Thesis (Ph. D.)--Institute of Paper Chemistry, 1967. / Includes bibliographical references (p. 78-80).

Developing hybrid processes for heavy oil recovery is a major area of interest in recent years. The need for such processes originates from the challenges of heavy oil recovery relating to fluid injectivity, reservoir heating, and oil displacement and production. These challenges are particularly profound in shaley thin oil deposits where steam injection is not feasible and other recovery methods should be employed. In this work, we aim to develop and optimize a hybrid process that involves moderate reservoir heating and chemical enhanced oil recovery (EOR). This process, in its basic form, is a three-stage scheme. The first stage is a short electrical heating, in which the reservoir temperature is raised just enough to create fluid injectivity. After electrical heating has created sufficient fluid injectivity, high-rate high-pressure hot water injection accelerates the raise in temperature of the reservoir and assists oil production. At the end of hot waterflooding the oil viscosities are low enough for an Alkali-Co-solvent-Polymer (ACP) chemical flood to be performed where oil can efficiently be mobilized and displaced at low pressure gradients. A key aspect of ultra-low IFT chemical flood, such as ACP, is the rheology of the microemulsions that form in the reservoir. Undesirable rheology impedes the displacement of the chemical slug in the reservoir and results in poor process performance or even failure. The viscosity of microemulsions can be altered by the addition of co-solvents and branched or twin-tailed co-surfactants and by an increase in temperature. To reveal the underlying mechanisms, a consistent theoretical framework was developed. Employing the membrane theory and electrostatics, the significance of charge and/or composition heterogeneity in the interface membrane and the relevance of each to the above-mentioned alteration methods was demonstrated. It was observed that branched co-surfactants (in mixed surfactant formulations) and temperature only modify the saddle-splay modulus (k ̅) and bending modulus (k) respectively, whereas co-solvent changes both moduli. The observed rheological behavior agrees with our findings. To describe the behavior of microemulsions in flow simulations, a rheological model was developed. A key feature of this model is the treatment of the microemulsion as a bi-network. This provides accuracy and consistency in the calculation of the zero-shear viscosity of a microemulsion regardless of its type and microstructure. Once model parameters are set, the model can be used at any concentration and shear rate. A link between the microemulsion rheological behavior and its microstructure was demonstrated. The bending modulus determines the magnitude of the viscous dissipations and the steady-shear behavior. The new model, additionally, includes components describing the effects of rheology alteration methods. Experimental viscosity data were used to validate the new microemulsion viscosity model. Several ACP corefloods showing the large impact of microemulsion viscosity on process performance were matched using the UTCHEM simulator with the new microemulsion rheology model added to the code. Finally, numerical simulations based on Peace River field data were performed to investigate the performance of the proposed hybrid thermal-chemical process. Key design parameters were identified to be the method of heating, duration of the heating, ACP slug size and composition, polymer drive size, and polymer concentration in the polymer drive. An optimization study was done to demonstrate the economic feasibility of the process. The optimization revealed that short electrical heating and high-rate high-pressure waterflooding are necessary to minimize the energy use and operational expenses. The optimum slug and polymer drive sizes were found to be ~0.25 PV and ~1 PV, respectively. It was shown that the well costs dominate the expenditure and the overall cost of the optimized process is in the range of 20-30 $⁄bbl of incremental oil production. / text

Slickwater with sand is the most commonly used hydraulic fracturing treatment for shale reservoirs. The slickwater treatment produces long skinny fractures, but only the near wellbore region is propped due to fast settling of sand. Adding gel into water can prevent the fast settling of sand, but gel may damage the fracture surface and proppant pack. Moreover, current water-based fracturing consumes a large amount of water, has high water leakage, and imposes high water disposal costs. The goal of this project is to develop non-damaging, less water-intensive fracturing treatments for shale gas reservoirs with improved proppant placement efficiency. Earlier studies have proposed to replace sand with ultra-light weight proppants (ULWP) to enhance proppant transport, but it is not used commonly in field. This study evaluates the performance of three kinds of ULWPs covering a wide range of specific gravity and representing the three typical manufacturing methods. In addition to replacing sand with ULWPs, replacing water with foams can be an alternative treatment that reduces water usage and decreases proppant settling. Polymer-added foams have been used in conventional reservoirs to improve proppant placement efficiency. However, polymers can damage shale permeability in unconventional reservoirs. This dissertation studies polymer-free foams (PFF) and evaluates their performance. This study uses both experiments and simulations to assess the productivity and profitability of the ULWP treatment and PFF treatment. First, a reservoir simulation model is built in CMG to study the impact of fracture conductivity and propped length on fracture productivity. This model assumes a single fracture intersecting a few reactivated natural fractures. Second, a 2D fracturing model is used to simulate the fracture propagation and proppant transport. Third, strength, API conductivity and gravity settling rates are measured for three ULWPs. Fourth, foam stability tests are conducted to screen the best PFF agents and the selected foams are put into a circulating loop to study their rheology. Finally, empirical correlations from the experiments are applied in the fracturing model and reservoir model to predict productivity by using the ULWPs with slickwater or using the PFFs with sand. Experimental results suggest that, at 4000 psi with concentrations varying from partial monolayer (0.05 lb/ft²) to multilayer (1 lb/ft²), ULW-1 (polymeric) is the most deformable with conductivity of 1-10 md-ft. ULW-2 (resin coated and impregnated ground walnut hull) is the second most deformable with similar conductivity. ULW-3 (resin coated porous ceramic) is the least deformable with conductivity of 20-1000 md-ft, which is comparable to sand. Three foam formulations (A, B: regular surfactant foam, C: viscoelastic surfactant foam) are selected based on the stability results of fourteen surfactants. All PFFs exhibit power-law rheological behavior in a laminar flow regime. The power law parameters of the regular surfactant PFF depend on both quality and pressure when quality is higher than 60% but depend on quality only when quality is lower than 60%. Simulation results suggest that under the optimal concentration of 0.04-0.06 v/v (0.37-0.55 lb/gal) for both ULW-1 and ULW-2, and 0.1 v/v (1.46 lb/gal) for ULW-3, 1-year cumulative production for 0.1 µD shale reservoir is higher than sand by 127% for ULW-1, 28% for ULW-2, and 38% for ULW-3. The productivity benefits decrease as shale permeability increases for all three ULWPs. ULW-1 and ULW-2 have higher productivity benefits for longer production time, while ULW-3 has relatively constant productivity benefits over time. The economic profit of ULW-1 when priced at $5/lb is 2.2 times larger than that of sand for 1-year production in 0.1 µD shale reservoirs; the acceptable maximum price is $10/lb for ULW-1, $6/lb for ULW-2, and $2.5/lb for ULW-3. The maximum price increases as production time increases. The PFFs with a quality of 60% carrying mesh 40 sand at a partial monolayer concentration of 0.04 v/v (0.88 lb/gal) can generate 50% higher productivity, 74% higher economic profit, and over 300% higher water efficiency than the best slickwater-sand case (mesh 40 sand at 0.1 v/v) for 1-year production in 0.1µD shale reservoirs. The benefits of using the PFFs decrease with increasing shale permeability, increasing production time, or decreasing pumping time. This dissertation gives a range of field conditions where the ULWP and PFF may be more effective than slickwater-sand fracturing. / text

Out of the growing body of evidence demonstrating the role of higher-order chromatin organization within the nucleus in regulating the functions of the linear sequence of DNA emerges the genome as a physical entity. DNA packs into hierarchical levels of chromatin condensation, which then tailor accessibility to the linear sequence for nuclear processes while also serving as a central feature of nuclear organization. Further, varying condensation state alters the physical properties of the chromatin fiber. These may then exert or facilitate forces aiding in the spatial organization within the nucleus. Yet, this complex concept of nuclear structure even neglects the dynamic aspects of the genome continuously fluctuating and undergoing structural remodeling within the nucleus. Thus, while chromatin position within the nucleus is critical for biological functions including transcription, we must reconcile a particular position of a gene locus with the dynamic and physical nature of chromatin. Here we characterize the physical aspects of the genome associated with its dynamic properties that aid in regulation. We focus on developing techniques that measure the evolution of physical properties associated with nuclear processes. We leverage these techniques, capable of quantifying and spatially resolving its structural state within the nucleus and elucidating the underlying physics of its dynamics, to illuminate physical features associated with cellular processes. Specifically, we investigate the nuclear structural changes associated with growth factor stimulation on primary human cells known to impact large scale gene expression pathways. We also demonstrate dysfunction associated with these physical mechanisms accompany disease pathologies. Thus, we unify the biological understanding of cellular processes within the context of physical features of genome structure, organization and dynamics that are critical to human health and disease.

Platelets play an important role in the haemostatic process in order to seal damaged blood vessels. The platelets form a platelet plug at the damaged area and prevent blood loss. Once the damage to the vessel wall has been covered, the platelets retract the coagulum, to allow the blood to flow freely in the vessel. Free oscillation rheometry (FOR) can be used for analysis of coagulation as measured by clotting time and changes in clot elasticity (G'). Clot G' provides information about the fibrin network in the coagulum and the platelets’ ability to retract the coagulum. FOR analysis is performed using the ReoRox® 4 instrument. The blood sample is added to a cylindrical sample cup, which is set into free oscillation. The frequency and damping of the oscillation is recorded over time as the blood coagulates. The change in G' is calculated from the frequency and damping measured. Patients with malignant haematological diseases are often thrombocytopaenic and require platelet transfusions to prevent or stop bleeding. To ensure good haemostatic function in the recipient it is important that the quality of the platelets used for transfusion is well preserved. The aim of this thesis was to determine the quality of platelet concentrates (PCs), during storage, using various in vitro methods, including FOR, and to investigate how various preparation processes affect the quality. We also investigated whether FOR can be used to evaluate the haemostatic status in subjects at risk for thrombosis or bleeding as well as how the haemostatic status was affected by a platelet transfusion. We show that FOR can provide information about the coagulation properties in subjects at risk of thrombosis (pregnant women) or bleeding (thrombocytopaenic patients). We also show that the coagulation as measured by FOR is influenced by red blood cells and the fibrinogen concentration. However, the presence of functional platelets accounted for 90% of the G'. Furthermore we present data that FOR can provide information on the haemostatic effect of platelet transfusions and on the function of the transfused platelets. PCs produced by two different cell separators showed similar quality during storage for 7 days as assessed by FOR analysis. Leukocytes in the PCs can cause transfusion-associated graft-versus-host disease which can be prevented by gamma irradiation of the PCs. Gamma irradiation did not affect the quality of PCs during 7 days of storage as analysed by FOR. The clotting time was unchanged during the storage period. The capacity of platelets to retract the coagulum was reduced from days 1 to 5 of storage as seen by a prolonged time to reach maximum G' and the reduced mean change in G' per minute. However, if sufficient time is allowed for the platelets to regain their function, the clot will be fully retracted (as seen by a well maintained maximum G'). The FOR parameters were similar for 5- and 7-day old PCs, which, combined with other in vitro tests (e.g. hypotonic shock response, changes in pH, swirling, lactate and glucose), support the prolongation of the platelet storage period to 7 days. Intercept™ treatment of PCs can be performed to inhibit replication of contaminating bacteria in PCs. Intercept™ treatment of PCs did not diminish the clot-promoting capacity of the platelets as assessed by FOR clotting time. In conclusion, FOR is a promising method for assessing hyper- and hypocoagulability. It can provide information on the haemostatic effect of platelet transfusions and the function of the transfused platelets. FOR was also shown to be useful for analysing PC quality during different preparation and storage conditions.

The interfaces of bubbles and droplets imbue foams and emulsions with extraordinary mechanical and chemical properties. The remarkably large interfacial area of these structures controls their thermodynamics and makes them practical and functional materials. When these interfaces are forced to touch, they can turn a dispersion of one fluid in another into a solid. These solid-like properties are evident in common household products such as shaving foam and mayonnaise, and our ability to control the fluid and solid properties of these materials is essential to their function. / Physics

No description available.

published_or_final_version / Mechanical Engineering / Master / Master of Philosophy

The oil and gas industry is often plagued by the formation of clathrate hydrates in oil pipelines. While the industry originally had a heuristic of avoidance of clathrate hydrates they are moving to a heuristic of risk management. To successfully implement a risk management heuristic, time dependent phenomena of clathrate hydrate formation and flowline plugging must be known. The study of time dependent phenomena of formation and agglomeration are investigated using a TA Instruments AR-G2 rheometer with a pressure cell capable of operating at up to 13.8 MPa. Pressurized rheological experiments examine clathrate hydrates formed in situ. Both shear and oscillatory experiments have been conducted on the samples, giving flow and viscoelastic parameters. Shear experiments show sharp increases in viscosity upon clathrate hydrate formation indicating rapid aggregation. Transient oscillation experiments show a sharp increase in the elastic and loss moduli followed by a decrease in the loss moduli. Thus, both in situ clathrate hydrate formation and annealing are quantified. In addition these oscillatory measurements provided a novel technique for non-destructive investigation of clathrate hydrate aggregation over time.

As the oil industry moves from a heuristic of avoidance of hydrates to a heuristic of risk management time dependent phenomena of hydrate formation and plugging must be known. One of the key parameters to this process is the aggregation of hydrate particles, the fractal networks they form, and the effect these two parameters have on flow. Unfortunately the aggregation and fractal structure information is extremely difficult to acquire experimentally, for this reason a three-dimension discrete element method (3D-DEM) model has been implemented. The 3D-DEM model calculates detailed solutions to Newton's equations of motion for individual particles. In addition these particles are coupled with the surrounding fluid through computational fluid dynamics (CFD). This coupled 3D-DEM can be used to investigate what the effects of shear, suspending viscosity, attractive forces, and other relevant variables have on the structure, stresses, and positions of the hydrate particles over time. In addition, the effect on viscosity has been calculated using CFD and compared back to basic hard sphere theory.