Clock synchronization for Wireless Sensor Networks (WSNs) has attracted lots of attention due to its importance for operations in WSNs. In traditional centralized clock synchronization algorithms, all the local information should be transmitted to a fusion center for processing, and the results need to be forwarded back to each individual sensor, thus resulting in a heavy burden on communication and computation in the network. In addition, it also lacks of adaptability to link failures and dynamic changes in the network topology, which greatly prevents their use in WSNs. Hence, in this thesis, we focus on developing energy-efficient distributed clock synchronization algorithms for WSNs. Firstly, global clock synchronization problem is investigated with time-varying clock parameters (skew and offset) owing to imperfect oscillator circuits. A distributed Kalman filter is developed for clock parameters tracking. The proposed algorithm only requires each node to exchange limited information with its direct neighbors, thus is energy efficient, scalable with network size, and is robust against changes in network connectivity. A low-complexity distributed algorithm based on Coordinate-Descent with Bootstrap (CD-BS) is also proposed to provide rapid initialization of the tracking algorithm. Simulation results show that the proposed distributed tracking algorithm achieves the long-term accuracy for the clock parameters close to the Bayesian Cramer-Rao Lower Bound. Secondly, the problem of global clock synchronization for WSNs in the presence of unknown exponential delays is studied. The joint maximum likelihood estimator of clock offsets, clock skews and fixed delays of the network is first formulated as a global linear programming (LP) problem. Based on the Alternating Direction Method of Multipliers (ADMM), we propose a fully-distributed synchronization algorithm that has low communication overhead and computation cost. Simulation results show that the proposed algorithm achieves better accuracy than consensus algorithm and the distributed least squares algorithm, and can always converge to the centralized optimal solution. Finally, global clock synchronization for WSNs under the exponentially distributed delays is re-visited with the fast convergence min-sum algorithm. The synchronization problem is cast into an optimization problem represented by factor graph, and a closed-form expression of the messages passed between nodes are derived. Simulation results show that this distributed algorithm can approach the centralized LP solution with faster convergence speed compared to ADMM-based algorithm. / published_or_final_version / Electrical and Electronic Engineering / Doctoral / Doctor of Philosophy

ITC/USA 2013 Conference Proceedings / The Forty-Ninth Annual International Telemetering Conference and Technical Exhibition / October 21-24, 2013 / Bally's Hotel & Convention Center, Las Vegas, NV / A Flight Test Instrumentation (FTI) system may consist of equipment that either supports PTPv1 (IEEE 1588 Std 2002) or PTPv2 (IEEE 1588 Std 2008). The challenge in such time distributed system is the poor compatibility between the two PTP protocol versions. This paper describes how to combine the PTP versions in the same network with minimum or no manual configuration.

Cognition is dynamic and complex, requiring specific sets of brain areas to cooperate for specific tasks. Neural synchronization is a proposed mechanism for transient functional integration of specific neural populations, enabling feature flexible binding and dynamic assignment of functional connectivity in the brain according to task demands. This thesis addresses the role of neural synchronization in selective attention and perceptual consciousness. The goals of this thesis are to test the hypothesis that synchronization between brain regions is relevant to network dynamics in selective attention and for perceptual organization, and to elucidate the function of synchronization in different frequency ranges. Using a selective visuospatial cuing paradigm it is shown that deploying attention to one visual hemifield yields transient long-distance gamma-band synchronization between contralateral visual cortex and other, widespread, brain regions. This is interpreted as a mechanism for establishing anticipatory biasing of communication in the cortex. Long-distance gamma synchrony, moreover, is periodically 'refreshed' at a theta rate, possibly serving to maintain this gamma network. While local alpha-band activity was found to be greater ipsilateral to the attended visual hemifield, alpha-band synchronization between primary visual cortex and higher visual areas was greater contralateral to attended locations. This suggests that local alpha synchrony is relevant for inhibition, while long-range alpha synchronization enacts functional coupling. The onset of a new conscious percept during binocular rivalry coincides with large-scale gamma-band synchronization which recurs at a theta rate. This suggests that gamma synchronization integrates features into a unified conscious percept while the theta cycle maintains that network. Using an audiovisual speech integration paradigm it is shown that large-scale gamma synchronization is greater when incongruence is detected between auditory and visual streams. This highlights an important distinction: neural synchronization reflects neural integration, not perceptual integration. Perceptual integration typically requires neural integration (feature binding), however, in this case detection of audiovisual mismatches requires cooperation within a distributed network, whereas audiovisual speech integration is largely accomplished in superior temporal cortex. These studies indicate that long-distance gamma synchronization establishes neural integration, the theta cycle maintains gamma synchronous networks, and local and long-range alpha synchrony reflect sustained inhibition and functional coupling mechanisms, respectively.

The mutual synchronization system composed of four oscillators is analysed in the work. The matrix differential equation with delayed arguments is the mathematical model of the synchronization system. The solution of the matrix differential equation is obtained applying the method of “steps” and Laplace transform. The solution involves the powers of the matrix describing the structure of internal links of the synchronization system. The powers of this matrix are calculated taking into account the eigenvalues and eigenvectors of the matrix. Applying solution of the matrix differential equation the step responses matrix of the system is obtained and transient responses are analysed. The dependence of the phase differences of the oscillators on initial conditions is analysed.

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Synchronization is one of the most important issues in wireless communication systems design and implementation. The requirement for synchronization is going high as the signal bandwidth and the system complexity increases. For instance, the ultra-short pulse width in ultra-wideband (UWB) communication systems poses problems to the conventional timing synchronization methods and the multi-node transmission poses problems to the existing carrier frequency offset (CFO) synchronization methods. Moreover, the impact of imperfect synchronization in these systems on the system performance is more negative than that of the conventional communication systems. Therefore, efficient synchronization algorithms are really in need. This dissertation presents several synchronization methods aiming to either improve the synchronization performance or reduce the synchronization complexity. The focus of this dissertation is on UWB systems and cooperative systems. Both timing synchronization and carrier frequency synchronization problems have been investigated. Several different systems are considered, including the point to point block transmission based UWB communications, orthogonal frequency division multiplexing (OFDM) based one way and two way relaying communication systems and narrow band cooperative communication systems. For block transmission UWB systems, i.e., both OFDM and single carrier frequency domain equalization (SC-FDE) UWB systems, a new generic timing estimation method based on channel impulse response (CIR) estimation is proposed. The newly proposed method is superior to the existing methods not only in synchronization performance, but also in the algorithm complexity. For the multi-node cooperative communications, the CFO mitigation issue is studied with OFDM signaling. Due to the distributed nature of the cooperative system, the multiple CFO problem is inevitable and hard to solve. A two-step compensation scheme is designed to suppress the interference introduced by multiple CFO with low complexity. Moreover, timing synchronization in cooperative communications is studied, including the broadband OFDM based cooperative communication and the narrow band cooperative communication. A means of determining the optimal timing of the OFDM signal in asynchronous two way relay networks (TWRN) has been designed. A correlation based multi-delay estimation method is proposed for narrow band asynchronous cooperative communication systems. The synchronization issues covering both timing and carrier synchronization have been extensively studied in this dissertation. New synchronization methods have been proposed for the emerging transmission schemes such as high rate UWB transmission and the distributed cooperative transmission with challenges different from conventional wireless transmission schemes. / Graduate

Five studies were designed to characterize the effects of a non-steroidal aromatase inhibitor, letrozole, on ovarian function in cattle. The general hypothesis was that non-steroidal aromatase inhibitors have potential as a steroid-free option for the control of ovarian function for the purposes of fixed-time artificial insemination and embryo production. The specific objectives were to determine the effect of route and vehicle, type of aromatase inhibitor, and duration of aromatase inhibitor treatment (short vs prolonged) on ovarian follicles in cattle, and to test the efficacy of an aromatase inhibitor-based protocol to synchronize ovulation in cattle. In the first experiment, heifers were treated with letrozole intravenously (n=10) or intramuscularly (n=10) or allocated in iv and im control groups (n=5/group). During the second experiment, heifers were divided randomly into two groups (n=15/group) and an intravaginal device containing 1 g of letrozole or a blank device (control) was inserted. The third experiment was designed with the goal of formulating and testing an intravaginal device that provides biologically active circulating concentrations of an aromatase inhibitor for a minimum of 4 days. The biological significance of the pharmacokinetic differences between the letrozole intravaginal devices resulting from the third study was evaluated during the fourth study. A final study was designed to determine the effect of stage of the estrous cycle on the proportion of animals that ovulated and the synchrony of ovulation of heifers treated with an aromatase inhibitor-based ovulation-synchronization protocol and to determine subsequent pregnancy outcomes. In all the studies, the effects of aromatase inhibitor on ovarian function were assessed by transrectal ultrasound examination of the ovaries, and blood samples were collected for hormone concentration determination. Results demonstrated that route of administration, or more precisely, the nature of iii the vehicle used for the administration of letrozole (intravenous, intramuscular depot, short release intravaginal or prolonged release intravaginal) has an impact on the effects of letrozole on hormonal profiles and ovarian dynamics. The intramuscular route appeared to provide a prolonged release of letrozole from the injection site which had a marked effect on estradiol production, dominant follicle lifespan, and CL form and function. Letrozole treatment during the ovulatory follicle wave by means of a gel-based intravaginal releasing device during the second study resulted in more rapidly growing dominant follicles and larger ovulatory follicles, delayed ovulation (by 24 h) of a single follicle and formation of a CL that secreted higher levels of progesterone. A wax-based vehicle allowed for a steady and continuous delivery of the active compound over the treatment period. During the third study, the addition of a letrozole-containing gel coating increased the rate of initial absorption and hastened the increase on plasma concentrations of the active ingredient, while the letrozole-containing wax-based vehicle prolonged drug-delivery from the intravaginal device. When tested in vivo during the fourth study, we confirmed that letrozole-impregnated intravaginal devices formulated with a wax base plus a gel coat vehicle was most suitable for the application of a letrozole-based protocol for the synchronization of ovulation in cattle, since it effectively delivered elevated concentrations of letrozole, and reduced estradiol production resulting in increased follicular growth and lifespan, without adversely affecting progesterone production. The application of a letrozole-impregnated intravaginal device for 4 days, combined with PGF treatment at device removal and GnRH 24 h post-device removal increased the percentage of ovulations and synchrony of ovulation in cattle, regardless the stage of the estrous cycle at initiation of treatment. As observed in previous studies, the effects observed could be associated with an increase in circulating LH iv concentrations. However, the effects of treatment on gonadotropin concentrations are inconclusive, possibly due to inadequate sampling frequency. The impact of letrozole treatment of oocyte fertility remains unknown. The results of the five experiments support our general hypothesis that non-steroidal aromatase inhibitors have potential as a steroid-free option for the control of ovarian function in cattle. However, further research is needed in order to elucidate the effects of letrozole treatment during the proestrous on oocyte competence and fertility of the resulting ovulations in cattle.

Cognition is dynamic and complex, requiring specific sets of brain areas to cooperate for specific tasks. Neural synchronization is a proposed mechanism for transient functional integration of specific neural populations, enabling feature flexible binding and dynamic assignment of functional connectivity in the brain according to task demands. This thesis addresses the role of neural synchronization in selective attention and perceptual consciousness. The goals of this thesis are to test the hypothesis that synchronization between brain regions is relevant to network dynamics in selective attention and for perceptual organization, and to elucidate the function of synchronization in different frequency ranges. Using a selective visuospatial cuing paradigm it is shown that deploying attention to one visual hemifield yields transient long-distance gamma-band synchronization between contralateral visual cortex and other, widespread, brain regions. This is interpreted as a mechanism for establishing anticipatory biasing of communication in the cortex. Long-distance gamma synchrony, moreover, is periodically 'refreshed' at a theta rate, possibly serving to maintain this gamma network. While local alpha-band activity was found to be greater ipsilateral to the attended visual hemifield, alpha-band synchronization between primary visual cortex and higher visual areas was greater contralateral to attended locations. This suggests that local alpha synchrony is relevant for inhibition, while long-range alpha synchronization enacts functional coupling. The onset of a new conscious percept during binocular rivalry coincides with large-scale gamma-band synchronization which recurs at a theta rate. This suggests that gamma synchronization integrates features into a unified conscious percept while the theta cycle maintains that network. Using an audiovisual speech integration paradigm it is shown that large-scale gamma synchronization is greater when incongruence is detected between auditory and visual streams. This highlights an important distinction: neural synchronization reflects neural integration, not perceptual integration. Perceptual integration typically requires neural integration (feature binding), however, in this case detection of audiovisual mismatches requires cooperation within a distributed network, whereas audiovisual speech integration is largely accomplished in superior temporal cortex. These studies indicate that long-distance gamma synchronization establishes neural integration, the theta cycle maintains gamma synchronous networks, and local and long-range alpha synchrony reflect sustained inhibition and functional coupling mechanisms, respectively.

Since its introduction in the early 1980??s, the Global Positioning System (GPS) has become an important worldwide resource. Although the primary use of GPS is for position location, the inherent timing accuracy built into the system has allowed it become an important synchronisation resource for other systems. In most cases the GPS end user only requires a position estimate without awareness of the timing and synchronisation aspects of the system. A low accuracy position (at the several-metre level) with a low update rate of about 1Hz is often acceptable. However, obtaining more accurate position estimates (at the sub-metre level) at higher update rates requires the use of differential correction signals (DGPS) and greater processing power in the receiver. Furthermore, some extra challenges arise when simultaneously gathering information from a group of independently moving remote GPS receivers (rovers) at increased sampling rates (10Hz). This creates the need for a high bandwidth telemetry system and techniques to synchronise the position measurements for tracking each rover. This thesis investigates and develops an overall solution to these problems using GPS for both position location and synchronisation. A system is designed to generate relative position information from 30 or more rovers in real-time. The important contributions of this research are as follows: a) A GPS synchronised telemetry system is developed to transport GPS data from each rover. Proof of concept experiments show why a conventional RF Local Area Network (LAN) is not suitable for this application. The new telemetry system is developed using Field Programmable Gate Array (FPGA) devices to embed both the synchronising logic and the central processor. b) A new system architecture is developed to reduce the processing load of the GPS receiver. Furthermore, the need to transfer the DGPS correction data to the rover is eliminated. Instead, the receiver raw data is processed in a centralised Kalman filter to produce multiple position estimates in real-time. c) Steps are taken to optimise the telemetry data stream by using only the bare essential data from each rover. A custom protocol is developed to deliver the GPS receiver raw data to the central point with minimal latency. The central software is designed to extract and manage common elements such as satellite ephemeris data from the central reference receiver only. d) Methods are developed to make the overall system more robust by identifying and understanding the points of failure, providing fallback options to allow recovery with minimal impact. Based on the above a system is designed and integrated using a mixture of custom hardware, custom software and off-the-shelf hardware. Overall tests show that efforts to minimise latency, minimise power requirements and improve reliability have delivered good results.

This dissertation presents a novel satellite timekeeping system which does not require on-board atomic clocks as used by existing navigation satellite systems such as GPS, GLONASS or the planned GALILEO system. This concept is differentiated by the employment of a synchronization framework combined with lightweight steerable on-board clocks which act as transponders re-broadcasting the precise time remotely provided by the time synchronization network located on the ground. This allows the system to operate optimally when satellites are in direct contact with the ground station, making it suitable for a system like the Japanese Quasi-Zenith Satellite System, QZSS. Low satellite mass and low satellite manufacturing and launch cost are significant advantages of this novel system. Two possible implementations of the time synchronization network for QZSS are presented. Additionally, the problem of satellite communication interruption is analyzed and a solution is presented. Finally a positioning and timing quality analysis, aimed to provide understanding of the actual timing quality requirements for QZSS, is presented.