Indiana University-Purdue University Indianapolis (IUPUI) / Drug-Drug Interaction (DDI) is one of the major causes of adverse drug reaction (ADR) and has been demonstrated to threat public health. It causes an estimated 195,000 hospitalizations and 74,000 emergency room visits each year in the USA alone. Current DDI research aims to investigate different scopes of drug interactions: molecular level of pharmacogenetics interaction (PG), pharmacokinetics interaction (PK), and clinical pharmacodynamics consequences (PD). All three types of experiments are important, but they are playing different roles for DDI research. As diverse disciplines and varied studies are involved, interaction evidence is often not available cross all three types of evidence, which create knowledge gaps and these gaps hinder both DDI and pharmacogenetics research. In this dissertation, we proposed to distinguish the three types of DDI evidence (in vitro PK, in vivo PK, and clinical PD studies) and identify all knowledge gaps in experimental evidence for them. This is a collective intelligence effort, whereby a text mining tool will be developed for the large-scale mining and analysis of drug-interaction information such that it can be applied to retrieve, categorize, and extract the information of DDI from published literature available on PubMed. To this end, three tasks will be done in this research work: First, the needed lexica, ontology, and corpora for distinguishing three different types of studies were prepared. Despite the lexica prepared in this work, a comprehensive dictionary for drug metabolites or reaction, which is critical to in vitro PK study, is still lacking in pubic databases. Thus, second, a name entity recognition tool will be proposed to identify drug metabolites and reaction in free text. Third, text mining tools for retrieving DDI articles and extracting DDI evidence are developed. In this work, the knowledge gaps cross all three types of DDI evidence can be identified and the gaps between knowledge of molecular mechanisms underlying DDI and their clinical consequences can be closed with the result of DDI prediction using the retrieved drug gene interaction information such that we can exemplify how the tools and methods can advance DDI pharmacogenetics research. / 2 years

This research examines the relationship between quality management (QM) practices and performance in the healthcare industry via the conduct of three studies. The results of this research contribute both to advancing QM theory as well as in developing a unique text mining method that is illustrated by examining QM in the healthcare industry. Essay 1 explains the relationship between operational performance and QM practices in the healthcare industry. This study analyzed the findings from the literature using meta-analysis. We applied confirmatory semantic analysis (CSA) to examine the Baldrige winners' applications. Essay 2 examines the benefits associated with an effective QM program in the healthcare industry. This study addressed the research question about how effective QM practice results in improved hospital performance. This study compares the performance of Baldrige Award-winning hospitals with matching hospitals, state average, and national average. The results show that the Baldrige Award can lead to an increase in patient satisfaction in certain periods. Essay 3 discusses the contribution of an online clinic appointment system (OCAS) to QM practices. An enhanced trust model was built on understanding the mechanism of patients' trust formation in the OCAS. Understanding the determinants related to patients' trust and willingness to use OCAS can provide valuable guidance for medical institutions to establish health information technology-based services in the quality service improvement programs. This research has three significant contributions. First, this research analyzes the role of QM practices in the healthcare industry. Second, this research attempts to develop a unique text mining method. Third, this research provides a validated trust model and contributes to the body of research on the trust of healthcare information technology.

We all have access to large collections of digital text documents, which are useful only if we can make sense of them all and distill important information from them. Good document clustering algorithms that organize such information automatically in meaningful ways can make a difference in how effective we are at using that information. In this paper we use model-based document clustering algorithms as a base for bisecting methods in order to identify increasingly cohesive clusters from larger, more diverse clusters. We specifically use the EM algorithm and Gibbs Sampling on a mixture of multinomials as the base clustering algorithms on three data sets. Additionally, we apply a refinement step, using EM, to the final output of each clustering technique. Our results show improved agreement with human annotated document classes when compared to the existing base clustering algorithms, with marked improvement in two out of three data sets.

No description available.

No description available.

No description available.

The purpose of this dissertation was to use the technology of text mining and topic modeling to explore unobserved themes of medical case reports that involve medical imaging. Case reports have a valuable place in medical research because they provide educational benefits, offer evidence, and encourage discussions. Their form has evolved throughout the years, but they have remained a key staple in providing important information to the medical communities around the world with educational context and illuminating visuals. Examining medical case reports that have been published throughout the years on multiple medical subjects can be challenging, therefore text mining and topic modeling methods were used to analyze a large set of abstracts from medical case reports involving radiology. The total number of abstracts used for the data analysis was 68,845 that were published between the years 1975 to 2022. The findings indicate that text mining and topic modeling can offer a unique and reproducible approach to examine a large quantity of abstracts for theme analysis.

Yes / Online shopping is increasingly becoming people's first choice when shopping, as it is very convenient to choose products based on their reviews. Even for moderately popular products, there are thousands of reviews constantly being posted on e-commerce sites. Such a large volume of data constantly being generated can be considered as a big data challenge for both online businesses and consumers. That makes it difficult for buyers to go through all the reviews to make purchase decisions. In this research, we have developed models based on machine learning that can predict the helpfulness of the consumer reviews using several textual features such as polarity, subjectivity, entropy, and reading ease. The model will automatically assign helpfulness values to an initial review as soon as it is posted on the website so that the review gets a fair chance of being viewed by other buyers. The results of this study will help buyers to write better reviews and thereby assist other buyers in making their purchase decisions, as well as help businesses to improve their websites.

Vor dem Hintergrund des steigenden Interesses von computergestützter Textanalyse in Forschung und Praxis entwickelt dieser Beitrag auf Basis aktueller Literatur ein generisches Vorgehensmodell für Text-Mining-Prozesse. Das Ziel des Beitrags ist, die dabei anfallenden, umfangreichen Aktivitäten zu strukturieren und dadurch die Komplexität von Text-Mining-Vorhaben zu reduzieren. Das Forschungsziel stützt sich auf die Tatsache, dass im Rahmen einer im Vorfeld durchgeführten, systematischen Literatur-Review keine detaillierten, anwendungsneutralen Vorgehensmodelle für Text Mining identifiziert werden konnten. Aufbauend auf den Erkenntnissen der Literatur-Review enthält das resultierende Modell daher sowohl induktiv begründete Komponenten aus spezifischen Ansätzen als auch aus literaturbasierten Anforderungen deduktiv abgeleitete Bestandteile. Die Evaluation des Artefakts belegt die Nützlichkeit des Vorgehensmodells im Vergleich mit dem bisherigen Forschungsstand.

Motiviert durch den Erfolg des Web 2.0 und Social Media in vielen Bereichen des öffentlichen Lebens und der damit verbundenen Open-Innovation-Bewegung, die Kunden aktiv in den Innovationsprozess einbezieht, schlägt dieser Beitrag eine Integration von Wissensmanagement und Text Mining zur Verbesserung dieses Innovationsprozesses vor. Durch den beschriebenen Ansatz werden Kunden nicht nur motiviert, ihre Ideen und Bedürfnisse auf webbasierten Kommunikationsplattformen preiszugeben, sondern die entstehenden, textbasierten Daten können automatisiert ausgewertet und zur zielgerichteten und zeitnahen Weiterentwicklung der Produkte eingesetzt werden. Anhand zweier Anwendungsszenarien aus der Praxis werden das resultierende Prozessmodell dargestellt und dessen Potenziale veranschaulicht.