discovery of faded glory spas

This thesis project investigates a method of reconstruction. As a case study I have choosen to reconstruct Dramaten (The National Stage of Spoken Drama), an Art Noveau palace from the early 20th century, located in central Stockholm. The building still exists today and this is not a proposal to eraze it, the building merely serves as a platform to test the method on, but in this project the building is considered as lost. Since reconstructing the original form of the building would not result in a resurrection of the dead building nor is possible today, the aim is instead to reconstruct the building by recreating the collective memory of the building. To reconstruct the building as it once was perceived by its vistors and the city.

yes / Breast reconstruction is the opportunity that provides the chance of having breast after undergoing surgical removal of the breast tissue due to cancer-related surgery. However, this varies on the stage of the cancer diagnosis and the procedure undertaken. There are many regenerative medicine methods that provide several initiatives and direct solutions to problems such as the development of “bioactive tissue,” which can regenerate adipose tissues with similar normal functions and structures. There have been several studies which have previously explored for the improvement of breast reconstruction including different variations of biomaterials, different fabrication and processing techniques, cells as well as growth factors which enable bioengineers and tissue engineers to reconstruct a suitable breast for patients with breast cancer. Many factors such as shape, proper volume, mechanical properties have been studies but very scattered with not adequate solutions for existing patients worldwide. This review article aims to cover recent advances in biomaterials, which can be used for reconstruction of breasts as well as looking at the various factors that might lead to individuals needing reconstruction and the materials that are available. The focus would be to look at the various biomaterials that are available to use for reconstruction, their properties, and their structural integrity.

The behavior of animals is often complex and requires them to interact with their surroundings. Within the brain, there are specialized neural systems in place to create and store representations of space. In order to effectively utilize these spatial mappings, there must be coordination between sub-cortical systems, which are responsible for allocentric spatial processing, and cortical regions, which handle sensory processing in egocentric coordinates. The retrosplenial cortex is a candidate for the role in facilitating the transformation between different coordinates, as it is anatomically located between the hippocampus and sensory cortical areas and exhibits both egocentric and allocentric spatial responses. The first experiment explored the firing properties of neurons in the retrosplenial cortex in response to boundaries defined in egocentric coordinates. Based on previous research conducted in our lab, which showed that cells in the striatum respond to such boundaries, rats were implanted with electrodes to record the activity of neurons in the retrosplenial cortex while they roamed freely in an open field. The response properties of these neurons were analyzed as the arena was expanded, its shape altered, and boundaries were added and removed. A subgroup of neurons, referred to as Egocentric Boundary Cells, showed increased or decreased firing when the rat was at a specific distance and direction from any of the arena's boundaries. These cells showed no preference for any particular boundary, and their firing was not biased by the animal's angular velocity or turning behavior, suggesting that they respond to boundaries in a general manner, regardless of the features of the boundary or the animal's behavior. Building on experiment one, the second experiment examined the behavior of retrosplenial neurons in rats during open field exploration when alterations were made to the environment. In three separate sessions, a subset of neurons recorded showed either an increase or decrease in their mean firing rate throughout the entire session in which the environment was altered, then returned to prior levels when the environment was returned to a familiar configuration. These alterations included the introduction of an object, rotation of boundaries, expansion of boundaries, changes in the arena's geometry, and removal of boundaries. Similar proportions of neurons exhibited increases or decreases in firing rate for all experimental manipulations. Furthermore, the majority of retrosplenial neurons showed strong speed sensitivity. Some neurons showed an increase in firing rate as speed increased, others showed a decrease in firing rate as speed increased, and some had a specific speed at which their firing rate was the highest. These results support the idea that the RSC is involved in contextual and memory processing, scene processing, as well as transmitting information about self-movement to downstream regions. The third experiment analyzed the different poses of rats as they moved through open field arenas, using simultaneous high-resolution thermal, depth, and RGB cameras. This was organized into a new open-source dataset called Rodent3D. The three-dimensional posture of the animal was reconstructed from the two-dimensional videos using a model called OptiPose. We investigated aspects of the environment where the animals spent the most time looking, such as boundaries and objects, and the frequency and duration of behaviors such as rearing and changes in heading. Finally, we discuss the significance of our model and the potential uses of our unique dataset for the fields of neuroscience and computer vision, as well as future research plans. These experiments demonstrated that the retrosplenial cortex is a vital region for spatial processing, particularly emphasizing egocentric responses. We show that aspects of the environment, such as boundaries, the presence of objects, and changes to the local features induce multiple changes in spatial firing properties of neurons. We also provide a novel open-source model and dataset that provides an innovative tool for more rigorous behavioral analysis that can be used in many disciplines. Altogether, these results suggest that the retrosplenial cortex plays a crucial role as a hub for egocentric spatial processing and coordinating of spatial reference frames to support spatial memory and navigation.

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