This bachelor thesis examines how three decades of textbooks in the subject religion for middle-school inform students about Jesus' life and to what level they conform to their decade's specific regulatory documents. The results are analyzed through an analysis schedule, showing if the texts are stating, explaining, analyzing, or normative in character and with the help of a secularisation theory determine if this is something that changes over time. The outcome of the analysis shows that textbooks written in the 1950s are both explaining and normative to their character and correspond well to the regulatory documents. This is also the conclusion for textbooks in the 1980s but these textbooks show an increasing amount of analyzing texts with just a few normative elements. Comparing textbooks from these decades to today's textbooks, the result shows that today's textbooks don't match the regulatory documents' requirements of emphasizing that students analyze and find their identity. Instead, these textbooks are to a wider range stating to their character but at the same time having no normative elements at all. An interesting result is also the fact that the textbooks from the three decades more or less include the same information about Jesus' life but, as written earlier, there are bigger differences over time in how the textbooks describe this information. The results support one interpretation of the secularisation theory, according to which a country's textbooks tend to be less normative the more secular the country is.

This dissertation develops three game-theoretic models in each of its three chapters to explore the strategic implications of transparency in the administrative state. Each model contains a similar set of three players: a political principal, an agent representing an agency or a bureaucrat, and an interested third party. The models consider the utility of transparency as a tool for mitigating regulatory capture, in which the third party influences the agent to serve its interest rather than the principal's. Chapter 1, "Transparency and Media Scrutiny in the Regulatory Process," models transparency as the volume of records that the media receives from the agent, which raises the likelihood of news alleging low costs to the interest group after the agent's proposal of lax regulation. Such reports cost these two players and may deter the group from capturing the agent. Among other things, the model describes costs due to distorted policy proposals and loss of information when greater transparency causes inaccurate reports to increase along with accurate ones. In Chapter 2, "Transparency and Power in Rulemaking," transparency is a requirement for the agent to disclose an item of information, such as his message from the regulated party or his signal about the cost of regulation. The agent can always disclose this information, but doing so may increase the principal's power to set regulation higher than he or the regulated party desires. A key result is that transparency is not necessary for the principal to know as much as the agent does but may discourage the generation of the message or signal. Chapter 3, "A Reverse Rationale for Reliance on Regulators," suggests that an agent can benefit a principal not by gathering information from an outsider that she cannot access, but by preventing her from obtaining or acting on this information. The agent benefits the principal when he induces additional effort in the outside party's information generation because he is more adversarial toward that party than she is. Mandatory disclosure of the agent's information is harmful because it effectively allows the outsider to communicate directly with the principal and provide lower quality information.

Recent work has shown that the regulatory fit between global approach/avoidance goals and the local approach/avoidance mechanisms of goal pursuit influence cognition and behavior in predictable ways. A regulatory fit leads to an increase in motivation and engagement relative to a regulatory mismatch. The increase in engagement can lead to an increase in cognitive flexibility on cognitively demanding tasks. This work is composed of three inter-related studies that examine how the fit between global performance incentives and local mechanisms of goal pursuit influence decision-making and categorization. In Study 1 I examine how the interaction between global performance incentives and local goal pursuit mechanisms influences decision-making strategies in an experience-based decision-making paradigm. In this paradigm decision-making strategies can be classified as more exploratory or more exploitative. I find that participants in a regulatory fit would exhibit more exploratory decision-making patterns than participants in a regulatory mismatch. In Study 2 I examine how social pressure is related to approach and avoidance-based performance incentives using two types of category-learning tasks. I test the hypothesis that increasing performance pressure will induce an avoidance-based prevention focus which then interacts with the local mechanism of goal pursuit employed in the task (maximizing points gained or minimizing points lost). Participants either perform an explicit, rule-based category-learning task, or an implicit information-integration category-learning task. Behavioral and model-based analyses support the hypothesis that social pressure induces a prevention focus. When the pressure-induced prevention focus aligns with the local goal-pursuit mechanism participants perform better on the rule-based task, but worse on the information-integration task. Study 3 examines the effects of social pressure on categorization in highly-trained participants. Participants performed over 2500 training trials of either a rule-based or an information-integration category-learning task, and then performed another 640 trials after half received a manipulation designed to raise social pressure. Performance was worse on both the rule-based and information-integration task for participants who were under high social pressure compared to participants under low social pressure. The results from all three projects suggest that motivational incentives have a large effect on cognitively demanding tasks. / text

With many states recently enacting either renewable energy mandates or goals,the small hydropower industry has a unique opportunity to supply a growing portion of U.S. electricity supply. But the procedure to obtain a license for project development is unwieldy, increasingly wrought with regulatory hurdles at both the state and Federal levels. Government incentives exist that promote the development of small hydropower,but are insufficient to overcome the regulatory barriers faced by the industry. Although it is possible for small hydropower to supply a growing share of energy production in the U.S., it is unlikely that the full potential will be realized without substantial changes to the renewable energy regulatory system. This study describes the current state of the regulatory system governing the development of small hydropower facilities in the United States. A basic overview of hydroelectric technology is discussed, followed by a detailed description of the process through which a project developer must apply for a Federal license to construct and operate a hydropower project. The current state of the U.S. small hydropower industry is examined, considering the potential opportunity for the industry to supply a growing share of the U.S. electricity supply. This analysis is supplemented by a discussion of the costs of project construction and an investigation into the regulatory barriers to project development. / text

Firms are believed to engage in strategic political management (SPM) in attempts to shape public policy in favorable ways and enhance their economic returns. Extant research has broadly considered the motivations leading to corporate political activity, focusing on the effects of market power using metrics such as firm size and industry concentration to investigate this phenomenon. More recently, scholars have proposed a more nuanced perspective on the subject, suggesting that different types of SPM may exist. For example, both Baysinger (1984) and Oliver and Holzinger (2008) have distinguished between corporate political strategies designed to maintain or alter the firm’s political environment. In this study, I seek to more critically explore this distinction. I propose that at least two different types of SPM exist: defensive SPM, which is directed at protecting existing competitive advantage, and offensive SPM, which is focused on creating new forms of competitive advantage. I further propose that the threats and opportunities in a firm’s regulatory environment are important motivators of these different types of SPM. In the context of the natural gas industry in Texas from 1999-2009, I find that the degree of regulatory uncertainty in the firm’s political environment influences it to engage in defensive SPM. I also find that the size of the firm’s asset inventory influences it to engage in offensive SPM. Furthermore, I find that regulatory uncertainty negatively moderates the relationship between the size of a firm’s asset inventory and its likelihood of investing in offensive SPM. / text

Walking for active transportation (AT) has been associated with individuals meeting the recommended physical activity levels. Global and local (i.e., Saskatoon) reported walking rates are low. Barriers perceived as a challenge (i.e., frequent and limiting) may influence walking. Individual differences, such as self-regulatory efficacy (SRE), may help people persist in overcoming challenging barriers, with those being more efficacious having greater persistence than their lower efficacy counterparts. The overall purpose of the present self-efficacy theory-based study was to examine whether individuals with higher and lower SRE differed in their persistence to overcome barriers to walking to/from a university campus under two experimental conditions (i.e., higher versus lower challenge). The experimental study design was a two (between: higher versus lower SRE to overcome barriers) by two (within: higher versus lower challenge vignette) mixed factorial, with three measures of persistence as the dependent variables (i.e., number of written solutions to overcoming barriers, time taken to record the solutions, and anticipatory perseverance to overcome barriers to walking in the near future). Based on self-efficacy theory and past research, individuals who had higher SRE were expected to have significantly higher persistence than their lower SRE counterparts after reading the higher challenge vignette. Participants were young adults who walked to/from a university campus. Higher and lower SRE groups were identified via a median split (nhigher = 22; nlower = 23). Each participant read a higher and lower challenge vignette (i.e., order counterbalanced across participants) in a lab-based setting, followed by completion of persistence measures after each vignette reading. Findings from a series of two by two ANOVAS provided partial support of the study hypothesis. A significant interaction between SRE groups and challenge vignettes was found with the persistence measure of time spent reporting coping solutions, F(1,43) = 4.64, p = .037. As expected, results from simple main effects showed the higher SRE group significantly differed from the lower SRE group under the higher challenge vignette condition, F (1,43) = 5.27, p = .027, by spending significantly more time reporting solutions. No other significant interactions were found between SRE groups x vignettes with the remaining measures of persistence: (1) number of reported solutions F (1,43) = 3.15, p = .083, and (2) anticipatory perseverance F (1,43) = 0.05, p = .82. The present study contributed new information on challenging barriers to walking for AT. Findings from the experiment partially supported contentions from self-efficacy theory about the importance of SRE beliefs to persistence when individuals are challenged. Future research should continue to examine the potential role that SRE beliefs play in whether individuals walk for AT.

Engaging in 150+ minutes of moderate to vigorous exercise is a recommended self-management strategy for arthritis. Considering the low levels of exercise among individuals with arthritis, national calls have been made for investigation of theory-based processes important for adherence. Self-regulation may be a key process important for persisting with exercise plans in the face of arthritis pain anxiety. The present study examined relationships based upon a known model (Fear Avoidance [FA] model) used to understand self-regulatory behavioral responses to pain anxiety – an unexamined relationship in the arthritis and exercise literature. Primary study purposes involved examination of predictors (pain, pain anxiety, and pain acceptance) of maladaptive and adaptive self-regulatory responses among adults with arthritis who exercise. The secondary purpose examined whether participants who met the recommended dose of exercise over a two-week period significantly differed in their pain cognitions and self-regulatory responses to pain anxiety compared to less active counterparts. Participants were 136 adults (Mage = 49.75 ± 13.88years) with self-reported medically-diagnosed arthritis. Online surveys of pain cognitions and demographics were completed at baseline, followed by self-reported exercise two weeks later. Hierarchical multiple regression analyses illustrated that: (a) pain anxiety was a significant, positive predictor of the use of maladaptive self- regulatory responses (p < .001) and (b) the interaction of pain anxiety x pain acceptance was a significant predictor of the adaptive self-regulatory responses relationship (p < .05). Follow-up analyses illustrated that pain acceptance was a moderator of the pain anxiety – adaptive self-regulatory responses relationship. Participants with higher pain acceptance used adaptive responses less frequently when anxiety was lower than participants with lower acceptance. When pain anxiety was higher, both higher and lower pain acceptance was associated with the more frequent use of adaptive self-regulatory responses. A MANOVA analysis illustrated that participants meeting the recommended exercise dose had significantly lower pain anxiety, higher pain acceptance, and used maladaptive self-regulatory responses less compared to the group not meeting the dose (p’s ≤ .01). Taken together, findings provide the first ever support for FA model predictions in the arthritis – exercise domain. The results of this observational study suggest a next step could be an extended longitudinal study design with multiple time periods of assessment (e.g., measures once a month over a six-month period). Observing the relationships over time would provide a better understanding of within-person changes in the psychosocial variables relative to exercise. Such research would provide a profile of individuals’ levels of anxiety, acceptance, and self-regulatory responses when they either decrease or completely avoid exercise and when they adhere. Obtaining a social cognitive profile of people at risk for exercise avoidance may be a useful tool in the future to identify those who are in need of intervention to deal with their pain anxiety.

Iron homeostasis is regulated by iron regulatory proteins, IRP1 and IRP2, which bind to iron responsive elements (IRE) in the mRNA of proteins of iron metabolism such as ferritin (iron storage). IRP2 undergoes iron-mediated degradation, and this pathway shares notable similarities with that of hypoxia-inducible factor 1 (HIF-1). It has been reported that oxidative stress marked by increased reactive oxygen species (ROS) signal HIF-1 stabilization in hypoxia. The role of ROS in IRP2 regulation is not well-established. We show that the degree of hypoxia induces differential effects on iron-mediated degradation of IRP2, such that IRP2 levels are 3-fold higher when exposed to 0.1% O 2 compared to 3% O2 after 4 hours of iron treatment. Hydrogen peroxide (H2O2) affects IRP2 by inducing IRE-binding activity after 12 hours, which is accompanied by decreased ferritin levels. Furthermore, the ability of H2O2 to protect IRP2 against iron-dependent degradation is similar to that of hypoxia. Finally, both intracellular and extracellular sources of oxidative stress protect IRP2 from ascorbate-mediated degradation. Taken together, these results support a role of ROS in protecting IRP2 against iron-mediated degradation and indicate that oxidative stress modulates downstream effects of IRP2.

Genetic regulatory networks are of great importance in terms of scientific interests and practical medical importance. Since a number of high-throughput measurement devices are available, such as microarrays and sequencing techniques, regulatory networks have been intensively studied over the last decade. Based on these high-throughput data sets, statistical interpretations of these billions of bits are crucial for biologist to extract meaningful results. In this thesis, we compare a variety of existing regression models and apply them to construct regulatory networks which span trancription factors and microRNAs. We also propose an extended algorithm to address the local optimum issue in finding the Maximum A Posterjorj estimator. An E. coli mRNA expression microarray data set with known bona fide interactions is used to evaluate our models and we show that our regression networks with a properly chosen prior can perform comparably to the state-of-the-art regulatory network construction algorithm. Finally, we apply our models on a p53-related data set, NCI-60 data. By further incorporating available prior structural information from sequencing data, we identify several significantly enriched interactions with cell proliferation function. In both of the two data sets, we select specific examples to show that many regulatory interactions can be confirmed by previous studies or functional enrichment analysis. Through comparing statistical models, we conclude from the project that combining different models with over-representation analysis and prior structural information can improve the quality of prediction and facilitate biological interpretation. Keywords: regulatory network, variable selection, penalized maximum likelihood estimation, optimization, functional enrichment analysis.

Numerous studies have demonstrated that tumour cells have the ability to alter immune function to create an immune suppressed environment. This allows tumour cells to escape immune surveillance and consequently the tumour can progress. Dendritic and T cells have critical roles in immune activation and tolerance and are thus major targets of tumour-mediated immune suppression. Understanding the mechanism(s) by which tumour cells modulate the immune system will facilitate the development of immune system-based therapies for cancer treatments. In this study we sought to determine the nature of, and cellular and molecular mechanisms underlying, changes in immune status during tumour progression using mouse models of prostate cancer. Detailed analysis of the immunological status in a mouse prostate dysplasia model (12T-7slow) revealed that immune suppression accompanied tumour progression. We found that T cells isolated from tumour-bearing hosts were hypo-responsive to antigen stimulation. Furthermore, we demonstrated that CD4+CD25+ regulatory T cells were responsible, at least in part, for this alteration. Anti-CD25 antibody treatment reduced, but did not prevent, tumour growth in either a transplanted prostate tumour model or a spontaneously developing prostate tumour model. In addition, an altered dendritic cell phenotype and an elevated frequency of CD4+CD25+ regulatory T cells were observed within the tumour mass. Similar alterations were observed in the prostate-specific Pten knockout mice which develop advanced prostate adenocarcinoma. Interestingly, evidence of immune activation, such as an increased frequency of activated T cells, was detected in the tumour microenvironment in both mouse prostate tumour models. To identify factors that may play critical roles in the altered immune cell phenotype observed in the tumour microenvironment, a global gene expression profiling analysis was carried out to evaluate the changes in immune-related gene expression patterns. This analysis provided additional evidence for the co-existence of immune suppression and immune activation. Moreover, subsequent analyses suggested that one differentially expressed transcript, interferon regulatory factor 7, and its target genes might be involved in modulating immune cells and/or tumour progression. Taken together, these studies have important implications for designing specific and effective anti-tumour immune therapy strategies that involve manipulation of tumour cells, dendritic cells and regulatory T cells.