This paper studies the impacts on flight trajectories, such as lateral and vertical changes, when avoiding the formation of persistent contrails for transatlantic flights. A sophisticated Earth-System Model (EMAC) coupled with a flight routing submodel (AirTraf) and a contrail submodel (CONTRAIL) is used to optimize flight trajectories concerning the flight time and the flight distance through contrail forming regions (contrail distance). All the trajectories are calculated taking into account the effects of the actual and local meteorological parameters, e.g., wind, temperature, relative humidity, etc. A full-year simulation has been conducted based on a daily flight schedule of 103 transatlantic flights. The trade-off between the flight time and contrail distance shows a large daily variability, meaning for the same increase in flight time, the reduction in contrail distance varies from 20% to 80% depending on the daily meteorological situation. The results confirm that the overall changes in flight trajectories follow a seasonal cycle corresponding to the nature of the potential contrail coverage. In non-summer seasons, the southward and upward shifts of the trajectories are favorable to avoid the contrail formation. In summer, the northward and upward shifts are preferred. A partial mitigation strategy for up to 40% reduction in contrail distance can be achieved throughout all the seasons with a negligible increase in flight time (less than 2%), which represents a reasonable trade-off between flight time increase and contrail avoidance.

Trajectory planning is important in many applications involving unmanned aerial vehicles, underwater vehicles, spacecraft, and industrial manipulators. It is still a challenging task to rapidly find an optimal trajectory while taking into account dynamic and environmental constraints. In this dissertation, a unified, varying manifold based optimal trajectory planning method inspired by several predator-prey relationships is investigated to tackle this challenging problem. Biological species, such as hoverflies, ants, and bats, have developed many efficient hunting strategies. It is hypothesized that these types of predators only move along paths in a carefully selected manifold based on the prey’s motion in some of their hunting activities. Inspired by these studies, the predator-prey relationships are organized into a unified form and incorporated into the trajectory optimization formulation, which can reduce the computational cost in solving nonlinear constrained optimal trajectory planning problems. Specifically, three motion strategies are studied in this dissertation: motion camouflage, constant absolute target direction, and local pursuit. Necessary conditions based on the speed and obstacle avoidance constraints are derived. Strategies to tune initial guesses are proposed based on these necessary conditions to enhance the convergence rate and reduce the computational cost of the motion camouflage inspired strategy. The following simulations have been conducted to show the advantages of the proposed methods: a supersonic aircraft minimum-time-to-climb problem, a ground robot obstacle avoidance problem, and a micro air vehicle minimum time trajectory problem. The results show that the proposed methods can find the optimal solution with higher success rate and faster iv convergent speed as compared with some other popular methods. Among these three motion strategies, the method based on the local pursuit strategy has a relatively higher success rate when compared to the other two. In addition, the optimal trajectory planning method is embedded into a receding horizon framework with unknown parameters updated in each planning horizon using an Extended Kalman Filter

Spacecraft trajectory optimization is a near-infinite problem space with a wide variety of models and optimizers. As trajectory complexity increases, so too must the capabilities of modern optimizers. Common objective cost functions for these optimizers include the propellant utilized by the spacecraft and the time the spacecraft spends in flight. One effective method of minimizing these costs is the utilization of one or multiple gravity assists. Due to the phenomenon known as the Oberth effect, fuel burned at a high velocity results in a larger change in orbital energy than fuel burned at a low velocity. Since a spacecraft is flying fastest at the periapsis of its orbit, application of impulsive thrust at this closest approach is demonstrably capable of generating a greater change in orbital energy than at any other location in a trajectory. Harnessing this extra energy in order to lower relevant cost functions requires the modeling of these “powered flybys” or “powered gravity assists” (PGAs) within an interplanetary trajectory optimizer. This paper will discuss the use and modification of the Spacecraft Trajectory Optimization Suite, an optimizer built on evolutionary algorithms and the island model paradigm from the Parallel Global Multi-Objective Optimizer (PaGMO). This variant of STOpS enhances the STOpS library of tools with the capability of modeling and optimizing single and multiple powered gravity assist trajectories. Due to its functionality as a tool to optimize powered flybys, this variant of STOpS is named the Spacecraft Trajectory Optimization Suite - Flybys with Impulsive Thrust Engines (STOpS-FLITE). In three test scenarios, the PGA algorithm was able to converge to comparable or superior solutions to the unpowered gravity assist (uPGA) modeling used in previous STOpS versions, while providing extra options of trades between time of flight and propellant burned. Further, the PGA algorithm was able to find trajectories utilizing a PGA where uPGA trajectories were impossible due to limitations on time of flight and flyby altitude. Finally, STOpS-FLITE was able to converge to a uPGA trajectory when it was the most optimal solution, suggesting the algorithm does include and properly considers the uPGA case within its search space.

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Simulation of maneuvers with multibody models of rotorcraft vehicles is an important research area due to its complexity. During the maneuvering flight, some important design limitations are encountered such as maximum loads and maximum turning rates near the proximity of the flight envelope. This increases the demand on high fidelity models in order to define appropriate controls to steer the model close to the desired trajectory while staying inside the boundaries. A framework based on the hierarchical decomposition of the problem is used for this study. The system should be capable of generating the track by itself based on the given criteria and also capable of piloting the model of the vehicle along this track. The generated track must be compatible with the dynamic characteristics of the vehicle. Defining the constraints for the maneuver is of crucial importance when the vehicle is operating close to its performance boundaries. In order to make the problem computationally feasible, two models of the same vehicle are used where the reduced model captures the coarse level flight dynamics, while the fine scale comprehensive model represents the plant. The problem is defined by introducing planning layer and control layer strategies. The planning layer stands for solving the optimal control problem for a specific maneuver of a reduced vehicle model. The control layer takes the resulting optimal trajectory as an optimal reference path, then tracks it by using a non-linear model predictive formulation and accordingly steers the multibody model. Reduced models for the planning and tracking layers are adapted by using neural network approach online to optimize the predictive capabilities of planner and tracker. Optimal neural network architecture is obtained to augment the reduced model in the best way. The methodology of adaptive learning rate is experimented with different strategies. Some useful training modes and algorithms are proposed for these type of applications. It is observed that the neural network increased the predictive capabilities of the reduced model in a robust way. The proposed framework is demonstrated on a maneuvering problem by studying an obstacle avoidance example with violent pull-up and pull-down.

Dans cette thèse, nous avons étudier une méthode de classification et d'évaluation des modalités de transport utilisées par les porteurs de mobile durant leurs trajets quotidiens. Les informations de mobilité sont collectées par un opérateur au travers des logs du réseau téléphonique mobile qui fournissent des informations sur les stations de base qui ont été utilisées par un mobile durant son trajet. Les signaux (appels/SMS/3G/4G) émis par les téléphones sont une source d'information pertinente pour l'analyse de la mobilité humaine, mais au-delà de ça, ces données représentent surtout un moyen de caractériser les habitudes et les comportements humains. Bien que l'analyse des metadata permette d'acquérir des informations spatio-temporelles à une échelle sans précédent, ces données présentent aussi de nombreuses problématiques à traiter afin d'en extraire une information pertinente. Notre objectif dans cette thèse est de proposer une solution au problème de déduire la trajectoire réelle sur des réseaux de transport à partir d'observations de position obtenues grâce à l'analyse de la signalisation sur les réseaux cellulaires. Nous proposons « CT-Mapper" pour projecter les données de signalisation cellulaires recueillies auprès de smartphone sur le réseau de transport multimodal. Notre algorithme utilise un modèle de Markov caché et les propriétés topologiques des différentes couches de transport. Ensuite, nous proposons « LCT-Mapper » un algorithme qui permet de déduire le mode de transport utilisé. Pour évaluer nos algorithmes, nous avons reconstruit les réseaux de transport de Paris et de la région (Ile-de-France). Puis nous avons collecté un jeu de données de trajectoires réelles recueillies auprès d'un groupe de volontaires pendant une période de 1 mois. Les données de signalisation cellulaire de l'utilisateur ont été fournies par un opérateur français pour évaluer les performances de nos algorithmes à l'aide de données GPS. Pour conclure, nous avons montré dans ce travail qu'il est possible d'en déduire la trajectoire multimodale des utilisateurs d'une manière non supervisée. Notre réalisation permet d'étudier le comportement de mobilité multimodale de personnes et d'explorer et de contrôler le flux de la population sur le réseau de transport multicouche / Around half of the world population is living in cities where different transportation networks are cooperating together to provide some efficient transportation facilities for individuals. To improve the performance of the multimodal transportation network it is crucial to monitor and analyze the multimodal trajectories, however obtaining the multimodal mobility data is not a trivial task. GPS data with fine accuracy, is extremely expensive to collect; Additionally, GPS is not available in tunnels and underground. Recently, thanks to telecommunication advancement cellular dataset such as Call Data Records (CDRs), is a great resource of mobility data, nevertheless, this kind of dataset is noisy and sparse in time. Our objective in this thesis is to propose a solution to this challenging issue of inferring real trajectory and transportation layer from wholly cellular observation. To achieve these objectives, we use Cellular signalization data which is more frequent than CDRs and despite their spatial inaccuracy, they provide a fair source of multimodal trajectory data. We propose 'CT-Mapper’ to map cellular signalization data collected from smart phones over the multimodal transportation network. Our proposed algorithm uses Hidden Markov Model property and topological properties of different transportation layers to model an unsupervised mapping algorithm which maps sparse cellular trajectories on multilayer transportation network. Later on, we propose ‘LCT-Mapper’ an algorithm to infer the main mode of trajectories. The area of study in this research work is Paris and region (Ile-de-France); we have modeled and built the multimodal transportation network database. To evaluate our proposed algorithm, we use real trajectories data sets collected from a group of volunteers for a period of 1 month. The user's cellular signalization data was provided by a french operator to assess the performance of our proposed algorithms using GPS data as ground truth. An extensive set of evaluation has been performed to validate the proposed algorithms. To summarize, we have shown in this work that it is feasible to infer the multimodal trajectory of users in an unsupervised manner. Our achievement makes it possible to investigate the multimodal mobility behavior of people and explore and monitor the population flow over multilayer transportation network

This PhD thesis explores issues around acquired brain injury, focusing particularly on changing relationships between patients and carers and the trajectories they follow from the point of injury or diagnosis as a reconstructed life unfolds. Patients are identified as having strategies of adaptation and carers as taking on levels of agency, both of which shift according to time, context and other complex interactions. Each impacts on the other to produce an internal dynamic, the functionality of which is explored. Issues of care delivery are also raised, including the effects of mismatched expectations and of sharing or restricting information. This research is qualitative and based on the principles of grounded theory. 62 interviews were conducted involving 82 people (52 patients and 30 carers) and additional evidence was gathered from professional records, media reports and personal diaries. Themes were developed that can be linked together to form a trajectory of care, inside of which there is a finely balanced ecology. It is proposed that this trajectory although developed around data from people with brain injury is also applicable to other chronic conditions.

Dementia is increasing recognized as a major problem to public health worldwide. Prevention and treatment strategies are in critical need. Nowadays, research for dementia usually featured as complex longitudinal studies, which provide extensive information and also propose challenge to statistical methodology. The purpose of this dissertation research was to apply statistical methodology in the field of dementia to strengthen the understanding of dementia from three perspectives: 1) Application of statistical methodology to investigate the association between potential risk factors and incident dementia. 2) Application of statistical methodology to analyze changes over time, or trajectory, in cognitive tests and symptoms. 3) Application of statistical learning methods to predict development of dementia in the future. Prevention of Alzheimer’s disease with Vitamin E and Selenium (PREADViSE) (7547 subjects included) and Alzheimer’s disease Neuroimaging Initiative (ADNI) (591 participants included) were used in this dissertation. The first study, “Self-reported sleep apnea and dementia risk: Findings from the PREADViSE Alzheimer’s disease prevention trial ”, shows that self-reported baseline history of sleep apnea was borderline significantly associated with risk of dementia after adjustment for confounding. Stratified analysis by APOE ε4 carrier status showed that baseline history of sleep apnea was associated with significantly increased risk of dementia in APOE ε4 non-carriers. The second study, “comparison of trajectories of episodic memory for over 10 years between baseline normal and MCI ADNI subjects,” shows that estimated 30% normal subjects at baseline assigned to group 3 and 6 stay stable for over 9 years, and normal subjects at baseline assigned to Group 1 (18.18%) and Group 5 (16.67%) were more likely to develop into dementia. In contrast to groups identified for normal subjects, all trajectory groups for MCI subjects at baseline showed the tendency to decline. The third study, “comparison between neural network and logistic regression in PREADViSE trial,” demonstrates that neural network has slightly better predictive performance than logistic regression, and also it can reveal complex relationships among covariates. In third study, the effect of years of education on response variable depends on years of age, status of APOE ɛ4 allele and memory change.

Functional electrical stimulation (FES) involves artificial activation of paralyzed muscles via implanted electrodes. FES has been successfully used to improve the ability of tetraplegics to perform upper limb movements important for daily activities. The variety of movements that can be generated by FES is, however, limited to a few movements such as hand grasp and release. Ideally, a user of an FES system would have effortless command over all of the degrees of freedom associated with upper limb movement. One reason that a broader range of movements has not been implemented is because of the substantial challenge associated with identifying the patterns of muscle stimulation needed to elicit additional movements. The first part of this dissertation addresses this challenge by using a probabilistic algorithm to estimate the patterns of muscle activity associated with a wide range of upper limb movements.A neuroprosthetic involves the control of an external device via brain activity. Neuroprosthetics have been successfully used to improve the ability of tetraplegics to perform tasks important for interfacing with the world around them. The variety of mechanisms which they can control is, however, limited to a few devices such as special computer typing programs. Because motor areas of the cerebral cortex are known to represent and regulate voluntary arm movements it might be possible to sense this activity with electrodes and decipher this information in terms of a moment-by-moment representation of arm trajectory. Indeed, several methods for decoding neural activity have been described, but these approaches are encumbered by technical difficulties. The second part of this dissertation addresses this challenge by using similar probabilistic methods to extract arm trajectory information from electroencephalography (EEG) electrodes that are already chronically deployed and widely used in human subjects.Ultimately, the two approaches developed as part of this dissertation might serve as a flexible controller for interfacing brain activity with functional electrical stimulation systems to realize a brain-controlled upper-limb neuroprosthetic system capable of eliciting natural movements. Such a system would effectively bypass the injured region of the spinal cord and reanimate the arm, greatly increasing movement capability and independence in paralyzed individuals.