in the prevention and treatment of fears.

The extent to which conscious and unconscious mental processes contribute to our experiences of learning and the subsequent knowledge has been subject to great debate. Dual process theories of implicit learning and recognition memory bear many resemblances, but there are also important differences. This thesis uses subjective measures of awareness to explore these themes using the artificial grammar learning (AGL) and remember/know (R/K) procedures. Firstly, the relationship between response times associated with intuition and familiarity based responding (conscious judgment of unconscious structural knowledge) compared to rule and recollection based responding (conscious structural knowledge) in AGL were found to be strikingly similar to remembering and knowing; their R/K analogues. However, guessing (unconscious judgment knowledge) was also distinct from intuition and familiarity based responding. Secondly, implicit learning in AGL was shown to occur at test, which would not be expected in R/K. Finally, wider theories of cognition, unconscious thought and verbal overshadowing, were shown to have measurable effects on AGL and R/K respectively. The approach used in this thesis shows the merits of both in-depth analysis within a given method combined with the synthesis of seemingly disparate theories. This thesis has built upon the important distinction between conscious and unconscious structural knowledge but also suggests the conscious-unconscious division for judgment knowledge may be as important. Implicit learning and recognition memory tasks differ in the kinds of mental processes that subjective measures are sensitive toward; particularly so in situations where judgment knowledge is unconscious. Different theories and methods divide nature in different ways; the conscious-unconscious judgment distinction may prove an important one.

This thesis examines the relevance of Hegelian-Marxian theory to modern day philosophy of cognitive science. It is suggested that certain key Hegelian-Marxian ideas and themes, such as 'externalization', 'praxis' and 'dialectics', have parallels in modern day cognitive science and that, in some instances a direct connection can be traced from Marxian theory to recent cognitive science, via intermediaries such as Vygotsky, Merleau-Ponty and Levins & Lewontin. It is also suggested that the overarching trajectory of cognitive science is one that can be usefully understood in Marxian terms as a 'retreat from alienation.' Taking this as one's starting point enables one to unify otherwise disparate perspectives under a single banner. In addition it provides one with a means of evaluating individual accounts, such as Varela, Thompson and Rosch's 'Embodied Mind' and Clark and Chalmers' 'Extended Mind'. Conversely, some recent cognitive scientific accounts, such as Kirsh & Maglio's work on 'epistemic action', offer further illumination of ideas that are ambiguously expressed in Marxian theory.

Pause analysis is a method that investigates processes of writing by measuring the amount of time between pen strokes. It provides the field of second language studies with a means to explore the cognitive processes underpinning the nature of writing. This study examined the potential of using free handwritten copying of sentences as a means of investigating components of the cognitive processes of adults who have English as their Second Language (ESL). A series of one pilot and three experiments investigated possible measures of language skill and the factors that influence the quality of the measures. The pilot study, with five participants of varying English competence, identified copying without pre-reading to be an effective task and ‘median' at the beginning of words to be an effective measure. Experiment 1 (n=20 Malaysian speakers) found jumbled sentences at the letter and word levels to effectively differentiate test-taker competence in relation to grammatical knowledge. Experiment 2 (n=20 Spanish speakers) investigated the jumbling effects further, but found that participants varied their strategy depending on the order of the sentence types. As a result, Experiment 3 (n= 24 Malaysian speakers) used specific task instructions to control participant strategy use, so that they either attended to the meaning of the sentences, or merely copied as quickly as possible. Overall, these experiments show that it is feasible to apply pause analysis to cognitively investigate both grammar and vocabulary components of language processing. Further, a theoretical information processing model of copying (MoC) was developed. The model assists in the analysis and description of (1) the flow of copying processes; (2) the factors that might affect longer or shorter pauses amongst participants of varying competence level; and (3) sentence stimuli design.

No description available.

<p>’Dalens Ande’ är ett kommunalt konstprojekt i Säter. Enligt den ursprungliga planeringen skulle det pågå under tre somrar. Det ingår i hela Säterdalsprojektet, vilket syftar till att lyfta fram en säregen miljö och natur.</p><p>Konstutställningen Dalens Ande var redan den första sommaren (1998) mycket uppmärksammad, inte minst i lokalpressen.</p><p>Efterhand följde den affekterade insändardebatt som lett till den ’etiska vändning’ som denna uppsats huvudsakligen avser att belysa och analysera.</p><p>De tolv berörda konstnärerna har beslutat att avsäga sig vidare samarbete med Säters kommun sedan den insändarskribent som de sett sig kränkande behandlade av utsetts till kommunens kulturpristagare.</p><p>Här presenteras förutom ett urval av nämnda skriverier även som referenser en kort sammanfattning av Kants sedelära samt övrigt artikelmaterial som behandlar problemställningens delfrågor; yttrandefrihet kontra ärekränkning, pressetik och begreppet ’konstskandal’.</p>